Download or read book Specificity in Biological Interactions written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a Working Group at the Pontifical Academy of Sciences, November 9-11, 1983
Download or read book Specificity in Biological Interactions written by Carols Chagas and published by . This book was released on 1984 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Specificity in Biological Interactions written by Frank R. N. Gurd and published by . This book was released on 1954 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Specificity in Biological Interactions written by and published by . This book was released on 1954 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Working Group on Specificity in Biological Interactions written by Working Group on Specificity in Biological Interactions (1983, Roma) and published by . This book was released on 1984 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Working Group on Specificity in Biological Interactions written by Carlos Chagas and published by . This book was released on 1984 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Specificity in Biological Interactions written by C. Chagas and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Specificity in Protein Protein Interactions High Throughput Characterization of Rationally Designed and Naturally Evolved Coiled Coil Networks written by William Clifford Boldridge and published by . This book was released on 2021 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the major effectors of cellular processes, proteins are crucial to all biology. Although proteins are regulated in many fashions, protein-protein interactions are ubiquitous across different classes of proteins. In particular, proteins must interact specifically with certain partners to recapitulate the biology that constitutes life, despite cells containing hundreds of thousands of proteoforms, some fraction of which are highly similar to the intended target. Understanding how specificity in protein-protein interactions occurs has been challenging to investigate because prior techniques were limited to in throughput and ability to pinpoint sequences of interest. We create a high-throughput two-hybrid assay that marries gene synthesis with a next-generation sequencing readout, allowing us to investigate only those interactions of interest with a single experiment providing a quantitative characterization of tens of thousands of interactions. We use this to first to investigate specificity in designed coiled-coils--small alpha-helical proteins which despite a simple hydrophobic interface exhibit high a high-degree of specificity. After validating our assay on a previously published set of coiled-coils, we iteratively find increasingly large sets of orthogonal proteins, proteins where each on-target interaction is specifically preferred to all off-target interactions. In total we screen more than 26,000 interactions in three experiments, and use our data and improve coiled-coil design algorithms while also finding the largest sets of orthogonal proteins to date. While specificity can be designed with large changes to the protein sequence, nature must come by specificity through the slow tinkering of evolution. To investigate the origins of specificity in nature we characterized a bZip family descended from an ancestral homodimer where the extant paralogs do not heterodimerize. We use ancestral reconstruction to trace protein-protein interactions in the coiled-coil domain across the PAR and E4BP4 family, back to the ancestor of humans and cnidarians. We find specificity does not appear once, but rather eight times across our tree, and while the process begins immediately, the final acquisition of specificity takes substantial time. Finally we find that once interactions are lost they never return, and that there is no direct selection for the acquisition of specificity between paralogs.
Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
Download or read book Computational Systems Biology written by Andres Kriete and published by Academic Press. This book was released on 2013-11-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Download or read book Protein protein Recognition written by Colin Kleanthous and published by Frontiers in Molecular Biology. This book was released on 2000 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time totry to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of formingcomplexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrincomplexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by theinteraction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.
Download or read book Research at the Intersection of the Physical and Life Sciences written by National Research Council and published by National Academies Press. This book was released on 2010-03-25 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior-concepts familiar to physicists and chemists-are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions-and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.
Download or read book The Specificity of Serological Reactions written by Karl Landsteiner and published by Courier Corporation. This book was released on 2013-09-25 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nobel prizewinner's account of experiments he and colleagues carried out on antigens and serological reactions with simple compounds. Exceptionally broad coverage of basic immunology. Extensive bibliography.
Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2018-01-07 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.
Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
