Download or read book Statistical and Computational Pharmacogenomics written by Rongling Wu and published by CRC Press. This book was released on 2008-08-08 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the tremendous accumulation of data for genetic markers, pharmacogenomics, the study of the functions and interactions of all genes in the overall variability of drug response, is one of the hottest areas of research in biomedical science. Statistical and Computational Pharmacogenomics presents recent developments in statistical metho
Download or read book Statistical and Computational Pharmacogenomics written by Min Lin and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the tremendous accumulation of data for genetic markers, pharmacogenetics, the study of inherited variation in drug response, is one of the hottest areas of research in biomedical science. "Statistical Methods for Pharmacogenetics" presents recent developments in statistical methodology with a number of detailed worked examples that outline how these methods can be applied. The book provides the necessary background on genetics and modeling as well as the tools needed to understand and model the genetic variation for drug response. Accessible and comprehensive, it equips statisticians with a thorough understanding of this complex field and how computational skills can be employed.
Download or read book Pacific Symposium on Biocomputing 2005 written by Russ Altman and published by World Scientific. This book was released on 2005 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB 2005) is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. This latest volume in the prestigious conference series contains the contributions of top researchers from the US, the Asia-Pacific region and around the world. Sections are devoted to databases, algorithms, interfaces, visualization, modeling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The book is an essential source of ideas, discoveries and references for academics in biocomputing, bioinformatics researchers and computer scientists.The proceedings have been selected for coverage in: ? Biochemistry & Biophysics Citation Index(tm)? Index to Scientific & Technical Proceedings? (ISTP? / ISI Proceedings)? Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings)? CC Proceedings ? Biomedical, Biological & Agricultural Sciences
Download or read book Pharmacogenetics and Individualized Therapy written by Anke-Hilse Maitland-van der Zee and published by John Wiley & Sons. This book was released on 2012-04-02 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
Download or read book Biocomputing 2005 Proceedings Of The Pacific Symposium written by Russ B Altman and published by World Scientific. This book was released on 2004-12-16 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB 2005) is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. This latest volume in the prestigious conference series contains the contributions of top researchers from the US, the Asia-Pacific region and around the world. Sections are devoted to databases, algorithms, interfaces, visualization, modeling and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The book is an essential source of ideas, discoveries and references for academics in biocomputing, bioinformatics researchers and computer scientists.The proceedings have been selected for coverage in:
Download or read book Age Period Cohort Analysis written by Yang Yang and published by CRC Press. This book was released on 2016-04-19 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the ways in which statistical models, methods, and research designs can be used to open new possibilities for APC analysis. Within a single, consistent HAPC-GLMM statistical modeling framework, the authors synthesize APC models and methods for three research designs: age-by-time period tables of population rates or proportions, repeated cross-section sample surveys, and accelerated longitudinal panel studies. They show how the empirical application of the models to various problems leads to many fascinating findings on how outcome variables develop along the age, period, and cohort dimensions.
Download or read book Visualizing Data Patterns with Micromaps written by Daniel B. Carr and published by CRC Press. This book was released on 2010-04-29 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: After more than 15 years of development drawing on research in cognitive psychology, statistical graphics, computer science, and cartography, micromap designs are becoming part of mainstream statistical visualizations. Bringing together the research of two leaders in this field, Visualizing Data Patterns with Micromaps presents the many design vari
Download or read book Quantitative Methods for Precision Medicine written by Rongling Wu and published by CRC Press. This book was released on 2022-12-26 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.
Download or read book Bayesian Disease Mapping written by Andrew B. Lawson and published by CRC Press. This book was released on 2013-03-18 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition, many new Bayesian tools and methods have been developed for space-time data analysis, the predictive modeling of health outcomes, and other spatial biostatistical areas. Exploring these new developments, Bayesian Disease Mapping: Hierarchical Modeling in Spatial Epidemiology, Second Edition provides an up-to-date, cohesive account of the full range of Bayesian disease mapping methods and applications. A biostatistics professor and WHO advisor, the author illustrates the use of Bayesian hierarchical modeling in the geographical analysis of disease through a range of real-world datasets. New to the Second Edition Three new chapters on regression and ecological analysis, putative hazard modeling, and disease map surveillance Expanded material on case event modeling and spatiotemporal analysis New and updated examples Two new appendices featuring examples of integrated nested Laplace approximation (INLA) and conditional autoregressive (CAR) models In addition to these new topics, the book covers more conventional areas such as relative risk estimation, clustering, spatial survival analysis, and longitudinal analysis. After an introduction to Bayesian inference, computation, and model assessment, the text focuses on important themes, including disease map reconstruction, cluster detection, regression and ecological analysis, putative hazard modeling, analysis of multiple scales and multiple diseases, spatial survival and longitudinal studies, spatiotemporal methods, and map surveillance. It shows how Bayesian disease mapping can yield significant insights into georeferenced health data. WinBUGS and R are used throughout for data manipulation and simulation.
Download or read book Measurement Error written by John P. Buonaccorsi and published by CRC Press. This book was released on 2010-03-02 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last 20 years, comprehensive strategies for treating measurement error in complex models and accounting for the use of extra data to estimate measurement error parameters have emerged. Focusing on both established and novel approaches, Measurement Error: Models, Methods, and Applications provides an overview of the main techniques and illu
Download or read book Spatial Point Patterns written by Adrian Baddeley and published by CRC Press. This book was released on 2015-11-11 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Statistical Methodology and Software for Analyzing Spatial Point PatternsSpatial Point Patterns: Methodology and Applications with R shows scientific researchers and applied statisticians from a wide range of fields how to analyze their spatial point pattern data. Making the techniques accessible to non-mathematicians, the authors draw on th
Download or read book Mendelian Randomization written by Stephen Burgess and published by CRC Press. This book was released on 2015-03-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the Terminology and Methods of Mendelian Randomization for Epidemiological StudiesMendelian randomization uses genetic instrumental variables to make inferences about causal effects based on observational data. It, therefore, can be a reliable way of assessing the causal nature of risk factors, such as biomarkers, for a wide range of disea
Download or read book Correspondence Analysis in Practice Third Edition written by Michael Greenacre and published by CRC Press. This book was released on 2017-01-20 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on the author’s 45 years of experience in multivariate analysis, Correspondence Analysis in Practice, Third Edition, shows how the versatile method of correspondence analysis (CA) can be used for data visualization in a wide variety of situations. CA and its variants, subset CA, multiple CA and joint CA, translate two-way and multi-way tables into more readable graphical forms — ideal for applications in the social, environmental and health sciences, as well as marketing, economics, linguistics, archaeology, and more. Michael Greenacre is Professor of Statistics at the Universitat Pompeu Fabra, Barcelona, Spain, where he teaches a course, amongst others, on Data Visualization. He has authored and co-edited nine books and 80 journal articles and book chapters, mostly on correspondence analysis, the latest being Visualization and Verbalization of Data in 2015. He has given short courses in fifteen countries to environmental scientists, sociologists, data scientists and marketing professionals, and has specialized in statistics in ecology and social science.
Download or read book Design and Analysis of Quality of Life Studies in Clinical Trials written by Diane L. Fairclough and published by CRC Press. This book was released on 2010-01-07 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design Principles and Analysis Techniques for HRQoL Clinical TrialsSAS, R, and SPSS examples realistically show how to implement methods Focusing on longitudinal studies, Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition addresses design and analysis aspects in enough detail so that readers can apply statistical meth
Download or read book Flexible Imputation of Missing Data written by Stef van Buuren and published by CRC Press. This book was released on 2012-03-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Missing data form a problem in every scientific discipline, yet the techniques required to handle them are complicated and often lacking. One of the great ideas in statistical science—multiple imputation—fills gaps in the data with plausible values, the uncertainty of which is coded in the data itself. It also solves other problems, many of which are missing data problems in disguise. Flexible Imputation of Missing Data is supported by many examples using real data taken from the author's vast experience of collaborative research, and presents a practical guide for handling missing data under the framework of multiple imputation. Furthermore, detailed guidance of implementation in R using the author’s package MICE is included throughout the book. Assuming familiarity with basic statistical concepts and multivariate methods, Flexible Imputation of Missing Data is intended for two audiences: (Bio)statisticians, epidemiologists, and methodologists in the social and health sciences Substantive researchers who do not call themselves statisticians, but who possess the necessary skills to understand the principles and to follow the recipes This graduate-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by a verbal statement that explains the formula in layperson terms. Readers less concerned with the theoretical underpinnings will be able to pick up the general idea, and technical material is available for those who desire deeper understanding. The analyses can be replicated in R using a dedicated package developed by the author.
Download or read book Pharmacogenomics written by Showkat Ahmad Ganie and published by Elsevier. This book was released on 2023-06-13 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The editors lined up a group of worldwide experts to contribute to the book. Following a consistent chapter structure, the authors cover the foundational aspects of pharmacogenomics in the first four chapters of the book that include basic concepts, drug metabolism, drug discovery and development, and testing. The second part of the book is dedicated to detailed studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. Pharmacogenomics: From Discovery to Clinical Implementation is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. Researchers and graduate students in the related fields of Genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit of the structured approach of the book. - Provides an in-depth review of pharmacogenomics and its role in drug discovery/metabolism and its clinical impacts - Describes the practice of pharmacogenomics in the treatment of diabetes, cancers, cardiovascular diseases, psychiatric disorders, pulmonary diseases, infectious, gastroenterology, and autoimmune diseases - Uses a consistent chapter structure to support understanding of the fundamental concepts in the area
Download or read book Capture Recapture Methods for the Social and Medical Sciences written by Dankmar Bohning and published by CRC Press. This book was released on 2017-07-28 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capture-recapture methods have been used in biology and ecology for more than 100 years. However, it is only recently that these methods have become popular in the social and medical sciences to estimate the size of elusive populations such as illegal immigrants, illicit drug users, or people with a drinking problem. Capture-Recapture Methods for the Social and Medical Sciences brings together important developments which allow the application of these methods. It has contributions from more than 40 researchers, and is divided into eight parts, including topics such as ratio regression models, capture-recapture meta-analysis, extensions of single and multiple source models, latent variable models and Bayesian approaches. The book is suitable for everyone who is interested in applying capture-recapture methods in the social and medical sciences. Furthermore, it is also of interest to those working with capture-recapture methods in biology and ecology, as there are some important developments covered in the book that also apply to these classical application areas.
