Download or read book Review on Synthesis of Isoxazolines Pyrazolines Compounds written by Nadia Elkanzi and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: My book summarize with the different methods for synthesis of Isoxazoliens from 2-alkyn-1-one O-methyl oximes,1, 3-dipolar cycloaddition of phenyl vinylic selenide to nitrile oxides, reaction of alkenes or alkynes with ketones, Microwave irradiation of propane-l-(1,3-benzodioxol-5-yl)-3-phenyl-l,3-dione with hydroxylamine hydrochloride, Also pyrazoles synthesiszed by 3- Acetyl benzpyrid-4-imno-2-oxime hydrazine hydrate (phenyl hydrazine),2- cyanomethyl benzimidizole -2, 2- dicarboxaldehyde (94) reacts with hydrazine hydrate, condensation of acetic acid azide of hydrazine and/or phenyl hydrazine with ethyl cyanoacetate under fusion afforded the pyrazole.
Download or read book Pyridines From Lab to Production written by Eric F.V. Scriven and published by Academic Press. This book was released on 2013-01-08 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more. - Reviews tried and tested practical methods to help the reader select the best method for their research - Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative - Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on
Download or read book Microwave Assisted Organic Synthesis written by Jason Tierney and published by John Wiley & Sons. This book was released on 2009-02-12 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first reports on the application of microwaves in organicsynthesis date back to 1986, but it was not until the recentintroduction of specifically designed and constructed equipment,which countered the safety and reproducibility concerns, thatsynthetic application of microwaves has become established as alaboratory technique. Microwave assisted synthesis is now beingadopted in many industrial and academic laboratories to takeadvantage of the novel chemistry that can be carried out using avariety of organic reaction types. This book demonstrates the underlying principles of microwavedielectric heating and, by reference to a range of organic reactiontypes, it's effective use in synthetic organic chemistry. Toillustrate the impact microwave assisted organic synthesis can haveon chemical research, case studies drawn mainly from thepharmaceutical industry are presented.
Download or read book Russian Chemical Reviews written by and published by . This book was released on 1993 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bio Based Solvents written by François Jérôme and published by John Wiley & Sons. This book was released on 2017-06-29 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: A multidisciplinary overview of bio-derived solvent applications, life cycle analysis, and strategies required for industrial commercialization This book provides the first and only comprehensive review of the state-of-the-science in bio-derived solvents. Drawing on their own pioneering work in the field, as well as an exhaustive survey of the world literature on the subject, the authors cover all the bases—from bio-derived solvent applications to life cycle analysis to strategies for industrial commercialization—for researchers and professional chemists working across a range of industries. In the increasingly critical area of sustainable chemistry, the search for new and better green solvents has become a top priority. Thanks to their renewability, biodegradability and low toxicity, as well as their potential to promote advantageous organic reactions, green solvents offer the promise of significantly reducing the pernicious effects of chemical processes on human health and the environment. Following an overview of the current solvents markets and the challenges and opportunities presented by bio-derived solvents, a series of dedicated chapters cover all significant classes of solvent arranged by origin and/or chemical structure. Throughout, real-world examples are used to help demonstrate the various advantages, drawbacks, and limitations of each class of solvent. Topics covered include: The commercial potential of various renewably sourced solvents, such as glycerol The various advantages and disadvantages of bio-derived versus petroleum-based solvents Renewably-sourced and waste-derived solvents in the design of eco-efficient processes Life cycle assessment and predictive methods for bio-based solvents Industrial and commercial viability of bio-based solvents now and in the years ahead Potential and limitations of methodologies involving bio-derived solvents New developments and emerging trends in the field and the shape of things to come Considering the vast potential for new and better products suggested by recent developments in this exciting field, Bio-Based Solvents will be a welcome resource among students and researchers in catalysis, organic synthesis, electrochemistry, and pharmaceuticals, as well as industrial chemists involved in manufacturing processes and formulation, and policy makers.
Download or read book Advances in Heterocyclic Chemistry written by and published by Elsevier. This book was released on 2024-02-07 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Heterocyclic Chemistry, Volume 142, the latest release in this definitive series, combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Chapters in this new release include Recent advances in the Synthesis of Benzo[b]furans, Recent Advances in the Synthesis of 6-Membered Heterocycles via Domino and Multicomponent Reactions (from 2017-2022), Multi-component synthesis of isatin based bioactive heterocycles, Recent advances in the chemistry of pyrazolo[1,5-a]pyrimidines, The Literature of Heterocyclic Chemistry, Part XXI, 2021, and much more.Additional sections present the latest Advances in applications of dihydropyridines in organic chemistry and Strategies for the annulation of five-membered sulfur-nitrogen rings to benzene and heterocycles. - Considered the definitive serial in the field of heterocyclic chemistry - Serves as the go-to reference for organic chemists, polymer chemists, and many biological scientists - Provides the latest comprehensive reviews written by established authorities in the field - Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds
Download or read book Asymmetric Synthesis of Nitrogen Heterocycles written by Jacques Royer and published by John Wiley & Sons. This book was released on 2009-08-04 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here, all aspects of the topic are presented in a compact manner. The book is clearly structured, and divided into two sections -- asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom -- such that the necessary information may be found at a glance. The international team of authors provides important experimental procedures, including industrial applications. Essential for synthetic chemists in pharmaceutical and agrochemical chemistry.
Download or read book Stereoselective Multiple Bond Forming Transformations in Organic Synthesis written by Jean Rodriguez and published by John Wiley & Sons. This book was released on 2015-04-03 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combining the important research topic of multiple bond-formingtransformations with green chemistry, this book helps chemistsidentify recent sustainable stereoselective syntheticsequences. • Combines the important research topic ofmultiple bond-forming transformations with green chemistry andsustainable development • Offers a valuable resource for preparingcompounds with multiple stereogenic centers, an important field forsynthetic chemists • Organizes chapters by molecular structureof final products, making for a handbook-style resource • Discusses applications of the synthesisof natural products and of drug intermediates • Brings together otherwise-scatteredinformation about a number of key, efficient chemical reactions
Download or read book Solid Phase Organic Synthesis written by Patrick H. Toy and published by John Wiley & Sons. This book was released on 2012-01-10 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.
Download or read book Indian Journal of Chemistry written by and published by . This book was released on 1986 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nitroazoles Synthesis Structure and Applications written by Lyudmila Larina and published by Springer Science & Business Media. This book was released on 2009-08-28 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to the synthesis, application, structure, and physicochemical properties of nitroazoles (five-membered aromatic compounds). The book is unique in providing the first comprehensive treatment of nitroazoles.
Download or read book Bioactive Heterocyclic Compound Classes written by Clemens Lamberth and published by John Wiley & Sons. This book was released on 2012-08-16 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products, e. g. hormones, antibiotics, vitamins, etc. are composed of heterocyclic structures. Often, these compounds show beneficial properties and are therefore applied as pharmaceuticals to treat diseases or as insecticides, herbicides or fungicides in crop protection. This volume presents important pharmaceuticals. Each of the 20 chapters covers in a concise manner one class of heterocycles, clearly structuredas follows: * Structural formulas of most important examples (market products) * Short background of history or discovery * Typical syntheses of important examples * Mode of action * Characteristic biological activity * Structure-activity relationship * Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.) * References. A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the pharmaceutical chemistry.
Download or read book Synthetic Applications of 1 3 Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products Volume 59 written by Albert Padwa and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dipolar cycloaddition reactions have found many useful applications in chemistry, particularly with respect to the synthesis of compounds with new chiral centers. Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products updates the popular 1984 edition, featuring the advances made over the past twenty years and focusing on synthetic applications.
Download or read book Diversity Oriented Synthesis written by Andrea Trabocchi and published by John Wiley & Sons. This book was released on 2013-06-17 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
Download or read book Fluorine in Medicinal Chemistry and Chemical Biology written by Iwao Ojima and published by John Wiley & Sons. This book was released on 2009-03-23 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.
Download or read book Cobalt Catalysis in Organic Synthesis written by Marko Hapke and published by John Wiley & Sons. This book was released on 2020-04-06 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a much-needed account of the formidable "cobalt rush" in organic synthesis and catalysis Over the past few decades, cobalt has turned into one of the most promising metals for use in catalytic reactions, with important applications in the efficient and selective synthesis of natural products, pharmaceuticals, and new materials. Cobalt Catalysis in Organic Synthesis: Methods and Reactions provides a unique overview of cobalt-catalysed and -mediated reactions applied in modern organic synthesis. It covers a broad range of homogeneous reactions, like cobalt-catalysed hydrogenation, hydrofunctionalization, cycloaddition reactions, C-H functionalization, as well as radical and biomimetic reactions. First comprehensive book on this rapidly evolving research area Covers a broad range of homogeneous reactions, such as C-H activation, cross-coupling, synthesis of heterocyclic compounds (Pauson-Khand), and more Chapters on low-valent cobalt complexes as catalysts in coupling reactions, and enantioselective cobalt-catalyzed transformations are also included Can be used as a supplementary reader in courses of advanced organic synthesis and organometallic chemistry Cobalt Catalysis in Organic Synthesis is an ideal book for graduates and researchers in academia and industry working in the field of synthetic organic chemistry, catalysis, organometallic chemistry, and natural product synthesis.
Download or read book Organic Reaction Mechanisms 2014 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2018-04-10 with total page 1023 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms 2014, the 50th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2014. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. This volume includes a 5-year cumulative index.
