Download or read book Salivary Gland Development and Regeneration written by Seunghee Cha and published by Springer. This book was released on 2017-02-20 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive update on the latest information and knowledge which emerged from translational and basic science research endeavors, targeting the regeneration of salivary glands. The coverage includes salivary gland growth and development, stem cell therapy, bioengineering of salivary glands, and perspectives on and practical approaches to restoration of secretory function. More specifically, among the individual topics addressed are the various types of stem cell of value for cell replacement therapy, technological advances with respect to 3D printing, gene therapy, organ culture of salivary glands, and surgical aspects of the feasibility and practicality of transplantation. Readers will find helpful practical guidance on functional restorations of damaged salivary glands and stimulating insights into potential future directions in salivary gland regeneration research. The authors are all acknowledged experts from a range of academic and clinical backgrounds. Accordingly, the book will be of interest not only to clinicians, such as general dental practitioners, oral medicine specialists, and surgeons who manage dry mouth patients, but also to biomedical engineers, stem cell researchers, and transplant surgeons.

Download or read book Regeneration of Salivary Glands written by Guy Carpenter and published by . This book was released on 2017-03-31 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regeneration of Salivary Glands examines the current state of salivary regeneration by understanding the normal processes of development, function and tissue repair. It also explores the experimental and clinical approaches to stem cell therapy, mostly for irradiation induced salivary gland damage.Irradiation of head and neck cancers often involves the inclusion of salivary glands as it is difficult to focus the beams accurately enough. As a result, irritation of oral tissues and loss of saliva often lead to mucositis, which is the leading cause for patients not completing their treatments. Based on basic research that has shown stem cells develop into salivary glands, the regeneration process recapitulates aspects of this stem cell differentiation. This process involves several signaling pathways, but the Wnt pathway is of special interest as already shown in gut epithelial turnover and salivary gland stem cell differentiation.These challenges and new therapies developed in helping salivary gland regeneration are discussed in depth, and will be of interest to postgraduates and researchers in the fields of regenerative medicine and stem cell research.

Download or read book Salivary Glands written by Abigail S. Tucker and published by Karger Medical and Scientific Publishers. This book was released on 2010-01-01 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salivary glands are of utmost importance for several physiological functions ranging from the protection of teeth and surrounding soft tissues to the lubrication of the oral cavity, which is crucial for speech and perception of food taste. This publication highlights specific aspects of salivary gland development, investigating the mechanisms involved in embryonic development, the current research in stem cells, the ability of adult glands to regenerate and the signalling pathways involved in this process. Key stages of salivary gland development, moving from initiation to differentiation of the glands, are discussed, as well as unusual adaptations, ranging from making silk to making venom. The book finally provides new data on surgical techniques and diagnostic tools for clinicians involved in salivary gland disorders. Researchers and students with an interest in craniofacial sciences as well as clinicians dealing with salivary gland disorders will find this publication an excellent source of up-to-date information.

Download or read book Salisphere Development for Salivary Gland Regeneration written by Rimah Abdullah A. Saleem and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stem Cells in Craniofacial Development and Regeneration written by George T.J. Huang and published by John Wiley & Sons. This book was released on 2013-04-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells, Craniofacial Development and Regeneration is an introduction to stem cells with an emphasis on their role in craniofacial development. Divided into five sections, chapters build from basic introductory information on the definition and characteristics of stem cells to more indepth explorations of their role in craniofacial development. Section I covers embryonic and adult stem cells with a focus on the craniofacial region, while sections II-IV cover the development and regeneration of craniofacial bone, tooth, temporomandibular joint, salivary glands and muscle. Concluding chapters describe the current, cutting-edge research utilizing stem cells for craniofacial tissue bioengineering to treat lost or damaged tissue. The authoritative resource for dentistry students as well as craniofacial researchers at the graduate and post-graduate level, Stem Cells, Craniofacial Development and Regeneration explores the rapidly expanding field of stem cells and regeneration from the perspective of the dentistry and craniofacial community, and points the way forward in areas of tissue bioengineering and craniofacial stem cell therapies.

Download or read book Saliva Secretion and Functions written by A.J.M. Ligtenberg and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-31 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health professionals are more and more aware of the importance of saliva for oral health and well-being. As saliva secretion is steadily compromised with advancing age, it becomes a factor of concern in societies with an aging population, especially with a growing number of people who keep their own teeth. The numerous functions of saliva, like antimicrobial activity, lubrication, wound healing and its role in taste experience are only truly recognized when saliva secretion is hampered. In medical diagnostics, saliva shows its value as a safe and economical alternative to blood. This publication provides a comprehensive overview of the latest developments in salivary research by some of the world’s leading experts in the field. Chapters deal with various aspects: anatomy and physiology, e.g. regeneration of salivary glands, saliva functions, e.g. its protective and rheological properties, and diagnostics and disorders, e.g. xerostomia and hypersalivation. This book is not only recommended to basic scientists working in the field of oral biology, but also to dental students, dentists and health professionals who want to know more about one of the most underestimated bodily fluids.

Download or read book Stem Cells Heterogeneity Novel Concepts written by Alexander Birbrair and published by Springer. This book was released on 2019-04-23 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.

Download or read book Salivary Diagnostics written by David T. Wong and published by John Wiley & Sons. This book was released on 2009-03-16 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflects the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease.

Download or read book Textbook and Color Atlas of Salivary Gland Pathology written by Eric R. Carlson and published by John Wiley & Sons. This book was released on 2009-03-16 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook and Color Atlas of Salivary Gland Pathology: Diagnosis and Management provides its readers with a new, landmark text/atlas of this important discipline within oral and maxillofacial surgery, otolaryngology/head and neck surgery, and general surgery. Written by well-established clinicians, educators, and researchers in oral and maxillofacial surgery, this book brings together information on the etiology, diagnosis and treatment of all types of salivary gland pathology. Clear and comprehensive, the Textbook and Color Atlas of Salivary Gland Pathology offers complete explanation of all points, supported by a wealth of clinical and surgical illustrations to allow the reader to gain insight into every facet of each pathology and its diagnosis and treatment.

Download or read book Ten Cate s Oral Histology written by Antonio Nanci and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "150 color images with legends, 472 book figures with legends, 438 multiple choice test questions, and 119 interactive drag-and-drop exercises." -- from CD-ROM Welcome screen.

Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Histopathology of the Salivary Glands written by Henrik Hellquist and published by Springer. This book was released on 2014-09-09 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last 25 years it has become more and more evident that salivary gland pathology is by far the subject within head and neck pathology that causes most diagnostic challenges and problems for general pathologists. During courses the author has given, consultants and trainees alike have expressed the lack of a comprehensive, useful book on salivary gland pathology. Such a book needs to be broad and to illustrate almost every variant of all tumor entities. Another important feature to incorporate is the newly gained knowledge about genetics in salivary gland tumors, a knowledge that has emerged during the last 3-4 years only (and is growing continuously). A mapping of the immunophenotypes of salivary gland tumors is neither available today and will greatly benefit in routine diagnostic work.

Download or read book Organ Regeneration written by Takashi Tsuji and published by Humana Press. This book was released on 2017-03-31 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with a better understanding of organogenesis in developmental biology and next-generation organ regenerative therapy. This book focuses on recent studies of organ regeneration from stem cells using in vitro 3D cell culture and manipulation. The chapters cover topics such as generation of a 3D retinal tissue formation; functional salivary gland regeneration; liver regeneration using cultures liver bud; and in vivo model of small intestine. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Organ Regeneration: 3D Stem Cell Culture and Manipulation is a valuable resource for scientists and researchers who are interested in this field.

Download or read book Retinoic Acid Receptor Isoform specific Control of Mouse Salivary Gland Development and Regeneration written by Kara A. DeSantis and published by . This book was released on 2018 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Salisphere Development for Salivary Gland Regeneration written by Rimah Abdullah Saleem and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salivary gland stem/progenitor cells are considered a promising solution for ameliorating salivary gland damage. mTOR signalling is known to play a role during salivary gland atrophy as ligation of the salivary main excretory duct results in the activation of mammalian target of rapamycin (mTOR). Cultured mouse and human salivary gland stem/progenitor cells in vitro are able to form spherical non-adherent clusters named salispheres. As mTOR plays a role during glandular atrophy, salispheres were cultured from un-operated, ligated and de-ligated glands. This project aimed to understand several factors on the culture of salispheres. Indeed, mTOR is inactivated in healthy glands but activated during atrophy. Measuring changes in mTOR activity in growing salispheres highlighted the importance of this network for salisphere survival, and a potential correlation between glandular atrophy and salisphere culture. Rapamycin treatment illustrated the necessity of mTOR for growing salispheres, whereas LiCl treatment suggested that GSK-3 inhibition stimulated the expansion of salispheres. Interestingly, injury appeared to alter the growth behaviour of salispheres compared to controls. Mainly, salispheres adhere to a surface of the plastic dish and acquire fibroblastic-like structures suggesting that signalling alterations might be responsible for these changes. The detection of 4e-bp1 and S6 rp expression in salispheres suggested that mTOR was responsible for salisphere growth because it is involved in protein translation, but it was not responsible for the morphological modification post-injury. Changes in the ability of salispheres to adhere to a surface raised two questions. First, were morphological alterations mediated by the cytoskeletal rearrangement? For this reason, RhoA/ROCK and mTORC2 were investigated, as they are both involved in the cytoskeletal organisation.

Download or read book Tumor Suppressor Par 4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.