Download or read book Mathematical Modeling of the Immune System in Homeostasis Infection and Disease written by Gennady Bocharov and published by Frontiers Media SA. This book was released on 2020-02-24 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171).

Download or read book Modeling Human and Organizational Behavior written by Panel on Modeling Human Behavior and Command Decision Making: Representations for Military Simulations and published by National Academies Press. This book was released on 1998-08-14 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Simulations are widely used in the military for training personnel, analyzing proposed equipment, and rehearsing missions, and these simulations need realistic models of human behavior. This book draws together a wide variety of theoretical and applied research in human behavior modeling that can be considered for use in those simulations. It covers behavior at the individual, unit, and command level. At the individual soldier level, the topics covered include attention, learning, memory, decisionmaking, perception, situation awareness, and planning. At the unit level, the focus is on command and control. The book provides short-, medium-, and long-term goals for research and development of more realistic models of human behavior.

Download or read book Naming Game written by Guanrong Chen and published by Springer. This book was released on 2018-12-05 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a gradual introduction to the naming game, starting from the minimal naming game, where the agents have infinite memories (Chapter 2), before moving on to various new and advanced settings: the naming game with agents possessing finite-sized memories (Chapter 3); the naming game with group discussions (Chapter 4); the naming game with learning errors in communications (Chapter 5) ; the naming game on multi-community networks (Chapter 6) ; the naming game with multiple words or sentences (Chapter 7) ; and the naming game with multiple languages (Chapter 8). Presenting the authors’ own research findings and developments, the book provides a solid foundation for future advances. This self-study resource is intended for researchers, practitioners, graduate and undergraduate students in the fields of computer science, network science, linguistics, data engineering, statistical physics, social science and applied mathematics.

Download or read book Modelling of Complex Signals in Nerves written by Jüri Engelbrecht and published by Springer Nature. This book was released on 2021-05-11 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes fundamental physical principles, together with their mathematical formulations, for modelling the propagation of signals in nerve fibres. Above all, it focuses on the complex electro-mechano-thermal process that produces an ensemble of waves composed of several components, besides the action potential. These components include mechanical waves in the biomembrane and axoplasm, together with the temperature change. Pursuing a step-by-step approach, the content moves from physics and mathematics, to describing the physiological effects, and finally to modelling the coupling effects. The assumptions and hypotheses used for modelling, as well as selected helpful concepts from continuum mechanics, are systematically explained, and the modelling is illustrated using the outcomes of numerical simulation. The book is chiefly intended for researchers and graduate students, providing them with a detailed description of how to model the complex physiological processes in nerve fibres.

Download or read book Dissertation Abstracts International written by and published by . This book was released on 1996 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Spatial Analysis in Field Primatology written by Francine L. Dolins and published by Cambridge University Press. This book was released on 2021-02-18 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: A primatologist's guide to using geographic information systems (GIS); from mapping and field accuracy, to tracking travel routes and the impact of logging.

Download or read book Mathematical Modeling in the Environment written by Charles R. Hadlock and published by Cambridge University Press. This book was released on 1998 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduces some of the most important and widespread environmental issues with the emphasis throughout on fundamental principles and concepts.

Download or read book Mathematical Modelling written by Hemen Dutta and published by American Mathematical Society. This book was released on 2023-06-12 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of chapters that present several key principles and theories, as well as their potential uses in the development of mathematical models in areas like waves, thermodynamic, electromagnetics, fluid dynamics, and catastrophes. The techniques and methodologies used in this book, on the other hand, should have a long-term impact and be applicable to a wide range of different topics of study and research. Each chapter should also help readers in gaining a better knowledge of the underlying and connected concepts. The companion volume (Contemporary Mathematics, Volume 787) is devoted to theory and application.

Download or read book Mathematical Modeling and Computational Tools written by Somnath Bhattacharyya and published by Springer Nature. This book was released on 2020-04-20 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features original research papers presented at the International Conference on Computational and Applied Mathematics, held at the Indian Institute of Technology Kharagpur, India during November 23–25, 2018. This book covers various topics under applied mathematics, ranging from modeling of fluid flow, numerical techniques to physical problems, electrokinetic transport phenomenon, graph theory and optimization, stochastic modelling and machine learning. It introduces the mathematical modeling of complicated scientific problems, discusses micro- and nanoscale transport phenomena, recent development in sophisticated numerical algorithms with applications, and gives an in-depth analysis of complicated real-world problems. With contributions from internationally acclaimed academic researchers and experienced practitioners and covering interdisciplinary applications, this book is a valuable resource for researchers and students in fields of mathematics, statistics, engineering, and health care.

Download or read book The Structure of Intelligence written by Ben Goertzel and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: 0. 0 Psychology versus Complex Systems Science Over the last century, psychology has become much less of an art and much more of a science. Philosophical speculation is out; data collection is in. In many ways this has been a very positive trend. Cognitive science (Mandler, 1985) has given us scientific analyses of a variety of intelligent behaviors: short-term memory, language processing, vision processing, etc. And thanks to molecular psychology (Franklin, 1985), we now have a rudimentary understanding of the chemical processes underlying personality and mental illness. However, there is a growing feeling-particularly among non-psychologists (see e. g. Sommerhoff, 1990) - that, with the new emphasis on data collection, something important has been lost. Very little attention is paid to the question of how it all fits together. The early psychologists, and the classical philosophers of mind, were concerned with the general nature of mentality as much as with the mechanisms underlying specific phenomena. But the new, scientific psychology has made disappointingly little progress toward the resolution of these more general questions. One way to deal with this complaint is to dismiss the questions themselves. After all, one might argue, a scientific psychology cannot be expected to deal with fuzzy philosophical questions that probably have little empirical signifi cance. It is interesting that behaviorists and cognitive scientists tend to be in agreement regarding the question of the overall structure of the mind.

Download or read book Processing Symbolic Numerical Information and its Implications for Mathematics Learning written by Ricardo Moura and published by Frontiers Media SA. This book was released on 2022-06-21 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Successful Remembering and Successful Forgetting written by Aaron S. Benjamin and published by Psychology Press. This book was released on 2011-01-07 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this volume are testament to the many ways in which Robert Bjork’s ideas have shaped the course of research on human memory over four decades. It showcases the theoretical advances and recent findings by researchers whose work and careers have been influenced by Bjork. The first group of chapters explore the idea that forgetting is an adaptive response to the demands of a retrieval system fraught with competition - an idea that has helped recalibrate conceptualizations of memory away from one in which in which the computer is the dominant metaphor. Several chapters then review the application of research on learning and memory to enhancing human performance, reflecting Bjork’s staunch commitment to translating his findings and theories to real-world settings. Later chapters address topics that are relevant to the translation of cognitive psychology to human performance, and in particular recognize the critical role of metacognition in such problems. The final chapters cover a variety of issues related to how remembering can be enhanced, and how research on remembering can be profitably guided by the use of mathematical modeling. This volume will appeal to researchers and graduate students of human learning, memory, and forgetting, and will also benefit an audience working in applied domains, such as training and education.

Download or read book Guide to Automotive Connectivity and Cybersecurity written by Dietmar P.F. Möller and published by Springer. This book was released on 2019-04-03 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive text/reference presents an in-depth review of the state of the art of automotive connectivity and cybersecurity with regard to trends, technologies, innovations, and applications. The text describes the challenges of the global automotive market, clearly showing where the multitude of innovative activities fit within the overall effort of cutting-edge automotive innovations, and provides an ideal framework for understanding the complexity of automotive connectivity and cybersecurity. Topics and features: discusses the automotive market, automotive research and development, and automotive electrical/electronic and software technology; examines connected cars and autonomous vehicles, and methodological approaches to cybersecurity to avoid cyber-attacks against vehicles; provides an overview on the automotive industry that introduces the trends driving the automotive industry towards smart mobility and autonomous driving; reviews automotive research and development, offering background on the complexity involved in developing new vehicle models; describes the technologies essential for the evolution of connected cars, such as cyber-physical systems and the Internet of Things; presents case studies on Car2Go and car sharing, car hailing and ridesharing, connected parking, and advanced driver assistance systems; includes review questions and exercises at the end of each chapter. The insights offered by this practical guide will be of great value to graduate students, academic researchers and professionals in industry seeking to learn about the advanced methodologies in automotive connectivity and cybersecurity.

Download or read book Animal Cognition written by Thomas R. Zentall and published by Psychology Press. This book was released on 2013-12-02 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prepared as a tribute to Donald A. Riley, the essays that appear here are representative of a research area that has loosely been classified as animal cognition -- a categorization that reflects a functionalist philosophy that was prevalent in Riley's laboratory and that many of his students absorbed. According to this philosophy, it is acceptable to hypothesize that an animal might engage in complex processing of information, as long as one can operationalize evidence for such a process and the hypothesis can be presented in the context of testable predictions that can differentiate it from other mechanisms. The contributions to this volume represent the three most important areas of research in animal cognition -- stimulus representation, memory processes, and perceptual processes -- although current research has considerably blurred these distinctions.

Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1991 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Product Integrity and Reliability in Design written by John W. Evans and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book develops the root-cause approach to reliability - often referred to as "physics of failure" in the reliability engineering field. It approaches the subject from the point of view of a process and integrates the necessary methods to support that process. The book can be used to teach first- or second-year postgraduate students in mechanical, electrical, manufacturing and materials engineering about addressing issues of reliability during product development. It will also serve practicing engineers involved in the design and development of electrical and mechanical components and systems, as a reference.

Download or read book Mathematical Modeling toward Understanding Humans and Animals from Decision Making to Motor Controls written by Hiroshi Yamada and published by Frontiers Media SA. This book was released on 2020-12-30 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.