Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features * A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher * Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Download or read book Structure and Function in Cilia and Flagella written by Peter Satir and published by . This book was released on 1956 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Flagella and Cilia written by Rustem E. Uzbekov and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motility is an inherent property of living organisms, both unicellular and multicellular. One of the principal mechanisms of cell motility is the use of peculiar biological engines flagella and cilia. These types of movers already appear in prokaryotic cells. However, despite the similar function, bacteria flagellum and eukaryote flagella have fundamentally different structures. Chapter One of this book by Drs. Meijiao Wang, Li Zhang and Hanna Li is devoted to a comparative analysis of the flagella of prokaryotes and eukaryotes.Its believed that flagellum in eukaryotic cells appeared for the first time in ancient flagellates. In Chapter Two, Drs. P. Huitorel, M. Cachon and J. Cosson summarize the results of their long-term studies of flagellum dinoflagellates. The "evolutionary invention" of the ancient flagellates proved to be so successful that the axonemal structure in flagellum has not changed for hundreds of millions of years. In the third chapter, Drs. V. Bondarenko, G. Prokopchuk and J. Cosson reported the analyses of kinetic characteristics of flagella motions in fish using the most modern methodologies.In Chapter Four, Drs. R. Uzbekov, A. Garanina, J. Burlaud-Gaillard and C. Bressac described spermiogenesis of the parasitic wasps Cotesia congregata. Their data showed that significant shortening of the flagella occurs during the formation of the mature spermatozoon and this flagella has been the shortest spermatozoon flagella described in the animal kingdom until now. Centriole in this spermatozoon is transformed into a special structure known as the "cogwheel structure" that does not contain microtubules.In the process of multicellular organism evolution, flagella, which ensure the mobility of individual cells, gave origin to two types of cilia. Motile cilia in the tissues like cerebral ventricles, respiratory epithelium and oviducts moved liquid flows relatively to immobile cell layers. The second type of cilia (primary cilia) lost motility function and acquired cellular sensitivity function. Moving and sensitive cilia grow from basal bodies, which originate from centrioles. Chapter Five by Drs. I. Alieva, C. Staub, S. Uzbekova and R. Uzbekov discusses which of the centrioles mother or daughter creates the moving cilium and sensitive cilium.In Chapter Six, Drs. D. Conkar and E. Nur Firat-Karalar describe in detail the biochemical aspects of primary cilium assembly pathways, intraflagellar transport and ectosome release. This chapter provides an overview of the trafficking pathways involved in ciliary compartmentalization and describes the primary ciliary as a sensitive "cell's antenna", participating in many regulatory processes in the cell.Defects in flagella and cilia cause many hereditary diseases. Different examples of ciliopathy are described in Chapter Seven by Drs. E. Bragina, E. Blanchard and R. Uzbekov.A wide review of experimental models, organisms and analytical methods to study flagella and cilia are presented to readers who want to learn about their main research directives.

Download or read book The Biology of Cilia and Flagella written by M. A. Sleigh and published by Elsevier. This book was released on 2016-01-11 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biology of Cilia and Flagella reviews advances in the study of cilia and flagella since 1928. This book focuses on four main topics—structure of cilia, factors that affect ciliary activity, movement of cilia and flagella, and coordination of beat of cilia. In these topics, this compilation specifically discusses the intracellular structures associated with ciliary bases; viscosity of the medium and ciliary activity, and energy relationships of cilia and flagella. The compounding of synchronously beating cilia, variations in shaft structure, and control of ciliary activity by the organism are also elaborated. This text likewise covers the determination of the rate of beat of cilia and root-fiber systems and coordination of ciliary beat. This publication is suitable for biologists and clinicians of other disciplines researching on the structure and physiology of cilia and flagella.

Download or read book Structure and Function in Cilia and Flagella Trichocystes Corps Trichocysto des Cnidocystes et Colloblastes written by Peter Satir and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Principles of Biology written by Lisa Bartee and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.

Download or read book Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. *Covers protocols for primary cilia across several systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians and scientists working in a wide range of fields

Download or read book Integrated Nano Biomechanics written by Takami Yamaguchi and published by William Andrew. This book was released on 2018-06-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated Nano-Biomechanics provides an integrated look into the rapidly evolving field of nanobiomechanics. The book demystifies the processes in living organisms at the micro- and nano-scale through mechanics, using theoretical, computational and experimental means. The book develops the concept of integrating different technologies along the hierarchical structure of biological systems and clarifies biomechanical interactions among different levels for the analysis of multi-scale pathophysiological phenomena. With a focus on nano-scale processes and biomedical applications, it is shown how knowledge obtained can be utilized in a range of areas, including diagnosis and treatment of various human diseases and alternative energy production. This book is based on collaboration of researchers from a unique combination of fields, including biomechanics, computational mechanics, GPU application, electron microscopy, biology of motile micro-organisms, entomological mechanics and clinical medicine. The book will be of great interest to scientists and researchers involved in disciplines, such as micro- and nano-engineering, bionanotechnology, biomedical engineering, micro- and nano-scale fluid-mechanics (such as in MEMS devices), nanomedicine and microbiology, as well as industries such as optical devices, computer simulation, plant based energy sources and clinical diagnosis of the gastric diseases. Provides knowledge of integrated biomechanics, focusing on nano-scale, in this rapidly growing research field Explains how the different technologies can be integrated and applied in a variety of biomedical application fields, as well as for alternative energy sources Uses a collaborative, multidisciplinary approach to provide a comprehensive coverage of nano-biomechanics

Download or read book Cilia written by Wallace F. Marshall and published by . This book was released on 2016-11-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly every cell in the human body has one or more protrusive structures called cilia or flagella. These power cell movement and fluid flow, sense the extracellular environment, coordinate cell signaling, and establish left-right asymmetry during development. Mutations in genes that encode cilia can lead to disorders known as ciliopathies. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines key aspects of ciliary biology-from the molecular to the organismal level-in normal physiology and disease. The contributors dissect the complex structures of motile and nonmotile (primary) cilia, discuss how the intraflagellar transport machinery moves cargo across the central axoneme, and review how the ciliary gate controls the composition of cilia and flagella. The roles of cilia in coordinating cellular responses to environmental stimuli via cell signaling pathways (e.g., Hedgehog) are also covered, as are physiological functions in processes such as fertilization, mucociliary clearance, and vision. The authors also survey the wide spectrum of ciliopathies, describing their genetic bases, pathogenic mechanisms, and clinical manifestations. This volume is therefore an indispensable reference for all cell and developmental biologists, as well as medical geneticists and clinical scientists wishing to understand and treat disorders involving ciliary dysfunction.

Download or read book Cell Organelles written by Reinhold G. Herrmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compartmentation of genetic information is a fundamental feature of the eukaryotic cell. The metabolic capacity of a eukaryotic (plant) cell and the steps leading to it are overwhelmingly an endeavour of a joint genetic cooperation between nucleus/cytosol, plastids, and mitochondria. Alter ation of the genetic material in anyone of these compartments or exchange of organelles between species can seriously affect harmoniously balanced growth of an organism. Although the biological significance of this genetic design has been vividly evident since the discovery of non-Mendelian inheritance by Baur and Correns at the beginning of this century, and became indisputable in principle after Renner's work on interspecific nuclear/plastid hybrids (summarized in his classical article in 1934), studies on the genetics of organelles have long suffered from the lack of respectabil ity. Non-Mendelian inheritance was considered a research sideline~ifnot a freak~by most geneticists, which becomes evident when one consults common textbooks. For instance, these have usually impeccable accounts of photosynthetic and respiratory energy conversion in chloroplasts and mitochondria, of metabolism and global circulation of the biological key elements C, N, and S, as well as of the organization, maintenance, and function of nuclear genetic information. In contrast, the heredity and molecular biology of organelles are generally treated as an adjunct, and neither goes as far as to describe the impact of the integrated genetic system.

Download or read book Flagella and Cilia written by Rustem E. Uzbekov and published by . This book was released on 2018 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motility is an inherent property of living organisms, both unicellular and multicellular. One of the principal mechanisms of cell motility is the use of peculiar biological engines - flagella and cilia. These types of movers already appear in prokaryotic cells. However, despite the similar function, bacteria flagellum and eukaryote flagella have fundamentally different structures. Chapter One of this book by Drs. Meijiao Wang, Li Zhang and Hanna Li is devoted to a comparative analysis of the flagella of prokaryotes and eukaryotes.It's believed that flagellum in eukaryotic cells appeared for the first time in ancient flagellates. In Chapter Two, Drs. P. Huitorel, M. Cachon and J. Cosson summarize the results of their long-term studies of flagellum dinoflagellates. The "evolutionary invention" of the ancient flagellates proved to be so successful that the axonemal structure in flagellum has not changed for hundreds of millions of years. In the third chapter, Drs. V. Bondarenko, G. Prokopchuk and J. Cosson reported the analyses of kinetic characteristics of flagella motions in fish using the most modern methodologies.In Chapter Four, Drs. R. Uzbekov, A. Garanina, J. Burlaud-Gaillard and C. Bressac described spermiogenesis of the parasitic wasps Cotesia congregata. Their data showed that significant shortening of the flagella occurs during the formation of the mature spermatozoon and this flagella has been the shortest spermatozoon flagella described in the animal kingdom until now. Centriole in this spermatozoon is transformed into a special structure known as the "cogwheel structure" that does not contain microtubules.In the process of multicellular organism evolution, flagella, which ensure the mobility of individual cells, gave origin to two types of cilia. Motile cilia in the tissues like cerebral ventricles, respiratory epithelium and oviducts moved liquid flows relatively to immobile cell layers. The second type of cilia (primary cilia) lost motility function and acquired cellular sensitivity function. Moving and sensitive cilia grow from basal bodies, which originate from centrioles. Chapter Five by Drs. I. Alieva, C. Staub, S. Uzbekova and R. Uzbekov discusses which of the centrioles - mother or daughter - creates the moving cilium and sensitive cilium.In Chapter Six, Drs. D. Conkar and E. Nur Firat-Karalar describe in detail the biochemical aspects of primary cilium assembly pathways, intraflagellar transport and ectosome release. This chapter provides an overview of the trafficking pathways involved in ciliary compartmentalization and describes the primary ciliary as a sensitive "cell's antenna", participating in many regulatory processes in the cell.Defects in flagella and cilia cause many hereditary diseases. Different examples of ciliopathy are described in Chapter Seven by Drs. E. Bragina, E. Blanchard and R. Uzbekov.A wide review of experimental models, organisms and analytical methods to study flagella and cilia are presented to readers who want to learn about their main research directives.

Download or read book Eukaryotic Membranes and Cytoskeleton written by Gáspár Jékely and published by Springer. This book was released on 2010-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence/absence of gene families with central roles in endomembrane and cytoskeleton dynamics in a variety of eukaryotic taxa and an understanding of eukaryote phylogeny allow the cellular machineries present in the last common ancestor of eukaryotes to be accurately reconstructed. Such a reconstruction is fundamental in order to understand eukaryotic diversification, since this is the ancestral cell from which all diversity arose. This book discusses the evolutionary origin and diversification of eukaryotic endomembranes and cytoskeleton from a cell biological and comparative genomic perspective.

Download or read book Ciliary and Flagellar Membranes written by R.A. Bloodgood and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: A volume entirely devoted to the nonaxonemal structures and functions of eukaryotic cilia and flagella. The fifteen chapters cover a wide spectrum of organisms (from protozoa and algae to birds and mammals) and an equally wide spectrum of topics (from sexual interactions in the algae to the binding

Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2018-01-07 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Download or read book Methods in Cilia and Flagella written by and published by Academic Press. This book was released on 2015-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to collect methods and protocols for studying cilia in a wide range of different cell types, so that researchers from many fields of biology can start exploring the role of cilia in their own system. Chapters are written by experts in the field Cutting-edge material