Download or read book Stereochemical Aspects of Drug Action and Disposition written by Michel F. Eichelbaum and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.
Download or read book Toxicology in Transition written by Gisela H. Degen and published by Springer. This book was released on 2011-12-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume contains the main papers presented at the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. Toxicology has become a less descriptive science because more importance has been placed on the mechanisms underlying toxic effects. This is reflected in symposia and workshops devoted to species differences in organ toxicity, receptor-mediated toxicity and stereochemical effects of xenobiotics. Recent progress in the fields of immunotoxicology, ecotoxicology, and neurotoxicology is highlighted and documented together with the present discussion on harmonized regulatory guidelines.
Download or read book Chirality in Drug Design and Development written by Indra K. Reddy and published by CRC Press. This book was released on 2004-03-15 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.
Download or read book Advances in Drug Research written by and published by . This book was released on 1970 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Metabolism written by Mino R. Caira and published by Springer Science & Business Media. This book was released on 2006-07-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Download or read book Smith and Williams Introduction to the Principles of Drug Design and Action written by H. Jphn Smith and published by CRC Press. This book was released on 2005-10-10 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest informatio
Download or read book Differentiation of Enantiomers I written by Volker Schurig and published by Springer. This book was released on 2013-12-16 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Download or read book Advances in Drug Research written by and published by Elsevier. This book was released on 1996-07-02 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume continues the trend for Advances in Drug Research of shorter, but more frequent volumes. In line with the tradition of the series, chapters on general themes are interspersed with chapters on specific drug classes and targets.
Download or read book Drug Stereochemistry written by Irving Wainer and published by CRC Press. This book was released on 1993-02-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.
Download or read book Generic Drug Product Development written by Isadore Kanfer and published by CRC Press. This book was released on 2007-11-15 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The assessment of bioequivalence is an important process whereby the bioavailability of a generic drug product is compared with its brand-name counterpart. Generic pharmaceutical products must be approved as therapeutic equivalents to the brand name alternative in order to be interchangeable. The demonstration of bioequivalence is an important comp
Download or read book Chirality in Drug Design and Synthesis written by C. Brown and published by Academic Press. This book was released on 2013-10-22 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chirality in Drug Design and Synthesis is a collection of papers that discusses the property of asymmetry in the structural and synthetic chemistry of natural products, including the significance of chirality in medicinal chemistry. These papers examine the need for the preparation and study of pure enantiomers of chiral drug substances and their mechanism of interaction with enzymes and receptors. These papers also investigate the techniques in studying these interactions, as well as analyze the methods for their synthesis in enantiomerically pure form. One paper discusses the pharmacological and pharmacokinetic analyses made that point to the differences in the activity and disposition of enantiometric pairs. Another paper reviews the implications of the neglect of stereoselectivity at the different levels during the examination process of racemic drugs. Since no general guidelines exists for the development of drugs with chiral centers, one paper suggests a case-by-case approach in evaluating the safety and efficacy of drugs, particularly as regards how isomers differ in their effects. This collection is suitable for the pharmacologist, medicinal chemists, toxicologists, mechanistic chemists and synthetic organic chemists.
Download or read book Chirality and Biological Activity written by Hartmut Frank and published by Wiley-Liss. This book was released on 1990 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reporting on the latest advances in molecular asymmetry, it explores the development of stereochemical analysis and its applications to the biosciences. Applications to pharmacology and therapeutics, food and beverage chemistry, the study of pesticides and other zenobiotics are also covered. Chapters examine the molecular principles of chiral recognition and biological selectivity and discuss stereoselectivity in drug action and metabolism. Some of the specific issues covered include: gas and liquid chromatography of enantiomers on chiral stationary phases; stereochemical assays of chiral drugs; pyrethroid isomers; configurational modification of peptide hormones; chiral fruit flavors; and human pharmacokinetics of enantiomers administered as racemates.
Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
Download or read book Textbook of Organic Medicinal and Pharmaceutical Chemistry written by Charles Owens Wilson and published by Lippincott Williams & Wilkins. This book was released on 1977 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chirality in Drug Research written by Eric Francotte and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
Download or read book Recent Advances in Anaesthesia and Intensive Care Volume 22 written by A. P. Adams and published by Cambridge University Press. This book was released on 2002-01-12 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advances in Anaesthesia and Intensive Care 22 is the latest volume in this very successful and long-established series (previously entitled Recent Advances in Anaesthesia and Analgesia) to present a series of cutting-edge topics for anaesthetists from some of the world's leading authorities in their subjects. As the title suggests, this and future volumes will have increased input from the field of intensive care, but the emphasis will remain on producing articles of high quality and interest to the reader and providing exceptional value for money.
Download or read book Biocatalysis in the Pharmaceutical and Biotechnology Industries written by Ramesh N. Patel and published by CRC Press. This book was released on 2006-09-26 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemic
