Download or read book Spermatogenesis Genetic Aspects written by Wolfgang Hennig and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spermatogenesis is one of the fundamental but at the same time also one of the most complex differentiation processes in higher eukaryotes. For a long time the development of spermatozoa has been considered as related solely to the needs of transfer of the paternal genome into the egg. Other paternal contributions to the development of the embryo were not seriously considered. Only recently has it become evident, from studies of mouse embryonic development by Solter and colleagues, that also the paternal genome carries regulatory information into the zygote since the development of a mouse embryo requires the presence of the maternal as well as of the paternal pronucleus. This means that we have to pay more attention to the development of male gametes, since the imprinting of the paternal genome obviously required for the early embryonic development must occur during male gamete development. Despite the fundamental character of sperm development as a cellular differentiation process, no coherent concepts for studies of this process exist. Many morphological, and in particular ultrastructural, details of sperm devel opment and sperm structure are known, but this knowledge has not been assembled into a consistent picture reflecting the basic features of this differ entiation process. One of the reasons for the failure to construct such a picture is the fact that also the genetics of sperm development is poorly developed. For elaborating concepts of early embryonic development the study of mutants has been, and still is, indispensible.
Download or read book Genetics of Human Infertility written by P.H. Vogt and published by Karger Medical and Scientific Publishers. This book was released on 2017-09-12 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.
Download or read book Molecular Signaling in Spermatogenesis and Male Infertility written by Rajender Singh and published by CRC Press. This book was released on 2019-11-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis
Download or read book The Genetics of Male Infertility written by Douglas T. Carrell and published by Springer Science & Business Media. This book was released on 2007-11-08 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
Download or read book Genetics of Male Infertility written by Mohamed Arafa and published by Springer Nature. This book was released on 2020-03-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique, case-based guide provides a thoughtful and comprehensive overview of the genetic basis of male infertility for the practicing clinician. In addition to discussing the molecular foundations of sperm production and the consequences of genetic abnormalities on various stages of sperm development, it examines the clinical aspects of acknowledged genetic disorders and their implications on male fertility. In so doing, it offers the necessary tools required by the clinician for the diagnosis and treatment of infertile men with genetic abnormalities. Moreover, it provides essential algorithms that may aid in counseling patients in the clinic. The text is arranged in four thematic sections for easy reference. The genetic foundation of male reproduction is presented in part 1, including regulation of sperm production, the structure of sperm chromatin, and spermatogenesis. The impact of genetic abnormalities on male infertility is the subject of part 2, covering sperm defects, mitochondrial function and DNA fragmentation. The clinical case material in part 3 illustrates real-world examples of genetic etiologies and the current diagnostic and therapeutic strategies for conditions such as vas asplasia, cryptorchidism, immotile cilia syndrome, sperm aneuploidy and other challenging scenarios. Casting forward, the fourth and final section presents an overview of future possibilities for management of genetic causes of male infertility, including gene editing. Fully exploring the clinical context of these genetic conditions in a practical manner that appeals to the practicing clinician, Genetics of Male Infertility is an exciting and essential text for reproductive medicine specialists, andrologists, urologists, researchers and all other clinicians treating infertile patients.
Download or read book Infertility in the Male written by Larry I. Lipshultz and published by Cambridge University Press. This book was released on 2009-09-24 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this canonical text on male reproductive medicine will cement the book's market-leading position. Practitioners across many specialties - including urologists, gynecologists, reproductive endocrinologists, medical endocrinologists and many in internal medicine and family practice – will see men with suboptimal fertility and reproductive problems. The book provides an excellent source of timely, well-considered information for those training in this young and rapidly evolving field. While several recent books provide targeted 'cookbooks' for those in a male reproductive laboratory, or quick reference for practising generalists, the modern, comprehensive reference providing both a background for male reproductive medicine as well as clinical practice information based on that foundation has been lacking until now. The book has been extensively revised with a particular focus on modern molecular medicine. Appropriate therapeutic interventions are highlighted throughout.
Download or read book Genetic Damage in Human Spermatozoa written by Elisabetta Baldi and published by Springer Science & Business Media. This book was released on 2013-08-16 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.
Download or read book The Nematode Caenorhabditis Elegans written by William Barry Wood and published by . This book was released on 1988 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Spermatogenesis written by and published by . This book was released on 1981 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Reproductomics written by José A. Horcajadas and published by Academic Press. This book was released on 2018-07-13 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. - Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine - Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data - Features chapter contributions by leading international experts
Download or read book The Testis written by Henry G. Burger and published by . This book was released on 1981 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Management of Male Infertility written by Giorgio Cavallini and published by Springer. This book was released on 2014-10-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasing importance. Clinicians will find that the book’s straightforward approach ensures that it can be easily and rapidly consulted.
Download or read book Sperm Biology written by Scott S. Pitnick and published by Academic Press. This book was released on 2008-11-21 with total page 683 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sperm Biology represents the first analysis of the evolutionary significance of sperm phenotypes and derived sperm traits and the possible selection pressures responsible for sperm-egg coevolution. An understanding of sperm evolution is fast developing and promises to shed light on many topics from basic reproductive biology to the evolutionary process itself as well as the sperm proteome, the sperm genome and the quantitative genetics of sperm. The Editors have identified 15 topics of current interest and biological significance to cover all aspects of this bizarre, fascinating and important subject. It comprises the most comprehensive and up-to-date review of the evolution of sperm and pointers for future research, written by experts in both sperm biology and evolutionary biology. The combination of evolution and sperm is a potent mix, and this is the definitive account. - The first review survey of this emerging field - Written by experts from a broad array of disciplines from the physiological and biomedical to the ecological and evolutionary - Sheds light on the intricacies of reproduction and the coevolution of sperm, egg and reproductive behavior
Download or read book Molecular Aspects of Spermatogenesis written by Dominic Poccia and published by Springer. This book was released on 1994 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Sperm Cell written by Christopher J. De Jonge and published by Cambridge University Press. This book was released on 2006-04-06 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 2006, this is a comprehensive and definitive account of the human male gamete. The volume summarizes many unique and revealing characteristics of the sperm cell. It provides a detailed overview of human sperm production, maturation and function, and looks at how these processes affect and influence fertility, infertility and ART. The volume thus provides a detailed review of the most important research and developments, augmented with pertinent references. This book will appeal to all practitioners and scientists in reproductive medicine and in particular to clinical scientists, graduate and post-graduate scientists, and laboratory personnel.
Download or read book Studies in Spermatogenesis written by N. M. Stevens and published by DigiCat. This book was released on 2022-11-13 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Spermatogenesis is a two part monograph written by American geneticist Nettie Maria Stevens which highlighted her increasingly promising focus of sex-determination studies and chromosomal inheritance. She observed that male mealworms produced two kinds of sperm, one with a large chromosome and one with a small chromosome. When the sperm with the large chromosome fertilized eggs, they produced female offspring, and when the sperm with the small chromosome fertilized eggs, they produced male offspring. The pair of sex chromosomes that she studied later became known as the X and Y chromosomes.
Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
