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Book Ruthenium and Osmium Nitrogen Mulitple Bonded Complexes with Chelating Nitrogen And or Oxygen Atom Donor Ligands

Download or read book Ruthenium and Osmium Nitrogen Mulitple Bonded Complexes with Chelating Nitrogen And or Oxygen Atom Donor Ligands written by Ka-Lai Yip and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Ruthenium and osmium-nitrogen mulitple bonded complexes with chelating nitrogen and/or oxygen atom donor ligands: synthesis, structures and reactivity studies" by Ka-lai, Yip, 葉嘉麗, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4501517 Subjects: Ruthenium compounds - Synthesis Osmium compounds - Synthesis Ligands Chelates

Book Ruthenium and Osmium nitrogen Mulitple Bonded Complexes with Chelating Nitrogen And or Oxygen Atom Donor Ligands

Download or read book Ruthenium and Osmium nitrogen Mulitple Bonded Complexes with Chelating Nitrogen And or Oxygen Atom Donor Ligands written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: (Uncorrected OCR) Abstract of thesis entitled RUTHENIUM AND OSMIUM-NITROGEN MULITPLE BONDED COMPLEXES WITH CHELATING NITROGEN AND / OR OXYGEN ATOM DONOR LIGANDS: SYNTHESIS, STRUCTURES AND REACTIVITY STUDIES Submitted by Yip Ka Lai for the degree of Doctor of Philosophy at The University of Hong Kong in March 2005 The chemistry of late transition metal-nitrido complexes have been a growing interest especially for nitrido-ruthenium(VI) and -osmium(VI) metal complexes. However, the reactivity studies on those nitride complexes are sparse in the literature. As a result, the reactivities of nitridoruthenium(VI) complexes toward nucleophilic, electrophilic and oxidizing agents were studied. [Ru^CNXL^Cl] [H2L1 = 2,6-bis(2,2-diphenyl-2-hydroxyethyl)pyridine] underwent nitrogen atom transfer reaction with PPI13, PPhMe2 (dimethylphenylphosphine) and dppe [l,2-bis(diphenylphosphino)ethylene] to give [RuIII(HL1)(PPh3)Cl2], [Ru^XPPhMe^Cl] and [RuIII(L1)(dppe)Cl], respectively. In the presence of py or Hpz, the reaction of [Ru^^XL^Cl] gave [RuIII(L1)(py)2Cl] and [RuIII(L1)(Hpz)3]Cl as respective products. An unsymmetrical u-nitrido dinuclear ruthenium complex, [Ru^L^ChCu-N^u^L'XCsHioN^l], was formed upon reaction of [Ru^CNXL^Cl] with 2,6-dimethylaniline. Excess (Me30)BF4 reacted with [Ru^CNXL^Cl] to give a dinuclear u-OH complex, [Ru2(N)2(L1)2(OH)]PF6. For the analogous reaction with [n-Bu4N][MVI(NXL)] [L = L2 and L3; M = Os and Ru; H4L = l,2-dichloro-4,5-bis(2-hydroxybenzamido)benzene, H4L = l,2-bis(2-hydroxybenzamido)benzene], protonation at the auxiliary ligand occurred to give [M^CNXHL)] as product. Oxidation of [n-Bu4N][OsVI(N)(L2)] by PhI(OAc)2 produced [n-Bu4N][OsVI(N)(L202)] in 10% yield. Based on X-ray crystal analysis, the coordinated phenoxy moiety was converted to a benzoquinone moiety while the Os=N group remained intact. A synthetic route for preparing ruthenium pyridyl-amine complexes bearing chelating tertiary amine 'ligands was developed. At pH 1.0, the cyclic vo.

Book Complexes of Ruthenium with Ligands Containing Nitrogen Donor Atoms microform

Download or read book Complexes of Ruthenium with Ligands Containing Nitrogen Donor Atoms microform written by Caesar V. (Caesar Valko) Senoff and published by National Library of Canada. This book was released on 1965 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Iron and Ruthenium Complexes with Nitrogen and Oxygen Donor Ligands for Anti Cancer and Anti Viral Studies

Download or read book Iron and Ruthenium Complexes with Nitrogen and Oxygen Donor Ligands for Anti Cancer and Anti Viral Studies written by LAI-MING ELLA. WONG and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Iron and Ruthenium Complexes With Nitrogen and Oxygen Donor Ligands for Anti-cancer and Anti-viral Studies" by Lai-Ming, Ella, Wong, 黃禮明, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled IRON AND RUTHENIUM COMPLEXES WITH NITROGEN AND OXYGEN DONOR LIGANDS FOR ANTI-CANCER AND ANTI-VIRAL STUDIES Submitted by Ella Lai-Ming Wong For the degree of Doctor of Philosophy at The University of Hong Kong in February 2006 Development of drug resistance in cancer chemotherapy has stimulated the search for new anti-cancer drugs. Due to the versatile oxidation states and diverse coordination chemistry, iron and ruthenium compounds are potential candidates for new anti-cancer agents and metallopharmaceuticals. In this study, iron(II) complexes containing polypyridines as auxiliary ligand and ruthenium-oxo oxalato cluster were synthesized and characterized by X-ray crystallography, and their anti-cancer and anti-viral properties were examined. The iron(II) complexes, [Fe(R-qpy)(CH CN) ](ClO ) [qpy = 3 2 4 2 2,2′ 6′,2″ 6″,2′″ 6′″,2″″-quinquepyridine, R = H (1a) and Ph (1b)] and [Fe(Py -OH)(CH CN)](ClO ) (2) [Py-OH = 5 3 4 2 5 2,6-bis[hydroxybis(2-pyridyl)methyl]pyridine] were stable in physiological buffers and exhibited significant cytotoxicities against some established human cancer cell lines. According to the MTT assay, their IC values were 0.1 - 70 50 M; they exhibited more pronounced cytotoxicities against hepatocellular carcinoma cells than against other type of cancer cells. Flow cytometry studies revealed that 1a could cause cell cycle arrest of HeLa cells at the S-phase, which involved DNA synthesis. Complex 1a was found to catalyze epoxidation, aziridination and amidation of hydrocarbons with good substrate conversions and high product yields. The iron(IV)-oxo and -imido reactive intermediates were generated in situ and their formulations were verified by mass spectroscopy. By Evan''s method, the result supported the iron(IV) formulation with a low-spin d electronic configuration (S = 1). A ruthenium-oxo oxalato cluster formulated as Na [Ru ( -O) (C O ) ] (3) 7 4 3 4 2 4 6 was prepared. Structural studies and magnetic measurements revealed that the ruthenium atoms adopted the oxidation states of +III, +III, +III and +IV. Complex 3 showed anti-HIV properties on infected cells. Using the HIV-1(BaL) virus infected Hut/CCR5 cells, 3 was found to exhibit >90% inhibition on viral replication at 5 M concentration. Similar findings were obtained with other HIV-infected cell lines including GHOST/CXCR4 and PBMCs. Complex 3 was non-cytotoxic to these cells even at 50 M concentration. Relevant to anti-HIV activity, 3 was found to inhibit HIV-1 reverse transcriptase activity in vitro with IC = 2 nM. 50 III A series of ruthenium complexes, cis-[Ru (Me -tet)Cl ]ClO [Me -tet = 6 2 4 6 N, N, N′, N′-tetramethyl-3,6-dimethyl-3,6-diazaoctane-1,8-diamine], III III trans-[Ru (pyz) Cl]Cl (pyz = pyrazole), trans-[Ru (3Mepyz) Cl ]Cl 4 2 4 2 II III [3Mepyz = 3-methylpyrazole], [Ru (3Mepyz) ]Cl, [Ru (salen)(H O) ]Y 6 2 2 2 [H-salen = N, N''-bis(salicylidene)ethylenediamine, Y = Cl and PF ], 2 6 III cis-[Ru (cyclen)Cl]Cl [cyclen = 1,4,7,10-tetraazacyclododecane], 2III trans-[Ru (BiIml) Cl]Y [BiIml = biimidazole, Y = Cl and PF], and 2 2 6 II cis-[Ru (BiIml) (DMSO) ](ClO ) were examined for anti-cancer activities. 2 2 4 2 Their IC values were 4 - 100 M and their cytotoxicities could be affected by 50 the auxiliary ligands. The reduction potentials of the ruthenium compounds were +/0 in

Book The Chemistry of Ruthenium Rhodium Palladium Osmium Iridium and Platinum

Download or read book The Chemistry of Ruthenium Rhodium Palladium Osmium Iridium and Platinum written by Stanley E. Livingstone and published by Elsevier. This book was released on 2017-01-31 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Ruthenium, Rhodium, Palladium, Osmium, Iridium and Platinum

Book Comprehensive Coordination Chemistry II

Download or read book Comprehensive Coordination Chemistry II written by J. A. McCleverty and published by Elsevier Science. This book was released on 2003-12-17 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Coordination Chemistry II (CCC II) is the sequel to what has become a classic in the field, Comprehensive Coordination Chemistry, published in 1987. CCC II builds on the first and surveys new developments authoritatively in over 200 newly comissioned chapters, with an emphasis on current trends in biology, materials science and other areas of contemporary scientific interest.

Book Synthesis and Reactivity of Compounds Containing Ruthenium carbon nitrogen and oxygen Bonds

Download or read book Synthesis and Reactivity of Compounds Containing Ruthenium carbon nitrogen and oxygen Bonds written by and published by . This book was released on 1990 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The products and mechanisms of the thermal reactions of several complexes of the general structure (PMe3)4Ru(X)(Y) and (DMPM)2Ru(X)(Y) where X and Y are hydride, aryl, and benzyl groups, have been investigated. The mechanism of decomposition depends critically on the structure of the complex and the medium in which the thermolysis is carried out. The alkyl hydride complexes are do not react with alkane solvent, but undergo C-H activation processes with aromatic solvents by several different mechanisms. Thermolysis of (PMe3)4Ru(Ph)(Me) or (PMe3)4Ru(Ph)2 leads to the ruthenium benzyne complex (PMe3)4Ru([eta]2-C6H4) (1) by a mechanism which involves reversible dissociation of phosphine. In many ways its chemistry is analogous to that of early rather than late organo transition metal complexes. The synthesis, structure, variable temperature NMR spectroscopy and reactivity of ruthenium complexes containing aryloxide or arylamide ligands are reported. These complexes undergo cleavage of a P-C bond in coordinated trimethylphosphine, insertion of CO and CO2 and hydrogenolysis. Mechanistic studies on these reactions are described. The generation of a series of reactive ruthenium complexes of the general formula (PMe3)4Ru(R)(enolate) is reported. Most of these enolates have been shown to bind to the ruthenium center through the oxygen atom. Two of the enolate complexes 8 and 9 exist in equilibrium between the O- and C-bound forms. The reactions of these compounds are reported, including reactions to form oxygen-containing metallacycles. The structure and reactivity of these ruthenium metallacycles is reported, including their thermal chemistry and reactivity toward protic acids, electrophiles, carbon monoxide, hydrogen and trimethylsilane. 243 refs., 10 tabs.

Book Iron and Ruthenium Complexes with Nitrogen and Oxygen Donor Ligands for Anti cancer and Anti viral Studies

Download or read book Iron and Ruthenium Complexes with Nitrogen and Oxygen Donor Ligands for Anti cancer and Anti viral Studies written by Lai-Ming Wong (Ella) and published by . This book was released on 2006 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Complexes of Rhenium V with Bidentate Nitrogen and Oxygen Donor Ligands

Download or read book Complexes of Rhenium V with Bidentate Nitrogen and Oxygen Donor Ligands written by Joanne Perils and published by . This book was released on 1995 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Ruthenium Diphosphine Complexes with Auxiliary Nitrogen donor Ligands

Download or read book Ruthenium Diphosphine Complexes with Auxiliary Nitrogen donor Ligands written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Ruthenium and Osmium Complexes with Sulfur and Selenium donor Ligands

Download or read book Ruthenium and Osmium Complexes with Sulfur and Selenium donor Ligands written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: HKUST Call Number: Thesis CHEM 2000 Lau.

Book Synthesis and Reactivity of Ruthenium II and Osmium II Organometallic Imido Complexes

Download or read book Synthesis and Reactivity of Ruthenium II and Osmium II Organometallic Imido Complexes written by Richard Ira Michelman and published by . This book was released on 1992 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Dissertation Abstracts International

Download or read book Dissertation Abstracts International written by and published by . This book was released on 1985 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: