Download or read book Structural and Mechanistic Enzymology written by and published by Academic Press. This book was released on 2012-10-22 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design. Focuses on the recent success in structural and mechanistic enzymology Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design
Download or read book Structural and Mechanistic Enzymology written by and published by Academic Press. This book was released on 2017-07-17 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural and Mechanistic Enzymology, Volume 109, the latest release in the Advances in Protein Chemistry and Structural Biology series, is an essential resource for protein chemists. Chapters in this new volume include Collagenolytic Matrix Metalloproteinase Structure–Function Relationships: Insights from Molecular Dynamics Studies, Computational Glycobiology: Mechanistic Studies of Carbohydrate-Active Enzymes and Implication for Inhibitor Design, Computational Biochemistry─Enzyme Mechanisms Explored, and A Paradigm for C─H Bond Cleavage: Structural and Functional Aspects of Transition State Stabilization by Mandelate Racemase. This series presents new information on protocols and analysis of proteins, with each volume guest edited by leading experts in a broad range of protein-related topics. This volume presents state-of-the-art contributions, providing insights into the relationship between enzyme structure, catalysis, and function. Provides cutting-edge developments in protein chemistry and structural biology Features new information about protocols and analysis of proteins Contains chapters written by authorities in their respective fields Targeted to a wide audience of researchers, specialists and students
Download or read book Mechanistic Enzymology written by Justin M. Miller and published by ACS Symposium. This book was released on 2021-06-15 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is about Mechanistic Enzymology: Bridging Structure and Function"--
Download or read book Structural and Mechanistic Enzymology written by Christo Christov and published by Academic Press. This book was released on 2012-05-29 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Other volumes cataloged as a serial, see LCCN: 2009237250
Download or read book Enzymes written by Robert Allen Copeland and published by Wiley-VCH. This book was released on 1996 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.
Download or read book Food Enzymes written by Dominic W.S. Wong and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food Enzymes: Structure and Mechanism is the first volume to bring together current information on the structures and mechanisms of important food enzymes. It provides an in-depth discussion of the dynamic aspects of enzyme structures and their relationship to the chemistry of catalysis. The book emphasizes aspects of the chemistry of enzyme structure and mechanism seldom covered in the food science literature. It includes a thorough discussion of the genetic modification of enzyme structures and functions with reference to specific food enzymes. More than 100 illustrations enhance the clarity of important concepts. Comprehensive references reflect the current state of knowledge on enzyme actions.
Download or read book Structure and Mechanism in Protein Science written by Alan Fersht and published by . This book was released on 2017 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enzymes written by Robert A. Copeland and published by John Wiley & Sons. This book was released on 2004-04-07 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and expanded-a solid foundation for understandingexperimental enzymology. This practical, up-to-date survey is designed for a broadspectrum of biological and chemical scientists who are beginning todelve into modern enzymology. Enzymes, Second Editionexplains the structural complexities of proteins and enzymes andthe mechanisms by which enzymes perform their catalytic functions.The book provides illustrative examples from the contemporaryliterature to guide the reader through concepts and data analysisprocedures. Clear, well-written descriptions simplify the complexmathematical treatment of enzyme kinetic data, and numerouscitations at the end of each chapter enable the reader to accessthe primary literature and more in-depth treatments of specifictopics. This Second Edition of Enzymes: A Practical Introductionto Structure, Mechanism, and Data Analysis features refinedand expanded coverage of many concepts, while retaining theintroductory nature of the book. Important new featuresinclude: A new chapter on protein-ligand binding equilibria Expanded coverage of chemical mechanisms in enzyme catalysisand experimental measurements of enzyme activity Updated and refined discussions of enzyme inhibitors andmultiple substrate reactions Coverage of current practical applications to the study ofenzymology Supplemented with appendices providing contact information forsuppliers of reagents and equipment for enzyme studies, as well asa survey of useful Internet sites and computer software forenzymatic data analysis, Enzymes, Second Edition isthe ultimate practical guide for scientists and students inbiochemical, pharmaceutical, biotechnical, medicinal, andagricultural/food-related research.
Download or read book Molecular Structure and Energetics Mechanistic Principles of Enzyme Activity written by Joel F. Liebman and published by Wiley-Interscience. This book was released on 1989-01-16 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Internationally renowned experts apply from an interdisciplinary perspective mechanistic principles such as the requirements for electron transfer, the role of binding and proximity, stereoelectronic effects, and structural determination of reaction coordinates to fundamental classes of enzymatic reactions.
Download or read book Mechanistic Principles of Enzyme Activity written by Joel F. Liebman and published by Wiley-VCH. This book was released on 1988 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Folding written by C. M. Dobson and published by Cambridge University Press. This book was released on 1995 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses the molecular mechanisms controlling protein folding in vivo and in vitro.
Download or read book Enzyme Structure and Mechanism written by Alan Fersht and published by W.H. Freeman. This book was released on 1977-01-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enzymatic Plastic Degradation written by and published by Academic Press. This book was released on 2021-02-10 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymatic Plastic Degradation, Volume 648 in the Methods in Enzymology series, continues the legacy of this premier serial with chapters authored by leaders in the field. Chapters in this latest release include Evaluating plastic pollution and environmental degradation, Assessment methods for microplastic pollution in the oceans and fresh water, Exploring microbial consortia from various environments for plastic degradation, Characterization of filamentous fungi for attack on synthetic polymers via biological Fenton chemistry, Synthesis of radioactive-labeled nanoplastics for assaying the environmental (microbial) PS degradation, Exploring metagenome for plastic degrading enzymes, Cutinases from thermophilic bacteria (actinomycetes): from identification to functional and structural characterization, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Covers the latest research and technologies in enzymatic plastic degradation
Download or read book Comprehensive Natural Products Chemistry Enzymes enzyme mechanisms proteins and aspects of NO chemistry written by Derek H. R. Barton and published by Elsevier Publishing Company. This book was released on 1999 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume describes the dramatic advances in studies of the structure and function of enzymes which have led to an understanding of the rich chemistry used by nature to construct molecules and how the enzymes of natural products biosynthesis catalyze these reactions. Natural products are synthesized from simple precursors through a series of enzyme mediated reactions that are exquisitely selective and efficient. Questions about the mechanisms of these reactions and what features of enzyme catalytic sites are important for stabilizing transition states and reactive intermediates have been addressed by combining studies in mechanistic organic chemistry, structural biology, and molecular genetics. Except in rare instances, the enzymes of natural products biosynthesis are not found in abundance, and as a consequence, they are not readily available for study from natural sources. This situation has changed through the dramatic advances in gen
Download or read book RNA Helicases written by and published by Academic Press. This book was released on 2012-11-13 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes
Download or read book Evaluation of Enzyme Inhibitors in Drug Discovery written by Robert A. Copeland and published by John Wiley & Sons. This book was released on 2005-04-01 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.
Download or read book Advances in Enzymology and Related Areas of Molecular Biology Volume 76 written by Eric J. Toone and published by Wiley. This book was released on 2008-11-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological processes, and their applications in both the laboratory and industry. Each volume in the series features contributions from leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability. Volume 76 focuses on the most recent advances in the field of practical preparative enzymology. Enzymes have long been recognized and utilized for the preparation of specialty chemicals, and enzymatic resolution and desymmetrization are mainstays of the fine chemical industry. Today, some of the most intriguing enzymatic synthetic approaches involve the construction of complex pathways within cells to prepare molecules much more complex than those that can be reasonably developed in cell-free applications; this volume considers some of those processes. Koffas and coworkers provide an overview of the construction of complex biosynthetic pathways for the preparation of a variety of both fine and commodity chemicals, including biofuels. The development of highly efficient pathways involves a combination of rational design and, increasingly, evolutionary approaches, and Schmidt-Dannert reviews the use of evolutionary strategies in synthetic biology. Glycosylation of myriad biologically active species impacts both in vivo activity and ADME behavior. The addition of carbohydrate moieties to complex organic molecules represents a daunting synthetic challenge, and Williams and Thorson review the various strategies for enzymatic glycosylation of complex natural products. Finally, Pimkin and Markham review the structure, activity, and mechanism of inosine monophosphate dehydrogenase, a central enzyme of purine biosynthesis. With its wide range of topics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.
