Download or read book Skeletal Muscle Immunometabolism written by Nicolas J. Pillon and published by Frontiers Media SA. This book was released on 2021-06-29 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Essential Aspects of Immunometabolism in Health and Disease written by Niels Olsen Saraiva Camara and published by Springer Nature. This book was released on 2021-10-21 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.
Download or read book Skeletal Muscle as a Therapeutic Target for Natural Products to Reverse Metabolic Syndrome written by Sithandiwe Eunice Mazibuko-Mbeje and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural compounds, especially polyphenols have become a popular area of research mainly due to their apparent health benefits. Increasing the phenolic content of a diet, apart from its antioxidant benefit, has a beneficial effect on signaling molecules involved in carbohydrate and lipid metabolism. These effects could potentially protect against metabolic syndrome, a cluster of metabolic complications such as obesity, insulin resistance and type 2 diabetes that is characterized by a dysregulated carbohydrate, and lipid metabolism. Research continues to investigate various natural compounds for their amelioration of impaired signaling mechanisms that may lead to dysregulated metabolism to find means to improve the life expectancy of patients with metabolic syndrome. In this chapter, a systematic search through major databases such as MEDLINE/PubMed, EMBASE, and Google Scholar of literature reporting on the ameliorative potential of commonly investigated natural products that target skeletal muscle to ameliorate metabolic syndrome associated complications was conducted. The selected natural products that are discussed include apigenin, aspalathin, berberine, curcumin, epigallocatechin gallate, hesperidin, luteolin, naringenin, quercetin, resveratrol, rutin, and sulforaphane.
Download or read book Muscles as Molecular and Metabolic Machines written by Peter W. Hochachka and published by CRC Press. This book was released on 2019-06-04 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1994, this book explores the paradigm of muscles as molecular and metabolic machines in which all structures and functions are exquisitely integrated and matched to each other. The analysis begins with a standard reductionist approach-reviewing the integrated machine parts. The key working components of the complete muscle machine are proteins (soluble, organelle, or membrane localized), and a conservative count indicates that today more than 100 such machine parts are known, essentially all occurring as cell specific isoforms. Random assortment of these machine parts or protein isoforms could generate an astronomical number of "muscle machines" and an equally enormous number of muscle fiber types. The question is, why aren't such large numbers ever seen? To attack this problem, the reductionist approach is complemented with an integrationist/adaptational one. Evidence is presented that the more highly specialized the muscle type, the further one moves from the above extreme; in the most highly specialized muscles, typically only one fiber type is found. It is argued that instead of random assortment of isoforms or machine parts, only specific and often unique combinations can work in appropriate fashion. A few established examples of this fundamental principle are reviewed, but emphasis is placed on the fact that we know dreadfully little about why this is so and what kinds of further studies are needed. The issue of why the very large numbers of fiber types theoretically possible are never even approximately realized has never before been addressed. Indeed, it is rarely recognized. Muscles as Molecular and Metabolic Machines is the first work of its kind on the subject.
Download or read book Skeletal Muscle written by Victor R. Preedy and published by Cambridge University Press. This book was released on 2002-01-04 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic and functional impairments in skeletal muscle occur frequently, often in diverse conditions and each with different aetiologies, methods of diagnosis and treatment. This comprehensive text brings the complex facets of skeletal muscle pathology, diagnosis and management together.
Download or read book Noninvasive Evaluation of Metabolic Capacities in Human Skeletal Muscles written by Glenn A. Walter and published by . This book was released on 1997 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathways Controlling Metabolic and Hypertrophic Responses in Skeletal Muscle written by and published by . This book was released on 2015 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Skeletal Muscle Damage and Repair written by Peter M. Tiidus and published by Human Kinetics. This book was released on 2008 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempts to cover a wide range of both basic research and applied clinical topics related to skeletal muscle damage and repair mechanisms and their application. This book examines muscle damage and repair mechanisms and issues in specific populations including older adults and special populations.
Download or read book Metabolic and Contractile Properties of in Situ Skeletal Muscle in 2 deoxyglucose Treated Rats written by David Michael Carattini and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms Regulating Metabolic and Mitogenic Events in Skeletal Muscle written by Jeffrey W. Ryder and published by . This book was released on 2000 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Insulin Action written by Ashok K. Srivastava and published by Springer Science & Business Media. This book was released on 1998-05-31 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996 the 75th anniversary of the discovery of insulin was celebrated at the University of Toronto, the scene of that discovery in 1921. This volume was stimulated by the scientific program which was staged at that time and brought together much of the world's best talent to discuss and analyze the most recent developments in our understanding of pancreatic function, insulin secretion, the interaction of insulin with its target tissues, the mechanism of insulin action at the cellular level, and the defects which underlie both Type I (insulin-dependent diabetes mellitus, IDDM) and Type II (noninsulin-dependent diabetes mellitus, NIDDM) forms of the disease. We have chosen to focus the present volume on work related to insulin action.
Download or read book Study of Molecular and Metabolic Changes in Skeletal Muscle in Response to Cancer written by Cynthia Stretch and published by . This book was released on 2013 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, wasting of skeletal muscle driven by reduced food intake and abnormal metabolism. Cachexia has a negative impact on quality of life, response to chemotherapy and survival. Cachexia research is undeveloped with respect to understanding molecular changes involved and its classification / diagnostic criteria (there are no clinically useful predictors and diagnostic tests). The purpose of this research was to take advantage of gene expression (transcriptomic) and metabolite (metabolomic) profiling to address these gaps. Patients with cancer consented to provide skeletal muscle biopsy (n=134) for gene expression array or plasma and urine (n=93) for nuclear magnetic resonance spectroscopy and mass spectrometry. Omic data output was examined in relation to different dimensions of cachexia phenotype; gene expression was examined in relation to weight loss, muscle mass and muscle radiation attenuation and metabolites were examined in relation to muscle loss, muscle and fat mass, metabolic rate and food intake. Statistical analysis included standard statistical tests and machine learning methods. Muscle gene expression varied strongly in relation to muscle attenuation, and to a much lesser degree with weight loss and muscle mass. Differential expression suggests low attenuation muscle has persistent inflammation, increased degradation, altered energy metabolism, increased extracellular matrix components and altered growth signalling. Urinary metabolites reflected muscle mass and to a lesser extent fat mass, and could be used to predict muscle mass and rate of muscle loss with 98% and 82% accuracy, respectively. Urinary metabolites related to muscle mass and muscle loss were associated with amino acid and ATP synthesis. Overall, transcriptomics work revealed a molecular signature for low muscle attenuation, which parallels many gene expression changes observed during aberrant muscle repair and metabolic syndrome. This explorative transcriptomic study provides multiple potentially crucial pathways that have yet to be studied in detail in cachexia. Metabolomics work revealed that urine metabolites are most reflective of muscle mass and its change. This work suggests that it may be possible to develop a metabolomics-based tool to assess skeletal muscle mass in cancer. Validation of urine metabolomics to predict muscle mass loss is warranted.
Download or read book Metabolic and Mitogenic Signal Transduction Cascades in Skeletal Muscle written by Mei Yu and published by . This book was released on 2003 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Metabolic Fates of Amino Acids in Skeletal Muscle written by Tse-Wen Chang and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Multi Scale Examination of Skeletal Muscle s Contribution to Local and Systemic Immunomodulation written by Joseph J. Bivona (III) and published by . This book was released on 2022 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The innate immune system requires input from a myriad of tissues and cell types to adequately prepare, locate, and neutralize infections. Skeletal muscle's widespread distribution throughout the body and its potent ability to secrete cytokines makes it a vital signaling organ to alert the immune system during both localized and systemic injuries and illnesses. This dissertation first deciphers the crosstalk between skeletal muscle myocytes and macrophages during acute lung injury, reporting the macrophage-derived cytokine, tumor necrosis factor [alpha], to be necessary for eliciting the full potential of the skeletal muscle inflammatory milieu. Next, the total contribution of skeletal muscle mediators is quantified using muscle specific knockouts for toll-like receptor 4, interleukin-6, and C-C motif chemokine ligand 2. These novel mouse strains allow for targeted ablation of the receptor and effector molecules involved in endotoxemia specifically in myocytes, providing insight on the proportion of inflammatory cytokines derived from these muscle cells. Finally, to improve skeletal muscle and exercise research, a novel, open-source mouse exercise wheel is presented that allows for controllable and trackable experimentation. This device improves upon existing methods by allowing researchers to limit animals based on time- and distance- milestones. Together, these data provide a comprehensive examination spanning from molecular signaling to animal modeling of the mechanisms and magnitude to which skeletal muscle regulates immune homeostasis.
Download or read book Contractile and Metabolic Protein Adaptations in Skeletal Muscle During Increased Functional Demand written by William Oliver Kline and published by . This book was released on 1996 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Exercise Immunology written by Bente Klarlund Pedersen and published by . This book was released on 1997-01-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
