Download or read book Signal Transduction in Cell Volume Regulation written by Nicolaas Jacobus Henricus Raat and published by . This book was released on 1995 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zsfassung in niederländ. Sprache.
Download or read book Signal Transduction Involved in Cell Volume Regulation written by Thea van der Wijk and published by . This book was released on 2001 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms and Significance of Cell Volume Regulation written by Florian Lang and published by Karger Medical and Scientific Publishers. This book was released on 2006 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is essential for the survival of cells to maintain their volume within certain limits: Profound alterations interfere with the integrity of the cell membrane and the cytoskeletal architecture. Cells use various methods to adjust osmotic pressure gradients which in turn govern water movement across cell membranes. The most rapid and efficient means is ion transport across the cell membrane. However, to avoid excessive alterations of intracellular ion concentration, cells additionally employ organic osmolytes for osmoregulation and modify their metabolism, thus generating or disposing osmotically active organic substances. But a given cell uses only part of the cell volume regulatory mechanisms at their disposal: The large repertoire available allows for a selection of those which have the least untoward impact on cell function.The present book is a collection of reviews on the various aspects of cell volume regulation, written by internationally leading experts, and constitutes a valuable addition to the library of those working in the field.
Download or read book Cellular and Molecular Physiology of Cell Volume Regulation written by Kevin Strange and published by CRC Press. This book was released on 2020-01-16 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to regulate cell volume in the face of osmotic challenge is one of the most fundamental of cellular homeostatic mechanisms. Cellular and Molecular Physiology of Cell Volume Regulation is an integrated collection of articles describing key aspects of cell volume control. The book has been organized around concepts and cellular/molecular processes rather than around mechanisms of volume regulation in specific cell types in order to make it more accessible to a multidisciplinary audience of students, instructors, and researchers.
Download or read book Cell Volume and Signaling written by Peter Lauf and published by Springer Science & Business Media. This book was released on 2006-11-30 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).
Download or read book Regulation of Signal Transduction in Human Cell Research written by Nariyoshi Shinomiya and published by Springer. This book was released on 2018-02-15 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
Download or read book Cell Volume Regulation written by Florian Lang and published by S. Karger AG (Switzerland). This book was released on 1998 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a unique compilation of reviews on cell volume regulation in health and disease, with contributions from leading experts in the field. The topics covered include mechanisms and signaling of cell volume regulation and the effect of cell volume on cell function, with special emphasis on ion channels and transporters, kinases and gene expression. Several chapters elaborate on how cell volume regulatory mechanisms participate in the regulation of epithelial transport, urinary concentration, metabolism, migration, cell proliferation and apoptosis. Last but not least, this publication is an excellent guide to the role of cell volume in the pathophysiology of hypercatabolism, diabetes mellitus, brain edema, hemoglobinopathies, tumor growth and metastasis, to name just a few. Providing deeper insights into an exciting area of research which is also of clinical relevance, this publication is a valuable addition to the library of those interested in cell volume regulation.
Download or read book Signal Transduction of Volume Regulation in Villus Epithelial Cells written by R. John MacLeod and published by . This book was released on 1996 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signal Transduction Pathways Mechanisms and Diseases written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
Download or read book Introduction to Cellular Signal Transduction written by Ari Sitaramayya and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of biological communication has grown significantly during the past decade. The advances in knowledge about the chemical nature of signals and their corresponding reception by specialized cells have led to identification, characterization, purification, cloning, and expression of specific receptor molecules. While the earlier literature emphasized com partmentalized treatment of informational molecules and their interaction with receptors, the progress in the recent past has allowed cross-fertilization in the examination of the of actions and mechanisms of steroid and protein hormones and other messengers. Investigators now have an increased ap preciation of the multiple effects of specific hormones and of the diverse responses by receptor proteins to closely related ligands. The task of compil ing this enormous literature into a focused treatise was undertaken with the launching of the series Hormones in Health and Disease. This latest volume, An Introduction to Cellular Signal Transduction, complements the previous monographs in the series and brings to the fore recent developments in the field of biochemical communication. This volume combines discussions on the basic tenets of the signal transduction process and its relevance to health and disease. While various chapters provide exhaustive dissection of specific topics for researchers in the field, the book is also an excellent vehicle for introducing students and new investigators to the subject. The contributors of the chapters are active and accomplished scientists brought together on a common platform by the editor, Dr.
Download or read book Membranes and Cell Signaling written by Edward Bittar and published by Elsevier. This book was released on 1997-05-12 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does not go far enough. As it turns out, there is now another version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be. We have chosen not to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.
Download or read book Regulation of Cellular Signal Transduction Pathways by Desensitization and Amplification written by David R. Sibley and published by . This book was released on 1994-03-29 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amplification and desensitization are recognized phenomena in signal transduction systems. This study has been designed to inform biochemists, pharmacologists and other experimental biologists interested in cellular signalling systems.
Download or read book Signal Transduction Mechanisms written by J.A. Barnes and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of an International Symposium on `Second Messenger Systems - Molecular, Cellular and Behavioural Aspects', which was held at Tobago on June 16-17, 1994. The interaction of an extracellular agonist (First Messenger) with its plasma membrane receptor leads to the transmission of a signal across the cell membrane and results in the production and/or activation of other signalling molecules (Second Messengers). These Second Messengers control the action of many protein kinases and protein phosphatases and so lead to cellular responses. Although the biochemical basis of the transduction of signals in the main signalling systems in eukaryotic cells is probably largely known, intensified research is ongoing in the following areas: the discovery of specific substrates for many protein kinases, elucidation of the biological significance of the differential tissue expression and heterogeneity of many signalling proteins, and the unravelling of diverse interactions (such as signal potentiation, synergism, antagonism and neuronal co-transmission) between signalling systems. As knowledge from such studies accumulates, it is becoming clear that the `cross talk' interactions between signalling systems are important features of dynamic cell regulation. This volume is designed to summarize some aspects of the current work on various Second Messenger Systems and the integration of signals with respect to plasma membrane receptors. Second Messenger generation and degradation, protein kinase and phosphatase, cell cycle control, and cellular learning and memory.
Download or read book Ion Channel Regulation written by and published by Academic Press. This book was released on 1999-04-22 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases. How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity. Reviews brain functioning at the fundamental, molecular level Describes key systems that control signaling between and within cells Explains how channels are used to stimulate growth and changes to activity of the nucleus and genome
Download or read book Model Systems in Signal Transduction written by Shirish Shenolikar and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, distinguished investigators discuss their research on intracellular signal transduction in microorganisms. The findings presented aim to shed new light on fundamental processes of cell regulation in complex as well as simple organisms.
Download or read book Cell Volume Regulation written by Yasunobu Okada and published by Elsevier Science & Technology. This book was released on 1998 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. Cell volume regulation is of fundamental importance to animal cells, since persistent swelling or shrinkage results in cell death. Osmotic perturbation confronts the cells withthe problem of volume regulation, because most animal cell membrane are highly permeable to water.A number of cellular physiological activities are associated with osmotic perturbation to cells. Those include active solute uptake by enterocytes, renal tubular cells or hepatocytes, fluid and electrolyte secretion by glandular cells, cell mitogenesis or proliferation, cell differentiation, hormonal action on hepatocytes, lymphocytes or cardiac myocytes, excitation in neurons, and glutamate receptor activation in brain neurons or glial cells. Also, in kidney medulla and intestinal tissues, not only epithelial cells but also blood and mesenchymal cells may be subject to osmotic stress induced by increased extracellular osmolality.Under pathological conditions, cel
Download or read book Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems written by Marc Thiriet and published by Springer Science & Business Media. This book was released on 2012-09-26 with total page 1073 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.
