Download or read book Statistical Analysis of High dimensional Biomedical Data a Gentle Introduction to Analytical Goals Common Approaches and Challenges written by Jörg Rahnenführer and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Background In high-dimensional data (HDD) settings, the number of variables associated with each observation is very large. Prominent examples of HDD in biomedical research include omics data with a large number of variables such as many measurements across the genome, proteome, or metabolome, as well as electronic health records data that have large numbers of variables recorded for each patient. The statistical analysis of such data requires knowledge and experience, sometimes of complex methods adapted to the respective research questions. Methods Advances in statistical methodology and machine learning methods offer new opportunities for innovative analyses of HDD, but at the same time require a deeper understanding of some fundamental statistical concepts. Topic group TG9 "High-dimensional data" of the STRATOS (STRengthening Analytical Thinking for Observational Studies) initiative provides guidance for the analysis of observational studies, addressing particular statistical challenges and opportunities for the analysis of studies involving HDD. In this overview, we discuss key aspects of HDD analysis to provide a gentle introduction for non-statisticians and for classically trained statisticians with little experience specific to HDD. Results The paper is organized with respect to subtopics that are most relevant for the analysis of HDD, in particular initial data analysis, exploratory data analysis, multiple testing, and prediction. For each subtopic, main analytical goals in HDD settings are outlined. For each of these goals, basic explanations for some commonly used analysis methods are provided. Situations are identified where traditional statistical methods cannot, or should not, be used in the HDD setting, or where adequate analytic tools are still lacking. Many key references are provided. Conclusions This review aims to provide a solid statistical foundation for researchers, including statisticians and non-statisticians, who are new to research with HDD or simply want to better evaluate and understand the results of HDD analyses
Download or read book Statistical Analysis for High Dimensional Data written by Arnoldo Frigessi and published by Springer. This book was released on 2018-03-30 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features research contributions from The Abel Symposium on Statistical Analysis for High Dimensional Data, held in Nyvågar, Lofoten, Norway, in May 2014. The focus of the symposium was on statistical and machine learning methodologies specifically developed for inference in “big data” situations, with particular reference to genomic applications. The contributors, who are among the most prominent researchers on the theory of statistics for high dimensional inference, present new theories and methods, as well as challenging applications and computational solutions. Specific themes include, among others, variable selection and screening, penalised regression, sparsity, thresholding, low dimensional structures, computational challenges, non-convex situations, learning graphical models, sparse covariance and precision matrices, semi- and non-parametric formulations, multiple testing, classification, factor models, clustering, and preselection. Highlighting cutting-edge research and casting light on future research directions, the contributions will benefit graduate students and researchers in computational biology, statistics and the machine learning community.
Download or read book Analyzing the Large Number of Variables in Biomedical and Satellite Imagery written by Phillip I. Good and published by John Wiley & Sons. This book was released on 2011-05-18 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book grew out of an online interactive offered through statcourse.com, and it soon became apparent to the author that the course was too limited in terms of time and length in light of the broad backgrounds of the enrolled students. The statisticians who took the course needed to be brought up to speed both on the biological context as well as on the specialized statistical methods needed to handle large arrays. Biologists and physicians, even though fully knowledgeable concerning the procedures used to generate microaarrays, EEGs, or MRIs, needed a full introduction to the resampling methods—the bootstrap, decision trees, and permutation tests, before the specialized methods applicable to large arrays could be introduced. As the intended audience for this book consists both of statisticians and of medical and biological research workers as well as all those research workers who make use of satellite imagery including agronomists and meteorologists, the book provides a step-by-step approach to not only the specialized methods needed to analyze the data from microarrays and images, but also to the resampling methods, step-down multi-comparison procedures, multivariate analysis, as well as data collection and pre-processing. While many alternate techniques for analysis have been introduced in the past decade, the author has selected only those techniques for which software is available along with a list of the available links from which the software may be purchased or downloaded without charge. Topical coverage includes: very large arrays; permutation tests; applying permutation tests; gathering and preparing data for analysis; multiple tests; bootstrap; applying the bootstrap; classification methods; decision trees; and applying decision trees.
Download or read book Statistical Analysis of High Dimensional Data written by Lingyan Ruan and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This century is surely the century of data (Donoho, 2000). Data analysis has been an emerging activity over the last few decades. High dimensional data is in particular more and more pervasive with the advance of massive data collection system, such as microarrays, satellite imagery, and financial data. However, analysis of high dimensional data is of challenge with the so called curse of dimensionality (Bellman 1961). This research dissertation presents several methodologies in the application of high dimensional data analysis. : The first part discusses a joint analysis of multiple microarray gene expressions. Microarray analysis dates back to Golub et al. (1999). It draws much attention after that. One common goal of microarray analysis is to determine which genes are differentially expressed. These genes behave significantly differently between groups of individuals. However, in microarray analysis, there are thousands of genes but few arrays (samples, individuals) and thus relatively low reproducibility remains. It is natural to consider joint analyses that could combine microarrays from different experiments effectively in order to achieve improved accuracy. In particular, we present a model-based approach for better identification of differentially expressed genes by incorporating data from different studies. The model can accommodate in a seamless fashion a wide range of studies including those performed at different platforms, and/or under different but overlapping biological conditions. Model-based inferences can be done in an empirical Bayes fashion. Because of the information sharing among studies, the joint analysis dramatically improves inferences based on individual analysis. Simulation studies and real data examples are presented to demonstrate the effectiveness of the proposed approach under a variety of complications that often arise in practice.
Download or read book Statistical Diagnostics for Cancer written by Matthias Dehmer and published by John Wiley & Sons. This book was released on 2012-11-28 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This ready reference discusses different methods for statistically analyzing and validating data created with high-throughput methods. As opposed to other titles, this book focusses on systems approaches, meaning that no single gene or protein forms the basis of the analysis but rather a more or less complex biological network. From a methodological point of view, the well balanced contributions describe a variety of modern supervised and unsupervised statistical methods applied to various large-scale datasets from genomics and genetics experiments. Furthermore, since the availability of sufficient computer power in recent years has shifted attention from parametric to nonparametric methods, the methods presented here make use of such computer-intensive approaches as Bootstrap, Markov Chain Monte Carlo or general resampling methods. Finally, due to the large amount of information available in public databases, a chapter on Bayesian methods is included, which also provides a systematic means to integrate this information. A welcome guide for mathematicians and the medical and basic research communities.
Download or read book Statistical Methods for the Analysis of Biomedical Data written by Robert F. Woolson and published by John Wiley & Sons. This book was released on 2002-05-23 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition adds a chapter on multiple linear regression in biomedical research, with sections including the multiple linear regressions model and least squares; the ANOVA table, parameter estimates, and confidence intervals; partial f-tests; polynomial regression; and analysis of covariance. * Organized by problem rather than method, so it guides readers to the correct technique for solving the problem at hand.
Download or read book Medical Biostatistics for Complex Diseases written by Frank Emmert-Streib and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. They are characterized by the systems properties of gene networks and their interrelations, instead of individual genes, whose malfunctioning manifests in pathological phenotypes, thus making the analysis of the resulting large data sets particularly challenging. This is why novel approaches are needed to tackle this problem efficiently on a systems level. Written by computational biologists and biostatisticians, this book is an invaluable resource for a large number of researchers working on basic but also applied aspects of biomedical data analysis emphasizing the pathway level.
Download or read book Statistical Learning for Biomedical Data written by James D. Malley and published by Cambridge University Press. This book was released on 2011-02-24 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is for anyone who has biomedical data and needs to identify variables that predict an outcome, for two-group outcomes such as tumor/not-tumor, survival/death, or response from treatment. Statistical learning machines are ideally suited to these types of prediction problems, especially if the variables being studied may not meet the assumptions of traditional techniques. Learning machines come from the world of probability and computer science but are not yet widely used in biomedical research. This introduction brings learning machine techniques to the biomedical world in an accessible way, explaining the underlying principles in nontechnical language and using extensive examples and figures. The authors connect these new methods to familiar techniques by showing how to use the learning machine models to generate smaller, more easily interpretable traditional models. Coverage includes single decision trees, multiple-tree techniques such as Random ForestsTM, neural nets, support vector machines, nearest neighbors and boosting.
Download or read book Introduction to Statistical Analysis of Laboratory Data written by Alfred Bartolucci and published by John Wiley & Sons. This book was released on 2015-11-02 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Statistical Analysis of Laboratory Data presents a detailed discussion of important statistical concepts and methods of data presentation and analysis Provides detailed discussions on statistical applications including a comprehensive package of statistical tools that are specific to the laboratory experiment process Introduces terminology used in many applications such as the interpretation of assay design and validation as well as “fit for purpose” procedures including real world examples Includes a rigorous review of statistical quality control procedures in laboratory methodologies and influences on capabilities Presents methodologies used in the areas such as method comparison procedures, limit and bias detection, outlier analysis and detecting sources of variation Analysis of robustness and ruggedness including multivariate influences on response are introduced to account for controllable/uncontrollable laboratory conditions
Download or read book Introduction to Statistics for Biomedical Engineers written by Kristina Marie Ropella and published by Morgan & Claypool Publishers. This book was released on 2007 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a bare-bones coverage of the most basic statistical analysis frequently used in biomedical engineering practice. The text introduces students to the essential vocabulary and basic concepts of probability and statistics that are required to perform the numerical summary and statistical analysis used in the biomedical field.
Download or read book Statistical Methods For Biomedical Research written by Ji-qian Fang and published by World Scientific. This book was released on 2021-03-18 with total page 1159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book consists of four parts with 32 chapters adapted for four short courses, from the basic to the advanced levels of medical statistics (biostatistics), ideal for biomedical students. Part 1 is a compulsory course of Basic Statistics with descriptive statistics, parameter estimation and hypothesis test, simple correlation and regression. Part 2 is a selective course on Study Design and Implementation with sampling survey, interventional study, observational study, diagnosis study, data sorting and article writing. Part 3 is a specially curated course of Multivariate Analyses with complex analyses of variance, variety of regressions and classical multivariate analyses. Part 4 is a seminar course on Introduction to Advanced Statistical Methods with meta-analysis, time series, item response theory, structure equation model, multi-level model, bio-informatics, genetic statistics and data mining.The main body of each chapter is followed by five practical sections: Report Writing, Case Discrimination, Computer Experiments, Frequently Asked Questions and Summary, and Practice & Think. Moreover, there are 2 attached Appendices, Appendix A includes Introductions to SPSS, Excel and R respectively, and Appendix B includes all the programs, data and printouts for Computer Experiments in addition to the Tests for Review and the reference answers for Case Discrimination as well as Practice & Think..This book can be used as a textbook for biomedical students at both under- and postgraduate levels. It can also serve as an important guide for researchers, professionals and officers in the biomedical field.
Download or read book Advances in Complex Data Modeling and Computational Methods in Statistics written by Anna Maria Paganoni and published by Springer. This book was released on 2014-11-04 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is addressed to statisticians working at the forefront of the statistical analysis of complex and high dimensional data and offers a wide variety of statistical models, computer intensive methods and applications: network inference from the analysis of high dimensional data; new developments for bootstrapping complex data; regression analysis for measuring the downsize reputational risk; statistical methods for research on the human genome dynamics; inference in non-euclidean settings and for shape data; Bayesian methods for reliability and the analysis of complex data; methodological issues in using administrative data for clinical and epidemiological research; regression models with differential regularization; geostatistical methods for mobility analysis through mobile phone data exploration. This volume is the result of a careful selection among the contributions presented at the conference "S.Co.2013: Complex data modeling and computationally intensive methods for estimation and prediction" held at the Politecnico di Milano, 2013. All the papers published here have been rigorously peer-reviewed.
Download or read book Biostatistical Methods written by Stephen W. Looney and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading biostatisticians and biomedical researchers describe many of the key techniques used to solve commonly occurring data analytic problems in molecular biology, and demonstrate how these methods can be used in the development of new markers for exposure to a risk factor or for disease outcomes. Major areas of application include microarray analysis, proteomic studies, image quantitation, genetic susceptibility and association, evaluation of new biomarkers, and power analysis and sample size.
Download or read book Health Informatics Data Analysis written by Dong Xu and published by Springer. This book was released on 2017-09-08 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of different biomedical data types, including both clinical and genomic data. Thorough explanations enable readers to explore key topics ranging from electrocardiograms to Big Data health mining and EEG analysis techniques. Each chapter offers a summary of the field and a sample analysis. Also covered are telehealth infrastructure, healthcare information association rules, methods for mass spectrometry imaging, environmental biodiversity, and the global nonlinear fitness function for protein structures. Diseases are addressed in chapters on functional annotation of lncRNAs in human disease, metabolomics characterization of human diseases, disease risk factors using SNP data and Bayesian methods, and imaging informatics for diagnostic imaging marker selection. With the exploding accumulation of Electronic Health Records (EHRs), there is an urgent need for computer-aided analysis of heterogeneous biomedical datasets. Biomedical data is notorious for its diversified scales, dimensions, and volumes, and requires interdisciplinary technologies for visual illustration and digital characterization. Various computer programs and servers have been developed for these purposes by both theoreticians and engineers. This book is an essential reference for investigating the tools available for analyzing heterogeneous biomedical data. It is designed for professionals, researchers, and practitioners in biomedical engineering, diagnostics, medical electronics, and related industries.
Download or read book Biostatistician The Comprehensive Guide written by VIRUTI SHIVAN and published by Viruti Satyan Shivan. This book was released on with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Biostatistician- The Comprehensive Guide" is an essential resource for anyone looking to delve into the intricate world of biostatistics, offering a clear, engaging, and comprehensive exploration of statistical methods in the context of biological research. This book stands out by weaving together theory and practice, enabling readers to grasp complex concepts while providing the tools needed to apply these techniques in real-world research settings. Designed for both beginners and seasoned professionals, it bridges the gap between statistical theory and its applications in biomedicine, making it a must-buy for anyone aiming to harness the power of data in life sciences. Without relying on images or illustrations, this guide focuses on the richness of written examples and the depth of explanations to ensure an accessible yet profoundly educational experience. It emphasizes practical skills, critical thinking, and the ethical considerations of biostatistical work, preparing readers not only to perform analyses but also to contribute to meaningful advancements in medical and biological research. Whether you're embarking on a career in biostatistics, seeking to improve your data analysis skills in a biological context, or aiming to make significant contributions to medical research, this book is your gateway to becoming a pivotal part of the future of life sciences.
Download or read book New Advances in Statistics and Data Science written by Ding-Geng Chen and published by Springer. This book was released on 2018-01-17 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is comprised of the presentations delivered at the 25th ICSA Applied Statistics Symposium held at the Hyatt Regency Atlanta, on June 12-15, 2016. This symposium attracted more than 700 statisticians and data scientists working in academia, government, and industry from all over the world. The theme of this conference was the “Challenge of Big Data and Applications of Statistics,” in recognition of the advent of big data era, and the symposium offered opportunities for learning, receiving inspirations from old research ideas and for developing new ones, and for promoting further research collaborations in the data sciences. The invited contributions addressed rich topics closely related to big data analysis in the data sciences, reflecting recent advances and major challenges in statistics, business statistics, and biostatistics. Subsequently, the six editors selected 19 high-quality presentations and invited the speakers to prepare full chapters for this book, which showcases new methods in statistics and data sciences, emerging theories, and case applications from statistics, data science and interdisciplinary fields. The topics covered in the book are timely and have great impact on data sciences, identifying important directions for future research, promoting advanced statistical methods in big data science, and facilitating future collaborations across disciplines and between theory and practice.
Download or read book Analyzing the Large Number of Variables in Biomedical and Satellite Imagery written by Phillip I. Good and published by John Wiley & Sons. This book was released on 2011-05-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book grew out of an online interactive offered through statcourse.com, and it soon became apparent to the author that the course was too limited in terms of time and length in light of the broad backgrounds of the enrolled students. The statisticians who took the course needed to be brought up to speed both on the biological context as well as on the specialized statistical methods needed to handle large arrays. Biologists and physicians, even though fully knowledgeable concerning the procedures used to generate microaarrays, EEGs, or MRIs, needed a full introduction to the resampling methods—the bootstrap, decision trees, and permutation tests, before the specialized methods applicable to large arrays could be introduced. As the intended audience for this book consists both of statisticians and of medical and biological research workers as well as all those research workers who make use of satellite imagery including agronomists and meteorologists, the book provides a step-by-step approach to not only the specialized methods needed to analyze the data from microarrays and images, but also to the resampling methods, step-down multi-comparison procedures, multivariate analysis, as well as data collection and pre-processing. While many alternate techniques for analysis have been introduced in the past decade, the author has selected only those techniques for which software is available along with a list of the available links from which the software may be purchased or downloaded without charge. Topical coverage includes: very large arrays; permutation tests; applying permutation tests; gathering and preparing data for analysis; multiple tests; bootstrap; applying the bootstrap; classification methods; decision trees; and applying decision trees.
