Download or read book Current Challenges in Pharmacovigilance written by World Health Organization and published by . This book was released on 2001-01-01 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of recent progress in the harmonization of terminology and processes affecting work on the clinical safety of medicines consensus is needed on standards for many difficult aspects of day-to-day pharmacovigilance that continue to pose problems for both the pharmaceutical industry and drug regulators. The CIOMS V Working Group has generated proposals for pragmatic approaches to dealing with such issues as: classification and handling of individual safety case reports from a variety of sources (spontaneous consumer reports solicited reports literature the Internet observational studies and secondary data bases disease and other registries regulatory ADR databases and licensor-licensee interactions); new approaches to case management and regulatory reporting practices (proper clinical evaluation of cases incidental vs other events patient and reporter identifiability seriousness criteria expectedness criteria case follow-up criteria and the role and structure of case narratives); improvements and efficiencies in the format content and reporting of periodic safety update reports (PSURs) (including results of an industry survey on PSUR workloads and practices; proposals for high case volume and long time-period reports simplification of certain PSURs summary bridging reports addendum reports license renewal reports for EU and Japan dealing with old products and other technical details); determination and use of population exposure (denominator) data (sources of data and a guide to analytical approaches for a variety of circumstances).The Group has also taken stock of the current state of expedited and periodic clinical safety reporting requirements around the world with summary data on regulations from more than 60 countries. Recommendations are made for enhancing the harmonization steps already taken as a result of previous CIOMS publications and the ICH process. In addition to dealing with unfinished and unresolved issues from previous CIOMS initiatives the report covers many emerging topics such as those involving new technologies. Its 20 Appendices provide a wealth of detailed explanations and reference information. It is the most comprehensive and recent treatment of difficult pharmacovigilance issues affecting the working practices and systems of drug safety and other pharmaceutical professionals.

Download or read book Energy Balance and Obesity written by Isabelle Romieu and published by IARC Working Group Report. This book was released on 2018-01-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the relationship between energy balance and obesity is essential to develop effective prevention programs and policies. The International Agency for Research on Cancer convened a Working Group of world-leading experts in December 2015 to review the evidence regarding energy balance and obesity, with a focus on low- and middle-income countries, and to consider the following scientific questions: (i) Are the drivers of the obesity epidemic related only to energy excess and/or do specific foods or nutrients play a major role in this epidemic? (ii) What are the factors that modulate these associations? (iii) Which types of data and/or studies will further improve our understanding? This book provides summaries of the evidence from the literature as well as the Working Group's conclusions and recommendations to tackle the global epidemic of obesity.

Download or read book Report written by United States. Congress. House and published by . This book was released on with total page 2134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Managing the Risks of Extreme Events and Disasters to Advance Climate Change Adaptation written by Intergovernmental Panel on Climate Change and published by Cambridge University Press. This book was released on 2012-05-28 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extreme weather and climate events, interacting with exposed and vulnerable human and natural systems, can lead to disasters. This Special Report explores the social as well as physical dimensions of weather- and climate-related disasters, considering opportunities for managing risks at local to international scales. SREX was approved and accepted by the Intergovernmental Panel on Climate Change (IPCC) on 18 November 2011 in Kampala, Uganda.

Download or read book The UN Working Group on Arbitrary Detention written by Jared Genser and published by Cambridge University Press. This book was released on 2019-09-26 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical guide to freeing political prisoners and provides a comprehensive review of this UN body's 1,200 jurisprudence cases.

Download or read book The United Nations Convention on the Rights of the Child written by Sharon Detrick and published by Martinus Nijhoff Publishers. This book was released on 1992-04-23 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction, by Jan Martenson.

Download or read book The Right to Conscientious Objection to Military Service and Turkey s Obligations under International Human Rights Law written by Ö. Çinar and published by Springer. This book was released on 2014-07-25 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study examines Turkey's non-recognition of the right to conscientious objection to military service and locates this non-recognition within the context of international human rights law - specifically United Nations and European Union system.

Download or read book Proceedings of the Workshop on Needs and Resources for Occupational Mortality Data written by and published by . This book was released on 1988 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Foreign Relations of the United States written by United States. Department of State and published by . This book was released on 1948 with total page 1610 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Compte Rendu written by and published by IGME. This book was released on 1985 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Foreign Relations of the United States 1948 Germany and Austria written by and published by . This book was released on 1976 with total page 1614 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Proceedings of the First USCG National Data Buoy Systems Scientific Advisory Meeting written by and published by . This book was released on 1969 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mycotoxin Control in Low and Middle Income Countries written by Christopher P. Wild and published by IARC Working Group Report. This book was released on 2016-02-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an evaluation of measures to reduce exposure to highly toxic and carcinogenic contaminants in staple diets in Africa as well as parts of Asia and Latin America. Many of the poorest people in these regions are exposed to the pervasive natural toxins, aflatoxins and fumonisins, on a daily basis by eating their staple diet of groundnuts, maize, and other cereals. Exposure to mycotoxins at these high levels substantially increases mortality and morbidity. Aflatoxins are a cause of human liver cancer, and fatalities from acute aflatoxin poisoning outbreaks occur in Africa and Asia. The International Agency for Research on Cancer convened a Working Group of world-leading experts to review the health effects of aflatoxins and fumonisins and to evaluate intervention measures. The panel concluded that these mycotoxins not only are a cause of acute poisoning and cancer but also are a likely contributor to the high levels of stunting in children in affected populations. The Working Group also identified effective measures to reduce exposure in developing countries. The panel evaluated 15 interventions, considering the strength of the evidence as well as its completeness and its transferability at an individual, community, or national level. Four of the interventions were judged to be ready for implementation: improvement of dietary diversity; crop sorting; post-harvest measures, including improved storage; and, in Latin America for maize, optimized nixtamalization. These recommendations would be relevant for investment of public, nongovernmental organization, and private funds at the scale of the subsistence farmer, the smallholder, and through to a more advanced value chain.

Download or read book NASA Reference Publication written by and published by . This book was released on 1981 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Report Work group reports written by Commission for the Control of Huntington's Disease and Its Consequences and published by . This book was released on 1977 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Technical Abstract Bulletin written by and published by . This book was released on with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Marine Structures Engineering Specialized Applications written by Gregory Tsinker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine Structures Engineering is designed to help engineers meet the growing worldwide demand for construction of new ports and the modernization of existing ports and terminals. It provides an authoritative guide to the design, construction, rehabilitation, repair, and maintenance of port and harbor structures. Each chapter is self-contained, allowing readers to access specific information. The Author draws on his extensive experience in offshore structure and port engineering to demonstrate evaluation, rehabilitation, repair, and maintenance of in-service marine structures. Also covered in detail are state-of-the-art approaches to: *marine structures in cold regions, with special attention to the role of ice loads, permafrost, and other ice effects *shiplifts, marine railways, shipways, and dry docks *offshore moorings *floating breakwaters *marinas *structures that protect bridge piers from ship impact. Offering practical information on all aspects of marine structures, this book serves as an indispensable resource to all engineers and professionals involved in design, construction, maintenance, and modernization of ports and harbors.