Download or read book Serpin Structure and Evolution written by James Whisstock and published by Academic Press. This book was released on 2011-11-16 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. This volume in the Methods in Enzymology series comprehensively covers the topic of serpins With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems

Download or read book Biology of Serpins written by James Whisstock and published by Academic Press. This book was released on 2011-07-18 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of Methods in Ezymology is split into 2 parts and comprehensively covers the subject.

Download or read book Chemistry and Biology of Serpins written by Frank C. Church and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of an International Symposium held in Chapel Hill, North Carolina, April 13-16, 1996

Download or read book Serpin Structure and Evolution written by and published by Academic Press. This book was released on 2011-11-07 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. - This volume in the Methods in Enzymology series comprehensively covers the topic of serpins - With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems

Download or read book Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity written by Gary A. Silverman and published by World Scientific. This book was released on 2007 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Massive thrombosis or bleeding, hereditary angioedema, Alzheimer''s disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.

Download or read book The Serpin Family written by Margarethe Geiger and published by Springer. This book was released on 2015-11-13 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.​

Download or read book The Serpin Family in the Cardiovascular System written by Marie-Christine Bouton and published by Frontiers Media SA. This book was released on 2022-03-03 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Proteases in Health and Disease written by Enrico Di Cera and published by Academic Press. This book was released on 2011-01-24 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

Download or read book Mechanisms of Catalysis written by and published by Academic Press. This book was released on 1991-01-28 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Download or read book Serpins written by Alexandra Lucas and published by . This book was released on 2018 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest methods used to study and define serpin molecular structure, basic protease inhibition, serpin targets, and the roles of serpin in biology and disease using animal models. The chapters in this book cover topics such as crystallography and phage display, peptide design, phospholipid binding, and thrombus formation to microbiome analysis and development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, Serpins: Methods and Protocols is a valuable resource for researchers and scientists interested in learning more about this evolving field.

Download or read book Tick Host Pathogen Interactions written by Sarah Irène Bonnet and published by Frontiers Media SA. This book was released on 2018-08-24 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Besides causing direct damage associated with blood feeding and in some cases through the excretion of toxins with their saliva, the main relevance of ticks lies in the wide variety of pathogens that they can transmit, including viruses, bacteria, protozoa and helminths. Owing to socioeconomic and environmental changes, tick distribution is changing with incursions of ticks and tick-borne diseases occurring in different regions of the world when the widespread deployment of chemical acaricides and repellents has led to the selection of resistance in multiple populations of ticks. New approaches that are environmentally sustainable and that provide broad protection against current and future tick-borne pathogen (TBP) are thus urgently needed. Such development, however, requires improved understanding of factors resulting in vector competence and tick-host-pathogen interactions. This Research Topic provides an overview of known molecular tick-host-pathogen interactions for a number of TBPs and highlights how this knowledge can contribute to novel control and prevention strategies for tick-borne diseases.

Download or read book Activation of Viruses by Host Proteases written by Eva Böttcher-Friebertshäuser and published by Springer. This book was released on 2018-05-22 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.

Download or read book Comparative Hemostasis in Vertebrates written by James H. Lewis and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author examines hemostasis in animals from all seven major vertebrate classes. Her research provides unique insights into the phylogenetic development of the various phases and components of hemostasis. This monograph is a valuable reference for students, researchers, and teachers of biology, zoology, veterinary science, and human medicine.

Download or read book Biochemical Studies of a Novel Serpin and Its Target Protease written by Hongming Wang and published by . This book was released on 1996 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biological Sequence Analysis written by Richard Durbin and published by Cambridge University Press. This book was released on 1998-04-23 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Download or read book Viruses as Therapeutics written by Alexandra R. Lucas and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Laboratory Hematology Practice written by Kandice Kottke-Marchant and published by John Wiley & Sons. This book was released on 2012-05-07 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.