Download or read book Sigma PCP and NMDA Receptors written by and published by . This book was released on 1993 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sigma PCP and NMDA Receptors written by Errol B. De Souza and published by . This book was released on 1993 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiple Sigma and PCP Receptor Ligands written by Jean-Marc Kamenka and published by . This book was released on 1992 with total page 1016 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sigma and Phencyclidine like Compounds as Molecular Probes in Biology written by Edward F. Domino and published by . This book was released on 1988 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sigma Receptors written by Yossef Itzhak and published by Academic Press. This book was released on 1994-05-28 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sigma receptor was originally thought to be a subset of the opioid receptor family, and it is less than 10 years since it was recognized that this receptor represents unique binding sites in mammalian brain and peripheral organs, distinct from any other known neurotransmitter receptor.
Download or read book Sigma Proteins Evolution of the Concept of Sigma Receptors written by Felix J. Kim and published by Springer. This book was released on 2017-10-05 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of “sigma receptors” to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives.
Download or read book Sigma Receptors written by Rae R. Matsumoto and published by Springer Science & Business Media. This book was released on 2007-02-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
Download or read book Sigma Opioid Phencyclidine like Compounds as Molecular Probes in Biology written by and published by . This book was released on 1987 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuropharmacology of PCP Sigma and N methyl D aspartate Receptors written by David Thomas Manallack and published by . This book was released on 1988 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Study of PCP sigma Receptor Populations in Hippocampus of Mouse written by Anupa Kanna Doraiswami and published by . This book was released on 1988 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Study of PCP sigma Opiate Receptors in the Mouse Brain written by Kathleen Joan Karbon and published by . This book was released on 1988 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Veterinary Pain Management E Book written by James S. Gaynor and published by Elsevier Health Sciences. This book was released on 2008-01-29 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: You can trust this user-friendly guide to help you meet the increasing need for effective pain management in the animals you treat. It provides instant access to clinically relevant information on pain assessment, pharmaceutical and non-pharmaceutical treatment options, guidelines for managing acute and chronic pain, and unique aspects of pain management in dogs, cats, horses, cattle, birds, reptiles, ferrets, and rabbits. User-friendly format helps you quickly and easily find essential pain management information. Helpful boxes and tables provide at-a-glance access to pharmacologic protocols and clinical applications, including dosages, indications, contraindications, and side effects. Complementary and alternative treatment strategies are included throughout to assist you in using the latest non-pharmacological pain interventions. Case studies clearly illustrate the practical applications of key concepts in the clinical setting and help you sharpen your pain assessment and management skills. New contributors — many of the most respected experts in the field — share their insights and experiences to bring you the most current thinking in this ever-changing discipline. Completely revised and updated content throughout ensures you are using the best and most current information available on analgesic drugs and pain management techniques. An expanded chapter on Pain Management in Horses and Cattle explores the latest advances in treating this group of animals. Eight new chapters offer cutting-edge coverage of hot topics in the field, including: Pain Management in the Cat Pain Management for the Pet Bird Clinical Approaches to Analgesia in Reptiles Clinical Approaches to Analgesia in Ferrets and Rabbits Physical Therapy and Rehabilitation in Dogs Rehabilitation Methods and Modalities for the Cat Quality of Life Issues Hospice and Palliative Care
Download or read book Acetylcholine Sigma Receptors CCK and Eicosanoids Neurotoxins written by T. W. Stone and published by Taylor & Francis. This book was released on 1993 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phencyclidine written by National Institute on Drug Abuse and published by . This book was released on 1986 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proteomic Methods in Neuropsychiatric Research written by Paul C. Guest and published by Springer. This book was released on 2017-04-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies. This book describes the step-by-step use of proteomic methods such as two-dimensional gel electrophoresis, multiplex immunoassay, liquid chromatography mass spectrometry (LC-MS) and selective reaction monitoring MS, to increase our understanding of these diseases, with the ultimate aim of improving patient care. The volume will be of high interest to clinical scientists, physicians and pharmaceutical company scientists as it gives insights into the latest technologies enabling the revolution of personalized medicine. It is of direct interest to both technical and bench biomarker scientists as it gives step by step instructions on how to carry out each of the protocols. It is also of interest to researchers as each technique will be presented in the context of a specific neurological disorder, including Alzheimer's disease, multiple sclerosis, autism spectrum disorders, schizophrenia, major depressive disorder and bipolar disorder. Finally, it will also highlight the future research efforts in this field, which are endeavoring to convert proteomic platforms to the form of hand held devices which can be used in a point of care setting and return diagnostic results within the timeframe of a visit to the general practitioner.
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Download or read book Stahl s Essential Psychopharmacology written by Stephen M. Stahl and published by Cambridge University Press. This book was released on 2008-03-27 with total page 1057 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stahl's Essential Psychopharmacology has established itself as the preeminent source of education and information in its field. This much-expanded third edition relies on advances in neurobiology and recent clinical developments to explain the concepts underlying drug treatment of psychiatric disorders. New neurotransmitter systems; theories on schizophrenia; clinical advances in antipsychotic and antidepressant therapy; coverage of attention deficit disorder and drug abuse; and new coverage of sleep disorders, chronic pain, and disorders of impulse control. The fully revised text is complemented with many new, instructive and entertaining illustrations, their captions may be used independent of the main text for a rapid introduction to the field or for review. This edition will be indispensable for students, scientists, psychiatrists, and other mental health professionals, enabling them to master the complexities of psychopharmacology and to plan treatment approaches based on current knowledge. Accreditation and Credit Designation Statements The Neuroscience Education Institute is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Neuroscience Education Institute designates this educational activity for a maximum of 90.0 AMA PRA Category 1 Credits(tm). Physicians should only claim credit commensurate with the extent of their participation in the activity. Sponsorship Information Sponsored by Neuroscience Education Institute Support This activity is supported solely by the sponsor. Neither the Neuroscience Education Institute nor Stephen M. Stahl, MD, PhD has received any funds or grants in support of this educational activity.
