Download or read book Studies Directed Towards the Total Synthesis of Spongistatin 1 altohyrtin A and Pectenotoxin II written by Glenn C. Micalizio and published by . This book was released on 2001 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of Spongistatin 1 written by David Glenn Washburn and published by . This book was released on 1999 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of Spongistatin 1 and the Cyclitols written by Edward B. Holson and published by . This book was released on 2003 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Spongistatin 1 altohyrtin A and Siphonariid Derived Marine Natural Products written by D. Y.-K. Chen and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of spongistatin 1 and Studies Towards the Gram scale Synthesis of spongistatin 1 written by Wenyu Zhu and published by . This book was released on 2003 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of the Spongistatins written by A. Hodgson and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Toward the Enantioselective Total Synthesis of Pectenotoxin 2 written by Dmitriy A. Bondar and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Studies toward the enantioselective total synthesis of the marine natural toxin pectenotoxin 2 are described. A successful approach to a fully functionalized precursor to the C(29)-C(40) F/G sector began with the establishment of a proper stereochemical relationship between the hydroxyl and methyl substituents at C(37) and C(38) and involved an anti-aldol reaction. The F ring framework was merged by means of vinyl anion coupling. A new hydroxyl-directed hydrogenation protocol featuring ionic bonding between an alkoxide and rhodium catalyst was invented to arrest the pronounced tendency of hydroxy dihydrofurans to undergo dehydration to form more stable furans. A great level of efficiency was gained by routing the synthesis of the C(16)-C(26) subunit through a common intermediate. The carbon framework was then assembled via a Julia coupling process. The resulting double bond was oxidized by way of a Sharpless asymmetric dihydroxylation reaction to produce two new sterecenters and form the ring E tetrahydrofuranyl system. Access to the C(1)-C(15) building block was achieved by convergent coupling of a lithiated alkane to a Weinreb amide. The spirocyclic A/B motif was next constructed in a synchronous manner by two-fold p-methoxybenzyl ether deprotection. Catalytic á-hydroxylation of a conjugated double bond was called upon to complete the oxygenation pattern of this fragment. Union of the C(1)-C(15) and C(16)-C(26) fragments by means of Julia olefination led to construction of the AB(CD)E eastern hemisphere of pectenotoxin 2. Although the route to this target is far from complete, knowledge collected herein should pave the way toward completion of the total synthesis of this fascinating natural product.

Download or read book Studies Directed Towards the Total Synthesis of Bryostatin written by Erick Moran Carreira and published by . This book was released on 1990 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of Spongistatin 1 written by D. Y.-K. Chen and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Towards the Total Synthesis of Pectenotoxin 4 written by Melodie Richardson and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toward the Gram scale Total Synthesis of Spongistatin 1 written by Chris Sfouggatakis and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Toward the Total Synthesis of Spongistatin 2 written by Mark David McBriar and published by . This book was released on 1999 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Total Synthesis of the EF Fragment of Spongistatin 1 en Route to a Spongistatin 1 Analog written by Joshua Ross Infantine and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A major goal of the Leighton group is the synthesis of biologically relevant polyketide natural products. Among the most potent and chemically intriguing member of this class is spongistatin 1. This molecule has interested biologists and chemists for more than two decades. In this thesis, we report a highly practical and efficient synthesis of the EF fragment of spongistatin 1. This relied on the rapid introduction of a complex stereochemical array using double cross-metathesis/Sharpless asymmetric dihydroxylation reactions to quickly build the F-ring of spongistatin. The six contiguous stereocenters of the F-ring were established in just five steps. A new one-pot asymmetric strained-silane mediated allylation was developed that was greatly improved over previous methods in regards to practicality and substrate scope. This methodology was used to introduce the sensitive chlorodiene side chain. Finally, completion of the EF fragment led to the synthesis of a spongistatin 1 analog, using our previously developed redesigned ABCD fragment.

Download or read book Total Synthesis of Spongistatins 1 and 2 written by Jason David Katz and published by . This book was released on 2001 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of Rhizoxin written by Benjamin Eric Blass and published by . This book was released on 1994 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Part 1 Study Directed Towards the Total Synthesis of Pancratistatin written by Donald Ronald Gauthier and published by . This book was released on 1995 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies Towards the Synthesis of Spongistatin 1 written by Mark Wild and published by . This book was released on 1999 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: