Download or read book Role of Membrane Microdomains in Compartmentation of CAMP Signaling written by Shailesh R. Agarwal and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Microdomains in the Cardiovascular System written by Viacheslav Nikolaev and published by Springer. This book was released on 2017-09-19 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.

Download or read book The Role of Caveolin associated Microdomains in Adult Cardiac Myocytes written by Brian P. Head and published by . This book was released on 2005 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Biomembranes and Biophysics in Immune Cell Signaling written by Yan Shi and published by Frontiers Media SA. This book was released on 2021-11-15 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Membrane Organization and Dynamics written by Amitabha Chattopadhyay and published by Springer. This book was released on 2017-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The chapters cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide the reader with a comprehensive understanding of the underlying membrane dynamics and function, which will help to develop robust dynamic models for the understanding of membrane function in healthy and diseased states. In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu. This volume will address the dynamic nature of membrane proteins within the membrane and will provide the reader with an up-to date overview of the theory and practical approaches that can be used. This volume will be invaluable to researchers working in a wide range of scientific areas, from biochemistry and molecular biology to biophysics and protein science. Students of these fields will also find this volume very useful. This book will also be of great use to those who are interested in the dynamic nature of biological processes.

Download or read book G Protein Coupled Receptors written by and published by Academic Press. This book was released on 2016-02-26 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation. - Covers the increasingly appreciated cell biology field of G-protein-coupled receptors - Includes both established and new technologies - Contributed by experts in the field - Covers topics such as signaling, trafficking, and regulation

Download or read book Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels written by George S. Baillie and published by Frontiers Media SA. This book was released on 2016-04-08 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

Download or read book Cardiomyocyte Microdomains An Emerging Concept of Local Regulation and Remodeling written by Alexey V. Glukhov and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cyclic Nucleotide Signaling written by Xiaodong Cheng and published by CRC Press. This book was released on 2015-05-07 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly inform

Download or read book Dynamics of cyclic nucleotide signaling in neurons written by Pierre Vincent and published by Frontiers Media SA. This book was released on 2015-09-16 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon…) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons.

Download or read book Cyclic Nucleotide Signaling and the Cardiovascular System written by Thomas Brand and published by MDPI. This book was released on 2018-07-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD

Download or read book Elucidating the Roles of Membrane Microdomains in Cellular Resilience written by Melody Nazarbegian and published by . This book was released on 2020 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma membrane compartments known as functional microdomains, such as membrane lipid rafts (MLRs) and caveolae, are critical in maintaining membrane structure and function which ultimately influences cellular survival. Numerous studies demonstrate that membrane microdomains are necessary for vital cellular functions like intracellular transport and cell signaling; but it remains unclear how plasma membrane organization is determined, how membrane microdomains regulate membrane repair, and how they work with intracellular organelles to enhance function. To define the role of membrane microdomains in facilitating cellular resilience, we focus on three specific areas: 1) circadian control of membrane dynamics, 2) membrane microdomain regulation of membrane repair, and 3) membrane microdomain regulation of intracellular function. Our findings suggest that membrane structural dynamics follow a daily oscillatory pattern, and that membrane composition and organization may be partially determined by Bmal1 dependent clock genes. Moreover, we found that over-expression of caveolin, a structural protein critical to caveolae, enhances the efficiency of membrane repair. Lastly, we expect that over-expression of caveolin will improve mitochondrial function in upcoming studies. These studies suggest that caveolae improve cellular resilience by enhancing membrane durability and organelle function. Thus, these studies establish a holistic understanding of the plasma membrane and its microdomains, laying the groundwork for further research on oscillatory rhythms at the membrane level, quantification and enhancement of membrane repair kinetics, and optimization of mitochondrial and membrane function via manipulations of membrane composition.

Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field

Download or read book Quantitative Biology written by Michael E. Wall and published by CRC Press. This book was released on 2012-08-25 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative methods are revolutionizing modern molecular and cellular biology. Groundbreaking technical advances are fueling the rapid expansion in our ability to observe, as seen in multidisciplinary studies that integrate theory, computation, experimental assays, and the control of microenvironments. Integrating new experimental and theoretical

Download or read book Protein Protein Interactions as New Drug Targets written by Enno Klussmann and published by Springer Science & Business Media. This book was released on 2008-05-20 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions. This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph

Download or read book Biomembranomics written by Hongda Wang and published by CRC Press. This book was released on 2023-11-23 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: The membrane is an intricately structured entity that performs numerous vital biological functions, including materials transport, signal transduction, energy transfer, and enzymatic reactions. Abnormal expression and distribution of certain membrane proteins are even associated with genetic disorders, neurodegenerative diseases, and malignant tumors. Despite the widely acknowledged significance of membranes, comprehensive and systematic research on membranes akin to genomics, proteomics, and metabolomics is still lacking. Furthermore, the broad concept of biomembranes is not confined to the plasma membrane alone; it also includes organelle membranes and membranes of endocytosis or exocytosis vesicles, which are also derived from the biomembrane system. This book introduces the concept of "omics" to membranes and proposes the term ‘biomembranomics.’ It compiles the latest advancements in structural analysis techniques for biomembranes, including single-molecule manipulation techniques, single-molecule fluorescence techniques, super-resolution fluorescence imaging, cryo-electron microscopy, mass spectrometry, molecular dynamics simulation, and hyphenated instrumental techniques. The book presents both classic and cutting-edge protocols in text and illustrative forms, serving as a valuable and applicable reference material. It provides a profound understanding of biomembrane organization at single-molecule level, paving new avenues for unveiling the relationship between membrane structure and function. Therefore, this book is essential reading for researchers across all related fields.