Download or read book Regulation of Inflammatory Genes in Trigeminal Ganglion Neurons and Glia in Response to Cocoa Enriched Diets written by Ryan J. Cady and published by . This book was released on 2008 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rats fed a diet enriched in cocoa have shown a decreased response to both chronic and acute inflammatory stimulus. The goal of my study was to identify the effects of a diet enriched in cocoa on neurons and glia of the trigeminal ganglion in response to inflammatory stimuli. Rats were fed a control diet, 1% cocoa, or 10% cocoa diet for 14 days prior to either an injection of capsaicin or CFA in either the V1 or V3 innervated regions of the face. Using immunohistochemistry, levels of several signaling proteins MKP1, MKP2, MKP3, active ERK, p38 and JNK as well as iNOS, and CGRP, were determined in the trigeminal ganglion. Expression of MKP1, and 3 were increased in response to both cocoa diets, while expression of p38, ERK, CGRP, and iNOS were decreased. Importantly, expression of MKP1, an anti-inflammatory protein, was increased basally in both neurons and glial cells. Results from my study provide evidence that cocoa may block peripheral sensitization through increases in MKP1, MKP2, and MKP3. Consistent with this, the expression of the inflammatory genes iNOS and CGRP were also decreased in rats on the high cocoa diet in response to acute and chronic inflammatory stimuli. Furthermore, my data suggests that cocoa may have important implications for the prevention of migraine and TMJ disorders. To my knowledge, this is first evidence to demonstrate that a dietary supplement can cause an up regulation of MKPs and thus is likely to have preventative affects on inflammatory and nociceptive responses during chronic and acute inflammation.
Download or read book Evidence for Neuron glia Signaling in Trigeminal Ganglia written by Srikanth Thalakoti and published by . This book was released on 2008 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this study was to investigate neuronal-glial cell signaling in trigeminal ganglia under basal and inflammatory conditions using an in vivo model of acute temporomandibular joint (TMJ) inflammation. Inflammation of the TMJ and release of inflammatory mediators that cause activation of trigeminal nerves is implicated in TMJ pathologies. While neuron-glia interactions are known to be involved in all stages of inflammation and pain associated with several CNS diseases, the role of neuron-glia interactions within the trigeminal ganglion under normal and inflammatory conditions is not known. In control animals, only minimal gap junction communication was observed between neuronal cell bodies and satellite glial cells. However, gap junction communication between these cell types was greatly increased in response to capsaicin stimulation of trigeminal nerves that provide sensory innervation of the TMJ. In addition, capsaicin stimulation of trigeminal nerves increased the expression of the inflammatory proteins MAPKs and MKPs in both neurons and glia in all regions of the ganglion. Interestingly, increased levels of these proteins were also observed in the contra-lateral ganglion. This is the first evidence, to my knowledge, of neuron-glia signaling via gap junctions within the trigeminal ganglion. Based on my findings, it is likely that neuronal-glial communication via gap junctions and paracrine signaling are involved in the development of peripheral sensitization within the trigeminal ganglion and, thus, are likely to play an important role in TMJ pathologies. Furthermore, propose that propagation of inflammatory signals within the ganglion may help to explain commonly reported symptoms of co-morbid conditions associated with TMJ disorders.
Download or read book Recent Advances in Arthroplasty written by Samo Fokter and published by BoD – Books on Demand. This book was released on 2012-01-27 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book was to offer an overview of recent insights into the current state of arthroplasty. The tremendous long term success of Sir Charnley's total hip arthroplasty has encouraged many researchers to treat pain, improve function and create solutions for higher quality of life. Indeed and as described in a special chapter of this book, arthroplasty is an emerging field in the joints of upper extremity and spine. However, there are inborn complications in any foreign design brought to the human body. First, in the chapter on infections we endeavor to provide a comprehensive, up-to-date analysis and description of the management of this difficult problem. Second, the immune system is faced with a strange material coming in huge amounts of micro-particles from the tribology code. Therefore, great attention to the problem of aseptic loosening has been addressed in special chapters on loosening and on materials currently available for arthroplasty.
Download or read book Methylxanthines written by Bertil B. Fredholm and published by Springer Science & Business Media. This book was released on 2010-09-22 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.
Download or read book Targeting the Broadly Pathogenic Kynurenine Pathway written by Sandeep Mittal and published by Springer. This book was released on 2015-11-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
Download or read book Jubb Kennedy Palmer s Pathology of Domestic Animals Volume 1 written by Grant Maxie and published by Elsevier Health Sciences. This book was released on 2015-08-16 with total page 1250 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an emphasis on the disease conditions of dogs, cats, horses, swine, cattle and small ruminants, Jubb, Kennedy, and Palmer's Pathology of Domestic Animals, 6th Edition continues its long tradition of being the most comprehensive reference book on common domestic mammal pathology. Using a body systems approach, veterinary pathology experts provide overviews of general system characteristics, reactions to insult, and disease conditions that are broken down by type of infectious or toxic insult affecting the anatomical subdivisions of each body system. The sixth edition now boasts a new full-color design, including more than 2,000 high-resolution images of normal and abnormal organs, tissues, and cells. Updated content also includes evolved coverage of disease agents such as the Schmallenberg virus, porcine epidemic diarrhea virus, and the porcine deltacoronavirus; plus new information on molecular-based testing, including polymerase chain reaction (PCR) and in-situ hybridization, keep you abreast of the latest diagnostic capabilities. - Updated content includes new and evolving pathogens and diagnostic techniques. - Updated bibliographies give readers new entry points into the rapidly expanding literature on each subject. - NEW! High-resolution color images clearly depict the diagnostic features of hundreds of conditions. - NEW! Introduction to the Diagnostic Process chapter illustrates the whole animal perspective and details the approaches to systemic, multi-system, and polymicrobial disease. - NEW! Coverage of camelids is now included in the reference's widened scope of species. - NEW! Team of 30+ expert contributors offers the latest perspective on the continuum of issues in veterinary pathology. - NEW! Expanded resources on the companion website include a variety of helpful tools such as full reference lists with entries linked to abstracts in Pub Med and bonus web-only figures. - NEW! Full-color design improves the accessibility of the text.
Download or read book Treatment of Chronic Pain by Interventional Approaches written by Timothy R. Deer and published by Springer. This book was released on 2014-12-08 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: From reviews of Deer, eds., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches: "Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches is a major textbook... [I]t should be a part of all departmental libraries and in the reference collection of pain fellows and pain practitioners. In fact, this text could be to pain as Miller is to general anesthesia." Journal of Neurosurgical Anesthesiology Edited by master clinician-experts appointed by the American Academy of Pain Medicine, this is a soft cover version of the Interventional sections of the acclaimed Deer, eds., Comprehensive Treatment of Chronic Pain by Medical, Interventional, and Integrative Approaches. It is intended as a primary reference for busy clinicians who seek up-to-date and authoritative information about interventional approaches to treating chronic pain. State-of-the-art coverage of full range of techniques: neural blockades, neurolysis blocks, and neurostimulation Review of clinically relevant anatomy and physiology "Key Points" preview contents of each chapter
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Download or read book Ross Wilson Anatomy and Physiology in Health and Illness written by Anne Waugh and published by Elsevier Health Sciences. This book was released on 2018-07-12 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of the hugely successful Ross and Wilson Anatomy & Physiology in Health and Illness continues to bring its readers the core essentials of human biology presented in a clear and straightforward manner. Fully updated throughout, the book now comes with enhanced learning features including helpful revision questions and an all new art programme to help make learning even easier. The 13th edition retains its popular website, which contains a wide range of 'critical thinking' exercises as well as new animations, an audio-glossary, the unique Body Spectrum© online colouring and self-test program, and helpful weblinks. Ross and Wilson Anatomy & Physiology in Health and Illness will be of particular help to readers new to the subject area, those returning to study after a period of absence, and for anyone whose first language isn't English. - Latest edition of the world's most popular textbook on basic human anatomy and physiology with over 1.5 million copies sold worldwide - Clear, no nonsense writing style helps make learning easy - Accompanying website contains animations, audio-glossary, case studies and other self-assessment material, the unique Body Spectrum© online colouring and self-test software, and helpful weblinks - Includes basic pathology and pathophysiology of important diseases and disorders - Contains helpful learning features such as Learning Outcomes boxes, colour coding and design icons together with a stunning illustration and photography collection - Contains clear explanations of common prefixes, suffixes and roots, with helpful examples from the text, plus a glossary and an appendix of normal biological values. - Particularly valuable for students who are completely new to the subject, or returning to study after a period of absence, and for anyone whose first language is not English - All new illustration programme brings the book right up-to-date for today's student - Helpful 'Spot Check' questions at the end of each topic to monitor progress - Fully updated throughout with the latest information on common and/or life threatening diseases and disorders - Review and Revise end-of-chapter exercises assist with reader understanding and recall - Over 120 animations – many of them newly created – help clarify underlying scientific and physiological principles and make learning fun
Download or read book Sinus Headache Migraine and the Otolaryngologist written by Mark E. Mehle and published by Springer. This book was released on 2017-01-31 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will serve as a comprehensive and useful guide for ENT physicians in the recognition, diagnosis, and treatment of patients who suffer from sinus headaches and migraines. The text reviews key issues such as identification and management of migraine, and appropriate surgical and nonsurgical treatment that is often not part of ENT resident training. With 20% of women and 6% of men having migraines (only 50% recognized) this text will serve to expand management options to physicians already operating on sinuses or seeing cosmetic patients with head and neck concerns. Other forms of intervention in migraineurs, such as surgery, Botulinum Toxin injections and adjunctive and integrative therapy, are covered. Sinus Headache, Migraine, and the Otolaryngologist will be an invaluable resource for ENT and allergy specialists, and any physician or medical professional with an interest in sinus headache or migraine.
Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
Download or read book Imaging of Orbital and Visual Pathway Pathology written by Wibke S. Müller-Forell and published by Springer Science & Business Media. This book was released on 2005-12-29 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deals with imaging of pathology of the visual system. This book is divided into two parts, general and special. In the general part, important basics of modern imaging methods are discussed. The knowledge on the indication, technique, and results of functional MR imaging is also presented.
Download or read book Headache and Comorbidities in Childhood and Adolescence written by Vincenzo Guidetti and published by Springer. This book was released on 2017-09-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide clinicians and other practitioners and professionals with up-to-date information on how to evaluate and manage headaches in children and adolescents, highlighting the most recent recommendations. Unlike in other books on the subject, detailed attention is devoted to the various comorbidities commonly associated with headache, including psychiatric comorbidities such as depression, anxiety, attention deficit hyperactivity disorder, and learning disabilities and medical conditions such as epilepsy, vascular disorders, brain tumors, atopic disease, and obesity. The intimate link between these conditions and headache is explained with a view to enabling the reader to recognize their presence and, on that basis, to institute the most effective pharmacological or non-pharmacological treatment strategy. Moreover, knowledge of the comorbidities associated with headache will help readers to understand more fully the causes of this serious disorder and also its consequences, e.g., for school performance, relationships, and daily activities. The authors are all international experts who care for children with headache or the other described disorders.
Download or read book Practical Psychopharmacology written by Joseph F. Goldberg and published by Cambridge University Press. This book was released on 2021-04-29 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.
Download or read book Webster s New World Medical Dictionary written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Webster's New World Medical Dictionary, Third Edition will help you understand and communicate your medical needs when it matters the most. Written by doctors and the experts at WebMD, this edition includes 8500 entries, including 500 new terms, a vitamin appendix, and a companion website to give you access to medical language.
Download or read book Integrative Pain Medicine written by Joseph F. Audette and published by Springer Science & Business Media. This book was released on 2008-02-26 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important book fills a need in the developing area of Pain Medicine. It provides physicians with an up-to-date resource that details the current understanding about the basic science underlying the mechanism of action of the various CAM therapies used for pain. It summarizes the clinical evidence both for efficacy and safety, and finishes with practical guidelines about how such treatments could be successfully and safely integrated into a Pain practice.
Download or read book Endometriosis in Adolescents written by Ceana H. Nezhat and published by Springer Nature. This book was released on 2020-11-13 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adolescent endometriosis is a previously overlooked disease in children, the true prevalence of which is still unknown but has been estimated between 19-73%. There are numerous initial challenges faced by adolescents suffering from delayed or undiagnosed endometriosis apart from experiencing chronic pain, such as: school/work absenteeism, false diagnoses/treatments, erroneous physician referrals, unnecessary radiological studies, radiation exposure, and emergency room visits as well as early exposure to narcotic pain medications and subsequent drug tolerance, resistance or even addiction. This text presents a clear history of physician and patient understanding and awareness of endometriosis in adolescents. It lays the groundwork for this condition with background information on endometriosis in general followed by a more focused look at endometriosis in adolescents. Leading experts in the field provide chapters on the different locations where endometriotic lesions can present in adolescents as well as identified risk factors and concomitant diseases of which it is important to be aware. In addition to the clinical presentation, this book also provides information on breaking down existing barriers, such as stigma, and current activism and awareness of this condition. Adolescent Endometriosis is a first-of-its-kind text that focuses exclusively on endometriosis in the adolescent population. Written by experts in the field, this book is a comprehensive resource for clinicians in all medical disciplines that treat adolescent age girls.
