Download or read book Studies Directed Towards the Total Synthesis of Macrolide Antibiotics written by Charles Tweedt Buse and published by . This book was released on 1978 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic Studies on Macrolide Antibiotics written by I. J. Burnside and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthetic and Modelling Studies on Macrolide Antibiotics written by Ian Stansfield and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of the Antibiotics actinobolin and bactobolin Intermolecular Diels alder Route to the Total Synthesis of 5 6 10 epi actinobolin written by Thaddeus R. Nieduzak and published by . This book was released on 1985 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of Bryostatin written by Erick Moran Carreira and published by . This book was released on 1990 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Total Synthesis of Macrolide Antibiotics written by John Powell Daub and published by . This book was released on 1983 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Synthesis of Ebelactone A And Maurenone written by Ravindar Kontham and published by LAP Lambert Academic Publishing. This book was released on 2012-03 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph features the studies directed towards the total synthesis of architecturally and biologically interesting polypropionate natural products (-)-Ebelactone-A and (-)-Maurenone utilizing desymmetrization as a key strategy. ( )-Ebelactone A, show structural characteristics in common with macrolide antibiotics. Ebelactones act as potent inhibitors of esterase s, lipases and N-formylmethionine amino peptidases, and they have shown to produce enhance immune responses. They are also reported to inhibit cutinases produced by fungal pathogens. Novel biological activity combined with unique and challenging structure of Ebelactone, made this compound an exciting target for the total synthesis. Secondly, this book described an efficient synthetic protocol for polypropionate natural product (-)-Maurenone, which was isolated by Faulkner et al. in 1986 from specimens of the pulmonate mollusc Siphonaria maura. This monograph is unique in dealing with many interesting synthetic protocols including full experimental procedures, analytical data for all synthetic materials and complete reference sections. This monograph can be served as a good hand book for synthetic organic chemists.

Download or read book Part A Studies Directed Towards the Total Synthesis of A 23187 Part B Formal Total Synthesis of A 23187 written by Eric L. Williams and published by . This book was released on 1980 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Recent Developments in the Total Synthesis of Macrolide Antibiotics written by and published by . This book was released on 1985 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Macrolide Antibiotics written by Satoshi Omura and published by Academic Press. This book was released on 2002-06-10 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.

Download or read book Studies Directed Towards the Total Synthesis of Rhizoxin written by Benjamin Eric Blass and published by . This book was released on 1994 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Ionophore Antibiotic X 14547A Enantioselective Synthesis of the Tetrahydropyran Unit written by Demetris Panagiotou Papahatjis and published by . This book was released on 1984 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Toward the Total Synthesis of Griseoviridin written by John Butera and published by . This book was released on 1985 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book DISCOVERY OF NOVEL MACROLIDE ANTIBIOTICS AND METHODOLOGY DEVELOPMENT OF N SULFINYL METALLODIENAMINES written by Xiao Jin and published by . This book was released on 2019 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: My Ph.D. research consists of two components: discovery of novel macrolide antibiotics and methodology development of N-sulfinyl metallodienamines. To tackle bacterial resistance, new antibiotics are desperately needed. My research objective is to address this need by designing, synthesizing, and evaluating novel macrolide antibiotics based on the best-in-class drug candidate, solithromycin. The drug discovery including following three projects: 1) Synthesis of solithromycin analogs wherein the desosamine sugar has been replaced with an acyclic amino alcohol surrogate; 2) In cellulo Click chemistry wherein the bacterial cell serves as the reaction vessel and the ribosome catalyzes the formation of triazole cycloadducts by testing different combinations of azide and alkyne fragments. One of the mechanisms of resistance to macrolide antibiotics is exemplified by methylation of A2058 by the methyltransferase encoded in erm genes. Methylation or dimethylation of A2058 leads to a steric clash with the macrolides and reduces the affinity of the macrolide for the ribosome. Thus, the bacterial resistant can be relieved via disrupting steric clashes between desosamine and A2058 residues. In 2017, I started a new project looking at the scope of the acyclic domino Michael/Mannich reaction to prepare chiral cyclohexenes developed by a previous group member, Dr. Vijay Chatare. This reaction is highly regioselective and stereoselective. Recent research showed that this reaction could be utilized on acroleins, acrylates and unsaturated ketones. Thus, we applied this useful methodology towards the concise total synthesis of (+)-ibogamine.

Download or read book Studies Directed Towards the Total Synthesis of Cyclopropano penicillins and cephalosporins written by Stephen Kane Boyer and published by . This book was released on 1976 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Towards the Total Synthesis of Sch 49 210 and Everninomicin Antibiotic 13 384 1 written by Scott Robert Conley and published by . This book was released on 1997 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Studies Directed Towards the Total Synthesis of Tedanolide written by Gregory C. Lane and published by . This book was released on 2000 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: