Download or read book Single Membrane Channels Formed by Connexins or Pannexins Focus on the Nervous System written by Juan Andrés Orellana and published by Frontiers Media SA. This book was released on 2016-09-26 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given that the extremely elaborated and dynamic functions performed by the nervous system require the close synchronization of brain cells, complex organisms have developed different mechanisms of intercellular communication. At this regard, paracrine signaling between neighboring cells is currently recognized as one of the most widely distributed mechanisms of synchronization in the brain parenchyma. In mammals, paracrine signaling is in part mediated by single membrane channels formed by connexins (connexons/hemichannels) or pannexins (pannexons), which are two different membrane protein families composed of about 20 and 3 members, respectively. Single membrane channels formed by these proteins serve as aqueous pores permeable to ions and small molecules, allowing the diffusional exchange between the intra- and extracellular milieu. Thus, connexin hemichannels and pannexons permit the release of significant quantities of autocrine/paracrine signaling molecules (e.g., ATP, glutamate, NAD+, adenosine and PGE2) into the extracellular milieu, as well as the uptake of small molecules. An increasing body of evidence has revealed that connexin hemichannels and pannexons play a crucial role in a plethora of brain processes including blood flow regulation, Ca2+ wave propagation, memory consolidation, glucose sensing and cell migration and adhesion. Considering the multiple cell signaling functions of these channels, their dysregulation is proposed not only as potential pathological biomarker, but it has been implicated in the pathogenesis and progression of diverse brain diseases (e.g., meningitis, Alzheimer’s disease and stroke). The aim of this Research Topic is to gather a collection of original research articles, method, protocols, short communications, opinions, perspectives, as well as review articles, providing the latest progress and insights in the field of connexin hemichannels and pannexons in the nervous system. Within this volume we plan to cover from basic research including channel structure, regulation, pharmacology and trafficking; to different biological functions in the physiology (behavior, plasticity, neurogenesis, blood flow control, neuron-glia crosstalk, cell migration and differentiation) as well as in the pathophysiology (neuroinflammation, mutation-related diseases, glial dysfunction and neurodegeneration) of the nervous system. We hope that this collection of articles will serve to understand how the signaling of connexin hemichannels and pannexons influences both normal and pathological brain function.
Download or read book Single Adults written by George Barna and published by . This book was released on 2002-02 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Single Christian Woman s Fight for Focus written by Sherabim Allen and published by SA4S MINISTRIES LLC. This book was released on 2010-02 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Dating Manifesto written by Lisa Anderson and published by David C Cook. This book was released on 2015-08-01 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Your attitudes about marriage and the path to marriage are wrong. Some you’ve inherited, some you’ve simply bought—hook, line, and sinker—and some you’ve made up yourself. They have translated into bad action (or no action) in dating and relationships. But it’s not too late; you can break the cycle of dating dysfunction and learn to honor marriage, marry well, and live intentionally while you wait. Lisa Anderson proves it’s possible. The Dating Manifesto is neither a cheesy formula for finding a spouse nor a feel-good book about how the person for you is “out there” if you only “believe.”Instead, it’s a challenge to wise up, own your junk, and chart a bold new course for your relationship future.
Download or read book The ONE Thing written by Gary Keller and published by Bard Press. This book was released on 2013-04-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: • More than 500 appearances on national bestseller lists • #1 Wall Street Journal, New York Times, and USA Today • Won 12 book awards • Translated into 35 languages • Voted Top 100 Business Book of All Time on Goodreads People are using this simple, powerful concept to focus on what matters most in their personal and work lives. Companies are helping their employees be more productive with study groups, training, and coaching. Sales teams are boosting sales. Churches are conducting classes and recommending for their members. By focusing their energy on one thing at a time people are living more rewarding lives by building their careers, strengthening their finances, losing weight and getting in shape, deepening their faith, and nurturing stronger marriages and personal relationships. YOU WANT LESS. You want fewer distractions and less on your plate. The daily barrage of e-mails, texts, tweets, messages, and meetings distract you and stress you out. The simultaneous demands of work and family are taking a toll. And what's the cost? Second-rate work, missed deadlines, smaller paychecks, fewer promotions--and lots of stress. AND YOU WANT MORE. You want more productivity from your work. More income for a better lifestyle. You want more satisfaction from life, and more time for yourself, your family, and your friends. NOW YOU CAN HAVE BOTH — LESS AND MORE. In The ONE Thing, you'll learn to * cut through the clutter * achieve better results in less time * build momentum toward your goal* dial down the stress * overcome that overwhelmed feeling * revive your energy * stay on track * master what matters to you The ONE Thing delivers extraordinary results in every area of your life--work, personal, family, and spiritual. WHAT'S YOUR ONE THING?
Download or read book Atomic Habits written by James Clear and published by Penguin. This book was released on 2018-10-16 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The #1 New York Times bestseller. Over 20 million copies sold! Translated into 60+ languages! Tiny Changes, Remarkable Results No matter your goals, Atomic Habits offers a proven framework for improving--every day. James Clear, one of the world's leading experts on habit formation, reveals practical strategies that will teach you exactly how to form good habits, break bad ones, and master the tiny behaviors that lead to remarkable results. If you're having trouble changing your habits, the problem isn't you. The problem is your system. Bad habits repeat themselves again and again not because you don't want to change, but because you have the wrong system for change. You do not rise to the level of your goals. You fall to the level of your systems. Here, you'll get a proven system that can take you to new heights. Clear is known for his ability to distill complex topics into simple behaviors that can be easily applied to daily life and work. Here, he draws on the most proven ideas from biology, psychology, and neuroscience to create an easy-to-understand guide for making good habits inevitable and bad habits impossible. Along the way, readers will be inspired and entertained with true stories from Olympic gold medalists, award-winning artists, business leaders, life-saving physicians, and star comedians who have used the science of small habits to master their craft and vault to the top of their field. Learn how to: make time for new habits (even when life gets crazy); overcome a lack of motivation and willpower; design your environment to make success easier; get back on track when you fall off course; ...and much more. Atomic Habits will reshape the way you think about progress and success, and give you the tools and strategies you need to transform your habits--whether you are a team looking to win a championship, an organization hoping to redefine an industry, or simply an individual who wishes to quit smoking, lose weight, reduce stress, or achieve any other goal.
Download or read book Focus on Single Parent Families written by Annice Yarber and published by Bloomsbury Publishing USA. This book was released on 2010-02-26 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking collection of writings on the growing phenomenon of single-parent families in the United States, and how it impacts society as a whole. Focus on Single-Parent Families: Past, Present, and Future brings together in one volume a range of cutting-edge research articles and essays on what has become the most dynamic change in family structure in U.S. history. It is the only resource to make the most insightful and important work being done on the single-parent family phenomena accessible to general readers. Focus on Single-Parent Families helps readers go beyond the stereotypes and look closely at the complexity of families with one parent and consider their place in society. It encompasses the wide variety of households with a single parent—a family structure that promises to continue to grow and diversify. Throughout, the book gauges the impact of the increasing number of single-parent families on the nation as a whole, particularly in regard to policies concerning family welfare, children's services and health care, schools, and other essential social institutions.
Download or read book Kingdom Single written by Tony Evans and published by NavPress. This book was released on 2018-08-21 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you’re single and feeling incomplete or even like a second-class citizen in Christian circles, Dr. Tony Evans wants to encourage you to live fully where you are. Kingdom Single will encourage you to see yourself as complete in Christ and free to serve Him. It will empower you to live as Kingdom men and women in a corrupt culture. Tony Evans is a much-loved pastor and known for his sense of knowing when to encourage and when to lovingly admonish, to help people become who God calls them to be. If you are single and reading this book—or if you lead or pastor singles—your identity in Christ will be affirmed. Additionally, you will receive coaching for what to look for in a prospective spouse, and be challenged to live godly lives while pursuing Kingdom causes.
Download or read book Undivided Devotion written by G. Steve Kinnard and published by . This book was released on 1997-10 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Text Book of Physiology written by Sir Michael Foster and published by . This book was released on 1891 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Joyfully Single in a Couples World written by Harold J. Sala and published by B&H Publishing Group. This book was released on 2013-02-01 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many facets of our world appear biased toward the couples’ lifestyle; there’s often an insinuation in advertisements, private conversations, and public gatherings that being alone means being unfulfilled--that singleness is a second-class status. How could that be true? In Joyfully Single in a Couples’ World, Bible teacher Harold J. Sala clearly states: “What I want to accomplish is to help singles understand that they can find contentment and peace where they are right now, that they don’t have to be married to be happy. I want to help them come to grips with who they are and to help them to discover where God wants them to go with their lives and futures. Finding God’s help to meet the present need is the key to peace and fulfillment.” Chapters on making peace with your dreams, handling other people’s expectations, the beauty of friendships, and God’s will guide readers to great joy in the here and now.
Download or read book Going Solo written by Robert Beeson and published by NavPress. This book was released on 2018-04-03 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: As parents face the difficult reality of a broken home, a sense of being completely overwhelmed can shut down the perspective they need to find restoration. Parents need to know that they can choose to define this season of their lives, instead of becoming defined by circumstances. They can deliberately look toward God and come to a deeper understanding of His true nature, power, and intimate care. As this former Christian music industry executive shares his story of divorce, his seven years as a single father, and his transition to a second marriage and a blended family, he also offers readers some hard-learned lessons and insights on being an effective, empathetic, and empowered single parent, answering crucial questions such as: How do I find peace when everything around me is chaos? How do I manage meeting needs when I have nothing to give? How and where do I begin again? The author addresses the fears and exhaustion of single parenting, while revealing the keys to gaining strength and courage for each day. He also shares how he found his “solo” relationship with his heavenly Father through his “solo” parenting season. Readers will learn five helpful habits and practical healing principles they can immediately apply in this season of life.
Download or read book Little Flower Yoga for Kids written by Jennifer Cohen Harper and published by New Harbinger Publications. This book was released on 2013-11-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wouldn’t it be great if your child could exercise, have fun, and build concentration skills all at the same time? In 2006, the Little Flower Yoga program was developed by teacher and certified yoga instructor Jennifer Cohen Harper, when her successful use of yoga in her kindergarten classroom led to requests by other students, teachers, and administrators for yoga programs of their own. Harper slowly began to teach more and more yoga classes, and eventually recruited other yoga teachers with education backgrounds to continue growing what had become a flourishing program. Little Flower Yoga for Kidsoffers this fun and unique program combining yoga and mindfulness in an easy-to-read format. Written specifically for parents and kids, the book aims at teaching children to pay attention, increase focus, and balance their emotions—all while building physical strength and flexibility. Based on a growing body of evidence that yoga and mindfulness practices can help children develop focus and concentration, the simple yoga exercises in this book can easily be integrated into their child’s daily routine, ultimately improving health, behavior, and even school achievement. The book details the five main components of the program: connect, breath, move, focus, and relax. Drawing on these components, Harper shares practical activities that parents can use with their children both on a daily basis and as applied to particularly challenging issues. And while this book is targeted to parents, teachers may also find it extremely useful in helping students achieve better attention and focus. For more information about this innovative program, visit www.littlefloweryoga.com.
Download or read book Knowledge Illustrated Scientific News written by Edwin Sharpe Grew and published by . This book was released on 1899 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transactions of the American Mathematical Society written by and published by . This book was released on 1913 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The A B C of the X Rays written by William Henry Meadowcroft and published by . This book was released on 1896 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: "One of the four American books on X-rays published in 1896. Thomas Edison was one of the first Americans to experiment with X rays after Ro ntgen's discovery. William H. Meadowcroft had worked with Edison since 1881, and in 1888 had written 'The A B C of the Electricity'. Thus, he was well-suited to write this early book about X rays. Edison himself supplied an account of his experiments with X rays to William Morton, who included them in Appendix B of his own book."--Antiquarian bookseller's description.
