Download or read book Structural variants and interactions written by A. Henschen and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-06-04 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keine ausführliche Beschreibung für "Structural variants and interactions" verfügbar.
Download or read book Plant Genetic Resources of Ethiopia written by Jan Engels and published by Cambridge University Press. This book was released on 1991-03-21 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the world centers of crop evolution and origin, Ethiopia has long been recognized as an important area of diversity for several major and various minor crops. Based on an international conference held in Addis Ababa, this book describes how plant genetic diversity in Ethiopia is of vital importance in breeding new varieties of crops with desirable characteristics, such as increased resistance to pests and diseases and greater adaptation to heat and drought. The three main sections in the book consider the Ethiopian center of diversity, germ plasm or genetic material collection and conservation in Ethiopia, and the evaluation and utilization of Ethiopian genetic resources. A broad range of food and feed crops and plants of medicinal and industrial importance are discussed, both at a national and international level. A brief account of conservation strategies and gene bank problems unique to Ethiopia is also given. The importance of Ethiopia's plant genetic resources to world agriculture has been demonstrated on more than one occasion. Plant breeders, geneticists, and botanists throughout the world will, therefore, find this unique book a valuable source of information and an essential reference work.
Download or read book Mobile DNA II written by Nancy L. Craig and published by Amer Society for Microbiology. This book was released on 2002 with total page 1204 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extension of the original volume, reflecting the latest advances in understanding these elements. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.
Download or read book Fibrinogen Structural Variants and Interactions written by Agnes Henschen and published by . This book was released on 1985 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fibrinogen written by and published by . This book was released on 1985 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Download or read book The Tomato Genome written by Mathilde Causse and published by Springer. This book was released on 2016-11-21 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the strategy used for sequencing, assembling and annotating the tomato genome and presents the main characteristics of this sequence with a special focus on repeated sequences and the ancestral polyploidy events. It also includes the chloroplast and mitochondrial genomes. Tomato (Solanum lycopersicum) is a major crop plant as well as a model for fruit development, and the availability of the genome sequence has completely changed the paradigm of the species’ genetics and genomics. The book describes the numerous genetic and genomic resources available, the identified genes and quantitative trait locus (QTL) identified, as well as the strong synteny across Solanaceae species. Lastly, it discusses the consequences of the availability of a high-quality genome sequence of the cultivated species for the research community. It is a valuable resource for students and researchers interested in the genetics and genomics of tomato and Solanaceae.
Download or read book Genomic Disorders written by James R. Lupski and published by Springer Science & Business Media. This book was released on 2007-11-10 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.
Download or read book Algorithms for Structural Variation Discovery and Protein protein Interaction Prediction written by Iman Hajirasouliha and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis has two main parts. In the first part, we will give an introduction on human genomic sequences, next-generation sequencing technologies, the structural differences among genomes of different individuals, and the 1000 Genomes Project. We will then discuss the problems of finding novel sequence insertions and mobile element insertions (e.g. Alu elements) in sequenced genomes. To identify those genomic variations with much higher accuracy than what is currently possible, we propose to move from the current model of (1) detecting genomic variations in individual nextgeneration sequenced (NGS) donor genomes independently, and (2) checking whether two or more donor genomes, indeed, agree or disagree on the variationswe will call this model the independent structural variation detection and merging (ISV & M) framework. As an alternative, we propose a new model in which genomic variation is detected among multiple genomes simultaneously. The second part of the thesis focuses on a different project which is concerned with gene tree alignment. The aim is to present the first efficient approach to the problem of determining the interaction partners among protein/domain families. This is a hard computational problem, in particular in the presence of paralogous proteins. We devise a deterministic algorithm which directly maximizes the similarity between two leaf labeled trees with edge lengths, obtaining a score optimal alignment of the two trees in question.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Framework for K 12 Science Education written by National Research Council and published by National Academies Press. This book was released on 2012-02-28 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science, engineering, and technology permeate nearly every facet of modern life and hold the key to solving many of humanity's most pressing current and future challenges. The United States' position in the global economy is declining, in part because U.S. workers lack fundamental knowledge in these fields. To address the critical issues of U.S. competitiveness and to better prepare the workforce, A Framework for K-12 Science Education proposes a new approach to K-12 science education that will capture students' interest and provide them with the necessary foundational knowledge in the field. A Framework for K-12 Science Education outlines a broad set of expectations for students in science and engineering in grades K-12. These expectations will inform the development of new standards for K-12 science education and, subsequently, revisions to curriculum, instruction, assessment, and professional development for educators. This book identifies three dimensions that convey the core ideas and practices around which science and engineering education in these grades should be built. These three dimensions are: crosscutting concepts that unify the study of science through their common application across science and engineering; scientific and engineering practices; and disciplinary core ideas in the physical sciences, life sciences, and earth and space sciences and for engineering, technology, and the applications of science. The overarching goal is for all high school graduates to have sufficient knowledge of science and engineering to engage in public discussions on science-related issues, be careful consumers of scientific and technical information, and enter the careers of their choice. A Framework for K-12 Science Education is the first step in a process that can inform state-level decisions and achieve a research-grounded basis for improving science instruction and learning across the country. The book will guide standards developers, teachers, curriculum designers, assessment developers, state and district science administrators, and educators who teach science in informal environments.
Download or read book Computational Biomedicine written by Peter Coveney and published by Oxford University Press, USA. This book was released on 2014-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Biomedicine unifies the different strands of a broad-ranging subject to demonstrate the power of a tool that has the potential to revolutionise our understanding of the human body, and the therapeutic strategies available to maintain and protect it.
Download or read book Advances in Protein Molecular and Structural Biology Methods written by Timir Tripathi and published by Academic Press. This book was released on 2022-01-14 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. - Presents a thorough overview of the latest and emerging methods and technologies for protein study - Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy - Includes computational and machine learning methods - Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins
Download or read book Multiple Regression and Beyond written by Timothy Z. Keith and published by Routledge. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Companion Website materials: https://tzkeith.com/ Multiple Regression and Beyond offers a conceptually-oriented introduction to multiple regression (MR) analysis and structural equation modeling (SEM), along with analyses that flow naturally from those methods. By focusing on the concepts and purposes of MR and related methods, rather than the derivation and calculation of formulae, this book introduces material to students more clearly, and in a less threatening way. In addition to illuminating content necessary for coursework, the accessibility of this approach means students are more likely to be able to conduct research using MR or SEM--and more likely to use the methods wisely. This book: • Covers both MR and SEM, while explaining their relevance to one another • Includes path analysis, confirmatory factor analysis, and latent growth modeling • Makes extensive use of real-world research examples in the chapters and in the end-of-chapter exercises • Extensive use of figures and tables providing examples and illustrating key concepts and techniques New to this edition: • New chapter on mediation, moderation, and common cause • New chapter on the analysis of interactions with latent variables and multilevel SEM • Expanded coverage of advanced SEM techniques in chapters 18 through 22 • International case studies and examples • Updated instructor and student online resources
Download or read book Problems and Solutions for Strachan and Read s Human Molecular Genetics 2 written by David James Matthes and published by . This book was released on 2001 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Long Range Control of Gene Expression written by Veronica van Heyningen and published by Academic Press. This book was released on 2011-09-02 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long-Range Control of Gene Expression covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced. Discusses the evolution of cis-regulatory sequences in drosophila Includes information on genomic imprinting and imprinting defects in humans Includes a chapter on epigenetic gene regulation in cancer
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
