Download or read book Safety Evaluation of the Safety Edge Treatment written by and published by . This book was released on 2011 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Between periods of maintenance, pavement-edge drop-offs can form along the edge of highways. When a driver runs off the roadway, such drop-offs can hinder reentry and may lead to driver overcorrection, loss of control, or overturning on the roadway or roadside. The safety edge is a treatment that is implemented in conjunction with pavement resurfacing and is intended to help minimize drop-off-related crashes. This report examines the safety effects, costs, and benefits of this low-cost treatment for two-lane and multilane rural highways. The safety research was conducted as an observational before-after evaluation of treated sites using the empirical Bayes method. The economic appraisal consisted of a benefit-cost analysis"--Technical report documentation page.
Download or read book Public Roads written by and published by . This book was released on 2011 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Safety Evaluation of Permanent Raised Pavement Markers written by Geni Brafman Bahar and published by Transportation Research Board. This book was released on 2004 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: "TRB's National Cooperative Highway Research Program (NCHRP) Report 518: Safety Evaluation of Permanent Raised Pavement Markers examines the safety performance of snowplowable permanent raised pavement markers on two-lane roadways and four-lane freeways"--Publisher's description.
Download or read book Guidance for Implementation of the AASHTO Strategic Highway Safety Plan written by Timothy R. Neuman and published by Transportation Research Board. This book was released on 2008 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Also available online via the Web pages of the TRB Cooperative Research Programs (www4.trb.org/trb/crp.nsf).
Download or read book Drug Safety Evaluation written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2016-11-07 with total page 914 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition
Download or read book Roadside Design Guide written by American Association of State Highway and Transportation Officials. Task Force for Roadside Safety and published by . This book was released on 1989 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Injury Medicine Third Edition written by Nathan D. Zasler, MD and published by Springer Publishing Company. This book was released on 2021-09-01 with total page 1891 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This updated textbook was much needed as there has been increased attention in recent years toward brain injuries. The book provides updated guidelines and clinical practice recommendations that support the intended audience of trainees and current practitioners. This update makes it the current standard text for any brain injury specialist." ---Doody's Review Service, 4 stars This revised and greatly expanded Third Edition of Brain Injury Medicine continues its reputation as the key core textbook in the field, bringing together evidence-based medicine and years of collective author clinical experience in a clear and comprehensive guide for brain injury professionals. Universally praised as the gold standard text and go-to clinical reference, the book covers the entire continuum of care from early diagnosis and assessment through acute management, rehabilitation, associated medical and quality of life issues, and functional outcomes. With 12 new chapters and expanded coverage in key areas of pathobiology and neuro-recovery, special populations, sport concussion, disorders of consciousness, neuropharmacology, and more, this "state of the science" resource promotes a multi-disciplinary approach to a complex condition with consideration of emerging topics and the latest clinical advances. Written by over 200 experts from all involved disciplines, the text runs the full gamut of practice of brain injury medicine including principles of public health and research, biomechanics and neural recovery, neuroimaging and neurodiagnostic testing, sport and military, prognosis and outcome, acute care, treatment of special populations, neurologic and other medical complications post-injury, motor and musculoskeletal problems, post-trauma pain disorders, cognitive and behavioral problems, functional mobility, neuropharmacology and alternative treatments, community reentry, and medicolegal and ethical issues. Unique in its scope of topics relevant to professionals working with patients with brain injury, this third edition offers the most complete and contemporary review of clinical practice standards in the field. Key Features: Thoroughly revised and updated Third Edition of the seminal reference on brain injury medicine Evidence-based consideration of emerging topics with new chapters covering pathobiology, biomarkers, neurorehabilitation nursing, neurodegenerative dementias, anoxic/hypoxic ischemic brain injury, infectious causes of acquired brain injury, neuropsychiatric assessment, PTSD, and capacity assessment Multi-disciplinary authorship with leading experts from a wide range of specialties including but not limited to physiatry, neurology, psychiatry, neurosurgery, neuropsychology, physical therapy, occupational therapy speech language pathology, and nursing New online chapters on survivorship, family perspectives, and resources for persons with brain injury and their caregivers Purchase includes digital access for use on most mobile devices or computers
Download or read book Medical Product Safety Evaluation written by Jie Chen and published by CRC Press. This book was released on 2018-09-03 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. The book is designed not only for biopharmaceutical professionals, such as statisticians, safety specialists, pharmacovigilance experts, and pharmacoepidemiologists, who can use the book as self-learning materials or in short courses or training programs, but also for graduate students in statistics and biomedical data science for a one-semester course. Each chapter provides supplements and problems as more readings and exercises.
Download or read book Human Factors Guidelines for Road Systems written by John L. Campbell and published by Transportation Research Board. This book was released on 2010 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: NCHRP report 600 explores human factors principles and findings for consideration by highway designers and traffic engineers. The report is designed to help the nonexpert in human factors to consider more effectively the roadway user's capabilities and limitations in the design and operation of highway facilities.
Download or read book U02 written by and published by . This book was released on 2009 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book QSAR in Safety Evaluation and Risk Assessment written by Huixiao Hong and published by Elsevier. This book was released on 2023-08-12 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: QSAR in Safety Evaluation and Risk Assessment provides comprehensive coverage on QSAR methods, tools, data sources, and models focusing on applications in products safety evaluation and chemicals risk assessment. Organized into five parts, the book covers almost all aspects of QSAR modeling and application. Topics in the book include methods of QSAR, from both scientific and regulatory viewpoints; data sources available for facilitating QSAR models development; software tools for QSAR development; and QSAR models developed for assisting safety evaluation and risk assessment. Chapter contributors are authored by a lineup of active scientists in this field. The chapters not only provide professional level technical summarizations but also cover introductory descriptions for all aspects of QSAR for safety evaluation and risk assessment. - Provides comprehensive content about the QSAR techniques and models in facilitating the safety evaluation of drugs and consumer products and risk assesment of environmental chemicals - Includes some of the most cutting-edge methodologies such as deep learning and machine learning for QSAR - Offers detailed procedures of modeling and provides examples of each model's application in real practice
Download or read book Safety Evaluation of Permanent Raised Pavement Markers written by and published by . This book was released on 2004 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Guide for the Planning Design and Operation of Pedestrian Facilities written by and published by AASHTO. This book was released on 2004 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Future of Predictive Safety Evaluation written by D.V. Parke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.
Download or read book Brain Injury Medicine 2nd Edition written by Nathan D. Zasler, MD and published by Demos Medical Publishing. This book was released on 2012-08-27 with total page 1549 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a clear and comprehensive guide to all aspects of the management of traumatic brain injury-from early diagnosis and evaluation through the post-acute period and rehabilitation. An essential reference for physicians and other health care professionals who work with brain injured patients, the book focuses on assessment and treatment of the wider variety of clinical problems these patients face and addresses many associated concerns such as epidemiology, ethical issues, legal issues, and life-care planning. Written by over 190 acknowledged leaders, the text covers the full spectrum of the practice of brain injury medicine including principles of neural recovery, neuroimaging and neurodiagnostic testing, prognosis and outcome, acute care, rehabilitation, treatment of specific populations, neurologic and other medical problems following injury, cognitive and behavioral problems, post-traumatic pain disorders, pharmacologic and alternative treatments, and community reentry and productivity.
Download or read book Guide for Pavement Friction written by and published by AASHTO. This book was released on 2008 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report contains guidelines and recommendations for managing and designing for friction on highway pavements. The contents of this report will be of interest to highway materials, construction, pavement management, safety, design, and research engineers, as well as others concerned with the friction and related surface characteristics of highway pavements.
Download or read book Format and Content of the Safety Analysis Report for Nuclear Power Plants written by IAEA and published by International Atomic Energy Agency. This book was released on 2021-09-22 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Safety Guide provides recommendations on the structure and content of the safety analysis report to be submitted by the operating organization to the regulatory body for authorization of the siting, construction, commissioning, operation and decommissioning of a nuclear power plant. It is intended to facilitate both the development of the safety analysis report by the operating organization and the checking of its completeness and adequacy by the regulatory body. The publication is a revision of IAEA Safety Standards Series No. GS-G-4.1, Format and Content of the Safety Analysis Report for Nuclear Power Plants, which it supersedes. The revision reflects feedback experience from the Fukushima Daiichi accident and the subsequent stress tests performed. It also describes good practices and experience from the use of safety analysis reports for newly built nuclear power plants in different States and informs on recent progress made in approaches to safety assessment.
