Download or read book Role of Neuropeptide Receptors in Neuroendocrinology written by Gilbert Holmes and published by . This book was released on 2022-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroendocrinology is a branch of biology which is concerned with the functional and anatomical interactions between the endocrine system and the nervous system. Major neuroendocrine systems are hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-thyroid axis, hypothalamic-pituitary-gonadal axis and hypothalamic-neurohypophyseal system. Neuropeptide receptors are the G-protein coupled class that comprises of seven transmembrane receptors. Peptides are released into the synaptic cleft and they activate these receptors through high affinity binding and also mediate internal signaling events through cytoplasmic G-protein coupled effector. When these receptors are activated, this inhibits and activates a variety of second messenger systems which results in cell firing, phosphorylation and dephosphorylation events, modulation of membrane threshold and alteration of gene expression. This book covers in detail some existent theories about the role of neuropeptide receptors in neuroendocrinology. It presents researches and studies performed by experts across the globe. Students, researchers, experts and all associated with this field will benefit alike from this book.
Download or read book Molecular Neuroendocrinology written by David Murphy and published by John Wiley & Sons. This book was released on 2016-01-19 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Neuroendocrinology: From Genome to Physiology, provides researchers and students with a critical examination of the steps being taken to decipher genome complexity in the context of the expression, regulation and physiological functions of genes in neuroendocrine systems. The 19 chapters are divided into four sectors: A) describes and explores the genome, its evolution, expression and the mechanisms that contribute to protein, and hence biological, diversity. B) discusses the mechanisms that enhance peptide and protein diversity beyond what is encoded in the genome through post-translational modification. C) considers the molecular tools that today’s neuroendocrinologists can use to study the regulation and function of neuroendocrine genes within the context of the intact organism. D) presents a range of case studies that exemplify the state-of-the-art application of genomic technologies in physiological and behavioural experiments that seek to better understand complex biological processes. • Written by a team of internationally renowned researchers • Both print and enhanced e-book versions are available • Illustrated in full colour throughout This is the third volume in a new Series ‘Masterclass in Neuroendocrinology’ , a co- publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Series Editors: John A. Russell, University of Edinburgh, UK and William E. Armstrong, The University of Tennessee, USA
Download or read book An Introduction to Neuroendocrinology written by Richard E. Brown and published by Cambridge University Press. This book was released on 1994-01-27 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
Download or read book Neuropeptide GPCRs in neuroendocrinology written by Jae Young Seong and published by Frontiers E-books. This book was released on 2014-11-07 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
Download or read book Orphan G Protein Coupled Receptors and Novel Neuropeptides written by Olivier Civelli and published by Springer Science & Business Media. This book was released on 2008-05-15 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms. The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.
Download or read book Neuropeptide Y and Drug Development written by Lars Grundemar and published by Elsevier. This book was released on 1996-11-15 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropeptide Y (NPY) is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions. This book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance. This book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets. The hypothalamic role of NPY and its relationship with eating disorders and diabetes The sympathetic nervous system role of NPY and its involvement in cardiovascular disorders Characterization of NPY receptor types and their brain distribution, molecular biology and pharmacology Development of peptide and non-peptide receptor antagonists
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2008-09-29 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Download or read book Neuropeptide Receptors written by Ivone Gomes and published by Biota Publishing. This book was released on 2013-04-01 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropeptides mediate their effects by binding and activating receptors that are responsible for converting these extracellular stimuli into intracellular responses. Most neuropeptides interact with G protein-coupled receptors that transduce the signal by activating heterotrimeric G proteins leading to alterations in second messenger systems to amplify the signal and elicit the intracellular response. In this review, we describe the general structure of G protein-coupled receptors including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, we summarize the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors). Using select examples of neuropeptide-receptor systems, we highlight the neuropeptides and corresponding receptors involved in modulation of pain and analgesia, body weight regulation, and hormonal regulation. Finally, we discuss the enzyme-linked tyrosine kinase receptors activated by growth factors and discuss the emerging concepts in targeting neuropeptide receptors for the identification of novel therapeutics targeting these systems. Table of Contents: Abbreviations / Overview of Neuropeptide Receptors / G Protein-Coupled Receptors: General Structure & Function / G Protein-Coupled Receptor Signaling / Neuropeptide Processing and Regulation / Neuropeptide Receptors / Perspectives / References
Download or read book Neuropeptides written by Fleur L. Strand and published by MIT Press. This book was released on 1999 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.
Download or read book Endocrinology Neuroendocrinology Neuropeptides written by E. Stark and published by . This book was released on 1981 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endocrinology Neuroendocrinology Neuropeptides written by E. Stark and published by Elsevier. This book was released on 2013-10-22 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Physiological Sciences, Volume 14: Endocrinology, Neuroendocrinology, Neuropeptides, Part II focuses on the research on neuropeptides, endocrinology, and neuroendocrinology. Composed of various contributions of able researchers, the first part of the book is divided into eight chapters. These chapters cover studies on the physiology, biochemistry, and localization of suspected hypothalamic releasing and inhibiting hormones. Researchers show how hormones react in different controlled environments. The second part of the selection deals with the use of in vitro systems in studying neuroendocrine regulation and steroid hormone action. This part is composed of four chapters wherein the extensive discussion of the processes involved is supported by experiments conducted on animals. The third part of the book covers the use of neurotransmitters in the control of anterior pituitary function. Composed of nine chapters, this part offers a thorough investigation of how neurotransmitters function in different controlled conditions. The fourth part of the selection, which is comprised of eight chapters, focuses on the function of neuropeptides as neurotransmitters. Studies are presented to elaborate the processes how neuropeptides can be converted to act as neurotransmitters. The last part, which covers nine chapters, deals exclusively with research on the effects of endogenous opioid peptides on the neuroendocrine system. The book is a great find for those interested in biochemistry.
Download or read book Neuropeptides written by Lawrence J. Whalley and published by . This book was released on 1982 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Neuroendocrinology written by Michael Wilkinson and published by Cambridge University Press. This book was released on 2019-01-03 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.
Download or read book Brain Peptides written by Antonio M. Gotto and published by North-Holland. This book was released on 1979 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Ramon Lim and published by Springer Science & Business Media. This book was released on 2006-09-18 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.
Download or read book Clinical Neuroendocrinology Neuropeptide Gpcrs written by Dylan Edwards and published by States Academic Press. This book was released on 2021-11-16 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The branch of biology which focuses on the relationship between the endocrine and the nervous system is termed as neuroendocrinology. The regulation of the activity of the hormones by the brain is studied within this field. The physiological processes in the body are regulated by a process known as neuroendocrine integration, wherein the endocrine and nervous system function together. The major neuroendocrine systems in the body are Hypothalamic-pituitary-adrenal axis (HPA axis), Hypothalamic-pituitary-thyroid axis (HPT axis), Hypothalamic-pituitary-gonadal axis (HPG axis) and Hypothalamic-neurohypophyseal system. GPCRs are G protein-coupled receptors, which can bind to numerous neuropeptides. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in the field of neuroendocrinology. It presents the complex subject of neuropeptide GPCRs in the most comprehensible and easy to understand language. The extensive content of this book provides the readers with a thorough understanding of the subject.
Download or read book Neuropeptides and Stress written by Yvette Tache and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropeptides and Stress presents a comprehensive survey by leading pioneers in the field of the knowledge and concepts implicating neuropeptides in the regulations of responses to stress. Topics covered include: recent advances on the regulation and modulation of the behavioral, endocrine, autonomic, gastrointestinal, immune and analgesic responses to stress by neuropeptides. Neuroanatomical and biological data are considered. Special emphasis is given to corticotropin-releasing factor (CRF) and opioid peptides.
