Download or read book Regulatory Mechanisms in Breast Cancer written by Marc E. Lippman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.

Download or read book Regulatory Mechanisms in the Metastatic Potential of Breast Cancer written by Louise Mary Kelly and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Download or read book Investigation of Regulatory Mechanisms and Functional Roles of Long Non coding RNA NDRG1 OT1 in Breast Cancer Cells written by 羅俊良 and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exploring Estrogen Receptor Gene Regulatory Mechanism in Breast Cancer written by Anne Chinenye Katchy and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regulatory Mechanisms Modulating the Co expression of ESR1 and Three Upstream Genes in Breast Cancer written by Jackie Anna White and published by . This book was released on 2013 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Gene Regulation and Therapeutics for Cancer written by Surinder K. Batra and published by CRC Press. This book was released on 2021-03-22 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.

Download or read book Molecular Mechanisms Underlying the Regulation of Gene Expression and Growth in Breast Cancer Cells written by Miao Sun and published by . This book was released on 2013 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is a serious public health issue, and a full understanding of its etiology and pathophysiology is a primary focus in the field. Molecularly, the combined action of a plethora of factors in multiple pathways is involved in the regulation of the breast tumoriogenic process. Characterization of a more complete spectrum of the molecular factors will provide insights into the development of new and improved diagnostic, prognostic and therapeutic tools for treating breast cancer. To this end, my studies utilize a combination of molecular biology and bioinformatic methods, to uncover the mechanisms underlying the regulation of gene expression and growth in human breast cancer cells. To investigate the molecular crosstalk of the estrogen and c-Jun N-terminal kinase 1 (JNK1) signaling pathways, I monitored the genomic localization of estrogen receptor [alpha] (ER[alpha]) and JNK1 in basal and estrogen-stimulated MCF-7 breast cancer cells. I found that JNK1 binds to the promoter of many genes. ER[alpha] is required for the binding of JNK1 to the estrogen-induced sites, and JNK1 in turn functions as a coregulator of ER[alpha]. The convergence of ER[alpha] and JNK1 at target promoters regulates estrogen-dependent gene expression, as well as downstream estrogendependent cell growth responses. Furthermore, the implication of long noncoding RNAs (lncRNAs) in breast cancer is also coming to light. I developed a computational approach that integrates information from multiple genomic datasets, and generated a comprehensive catalog of 1888 expressed lncRNA genes in MCF-7 cells. Almost half of them are first annotated in this study, and more than a quarter are estrogen-regulated. Close examination revealed many interesting features. Interestingly, cell type-specific expression of lncRNAs predicts the intrinsic molecular subtypes of breast cancer, suggesting its potential utility as prognostic marker. Lastly, by selecting lncRNAs with elevated expression in breast tumors, and whose differential expression across a wide spectrum of tissues and cell types correlates with important cell viability genes, we identified a number of lncRNAs that are required for the normal growth of human breast cancer cells. Collectively, my studies expanded our understanding of the molecular mechanisms underlying breast cancer biology, and suggested new targets for therapeutic interventions.

Download or read book Large Scale Structure And Dynamics Of Complex Networks From Information Technology To Finance And Natural Science written by Alessandro Vespignani and published by World Scientific. This book was released on 2007-06-28 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the culmination of three years of research effort on a multidisciplinary project in which physicists, mathematicians, computer scientists and social scientists worked together to arrive at a unifying picture of complex networks. The contributed chapters form a reference for the various problems in data analysis visualization and modeling of complex networks.

Download or read book MicroRNAs in Cancer written by Cesar Lopez-Camarillo and published by CRC Press. This book was released on 2013-02-22 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th

Download or read book Molecular Mechanisms of MicroRNA Regulation in Breast Cancer Cells written by Irene Kathryn Guttilla and published by . This book was released on 2010 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Breast Cancer Chemosensitivity written by Dihua Yu and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

Download or read book Regulation of LRIG1 Expression in Breast Cancer written by Catalina Simion and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present study, we investigated the regulation of the leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1 - a negative regulator of the ErbB family receptor tyrosine kinases) gene expression in human breast cancer cell lines and examined both its suppression and upregulation mechanisms. We first investigated the methylation status of the CpG islands in the LRIG1 promoter and determined if demethylation by the methylase inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) could restore LRIG1 expression in the cell lines. The methylation status around the promoter region of the LRIG1 was detected by bisulfite modification and subsequent PCR amplification. The messenger RNA (mRNA) and protein levels of these genes were determined by quantitative PCR (qPCR) and western blotting, respectively. We next investigated the correlation of LRIG1 levels with the estrogen receptor-alpha (ER[alpha]) in the human breast cancer cell line ZR-75-1. Meta analysis of gene expression data sets showed that LRIG1 expression is positively correlated to ER[alpha] status. Upon estradiol stimulation, LRIG1 transcript accumulates, as seen by qPCR. Tamoxifen and fulvestrant, ER[alpha] antagonists, blocked estrogen-induced LRIG1 expression, demonstrating that this is an ER[alpha] dependent event. Following depletion of endogenous LRIG1 by small interfering RNA, estrogen-dependent proliferation of ER[alpha] positive breast cancer cells is augmented. These findings suggest that LRIG1 is an estrogen-induced gene product that suppresses ER-dependent cell growth. Taken together, these analyses provide insight into the regulatory mechanisms which dictate LRIG1 expression in breast cancer cells. A detailed understanding of the mechanism by which this negative regulator is silenced in human tumours will lead to new approaches of restoring pathway function in cancerous cells, and eventually to new treatments of patients with ErbB-positive tumours.

Download or read book Rna based Mechanisms In Cancer written by Gary Brewer and published by World Scientific. This book was released on 2023-10-12 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address 'where do we go from here' and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.

Download or read book Computational driven Understanding of the Regulatory Mechanisms of the Breast Cancer Transcriptome and Its Implications for Drug Treatment written by Shujun Huang and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer (BC) is the most commonly diagnosed cancer and the major cause of cancer mortality among women worldwide. As a heterogenous disease, BC can be divided into four major molecular subtypes: luminal A, luminal B, HER2-enriched, and triple negative breast cancer (TNBC). The TNBC subtype shows the shortest survival time among the four groups and lacks effective targeted therapeutic strategies. Different BC subtypes display different transcriptome profiles. However, the dysregulated pathways and transcriptional regulators underlying the gene expression profiles of different BC subtypes have yet to be fully elucidated. Current research is investigating the dysregulated genes in BC with the aim to identify potential gene targets for BC while overlooking the fact these genes are often part of a pathway. Moreover, among the multi-omics data, gene expression profiles have been shown to be the most informative data for developing anti-cancer drug response prediction models in silico. But these models typically were developed with individual genes. Therefore, this thesis aimed to explore the breast cancer transcriptome with a focus on the TNBC subtype to address three major questions: 1) exploring the regulatory mechanisms driving the unique expression pattern of different BC subtypes; 2) identifying compounds that could affect the expression pattern of the top dysregulated pathways in BC; and 3) developing a drug response prediction model by using BC pathway activity profiles inferred from the transcriptome profiles. To address the first question, we collected the multi-omics data of BC samples from The Cancer Genome Atlas (TCGA) dataset, including gene expression, DNA methylation, copy number variation (CNV) and microRNA (miRNA) profiles, the transcription factor (TF)-binding data from TRRUST v2.0, and the miRNA-binding data from starBase v3.0. Using these data, the Lasso regression-based integrative analysis identified 25, 20, 15 and 24 key regulators for luminal A, luminal B, HER2-enriched and TNBC subtypes, respectively. A further look at the TNBC regulators found that many of them are regulating the FOXM1 (i.e., PID_FOXM1_PATHWAY) and PPARA (i.e., BIOCARTA_PPARA_PATHWAY) pathways. To address the second question, we focused on the FOXM1 and PPARA pathways. Using the Connectivity Map (CMAP) database, which provides drug-induced gene expression changes in MCF7 cell lines, we investigated how different compounds change the activity and expression pattern of the two pathways. Nineteen drugs (such as 5109870, MG-132, MG-262, celastrol, resveratrol, and cephaeline) were identified to decrease the FOXM1 pathway activity scores and reverse the FOXM1 pathway expression pattern while 13 drugs (such as cephaeline, pararosaniline, cycloheximide, monensin, wortmannin, and raloxifene) were identified to increase the PPARA pathway activity scores and reverse the PPARA pathway expression pattern. It may be of interest to validate these compounds experimentally. To address the third question, we collected the baseline gene expression profiles of 49 BC cell lines along with IC50 values of these cell lines to 220 drugs from the Genomics of Drug Sensitivity in Cancer (GDSC) dataset. Using these data, we developed a multiple-layer cell line-drug response network (ML-CDN2) by integrating a one-layer cell line similarity network based on the pathway activity profiles and a three-layer drug similarity network based on three types of drug information. ML-CDN2 demonstrated good prediction performance, with the Pearson correlation coefficient between the observed and predicted IC50 values for all cell line-drug pairs of 0.873. Moreover, the ML-CDN2 model could be used to predict the drug response for new BC cell line samples or new BC patient-derived samples. This thesis demonstrated the transcriptional regulators underlying the transcriptome profiles in different BC subtypes. Moreover, this thesis demonstrated the implications of the BC transcriptome in drug treatment by identifying the drugs to modulate the two dysregulated pathways in BC and developing the anti-cancer drug response prediction model for BC by incorporating the transcriptome profiles.

Download or read book Translation and Its Regulation in Cancer Biology and Medicine written by Armen Parsyan and published by Springer. This book was released on 2014-10-13 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.

Download or read book Perturbation of RNA Binding Protein Regulation in Cancer written by Pradeep Chaluvally Raghavan and published by Frontiers Media SA. This book was released on 2021-08-25 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: