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Book Clostridial Neurotoxins

    Book Details:
  • Author : Cesare Montecucco
  • Publisher : Springer Science & Business Media
  • Release : 2013-11-11
  • ISBN : 3642851738
  • Pages : 283 pages

Download or read book Clostridial Neurotoxins written by Cesare Montecucco and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown by BRUSHCHETIINI (1892) to move retroaxonally and to act at the spinal cord level. Soon thereafter VAN ERMENGEN (1897) demonstrated that botu lism is also due to intoxication with a protein toxin produced by bacteria of the genus Clostridium. These bacteria and their spores and ubiquitous, and the majority of them do not produce neurotoxins. The selective advantage of producing such potent toxin is still a matter of speculation (see Popoff, this volume). The next major advance was the discovery that tetanus neurotoxin 1 can be converted by formaldehyde treatment to a nonpathogenic but still fully immunogenic form, and that this can be used successfully as a vaccine to prevent tetanus (RAMON and DESCOMBEY 1925). Similar vaccines (toxoids) can be prepared with botulism neurotoxins (see MiDDLEBROOK and BROWN, this volume). The prevention oftetanus by vaccination (see Galatzka and Gasse, this volume) is one of the great successes of basic research coupled with an efficient public medicine service.

Book Clostridial Diseases of Animals

Download or read book Clostridial Diseases of Animals written by Francisco A. Uzal and published by John Wiley & Sons. This book was released on 2016-05-31 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clostridial Diseases of Animals is the first book to focus on clostridial diseases in domestic and wild animals, offering a comprehensive reference on these common diseases. Provides a single resource for all aspects of clostridial diseases Presents current, comprehensive information with a focus on clinical relevance Covers each disease in depth, including etiology, epidemiology, clinics, gross pathology, histopathology, diagnostics, diagnostic criteria, prophylaxis, control, and treatment Written by the world-leading experts in the field of clostridial diseases in animals Offers photographs and summary tables to support the concepts discussed in the text and aid in recognition

Book Infectious Diseases of Wild Birds

Download or read book Infectious Diseases of Wild Birds written by Nancy J. Thomas and published by John Wiley & Sons. This book was released on 2008-01-09 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free-living birds encounter multiple health hazards brought on by viruses, bacteria, and fungi, some which in turn can significantly impact other animal populations and human health. Newly emerging diseases and new zoonotic forms of older diseases have brought increased global attention to the health of wild bird populations. Recognition and management of these diseases is a high priority for all those involved with wildlife. Infectious Diseases of Wild Birds provides biologists, wildlife managers, wildlife and veterinary health professionals and students with the most comprehensive reference on infectious viral, bacterial and fungal diseases affecting wild birds. Bringing together contributions from an international team of experts, the book offers the most complete information on these diseases, their history, causative agents, significance and population impact. Focusing on more than just treatment, special emphasis is given to disease processes, recognition and epidemiology.

Book Human Emerging and Re emerging Infections

Download or read book Human Emerging and Re emerging Infections written by Sunit Kumar Singh and published by John Wiley & Sons. This book was released on 2015-11-09 with total page 2365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and re-emerging pathogens pose several challenges to diagnosis, treatment, and public health surveillance, primarily because pathogen identification is a difficult and time-consuming process due to the “novel” nature of the agent. Proper identification requires a wide array of techniques, but the significance of these diagnostics is anticipated to increase with advances in newer molecular and nanobiotechnological interventions and health information technology. Human Emerging and Re-emerging Infections covers the epidemiology, pathogenesis, diagnostics, clinical features, and public health risks posed by new viral and microbial infections. The book includes detailed coverage on the molecular mechanisms of pathogenesis, development of various diagnostic tools, diagnostic assays and their limitations, key research priorities, and new technologies in infection diagnostics. Volume 1 addresses viral and parasitic infections, while volume 2 delves into bacterial and mycotic infections. Human Emerging and Re-emerging Infections is an invaluable resource for researchers in parasitologists, microbiology, Immunology, neurology and virology, as well as clinicians and students interested in understanding the current knowledge and future directions of infectious diseases.

Book Field Manual of Wildlife Diseases

Download or read book Field Manual of Wildlife Diseases written by and published by Geological Survey (USGS). This book was released on 1999 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Botulinum Neurotoxins

    Book Details:
  • Author : Andreas Rummel
  • Publisher : Springer
  • Release : 2015-01-29
  • ISBN : 9783642448898
  • Pages : 0 pages

Download or read book Botulinum Neurotoxins written by Andreas Rummel and published by Springer. This book was released on 2015-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Book Lake Erie and Lake St  Clair Handbook

Download or read book Lake Erie and Lake St Clair Handbook written by S. J. Bolsenga and published by Wayne State University Press. This book was released on 1993 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn about the wonders of Lake Erie and Lake St. Clair in this fascinating and readable book. The most comprehensive reference source available about the lakes, Lake Erie and Lake St. Clair Handbook is an ideal guide for anglers, boaters, swimmers, beach walkers—anyone who uses and enjoys the lakes. The handbook explains, in simple terms, the reasons for the scenic beauty and the natural events that occur in the coastal and offshore waters of Lake Erie and Lake St. Clair, including the St. Clair, Detroit, and Niagara rivers extending from Sarnia, Ontario, to Niagara-on-the-Lake, New York. Individual chapters focus on the land, air, water, and life forms that comprise the natural history and environment of the region—the shoreline topography, wind and weather patterns, water temperature cycles and water level changes, the ecology, and indigenous animal life. Lake Erie and Lake St. Clair Handbook enhances our understanding and appreciation of the lakes and their surroundings by addressing fundamental questions about the Lake Erie region: • how Lake Erie was formed through glacial processes • why daily and seasonal weather patterns occur • causes of the water currents and waves • causes of temperature patterns in the lakes • the location of productive reef features • the species of fish and birds found in the area • the importance of the wetlands • the effect of current and past pollution on the aquatic life in the lakes

Book Natural Toxins 2

    Book Details:
  • Author : Bal Ram Singh
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 1461303613
  • Pages : 529 pages

Download or read book Natural Toxins 2 written by Bal Ram Singh and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.

Book Laboratory Diagnosis of Infectious Diseases

Download or read book Laboratory Diagnosis of Infectious Diseases written by Albert Balows and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1125 pages. Available in PDF, EPUB and Kindle. Book excerpt: those who deal with infectious diseases on a daily This two volume work stems from the belief of the Editors that infectious diseases are not only very basis. much with us today but, more importantly, that they There are several excellent textbooks dealing will continue to playa significant global role in mor with medical microbiology, and there are equally well-recognized books devoted to infectious dis bidity and mortality in all people. A continuing need for an informed and knowledgeable community of eases. The Editors of this work, on the other hand, laboratory scientists is fundamental. Data describing were persuaded that there was a need for a publica the global impact of infectious diseases are difficult tion that would bring together the most pertinent and to come by. Fortunately, a recent thoughtful and relevant information on the principles and practice of provocative publication by Bennett et al. (1987) pro the laboratory diagnosis of infectious diseases and vides us with data derived from several consultants include clinical relationships. While this two volume that clearly delineate the impact of infectious dis text is directed toward the role of the laboratory in eases on the United States today.

Book Manual on Meat Inspection for Developing Countries

Download or read book Manual on Meat Inspection for Developing Countries written by Drago Carl Herenda and published by Food & Agriculture Org.. This book was released on 1994 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Biological Toxins and Bioterrorism

Download or read book Biological Toxins and Bioterrorism written by P. Gopalakrishnakone and published by Springer. This book was released on 2015-01-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological toxins are an important part of our world, a reality with which we need to cope, so in parallel with understanding their mechanisms of action and thereby improving our fundamental knowledge, there are successful efforts to utilize them as therapeutics against some debilitating human and animal diseases. In view of the complexity of different types of biotoxins and the broad range of toxin structure, physiology, utility, and countermeasures including regulatory issues, it was thus aimed to compile a book on biotoxins and bioweapons. This reference work in the Toxinology handbook series gathers together knowledge from around the globe about naturally inspired and manufactured biological weapons. The authors describe how they work; how authorities may detect their presence, prevent their use, and diagnose their impacts; and the means by which medical and paramedical professionals may treat victims. Also described are how they have been used to further our knowledge and what insights they have given us into evolutionary and physiological processes. Finally, it is also discussed how these toxins can be used as therapeutics and what the implications of such therapeutics are to their use as biothreat agents. This volume provides a reference accessible to scientists, educators, and medical experts alike with an interest in biotoxins, focusing on the major toxins used as bioweapons. Regulatory agencies will also benefit from the information provided in this book. Some in the intended audience may need to understand how they elicit their effects and how we can defend ourselves against them. Others may be interested in the sometimes colorful histories that surround this subset of biotoxins that can be and, in some cases, have been used as weapons.

Book Livestock s Long Shadow

Download or read book Livestock s Long Shadow written by Henning Steinfeld and published by Food & Agriculture Org.. This book was released on 2006 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The assessment builds on the work of the Livestock, Environment and Development (LEAD) Initiative"--Pref.

Book Diseases of Wild Waterfowl

    Book Details:
  • Author : Gary A. Wobeser
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 1461559510
  • Pages : 318 pages

Download or read book Diseases of Wild Waterfowl written by Gary A. Wobeser and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Management of wild waterfowl has become increasingly intensive. Many birds now hatch in managed nesting cover or in artificial nesting structures, use man-made wetlands, and winter on crowded refuges while consuming a grain diet The water they use is often limited in supply and may contain residues from its many prior users. Unfortunately, intensified management often results in new problems, among which disease is important There are many similarities between the current form of management used for some waterfowl and that used in domestic animals. In both, the objective is to maintain a healthy, productive population. Dealing with health problems in waterfowl will benefit from combining the skills of veterinary medicine and wildlife ecology. Revisiting this book after 15 years allowed me to consider changes at the interface between the two disciplines. Veterinary medicine traditionally has been concerned with the individual and with treating sick animals, while the ecologist is concerned with populations and the manager has limited interest in treating sick birds. During this period there has been a marked increase in awareness among veterinarians that they have a responsibility in wildlife and conservation biology. Curricula of many veterinary colleges now include material on non-domestic animals and attempt to put disease in an ecological context. Also during this time, waterfowl managers have become more aware of disease as a factor in population biology and there are early attempts to put numbers to "disease" in models of continental waterfowl populations.

Book Role of Birds in Transmitting Zoonotic Pathogens

Download or read book Role of Birds in Transmitting Zoonotic Pathogens written by Yashpal Singh Malik and published by Springer Nature. This book was released on 2022-01-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zoonotic diseases pose a serious threat to global health and economy. Domestic and wild birds play crucial roles in transmission and spread of important zoonotic pathogens, with significant implications on human and avian health. Although zoonotic diseases have been extensively studied, information on various aspects of avian zoonotic pathogens have not been revisited or revised to any great extent. This book is a comprehensive and updated compilation of important zoonotic diseases that are transmitted by domestic and wild birds, and consists of 21 chapters that meticulously describe the (i) etiology and evolution, (ii) complex epidemiology, such as migration pathways in context of disease transmission, (iii) pathogenesis, (iv) clinical signs and necropsy findings, (v) diagnostics including latest molecular assays, and (vi) preventative and control strategies, with an emphasis on therapeutics and prophylaxis, of important zoonotic pathogens (bacterial, fungal, parasitic and viral) of avian origin in humans and birds. Each chapter is aptly supported by interactive tables and figures, and features an updated reference section. This book aims to create awareness and enlighten students of veterinary and human medicine on the role of birds in zoonoses, and would serve as a useful reference for working veterinarians, human doctors, and public health experts.

Book Significance  Prevention and Control of Food Related Diseases

Download or read book Significance Prevention and Control of Food Related Diseases written by Hussaini Makun and published by BoD – Books on Demand. This book was released on 2016-04-13 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food-borne diseases are major causes of morbidity and mortality in the world. It is estimated that about 2.2 million people die yearly due to food and water contamination. Food safety and consequently food security are therefore of immense importance to public health, international trade and world economy. This book, which has 10 chapters, provides information on the incidence, health implications and effective prevention and control strategies of food-related diseases. The book will be useful to undergraduate and postgraduate students, educators and researchers in the fields of life sciences, medicine, agriculture, food science and technology, trade and economics. Policy makers and food regulatory officers will also find it useful in the course of their duties.

Book Ostrich Production Systems

    Book Details:
  • Author : M. M. Shanawany
  • Publisher : Food & Agriculture Org.
  • Release : 1999
  • ISBN : 9789251043004
  • Pages : 280 pages

Download or read book Ostrich Production Systems written by M. M. Shanawany and published by Food & Agriculture Org.. This book was released on 1999 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of all aspects of ostrich production including a series of case histories from some countries that farm ostriches commercially: important countries such as South Africa, Namibia and Zimbabwe; newly re-emerging industries such as Australia; and countries where production is less developed, such as Kenya, Ethiopia and the United Arab Emirates (UAE).