Download or read book Risk Factors for Pancreatic Cancer Underlying Mechanisms and Potential Targets written by Guido Eibl and published by Frontiers Media SA. This book was released on 2015-04-22 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pancreatic Cancer has been and still is one of the deadliest types of human malignancies. The annual mortality rates almost equal incidence rates making this disease virtually universally fatal. The 5-year survival of patients with pancreatic cancer is a dismal 5% or less. Therapeutic strategies are extremely limited with gemcitabine extending the survival by a disappointing few weeks. The failure of several randomized clinical trials in the past decade investigating the therapeutic efficacy of different mono- and combination therapies reflects our limited knowledge of pancreatic cancer biology. In addition, biomarkers for early detection are sorely missing. Several pancreatic cancer risk factors have been identified. Unfortunately, the underlying mechanisms linking these risk factors to cancer development are poorly understood. Well known possible and probable risk factors for the development of pancreatic cancer are age, smoking, chronic pancreatitis, obesity, and type-2 diabetes mellitus. Age is certainly of the most important risk factors as most cases of pancreatic cancer occur in the elderly population. Smoking ten cigarettes a day increases the risk by 2.6 times and smoking a pack per day increases it by 5 folds. Chronic pancreatitis increases the risk of pancreatic cancer by up to 13 times. Patients with hereditary forms of chronic pancreatitis have an even higher risk. Obesity, a growing global health problem, increases the risk of pancreatic cancer by about 1.5 fold. Type-2 diabetes mellitus is also associated with an increased risk of pancreatic cancer by at least two-fold. The more recent the onset of diabetes, the stronger the correlation with pancreatic cancer is. In addition, heavy alcohol drinking, a family history of the disease, male gender and African American ethnicity are other risk factors for pancreatic cancer. Pancreatic cancer is characterized by several genetic alterations including mutations in the Kras proto-oncogene and mutations in the tumor suppressor genes p53 and p16. While Kras mutations are currently thought as early events present in a certain percentage of pancreatic intraepithelial neoplasias (PanINs), known precursor lesions of pancreatic ductal adenocarcinomas, mutations in tumor suppressor genes, e.g. p53, seem to accumulate later during progression. In addition, several intracellular signaling pathways are amplified or enhanced, including the MAPK/ERK and PI3K/AKT signaling modules. Overall, these genetic alterations lead to enhanced and sustained proliferation, resistance to cell death, invasive and metastatic potential, and angiogenesis, all hallmarks of cancers. The scope of this Research Topic is to collect data and knowledge of how risk factors increase the risk of initiation/progression of pancreatic cancer. Of particular interest are potential underlying molecular mechanisms. Understanding the molecular mechanisms and driving signaling pathways will ultimately allow the development of targeted interventions to disrupt the risk factor-induced cancer development. This Research Topic is interested in a broad range of risk factors, including genetic and environmental, and welcomes original papers, mini and full reviews, and hypothesis papers. Manuscripts that address the effect of combination of risk factors on pancreatic cancer development and progression are of great interest as well.
Download or read book Exploring Pancreatic Metabolism and Malignancy written by Ganji Purnachandra Nagaraju and published by Springer Nature. This book was released on 2019-11-23 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.
Download or read book Exploring Pancreatic Metabolism and Malignancy written by and published by . This book was released on 2019 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.
Download or read book Inflammation and Cancer written by Bharat B. Aggarwal and published by Springer. This book was released on 2014-05-12 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Download or read book Oncogenes and Carcinogenesis written by Pinar Erkekoglu and published by BoD – Books on Demand. This book was released on 2019-03-06 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncogenes are mutated and/or overexpressed at high levels in tumor cells. Tumors of the lung, breast, pancreas, and colon may display specific oncogenetic features. These tumors have been largely associated with exposure to environmental carcinogens and a variety of biological agents, including viruses. These carcinogens can induce specific genetic and epigenetic alterations in these tissues, leading to aberrant functioning of oncogenes and tumor suppressor genes. On the microRNAs (miRNAs) there are significant modifiers of both transcription and translation of oncogenes in carcinogenesis. In the last 50 years, several oncogenes and microRNAs related to these oncogenes have been identified in different types of human cancers. It is now clear that high expression of oncogenes, DNA damage response, and regulation of the cell cycle are related to the circadian clock. This book will mainly focus on the expressions of different oncogenes in breast, colon, and lung cancers. Moreover, readers will gain qualified scientific knowledge of the alterations in miRNAs in different types of cancers and the effects of the circadian clock on the expression of oncogenes in carcinogenesis.
Download or read book WHO Classification of Tumours of the Digestive System written by F. T. Bosman and published by International Agency for Research on Cancer. This book was released on 2010-10-15 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Molecular Biomarkers for Cancer Diagnosis and Therapy written by Ranbir Chander Sobti and published by Springer Nature. This book was released on with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Role of Transcription Factors in Gastrointestinal Malignancies written by Ganji Purnachandra Nagaraju and published by Springer. This book was released on 2018-03-27 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.
Download or read book Pancreatic Cancer written by Douglas B. Evans and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The MD Anderson Solid Tumor Oncology series presents cutting-edge surgical treatment and medical therapy for specific sites. This volume, Pancreatic Cancer, addresses epidemiology and molecular biology, inherited syndromes, staging, surgical techniques, multimodality therapy, and emerging therapies. The individual chapters focus on narrow, specific topics to produce a reference work of value to those interested in pancreatic cancer from a clinical and translational research perspective. A must-have for surgical oncologists and general surgeons.
Download or read book Hoffman and Abeloff s Hematology Oncology Review E Book written by Claudine Isaacs and published by Elsevier Health Sciences. This book was released on 2017-09-21 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: For those preparing for certification or recertification in hematology or oncology, Hoffman and Abeloff's Hematology-Oncology Review is a single-volume source of authoritative, up-to-date exam preparation. This unique question and answer review helps you succeed on today’s board exams with more than 1,000 board-style questions, answers, and rationales; comprehensive coverage of essential exam topics, and online practice tests. Includes 1,000+ board-style questions with answers and rationales explaining both correct and incorrect answers. Covers a broad range of topics compiled by experts in hematology and oncology, including cancer biology and genomics, immunotherapy, hematologic malignancies, solid tumor malignancies, non-malignant hematology, and supportive care. Uniquely designed as both a standalone review and a study companion to Abeloff’s Clinical Oncology and Hematology: Basic Principles and Practice.
Download or read book How Not to Die written by Michael Greger, M.D., FACLM and published by Flatiron Books. This book was released on 2015-12-08 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the physician behind the wildly popular NutritionFacts website, How Not to Die reveals the groundbreaking scientific evidence behind the only diet that can prevent and reverse many of the causes of disease-related death. The vast majority of premature deaths can be prevented through simple changes in diet and lifestyle. In How Not to Die, Dr. Michael Greger, the internationally-renowned nutrition expert, physician, and founder of NutritionFacts.org, examines the fifteen top causes of premature death in America-heart disease, various cancers, diabetes, Parkinson's, high blood pressure, and more-and explains how nutritional and lifestyle interventions can sometimes trump prescription pills and other pharmaceutical and surgical approaches, freeing us to live healthier lives. The simple truth is that most doctors are good at treating acute illnesses but bad at preventing chronic disease. The fifteen leading causes of death claim the lives of 1.6 million Americans annually. This doesn't have to be the case. By following Dr. Greger's advice, all of it backed up by strong scientific evidence, you will learn which foods to eat and which lifestyle changes to make to live longer. History of prostate cancer in your family? Put down that glass of milk and add flaxseed to your diet whenever you can. Have high blood pressure? Hibiscus tea can work better than a leading hypertensive drug-and without the side effects. Fighting off liver disease? Drinking coffee can reduce liver inflammation. Battling breast cancer? Consuming soy is associated with prolonged survival. Worried about heart disease (the number 1 killer in the United States)? Switch to a whole-food, plant-based diet, which has been repeatedly shown not just to prevent the disease but often stop it in its tracks. In addition to showing what to eat to help treat the top fifteen causes of death, How Not to Die includes Dr. Greger's Daily Dozen -a checklist of the twelve foods we should consume every day.Full of practical, actionable advice and surprising, cutting edge nutritional science, these doctor's orders are just what we need to live longer, healthier lives.
Download or read book Flavonoids Inflammation And Cancer written by Hollie Swanson and published by World Scientific. This book was released on 2015-08-13 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an insightful analysis of the chemopreventive actions of flavonoids. Flavonoids are naturally occurring constituents of plants that have been traditionally used as anti-inflammatory and anti-cancer medicines. In addition, human consumption of vegetables and fruits with high concentrations of flavonoids is associated with decreased cancer mortalities rates.Flavonoids, Inflammation and Cancer presents an in-depth analysis of the mechanisms by which flavonoids are thought to prevent inflammation and the development of GI and steroid-responsive cancers. In addition, the promise and pitfalls associated with using flavonoids as chemopreventive agents are discussed.This book is an invaluable reference for basic and clinical scientists who are interested in exploring the link between nutrition and cancer.
Download or read book Abernathy s Surgical Secrets E Book written by Alden H. Harken and published by Elsevier Health Sciences. This book was released on 2008-12-22 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this leading volume in the Secrets Series® offers the very latest overview of surgical practice. A two-color page layout, question-and-answer approach, and a list of the “Top 100 Secrets in surgery gives you the perfect concise board review or handy clinical reference, while updated coverage throughout equips you with all of the most current and essential knowledge in the field. Valuable pearls, tips, and memory aids make this the perfect resource for a fast surgical review or reference. Uses bulleted lists, tables, short answers, and a highly detailed index to expedite reference. Includes pearls, tips, and memory aids, making it perfect as a handy surgical review for board exams or clinical reference. Covers all of today’s most common surgical procedures and techniques. Presents a “Controversies section in many chapters that highlights the pros and cons of selected procedures and approaches. Features a compact trim size for enhanced portability. Features revisions throughout to provide you with an up-to-date overview of today’s surgical care and practice. Includes new chapters on mechanical ventilation, bariatric surgery, adrenal incidentaloma, mechanical circulatory support, and professionalism, to keep you current.
Download or read book Genetic Disorders of the Exocrine Pancreas written by Peter R. Durie and published by Karger Medical and Scientific Publishers. This book was released on 2002-01-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication summarizes important new scientific information and provides guidelines for genetic testing for hereditary pancreatitis as well as guidelines for the prevention, screening, and treatment of pancreatic cancer in hereditary pancreatitis. It also includes chapters on neonatal screening for cystic fibrosis, gene mutations in idiopathic pancreatitis, and clinical phenotypes of Shwachman-Diamond Syndrome. This book is required reading for all individuals with an interest in pancreatic disease.
Download or read book Diabetes and Cancer written by Kai Masur and published by Karger Medical and Scientific Publishers. This book was released on 2008-01-01 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interdisciplinary work revealing varied roles in biological processes of chronic diseases has led to a new field of research concerning common molecular and clinical features of chronic diseases. Epidemiological literature suggests an association between the history of metabolic syndrome/diabetes mellitus type 2 and the risk of developing a variety of cancers.This book, at the forefront of experimental and clinical research, is the first to highlight the common molecular links between these two diseases. These tight links indicate a complex interdependency between both diseases on a cellular and hormonal basis, which is influenced by a variety of aspects (e.g. nutritional, social and neuro-immunological factors). Special attention has been given to the fundamental role of the switch from oxidative phosphorylation to glycolysis of cancer cells - the Warburg effect.Offering insights into the interdisciplinary approaches of tomorrow, this publication will encourage endocrinologists, oncologists, diabetologists, general practitioners, diabetic nurses and students of life sciences working separately on various aspects of diabetes and cancer to come together and combine therapies and strategies.
Download or read book Viruses and Liver Cancer written by E. Tabor and published by Gulf Professional Publishing. This book was released on 2002-06-18 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatocellular carcinoma (HCC) is one of the most common human cancers. Its association with chronic hepatitis B and C virus infections is well established. As one of the first human cancers to be etiologically associated with any virus, it provides a model for studying viral carcinogenesis in humans. The latest concepts in molecular biology have been brought to bear on the study of HCC and have led to dramatic breakthroughs in our understanding of how it develops.
