Download or read book Sirtuin Biology in Medicine written by Kenneth Maiese and published by Academic Press. This book was released on 2021-03-04 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease Details the basic and clinical role of sirtuins for the development of new clinical treatments Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Download or read book Sirtuins written by Riekelt H. Houtkooper and published by Springer. This book was released on 2016-11-17 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Download or read book Sirtuin Biology in Cancer and Metabolic Disease written by Kenneth Maiese and published by Academic Press. This book was released on 2021-03-11 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Download or read book Sirtuin Biology in Cancer and Metabolic Disease written by Kenneth Maiese and published by Elsevier. This book was released on 2021-02-20 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Download or read book Sirtuins in Biology and Disease written by Tiago F. Outeiro and published by Frontiers E-books. This book was released on with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

Download or read book Introductory Review on Sirtuins in Biology Aging and Disease written by Leonard Guarente and published by Academic Press. This book was released on 2018-04-20 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Download or read book Sirtuin Biology in Endocrinology and Metabolic Disease written by Shay Welch and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sirtuins refer to a class of signaling proteins involved in metabolic regulation. They are members of the class III family of NAD-dependent histone deacetylases (HDAC). They are involved in a variety of physiological processes ranging from metabolism and endocrine function control to immune coordination and cellular responses to stress. Sirtuin-1 (SIRT1) plays an important role in epigenetics, immunology, and endocrinology. SIRT1's diverse roles include energy sensing metabolic homeostasis regulation, and deacetylation of histone and non-histone proteins in numerous tissues. It also facilitates neuro-endocrine regulation through hypothalamus-pituitary axis stimulation, and synthesis and maintenance of reproductive hormones via steroidogenesis. Some of the other functions involve maintenance of innate and adaptive immune systems via T and B cell maturation regulation, chronic inflammation, and autoimmune diseases. This book provides significant information of sirtuin biology as well as its importance in endocrinology and metabolic disease. It will provide comprehensive knowledge to the readers.

Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Download or read book Handbook of Nutrition Diet and Epigenetics written by Vinood B. Patel and published by Springer. This book was released on 2019-02-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Download or read book Histone Deacetylases the Biology and Clinical Implication written by Tso-Pang Yao and published by Springer Science & Business Media. This book was released on 2011-08-31 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Download or read book Molecular Basis and Emerging Strategies for Anti aging Interventions written by Syed Ibrahim Rizvi and published by Springer. This book was released on 2018-11-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Download or read book Handbook of the Biology of Aging written by Nicolas Musi and published by Academic Press. This book was released on 2015-08-20 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Download or read book Epigenetics and Dermatology written by Qianjin Lu and published by Academic Press. This book was released on 2015-02-16 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Download or read book Resveratrol written by Farid A. Badria and published by BoD – Books on Demand. This book was released on 2019-02-06 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book intends to strike a balance between developments in research and the fact that researchers must absorb and link to scientific advances with clinical practice so that the management of diseases can be based on sound physiological concepts. This book addresses several controversial issues regarding a natural molecule with fascinating pharmacological and therapeutic effects. The book contains three sections: Section 1: Pharmacology and Therapeutic Applications of Resveratrol; Section 2: Bioavailability, Metabolism, and Mode of Action of Resveratrol; Section 3: Resveratrol and Its Role in Chronic and Degenerative Diseases. Does it Add Life to Years or Years to Life? It is our hope that this book will motivate readers to approach the evidence on the use resveratrol and thereby spark an interest in making further contributions to the current scientific debate and treatment development efforts.

Download or read book Inflammation Advancing Age and Nutrition written by Irfan Rahman and published by Academic Press. This book was released on 2013-09-03 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes models of aging, including worm, mouse and human Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition Includes suggested nutritional interventions

Download or read book Modulators of Oxidative Stress written by Hande Gurer-Orhan and published by MDPI. This book was released on 2020-11-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.