Download or read book Self assembly of Stimuli responsive and Multicomponent Nanostructures written by McKensie Mason and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In nature, many biological processes are performed by the controlled recognition and interaction of small organic molecules that assemble into larger macrostructures. For example, protein subunits stack into microtubules and filaments that act to give cells structure and enable cell transport and mobility, and phospholipids assemble into bilayers that encase cells and regulate transfer of materials into and out of the cell. Biological building blocks such as proteins, lipids, and nucleic acids organize with amazing specificity into compartmentalized structures that adapt, reorganize, and interact with their environment to allow the biological functions that define life. Inspired by nature, organic peptide-based molecules that self-assemble into nanostructures have been studied as a way to develop responsive and adaptive materials. However, to fully simulate the complexity, specificity, and functionality of natural systems, it is important to understand and build synthetic building blocks with controllable assembly properties and interactions. Towards the goal of realizing self-assembled structures with well-defined and controllable properties, a pH-responsive coumarin-appended tetrapeptide was developed. By incorporating multiple ionizable functional groups onto a tetrapeptide scaffold, it was found that pH-modulation could affect the charge of the molecule, which further dictated the way that the units stacked and assembled into nanoscale structures. In fact, pH as a stimulus was found to control the assembly and disassembly of the molecule, the helical chirality of units as they stacked together, the surface charge, as well as the overall morphology of the assembled structure. The intricate control over the self-assembly pathways and properties granted by this pH-responsive molecule prompted further investigation into its utilization in more complex multicomponent materials. Many biological building blocks assemble into compartmentalized, self-sorted structures to accomplish their specific tasks. Similarly, herein self-assembling molecules were selected and combined that would ideally self-sort into distinct single-component structures, but integrate or interact on a supramolecular scale to form multicomponent architectures with well-defined molecular layers. A coumarin-containing tetrapeptide was combined with naphthalene diimide nanotubes as well as a coumarin-appended dipeptide nanofiber to study the molecular and supramolecular-level interactions of each combination. Strategies to characterize and direct these interactions were explored, and multilayered nanotube structures were finally realized. These examples demonstrate novel multicomponent materials composed of self-assembled building blocks that both assemble with self-recognition preferentially on a molecular scale but also interact with other structures via complementary electrostatic interactions between the nanostructure surfaces. Finally, the importance of understanding the self-assembly properties and supramolecular interactions of self-assembled peptides was applied to exploring the stability and biological interactions of a coumarin-appended dipeptide nanofiber with therapeutic properties for diabetes treatment. Fluorescence microscopy and energy transfer interactions showed the complexation of insulin with the self-assembled structures, likely contributing to the therapeutic benefits observed in treatment in animal models. Overall, these advances in pH-controllable self-assembly, directed assembly of two components into integrated multicomponent architectures, and interactions of self-assembled structures with insulin are hoped to lead to an increased understanding of how self-assembled molecules may interact in biological environments and towards making functional nanomaterials for biomedical and optoelectronic applications.

Download or read book Stimuli responsive Drug Delivery Systems written by Amit Singh and published by Royal Society of Chemistry. This book was released on 2018-07-09 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.

Download or read book Dendrimers for Drug Delivery written by Anil K. Sharma and published by CRC Press. This book was released on 2018-07-27 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: With chapters from highly skilled, experienced, and renowned scientists and researchers from around the globe, Dendrimers for Drug Delivery provides an abundance of information on dendrimers and their applications in the field of drug delivery. The volume begins with an introduction to dendrimers, summarizing dendrimer applications and the striking features of dendrimers. It goes on to present the details of usual properties, structure, classification, and methods of synthesis, with relevant examples. The toxicity of dendrimers is also discussed. The chapter authors provide an exhaustive amount of information about dendrimers and their biomedical applications, including biocompatibility and toxicity aspects, a very useful feature. This informative volume will be valuable resource that will help readers to create products derived from dendrimers and navigate through the regulatory, manufacturing, and quality control hurdles. It will be an important resource for researchers, scientists, upper-level students, and industry professionals.

Download or read book Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials written by Lia Rimondini and published by Frontiers Media SA. This book was released on 2021-04-13 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Self Assembly written by Jennifer J. McManus and published by Humana. This book was released on 2020-08-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.

Download or read book Supramolecular Chemistry in Water written by Stefan Kubik and published by John Wiley & Sons. This book was released on 2019-09-03 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides deep insight into the concepts and recent developments in the area of supramolecular chemistry in water Written by experts in their respective field, this comprehensive reference covers various aspects of supramolecular chemistry in water?from fundamental aspects to applications. It provides readers with a basic introduction to the current understanding of the properties of water and how they influence molecular recognition, and examines the different receptor types available in water and the types of substrates that can be bound. It also looks at areas to where they can be applied, such as materials, optical sensing, medicinal imaging, and catalysis. Supramolecular Chemistry in Water offers five major sections that address important topics like water properties, molecular recognition, association and aggregation phenomena, optical detection and imaging, and supramolecular catalysis. It covers chemistry and physical chemistry of water; water-mediated molecular recognition; peptide and protein receptors; nucleotide receptors; carbohydrate receptors; and ion receptors. The book also teaches readers all about coordination compounds; self-assembled polymers and gels; foldamers; vesicles and micelles; and surface-modified nanoparticles. In addition, it provides in-depth information on indicators and optical probes, as well as probes for medical imaging. -Covers, in a timely manner, an emerging area in chemistry that is growing more important every day -Addresses topics such as molecular recognition, aggregation, catalysis, and more -Offers comprehensive coverage of everything from fundamental aspects of supramolecular chemistry in water to its applications -Edited by one of the leading international scientists in the field Supramolecular Chemistry in Water is a one-stop-resource for all polymer chemists, catalytic chemists, biochemists, water chemists, and physical chemists involved in this growing area of research.

Download or read book Self Assembly of Nanostructures and Patchy Nanoparticles written by Shafigh Mehraeen and published by BoD – Books on Demand. This book was released on 2020-11-04 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Top-down approaches are currently the main contributor of fabricating microelectronic devices. However, the prohibitive cost of numerous technological steps in these approaches is the main obstacle to further progress. Furthermore, a large number of applications necessitate fabrication of complex and ultra-small devices that cannot be made using these approaches. New approaches based on natural self-assembly of matter need to be developed to allow for fabrication of micro and nanoelectronic devices. Self-assembly of nanostructures is a dynamic field, which explores physics of these structures and new ways to fabricate them. However, the major problem is how to control the properties of the nanostructures resulting from low dimensionality. This book presents recent advances made to address this problem, and fabricate nanostructures using self-assembly.

Download or read book Functional Organic and Hybrid Nanostructured Materials written by Quan Li and published by John Wiley & Sons. This book was released on 2018-01-25 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to explore the potential of tunable functionalities in organic and hybrid nanostructured materials in a unified manner. The highly experienced editor and a team of leading experts review the promising and enabling aspects of this exciting materials class, covering the design, synthesis and/or fabrication, properties and applications. The broad topical scope includes organic polymers, liquid crystals, gels, stimuli-responsive surfaces, hybrid membranes, metallic, semiconducting and carbon nanomaterials, thermoelectric materials, metal-organic frameworks, luminescent and photochromic materials, and chiral and self-healing materials. For materials scientists, nanotechnologists as well as organic, inorganic, solid state and polymer chemists.

Download or read book Nanostructured Polymer Blends written by Sabu Thomas and published by William Andrew. This book was released on 2013-11-28 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 30% of commercial polymers are blends or alloys or one kind or another. Nanostructured blends offer the scientist or plastics engineer a new range of possibilities with characteristics including thermodynamic stablility; the potential to improve material transparency, creep and solvent resistance; the potential to simultaneously increase tensile strength and ductility; superior rheological properties; and relatively low cost. Nanostructured Polymer Blends opens up immense structural possibilities via chemical and mechanical modifications that generate novel properties and functions and high-performance characteristics at a low cost. The emerging applications of these new materials cover a wide range of industry sectors, encompassing the coatings and adhesives industry, electronics, energy (photovoltaics), aerospace and medical devices (where polymer blends provide innovations in biocompatible materials). This book explains the science of nanostructure formation and the nature of interphase formations, demystifies the design of nanostructured blends to achieve specific properties, and introduces the applications for this important new class of nanomaterial. All the key topics related to recent advances in blends are covered: IPNs, phase morphologies, composites and nanocomposites, nanostructure formation, the chemistry and structure of additives, etc. - Introduces the science and technology of nanostructured polymer blends – and the procedures involved in melt blending and chemical blending to produce new materials with specific performance characteristics - Unlocks the potential of nanostructured polymer blends for applications across sectors, including electronics, energy/photovoltaics, aerospace/automotive, and medical devices (biocompatible polymers) - Explains the performance benefits in areas including rheological properties, thermodynamic stablility, material transparency, solvent resistance, etc.

Download or read book Nanoengineering of Biomaterials written by Sougata Jana and published by John Wiley & Sons. This book was released on 2022-04-18 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.

Download or read book Stimuli Responsive Polymers written by Navid Rabiee and published by Morgan & Claypool Publishers. This book was released on 2019-06-19 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a general introduction to nanogels, and designs of various stimuli-sensitive nanogels that are able to control drug release in response to specific stimuli. Nanogels are three-dimensional nanosized networks that formed by physically or chemically crosslinking polymers. They have highly interesting properties such as biocompatibility, high stability, particle size adjustment, drug loading capability and modification of the surface for active targeting. They can respond to stimuli which results in the controlled release of drug and targeting of the site.

Download or read book Supramolecular Gels written by Tifeng Jiao and published by John Wiley & Sons. This book was released on 2021-08-23 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supramolecular Gels Discover a current and authoritative overview of the cutting-edge in supramolecular gels from a leading voice in the field A promising new class of materials shows potential and is receiving increasing attention as an intelligent material for multifunctional systems. In a work that is sure to be of great interest to a wide variety of researchers, chemists, and engineers, Supramolecular Gels: Materials and Emerging Applications delivers an application-oriented and focused book exploring the most recent applications of supramolecular gels. This interdisciplinary book presents the underlying fundamentals of supramolecular gels before discussing their assembly mechanisms and structures. It also introduces different material systems, including composite supramolecular gels, organogels, hydrogels, self-healing, and graphene-based supramolecular gels. The book discusses current and emerging applications of these materials in devices like sensors and actuators, biomedical tools, and environmental applications. The distinguished author also offers valuable insights with respect to the design and character of brand-new versatile soft materials. Readers will also benefit from the inclusion of: A thorough introduction to the fundamentals of supramolecular gels, including their formation, classification, self-assembly, and mechanisms An exploration of supramolecular chirality and regulation in gel structures, as well as self-assembly and environmental applications of composite supramolecular gels Practical discussions of fluorescent organogels and hydrogels and their applications in analyte sensing An examination of self-healing and graphene-based supramolecular gels, and supramolecular gels for sensors and actuators Perfect for materials scientists, organic chemists, biochemists, catalytic chemists, and environmental chemists, Supramolecular Gels: Materials and Emerging Applications will also earn a place in the libraries of sensor developers and other professionals seeking a one-stop reference for this rapidly developing category of intelligent materials.

Download or read book Multicomponent Hydrogels written by Jagan Mohan Dodda and published by Royal Society of Chemistry. This book was released on 2023-05-22 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels are highly hydrated three dimensional networks with the ability to mimic the extracellular matrix of bodily tissues and have thus found application in a wide range of biomedical applications. Unique physiochemical properties such as biocompatibility, water permeability, stimuli responsiveness and self-healing characteristics make them especially useful for use as scaffolds and matrices drug delivery, tissue engineering/regeneration and sensing. Their weak and brittle nature, however, often limits their widespread application where improved mechanical strength is required. To resolve this problem, there has been a significant amount of research into the improvement of their mechanical properties. Among these efforts, versatile multicomponent hydrogels have received much attention as their physiochemical properties can be structurally engineered to provide a wide range of desired properties. These multicomponent formulations also allow for the combination of natural and synthetic polymers, which offers the scope to exploit the advantages of each component, with the synergistic effects resulting from mutual interactions. This book critically discusses the fundamental chemistry, synthesis, characterisation, physiochemical and biological properties of various types of multicomponent hydrogels. It reviews the different strategies employed in designing and synthesizing cutting-edge multicomponent hydrogels and their key applications in biomedical fields. The work is suitable for researchers working in the specific area of multicomponent hydrogels, and also more generally for those working in materials science, biomedical engineering, biomaterials science and tissue engineering.

Download or read book Nanostructured Polymer Blends written by Gity Mir Mohamad Sadeghi and published by Elsevier Inc. Chapters. This book was released on 2013-11-28 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Block copolymers (BCPs) consist of two or more chemically different polymers connected covalently, and are polymer alloys. Due to their thermodynamic incompatibility and chain connectivity, the phase separation between two (or more) blocks occurs only in a tens of nanometers range. Nanostructures are based on block copolymer self-assembly. They are functional nanomaterials less than 100nm in size and have received extensive scientific and technological attention due to their potential applications in electronic, biomedical, and optical materials. This chapter examines a variety of different synthetic strategies for preparation of linear diblock copolymers by anionic polymerization. Triblocks can be synthesized according to an appropriate synthetic pathway, depending on the monomers used and their sequence in the triblock chain. Nonlinear block copolymers including star block copolymers, graft copolymers, miktoarm star copolymers, cyclic block copolymers, and other complex architectures are explained. Microphase separation drives BCPs to self-assemble, resulting in ordered nanostructures, including spheres, cylinders, gyroids, and lamellae, depending on the composition of the BCP. In nanotechnology, self-assembly (SA) underlies various types of molecular structures built from nanoparticles, nanotubes, or nanorods. Supramolecular structures generated from amphiphilic block copolymers are characterized by a slow rate of intermicellar chain exchange which makes them interesting for a variety of applications. Basic principles of self-assembly and micellization of block copolymers in dilute solution, methods for stabilization of the macromolecular aggregates, are discussed. Stabilized nanoparticles, the so-called “smart materials,” which show responses to environmental changes (pH, temperature, ionic strength, etc.), are presented with a focus on their applications.

Download or read book Nanochemistry written by Ashutosh Sharma and published by CRC Press. This book was released on 2023-02-24 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book encompasses the fundamental concepts of Nanochemistry that involve the self-assemblage of nanostructures, surface stabilization, and functionalization of nanoparticles. It’s a review of the work of world-renowned scientists and is the first of its kind that gives a detailed fundamental understanding of physical, chemical, and biological methods of nanoparticle synthesis. There is a comprehension of different characterization techniques of nanoparticles. This book, for the first time, explains applications of such nanochemicals in nanomedicine, nanoimmunomedicine, lab-on-a-chip, organ-on-a-chip, bioimplants, cyborgs, hydrogen storage, electrochemical splitting of water, and construction industries.

Download or read book Self Healing Polymers written by Wolfgang H. Binder and published by John Wiley & Sons. This book was released on 2013-03-29 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-healing is a well-known phenomenon in nature: a broken bone merges after some time and if skin is damaged, the wound will stop bleeding and heals again. This concept can be mimicked in order to create polymeric materials with the ability to regenerate after they have suffered degradation or wear. Already realized applications are used in aerospace engineering, and current research in this fascinating field shows how different self-healing mechanisms proven successful by nature can be adapted to produce even more versatile materials. The book combines the knowledge of an international panel of experts in the field and provides the reader with chemical and physical concepts for self-healing polymers, including aspects of biomimetic processes of healing in nature. It shows how to design self-healing polymers and explains the dynamics in these systems. Different self-healing concepts such as encapsulated systems and supramolecular systems are detailed. Chapters on analysis and friction detection in self-healing polymers and on applications round off the book.

Download or read book Self assembling Biomaterials written by Helena S. Azevedo and published by Woodhead Publishing. This book was released on 2018-04-17 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. - Explores both theoretical and practical aspects of self-assembly in biomaterials - Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials - Examines the use of dynamic self-assembling biomaterials