Download or read book Solid State Nuclear Magnetic Resonance of the HIV 1 and Influenza Fusion Peptides Associated with Membranes written by Michele L. Bodner and published by . This book was released on 2006 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Secondary Structure and Membrane Insertion of the Membrane associated Influenza Fusion Peptide Probed by Solid state Nuclear Magnetic Resonance written by Yan Sun and published by . This book was released on 2009 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solid State NMR Studies of Structure and Dynamics of Membrane Associated Influenza Fusion Peptide written by Ujjayini Ghosh and published by . This book was released on 2016 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Local Secondary Structure and Strand Arrangements of the Membrane associated HIV 1 Fusion Peptide Oligomers Probed by Solid state Nuclear Magnetic Resonance written by Zhaoxiong Zheng and published by . This book was released on 2007 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Temperature Dependence Structural Plasticity and Resonance Assignment of Uniformly Labeled HIV 1 Fusion Peptides Associated with Membranes written by Michele L. Bodner and published by . This book was released on 2003 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book High Resolution Tertiary Structure of the Membrane associated HIV Fusion Peptides by Solid State Nuclear Magnetic Resonance written by Scott Schmick and published by . This book was released on 2012 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solid State Nuclear Magnetic Resonance Studies of the Influenza Fusion Peptide Associated with Membrane Bilayers written by Paul Parkanzky and published by . This book was released on 2006 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solid state Nuclear Magnetic Resonance Studies of the Structure and Membrane Insertion of HIV Fusion Peptides written by Wei Qiang and published by . This book was released on 2009 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis Enhanced Fusogenicity and Solid State NMR Measurements of Oligomeric HIV 1 Fusion Peptide Constructs written by Rong Yang and published by . This book was released on 2005 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structural Studies of the Influenza and HIV Viral Fusion Proteins and Bacterial Inclusion Bodies written by Jaime Lyn Curtis-Fisk and published by . This book was released on 2009 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Solid state Nuclear Magnetic Resonance Structural Studies of the HIV 1 Fusion Peptide in the Membrane Environment written by Jun Yang and published by . This book was released on 2003 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Function Study of HIV and Influenza Fusion Proteins written by Shuang Liang and published by . This book was released on 2017 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lipid Domains written by and published by Academic Press. This book was released on 2015-06-08 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information
Download or read book Nuclear Magnetic Resonance written by G. A. Webb and published by Royal Society of Chemistry. This book was released on 2005 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.
Download or read book Investigation of the Structure and Dynamics of the M2 Transmembrane Peptide of the Influenza A Virus by Solid state Nuclear Magnetic Resonance written by Sarah Diane Cady and published by . This book was released on 2009 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Coordination Among Proteins Lipids and Water in Membrane Fusion and Fission Probed by Solid state NMR written by Madeleine Sutherland and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For enveloped viruses such as HIV, influenza, and coronaviruses to enter host cells, the viral and cell envelopes must be fused together. Then, to exit the cell, a new virus particle will pinch off a piece of the host cell membrane. The two membranes must be physically separated to release the virus particle. This process is called "scission" in the context of viral exit and "fission" when simply discussing membrane division." Viral membrane remodeling proteins catalyze membrane fusion and fission to bring about viral entry and exit from host cells -- vital processes in the life cycle of enveloped viruses. The exact mechanism by which membrane remodeling proteins catalyze membrane fusion and fission is not yet fully understood. The membrane remodeling proteins may take any combination of the following actions to facilitate fusion and fission: 1. Directly altering the local curvature of the membrane 2. Altering the line tension at L[subscript o]/L[subscript d] phase boundaries 3. Forming protein clusters to act collectively on the membrane 4. Altering the local composition of the membrane at the site of fusion or fission 5. Physically disrupting the lipid assemblies, i.e. by inserting protein domains into the membrane and creating membrane defects In this work, we examine the extent to which HIV's membrane fusion protein gp41, and Influenza A's membrane fission protein M2, utilize these five processes to carry out their functions. We use solid-state NMR techniques to probe intermolecular interactions along those lines, with an emphasis on curvature and clustering. The contributions of both proteins and lipids to these processes will be examined. The goal is to better understand the mechanisms of HIV entry and influenza release, which can hopefully guide the development of better therapeutics and vaccines.
Download or read book Structure and Dynamics of Full length M2 Protein of Influenza A Virus from Solid state NMR written by Shu-Yu Liao (Ph. D.) and published by . This book was released on 2017 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid-state nuclear magnetic resonance (SSNMR) has been frequently used to elucidate the structure and dynamics of membrane proteins and fibrils that are difficult to characterize by Xray crystallography or solution NMR. This thesis focuses on the structure determination and the proton conduction mechanism of the full-length matrix protein 2 (M2) of influenza A virus. The M2 membrane protein can be separated into three domains: an N-terminal ectodomain (1-2 1), an cc-helical transmembrane domain (TM) (22-46) connected to an amphipathic helix (AH) and a Cterminal cytoplasmic tail (63-97). The TM domain of M2 is responsible for proton conduction ant the ectodomain has been the target for vaccine development. The cytoplasmic tail has been implicated in M2 interaction with other viral proteins from mutagenesis studies. Given the importance of both N- and C-termini, it is essential to determine the structure and the dynamics of M2FL. Furthermore, we are interested in how the cytoplasmic tail affects proton conduction and the interaction of the anti-viral drug amantadine with M2 in the presence of the C-terminus. Using uniformly 13C, 15N-labeled M2FL, our water-selected 2D 13C-13C correlation experiment indicated that N- and C- termini are on the surface of the lipid bilayer moreover combining with chemical shift prediction, we determined that these two domains are mostly disordered. Deleting the ectodomain of M2FL (M2(21-97)) proved that a small [beta]-strand is located at the N-terminus only in the DMPC-bound state. The M2 conformation is found to be cholesterol-dependent since [beta]-strand is not found in cholesterol-rich membranes. M2(21-97) shows cationic histidine at higher pH, in contrast to M2TM, indicating that the cytoplasmic tail shifts the His37 pKa equilibria. Quantification of the 15N intensities revealed two pKa's as opposed to of four in M2TM suggesting cooperative proton binding. A possible explanation is that the large number of positively charged residues in the cytoplasmic tail facilitates proton conduction. The cytoplasmic tail was also found to restore drug-binding as amantadine no longer binds to M2(21-61) a in virus-mimetic membrane. These results have extended our understanding of the influence of the cytoplasmic domain on the structure and proton conduction of M2.
