Download or read book Structure Mobility and Enzyme Activity in Protein polyelectrolyte Complexes written by Kevin Wayne Mattison and published by . This book was released on 2000 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physics of Protein polyelectrolyte Complexes written by Rituparna Samanta and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A mixture of proteins and polyelectrolytes are widely used in applications such as food systems, biosensors, protein purification, drug delivery. Experiments have demonstrated that the structures and phase behavior of protein-polyelectrolyte mixture can be dependent on a variety of factors, including the physical and chemical characteristics of proteins, polyelectrolytes, properties of solution, and temperature. Despite extensive experimental studies, there is still a lack of a theoretical framework to understand the fundamental physics which is capable of capturing the complexities of the phase behavior of protein-polyelectrolyte mixtures and be able to predict the impact of the component properties on the structure of these mixtures. Motivated by the lack of studies, in this thesis, we have built a single chain in mean-field based coarse-grained multibody simulation framework to study the phase behavior of protein and polyelectrolyte complexes. We have explored the influence of features such as the dielectric difference between the protein and the solvent, charge distribution of proteins, and the solution pH. Our results demonstrate that the pattern of charge heterogeneities can exert a significant influence on the resulting characteristics of the aggregates, in some cases leading to a transformation from polymer-bridged complexes to direct protein aggregates driven by attraction between oppositely charged patches. Later, we appended the framework to capture the influence of variable charge on proteins and polyelectrolytes due to variation in their dissociation characteristics in the presence of other charged species and properties of the solution. We probe the influence of charge patches on the bridging probabilities near the protein isoelectric points and in regimes in which the net charge of the protein is the same sign as that of the polyelectrolytes. Our results demonstrate that in the presence of dissociable polyelectrolytes, the probability of bridging of proteins capable of charge regulation is enhanced relative to proteins which are completely dissociated. For homogeneously charged proteins and/or proteins with weak charge heterogeneities, partially dissociated polyelectrolytes are seen to exhibit enhanced bridging characteristics compared to completely dissociated polyelectrolytes. In contrast, for proteins exhibiting strong charge heterogeneities, dissociable polyelectrolytes are seen to exhibit weaker bridging compared to completely dissociated polyelectrolytes. Upon including the feature of dielectric contrast in the model, our results demonstrated that the proteins experienced an increased repulsion with a lowering of the ratio of protein to the solvent dielectric constant. However, the influence of dielectric contrast diminishes with an increase in the particle volume fraction and/or its charge. In the presence of neutral polymers, similar effects manifest, but with the additional physics arising from the fact that the polymer-induced interactions are influenced by the dielectric contrast of the protein and solvent. Finally, we designed a framework to capture the phase diagram of the protein
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2000 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Crystal Growth Inhibition Technologies written by Zahid Amjad and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, academic researchers and technologists will find important information on the interaction of polymeric and non-polymeric inhibitors with a variety of scale forming crystals such as calcium phosphates, calcium carbonate, calcium oxalates, barium sulfate, calcium pyrophosphates, and calcium phosphonates. Moreover, the book delivers information to plant managers and formulators who would like to broaden and deepen their knowledge about processes involved in precipitation of sparingly soluble salts and learn more about the inhibitory aspects of various commercially available materials. Furthermore, experienced researchers will obtain fruitful and inspiring ideas from the easily accessible information about overlapping research areas, which will promote discoveries of new inhibitors (synthetic and/or natural) for the currently unmet challenges.
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1962 with total page 1472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods in Non Aqueous Enzymology written by Munishwar N. Gupta and published by Birkhäuser. This book was released on 2013-12-01 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extending the range of enzymatic catalysis by using non-aqueous media has now developed into a powerful approach in biochemistry and biotechnology. One peculiar feature which distinguishes it from the conventional enzymology (carried out in aqueous buffers) is that the awareness of different parameters that control and influence the behaviour of enzymes in such environments has emerged rather slowly. Science is about being able to repeat what somebody else has done. Absence of knowledge about such well-defined parameters/fac tors has sometimes made some workers rather cautious and diffident about using this approach in their laboratories. But for this, non-aqueous enzymol ogy would be more widely practised. It is these thoughts that made me feel that the availability of some well-defined protocols for various applications invol ving enzymes in non-aqueous environments would further catalyze the growth of this area. Hence this book, in which each chapter has some protocols in a specific area. The protocols are preceded by brief background material. The early chapters, which are of general importance, concern control of water ac tivity and stabilization via immobilization. Some subsequent chapters provide the protocols for transformations involving lipids and carbohydrates, peptide synthesis, and preparation of chiral compounds. The disproportionate focus on lipases is not a coincidence; this class of enzymes has been used more often than others in non-aqueous enzymology.
Download or read book Polymeric Biomaterials Structure and function written by Severian Dumitriu and published by CRC Press. This book was released on 2013 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of a bestseller, this comprehensive reference presents the latest polymer developments and most up-to-date applications of polymeric biomaterials in medicine. Expanded into two volumes, the first volume covers the structure and properties of synthetic and natural polymers as well as bioresorbable hybrid membranes, drug delivery systems, cell bioassay systems, and electrospinning for regenerative medicine. This substantially larger resource includes state-of-the-art research and successful breakthroughs in applications that have occurred in the last ten years.
Download or read book Polyelectrolytes written by Visakh P. M. and published by Springer. This book was released on 2014-09-03 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a valuable reference source to graduate and post graduate students, engineering students, research scholars polymer engineers from industry. The book provides the reader with current developments of theoretical models describing the thermodynamics polyelectrolytes as well as experimental findings. A particular emphasis is put on the rheological description of polyelectrolyte solutions and hydrogels.
Download or read book Nanozymes Next Wave of Artificial Enzymes written by Xiaoyu Wang and published by Springer. This book was released on 2016-07-27 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1994 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multilayer Thin Films written by Gero Decher and published by John Wiley & Sons. This book was released on 2012-06-11 with total page 1157 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second, comprehensive edition of the pioneering book in this fi eld has been completely revised and extended, now stretching to two volumes. The result is a comprehensive summary of layer-by-layer assembled, truly hybrid nanomaterials and thin fi lms, covering organic, inorganic, colloidal, macromolecular, and biological components, as well as the assembly of nanoscale fi lms derived from them on surfaces. These two volumes are essential for anyone working in the field, as well as scientists and researchers active in materials development, who needs the key knowledge provided herein for linking the field of molecular self-assembly with the bio- and materials sciences.
Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
Download or read book Molecular Biology written by and published by . This book was released on 1983 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cambridge Scientific Biochemistry Abstracts written by and published by . This book was released on 1989 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Viscosity of Polymer Solutions written by Miloslav Bohdanecký and published by Elsevier Science & Technology. This book was released on 1982 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
