Download or read book Searching for a Mechanism written by John N. Prebble and published by . This book was released on 2019 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traces the history of cell bioenergetics from the early notions of science in the Enlightenment through to the end of the twentieth century.
Download or read book In Search of Mechanisms written by Carl F. Craver and published by University of Chicago Press. This book was released on 2013-10-03 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscientists investigate the mechanisms of spatial memory. Molecular biologists study the mechanisms of protein synthesis and the myriad mechanisms of gene regulation. Ecologists study nutrient cycling mechanisms and their devastating imbalances in estuaries such as the Chesapeake Bay. In fact, much of biology and its history involves biologists constructing, evaluating, and revising their understanding of mechanisms. With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species.
Download or read book Evaluating Evidence of Mechanisms in Medicine written by Veli-Pekka Parkkinen and published by Springer. This book was released on 2018-07-13 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY license. This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.
Download or read book Chasing Pain The Search for a Neurobiological Mechanism written by Kenneth L. Casey and published by Oxford University Press. This book was released on 2019-02-22 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conceptual models of how pain is created influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Given the broad scope of pain experiences, realistic models of pain neurobiology must consider the correlation between pain and tissue damage and how it is strongly affected by neurological disease, emotionally compelling circumstances, and by complex cognitive processes. Recent discoveries have made it clear that both sensory and affective systems are strongly modulated by activity in other sensory pathways and by affective and cognitive processes originating in the brain. As a result, pain should then be conceived as emerging from the conjoint activity of both sensory and affective neural systems, each becoming a target for pain treatment. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically and physiologically unique structures in the nervous system. Observations made during the early and mid- 20th century showed that pain and pain-like behaviors normally require not only sensory detectors of noxious events (called nociceptors) but also brain affective (hedonic) mechanisms that generate emotional experience and expression. In Chasing Pain, pain specialists and neuroscientists will find a thoughtful discussion of the neuroscientific and clinical evidence that has led to contemporary concepts of pain neurobiology and how pain might emerge from neuronal activity. Written in a concise and annotated format, Doctor Kenneth Casey reveals that while contemporary research has greatly enriched our model of pain neurobiology, several important and therapeutically challenging clinical conditions remain poorly understood.
Download or read book Code of Federal Regulations written by and published by . This book was released on 2007 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Programs and Services written by National Library of Medicine (U.S.) and published by . This book was released on 1998 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in GPU Research and Practice written by Hamid Sarbazi-Azad and published by Morgan Kaufmann. This book was released on 2016-09-15 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in GPU Research and Practice focuses on research and practices in GPU based systems. The topics treated cover a range of issues, ranging from hardware and architectural issues, to high level issues, such as application systems, parallel programming, middleware, and power and energy issues. Divided into six parts, this edited volume provides the latest research on GPU computing. Part I: Architectural Solutions focuses on the architectural topics that improve on performance of GPUs, Part II: System Software discusses OS, compilers, libraries, programming environment, languages, and paradigms that are proposed and analyzed to help and support GPU programmers. Part III: Power and Reliability Issues covers different aspects of energy, power, and reliability concerns in GPUs. Part IV: Performance Analysis illustrates mathematical and analytical techniques to predict different performance metrics in GPUs. Part V: Algorithms presents how to design efficient algorithms and analyze their complexity for GPUs. Part VI: Applications and Related Topics provides use cases and examples of how GPUs are used across many sectors. - Discusses how to maximize power and obtain peak reliability when designing, building, and using GPUs - Covers system software (OS, compilers), programming environments, languages, and paradigms proposed to help and support GPU programmers - Explains how to use mathematical and analytical techniques to predict different performance metrics in GPUs - Illustrates the design of efficient GPU algorithms in areas such as bioinformatics, complex systems, social networks, and cryptography - Provides applications and use case scenarios in several different verticals, including medicine, social sciences, image processing, and telecommunications
Download or read book Evolutionary Computation in Gene Regulatory Network Research written by Hitoshi Iba and published by John Wiley & Sons. This book was released on 2016-01-21 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introducing a handbook for gene regulatory network research using evolutionary computation, with applications for computer scientists, computational and system biologists This book is a step-by-step guideline for research in gene regulatory networks (GRN) using evolutionary computation (EC). The book is organized into four parts that deliver materials in a way equally attractive for a reader with training in computation or biology. Each of these sections, authored by well-known researchers and experienced practitioners, provides the relevant materials for the interested readers. The first part of this book contains an introductory background to the field. The second part presents the EC approaches for analysis and reconstruction of GRN from gene expression data. The third part of this book covers the contemporary advancements in the automatic construction of gene regulatory and reaction networks and gives direction and guidelines for future research. Finally, the last part of this book focuses on applications of GRNs with EC in other fields, such as design, engineering and robotics. • Provides a reference for current and future research in gene regulatory networks (GRN) using evolutionary computation (EC) • Covers sub-domains of GRN research using EC, such as expression profile analysis, reverse engineering, GRN evolution, applications • Contains useful contents for courses in gene regulatory networks, systems biology, computational biology, and synthetic biology • Delivers state-of-the-art research in genetic algorithms, genetic programming, and swarm intelligence Evolutionary Computation in Gene Regulatory Network Research is a reference for researchers and professionals in computer science, systems biology, and bioinformatics, as well as upper undergraduate, graduate, and postgraduate students. Hitoshi Iba is a Professor in the Department of Information and Communication Engineering, Graduate School of Information Science and Technology, at the University of Tokyo, Toyko, Japan. He is an Associate Editor of the IEEE Transactions on Evolutionary Computation and the journal of Genetic Programming and Evolvable Machines. Nasimul Noman is a lecturer in the School of Electrical Engineering and Computer Science at the University of Newcastle, NSW, Australia. From 2002 to 2012 he was a faculty member at the University of Dhaka, Bangladesh. Noman is an Editor of the BioMed Research International journal. His research interests include computational biology, synthetic biology, and bioinformatics.
Download or read book Focus and Coherence in Discourse Processing written by Gert Rickheit and published by Walter de Gruyter. This book was released on 1995 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Focus and Coherence in Discourse Processing".
Download or read book Ant The Definitive Guide written by Steve Holzner and published by "O'Reilly Media, Inc.". This book was released on 2005-04-13 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Soon after its launch, Ant succeeded in taking the Java world by storm, becoming the most widely used tool for building applications in Java environments. Like most popular technologies, Ant quickly went through a series of early revision cycles. With each new version, more functionality was added, and more complexity was introduced. Ant evolved from a simple-to-learn build tool into a full-fledged testing and deployment environment.Ant: The Definitive Guide has been reworked, revised and expanded upon to reflect this evolution. It documents the new ways that Ant is being applied, as well as the array of optional tasks that Ant supports. In fact, this new second edition covers everything about this extraordinary build management tool from downloading and installing, to using Ant to test code. Here are just of a few of the features you'll find detailed in this comprehensive, must-have guide: Developing conditional builds, and handling error conditions Automatically retrieving source code from version control systems Using Ant with XML files Using Ant with JavaServer Pages to build Web applications Using Ant with Enterprise JavaBeans to build enterprise applications Far exceeding its predecessor in terms of information and detail, Ant: The Definitive Guide, 2nd Edition is a must-have for Java developers unfamiliar with the latest advancements in Ant technology. With this book at your side, you'll soon be up to speed on the premiere tool for cross-platform development.Author Steve Holzner is an award-winning author who s been writing about Java topics since the language first appeared; his books have sold more than 1.5 million copies worldwide.
Download or read book Expert MySQL written by Charles Bell and published by Apress. This book was released on 2007-04-01 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: MySQL remains one of the hottest open source database technologies. As the database has evolved into a product competitive with proprietary counterparts like Oracle and IBM DB2, MySQL has found favor with large scale corporate users who require high-powered features and performance. Expert MySQL is the first book to delve deep into the MySQL architecture, showing users how to make the most of the database through creation of custom storage handlers, optimization of MySQL's query execution, and use of the embedded server product. This book will interest users deploying MySQL in high-traffic environments and in situations requiring minimal resource allocation.
Download or read book Databases Information Systems and Peer to Peer Computing written by Wee Siong Ng and published by Springer Science & Business Media. This book was released on 2005-03-07 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the thoroughly refereed postproceedings of the Second International Workshop on Databases, Information Systems, and Peer-to-Peer Computing, DBISP2P 2004, held in Toronto, Canada in August 2004 in conjunction with VLDB 2004. The 14 revised full papers presented together with an invited keynote paper were carefully selected during two rounds of reviewing and improvement. The papers are organized in topical sections on query routing and processing, similarity search in P2P networks, adaptive P2P networks, and information sharing and optimization.
Download or read book The Art of Writing Reasonable Organic Reaction Mechanisms written by Robert B. Grossman and published by Springer Science & Business Media. This book was released on 2007-07-31 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.
Download or read book Practical Handbook of Genetic Algorithms written by Lance D. Chambers and published by CRC Press. This book was released on 2019-09-17 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Handbook of Genetic Algorithms, Volume 3: Complex Coding Systems contains computer-code examples for the development of genetic algorithm systems - compiling them from an array of practitioners in the field. Each contribution of this singular resource includes: unique code segments documentation descripti
Download or read book A comprehensive mechanism for hotel recommendation to achieve personalized search engine written by Ying Huang and published by Infinite Study. This book was released on with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: Search engines are as important as recommender systems for hotel selections. However, the recommended lists of search engines are usually non-personalized and low accuracy. In order to deal with these issues in search engines, a comprehensive mechanism for hotel recommendation is proposed. In this mechanism, we consider users’ personalized preferences by identifying users’ attributes about interest, trust and consumption capacity. Meanwhile, the quantification method for each attribute is presented by using fuzzy theory. Moreover, this paper improves the method to evaluate the hotel, which respects to the criteria price, rating, and online review by using fuzzy theory. In addition, this proposed approach uses TOPSIS, a classical multi-criteria decision making method, to improve the accuracy further. Finally, a case study is conducted based on Tripadvisor.com to illustrate the validity of the proposed method for hotel recommendation in search engines. The results of the case study indicate that it not only solves the problem of non-personalization, but also improves the accuracy in search engine.
Download or read book Reaction Mechanism in Organic Chemistry written by Hashmat Ali and published by S. Chand Publishing. This book was released on with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents all the aspects of Reaction Mechanism in an exhaustive and systematic manner. Taking a contemporary approach to the subject, it thrives on worked out mechanisms and solved examples for the students to understand and practice various categories of chemical reactions. Designed to meet the growing needs of undergraduate and postgraduate students, this book would also be useful as a reference text to the aspirants appearing for various national-level entrance examinations.
Download or read book Case Studies in Secure Computing written by Biju Issac and published by CRC Press. This book was released on 2014-08-29 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: In today’s age of wireless and mobile computing, network and computer security is paramount. Case Studies in Secure Computing: Achievements and Trends gathers the latest research from researchers who share their insights and best practices through illustrative case studies. This book examines the growing security attacks and countermeasures in the stand-alone and networking worlds, along with other pertinent security issues. The many case studies capture a truly wide range of secure computing applications. Surveying the common elements in computer security attacks and defenses, the book: Describes the use of feature selection and fuzzy logic in a decision tree model for intrusion detection Introduces a set of common fuzzy-logic-based security risk estimation techniques with examples Proposes a secure authenticated multiple-key establishment protocol for wireless sensor networks Investigates various malicious activities associated with cloud computing and proposes some countermeasures Examines current and emerging security threats in long-term evolution backhaul and core networks Supplies a brief introduction to application-layer denial-of-service (DoS) attacks Illustrating the security challenges currently facing practitioners, this book presents powerful security solutions proposed by leading researchers in the field. The examination of the various case studies will help to develop the practical understanding required to stay one step ahead of the security threats on the horizon. This book will help those new to the field understand how to mitigate security threats. It will also help established practitioners fine-tune their approach to establishing robust and resilient security for next-generation computing systems.
