Download or read book Sodium calcium Exchange and the Plasma Membrane in Cell Function written by André Herchuelz and published by . This book was released on 2007 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sodium Calcium Exchange and the Plasma Membrane Ca2 ATPase in Cell Function written by Andre Herchuelz and published by Wiley-Blackwell. This book was released on 2007-04-23 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ca2+ homeostasis and the plasma membrane Na+/Ca2+ exchanger are vital to many cellular functions and physiological processes. This volume, which is the proceedings of the fifth in a series of international conferences, includes contributions that merge molecular biology, biochemistry, biophysics, and physiology, providing novel insights that significantly advance our understanding of Na+/Ca2+ exchanger in areas ranging from molecular mechanisms to the involvement in human disease. Several important themes are addressed: (1) structure-function relationships of the exchanger; (2) regulation of the exchanger; (3) Na/Ca exchanger gene regulation; (4) cellular location and targeting of the exchanger; (5) NC(K)X and PMCA KO mice; (6) Na/Ca exchanger interactions with other proteins; (7) Na/Ca exchange in cardiac function; (8) Na/Ca exchange in neuronal function; (9) Ca2+-extruding mechanisms and apoptosis; (10) Na/Ca exchange in smooth muscle, kidney, and endocrine function; (11) Na/Ca exchange inhibitors: therapeutic opportunities. Experts in the field of the plasma membrane Ca2+-ATPase (PMCA) have also contributed. The rate of progress in this field has been rapidly increasing, and new concepts have emerged regarding the relation between molecular structure and physiological function. New ideas on physiological modes of regulation have been increasingly testable through the use of transgenic animal models. This volume and the conference that preceded it continue the tradition of sharing information to fuel new advances in this exciting and important area of research. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.
Download or read book Cellular and Molecular Physiology of Sodium calcium Exchange written by Jonathan Lytton and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many cellular functions and physiological processes are regulated by changes in cytoplasmic Ca2+, and the plasma membrane Na+/Ca2+ exchanger plays a prominent role in Ca2+ homeostasis in many different cell types. Despite rapid advances in our knowledge of the molecular operation of the exchanger, many intriguing issues remain unresolved, and recent discoveries have revealed certain concepts. This volume brings together contributions from an interdisciplinary group of distinguished scientists and young investigators from around the world who focus upon several emerging themes: the relationship of molecular structure to transport function; the relationship between exchanger isoforms and unique physiological roles; the physiological relevance of molecular regulation; the connection between exchanger localization and physiological function; the role of the Na+/Ca2+ exchanger in disease and as a potential therapeutic target; and the use of transgenic and gene-targeted models to unravel physiological questions.
Download or read book Store Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integration of Mitochondrial Function written by J.J. Lemasters and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: In aerobic tissues such as heart, brain, kidney, liver and brown fat, mitochon dria account for more than 20% of cell protein and play an essential role in res piration, ATP formation, ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis, thermogenesis and a variety of other metabolic activities. The mecha nisms by which these activities are integrated and regulated within the overall context of cellular physiology is of much current research interest. In order to bring together scientists examining the various diverse aspects of this overall pro blem, an International Conference on INTEGRATION OF MITOCHONDRIAL FUNC TION was held June 4-7, 1987 at the Hanes Art Center on the campus of the Uni versity of North Carolina at Chapel Hill. The chapters of this volume derive from presentations made at this conference. The focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi cant new experimental and theoretical advances concerning integration of mito chondrial function at the organelle, cell, tissue and whole organism levels of organization.
Download or read book Sodium calcium Exchange written by Donald W. Hilgemann and published by . This book was released on 1996 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume probes the underlying physiologic/biochemical processes of cellular sodium-calcium transport in cardiac function as well as in the nervous and vascular system. New methods for investigating molecular exchanger function are also discussed.
Download or read book Sodium calcium Exchange written by T. Jeff A. Allen and published by Oxford University Press, USA. This book was released on 1989 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction to the role of sodium-calcium exchange in calcium homeostasis contains a series of articles written by leading scientists which cover such topics as sodium-calcium exchange in intact cells, in photoreceptors and in sodium transporting epithelia.
Download or read book Calcium Entry Channels in Non Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Download or read book Intracellular Calcium Regulation written by Felix Bronner and published by Wiley-Liss. This book was released on 1990-03 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular Calcium Regulation Editor Felix Bronner A notable development in biological research is the recent widespread interest in the role played by calcium in cellular metabolism. Calcium homeostasis has been studied intensively for many years and mechanisms by which calcium absorption, excretion and bone deposition are effected and regulated are beginning to be understood in detail. It now appears there may exist a parallel between the maintenance and regulation of intracellular and extracellular calcium. This volume presents up-to-date information on intracellular calcium regulation and thus provides a foundation for studies that aim to explore the relationship between intracellular and extracellular calcium metabolism. Intracellular Calcium Regulation examines in detail what happens to calcium inside the cell and offers authoritative discussions on such topics as: calcium fluxes: defining the role played by the plasma membrane in regulating the cellular calcium level, the application of tracer techniques to an analysis of the cellular calcium pool, the compartments making up the pool and the rates of exchange between compartments processes of calcium entry into the cell: describing entry into cells that do not fire action potentials, as well as three types of voltage-sensitive calcium channels, including their distribution, pharmacology, molecular properties and modulation organelles, such as the endoplasmic reticulum, the Golgi complex, lysosomes, or mitochondria and their role in regulating intracellular calcium levels the new, exciting field of calcium-binding or calcium modulated proteins, such as troponin-C, parvalbumin, S-100 proteins, calbindins, and calmodulin, as well as some novel calcium-binding proteins like the 42C and 42A proteins, calcyclin and caltractin calcium efflux: analyzing the role and function of the plasma membrane calcium pump and the Na+/Ca2+ exchanger, including the kinetics of ATP hydrolysis, how calcium transport and ATP hydrolysis are linked, the kinetics and properties of the sodium-calcium exchange, its regulation and role in such specialized cells as retinal rods and cardiac myocytes calcium transport as carried out by resting, stimulated and excitable cells with emphasis on activated phospholipase C, involvement of the G proteins and protein kinase C calcium transport as carried out by the specialized transport cells of intestine and kidney, entry via calcium channels, intracellular diffusion as facilitated by the calcium-binding proteins, and extrusion via the Ca-ATPase. Intracellular Calcium Regulation will be of interest to researchers and graduate students in the areas of biochemistry, biophysics, cell biology, nutrition, gastroenterology, nephrology and anatomy.
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Channels Carriers and Pumps written by Wilfred D. Stein and published by Elsevier. This book was released on 2014-12-09 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered. Provides an introduction to the properties of transport proteins: channels, carriers, and pumps Presents up-to-date information on the structure of transport proteins and on their function and regulation Includes introductions to transport kinetics and to the cloning of genes that code transport proteins Furnishes a link between the experimental basis of the subject and theoretical model building
Download or read book Anatomy Physiology written by Lindsay Biga and published by . This book was released on 2019-09-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A version of the OpenStax text
Download or read book Endogenous Neuroprotection written by Bernhard Schaller and published by Nova Publishers. This book was released on 2008 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endogenous neuoprotection is a phenomenon where a brief episode of ischemia renders the brain resistant against a subsequent longer-asting ischemia event. Experimentally, the author was able to model hypoxic preconditioning in animal model. Increasing knowledge of this endogenous neuroprotectin by ischemic tolerance may help to minimize neuronal damage following ischemic stroke and hypoxic encephalopathy. This book is, therefore, the first overview of this important topic and will certainly influence further investigations in clinical and neuroscience research.
Download or read book Multiple Sclerosis As A Neuronal Disease written by Stephen Waxman and published by Elsevier. This book was released on 2005-05-27 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities. * Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis* Places MS in a new and important perspective that promises to open up new therapeutic avenues* Superbly illustrated and referenced
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
