Download or read book Regression of Atherosclerotic Lesions written by M. Rene Malinow and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advanced Study Institute on Regression of Atherosclerotic Lesions, sponsored by the North Atlantic Treaty Organization, was held in Maratea, Italy, September 11-13, 1983. The institute was designed to foster discussion of experimental data on the regression of atherosclerosis in animals and evidence of a similar phenomenon in humans. The participating scientists showed with anatomical and biochemical data, that atherosclerosis regresses in cholesterol fed animals after withdrawal of atherogenic stimuli. The existence of regression in humans was inferred from sequential angiographic visualization of arteries, but anatomical and biochemical characteristics of the process have not been defined. Two mechanisms are probably involved in such an angiographic regression. The first, which may occur when hyperlipidemia is partly or fully corrected or during undernutrition or other metabolic abnormalities, may be related to atherosclerosis changes noted in animals undergoing regression. The second type seems independent of changes in plasma lipid levels and may involve resolution of thrombi or other underlying arterial wall factors. The relative frequencies of the two mechanisms are unknown; whether they can occur simultaneously also warrants consideration. It is likely that an exciting milestone will be forthcoming when regression of atherosclerosis is unequivocally demonstrated in humans. Publication of these institute proceedings constitutes a valuable background for future developments.
Download or read book Regression of Atherosclerotic Lesions written by M. Rene Malinow and published by . This book was released on 2014-01-15 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Factors in Formation and Regression of the Atherosclerotic Plaque written by Gustav R.V. Born and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the field of atherosclerosis research has broadened in recent years. However the main focus remains on the physiopathology of the arterial wall and on its interaction with blood constituents. The purpose of this NATO Advanced Study Institute on "Factors in Formation and Regression of the Atherosclerotic Plaque" was to discuss the following points: a) The physiopathology of the arterial wall; b) Animal models; c) Methods of studying the progression and regression of atherosclerotic lesions quantitatively; d) The role of lipoproteins, platelets, smoke, alcohol, etc. in the formation of atherosclerotic lesions; e) The pharmacological and dietary control of "risk factors." This volume is a collection of the most relevant presentations on these topics. We hope it will provide a background for young scientists as well as a stimulus for further research to biologists and clinicians. We wish to acknowledge the support of NATO and the Nutrition Foundation of Italy in organizing this Advanced Study Institute.
Download or read book Atlas of Atherosclerosis Progression and Regression written by Herbert C. Stary and published by CRC Press. This book was released on 2003-06-04 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, the Second Edition of the Atlas of Atherosclerosis Progression and Regression contains new material and new illustrations from Dr. Stary's groundbreaking work in the field of atherosclerosis diagnosis, prevention, and treatment. Over 100 photographs show arterial and lesion structure and individual components in unprecedented detail. These images allow you to compare and contrast healthy arteries with those developing and regressing lesions. They illustrate the successive steps in the natural history of human atherosclerotic disease from the microscopically visible, lipid-filled macrophages in susceptible locations of arteries to lesion forms that produce clinical symptoms. The book provides an up-to-date, pathology-based framework of morphologies of atherosclerotic vascular lesions that serves as a basis for correlation with morphologies determined by a variety of clinical imaging techniques. Demonstrating the evolution of arterial lesions form the clinically silent to the clinically relevant, An Atlas of Atherosclerosis Progression and Regression is a teaching aid and diagnostic tool for recognizing changes in lesion progression, stabilization, or regression. About the author: Dr. Stary is Professor of Pathology at the Louisiana State University Health Sciences Center in New Orleans. He came to New Orleans via the Departments of Pathology of the McGill (Montreal) and Yale (New Haven) Medical Schools. For 7 years, Dr. Stary also served as chairman of the American Heart Association's Committee on Vascular Lesions.
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Download or read book Factors in Formation and Regression of the Atherosclerotic Plaque written by Gustav R V Born and published by . This book was released on 1982-09-01 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book An Atlas of Atherosclerosis Progression and Regression written by Herbert C. Stary and published by CRC Press. This book was released on 1999-06-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, the Second Edition of the Atlas of Atherosclerosis Progression and Regression contains new material and new illustrations from Dr. Stary's groundbreaking work in the field of atherosclerosis diagnosis, prevention, and treatment. Over 100 photographs show arterial and lesion structure and individual components in unprecedented detail. These images allow you to compare and contrast healthy arteries with those developing and regressing lesions. They illustrate the successive steps in the natural history of human atherosclerotic disease from the microscopically visible, lipid-filled macrophages in susceptible locations of arteries to lesion forms that produce clinical symptoms. The book provides an up-to-date, pathology-based framework of morphologies of atherosclerotic vascular lesions that serves as a basis for correlation with morphologies determined by a variety of clinical imaging techniques. Demonstrating the evolution of arterial lesions fo rm the clinically silent the clinically relevant, An Atlas of Atherosclerosis Progression and Regression is a teaching aid and diagnostic tool for recognizing changes in lesion progression, stabilization, or regression. About the author: Dr. Stary is Professor of Pathology at the Louisiana State University Health Sciences Center in New Orleans. He came to New Orleans via the Departments of Pathology of the McGill (Montreal) and Yale (New Haven) Medical Schools. For 7 years, Dr. Stary also served as chairman of the American Heart Association's Committee on Vascular Lesions.
Download or read book The Effects of Hypocholesterolemic Regimens on Regression of the Histopathologic Manifestations of Atherosclerotic Lesions written by Jose Anibal Torres and published by . This book was released on 1989 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Computed Tomography written by James Stirrup and published by Oxford University Press, USA. This book was released on 2020-01-02 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen a marked increase in cardiovascular computed tomography (CT) imaging, with the technique now integrated into many imaging guidelines, such as those published by ESC and NICE. Rapid clinical and technological progress has created a need for guidance on the practical aspects of CT image acquisition, analysis and interpretation. The Oxford Specialist Handbook of Cardiovascular CT, now revised for the second edition by practising international experts with many years of hands-on experience, is designed to fulfil this need. The Handbook is a practical guide on performing, analysing and interpreting cardiovascular CT scans, covering all aspects from patient safety to optimal image acquisition to differential diagnoses of tricky images. It takes an international approach to both accreditation and certification, highlighting British, European, and American examinations and courses. The format is designed to be accessible and is laid out in easy to navigate sections. It is meant as a quick-reference guide, to live near the CT scanner, workstation, or on the office shelf. The Handbook is aimed at all cardiovascular CT users (Cardiologists, Radiologists and Radiographers), particularly those new to cardiovascular CT, although even the advanced user should find useful tips and tricks within.
Download or read book Frontiers in Cardiovascular Health written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Frontiers in Cardiovascular Health varies between and within nations, depend ing upon the level at which the battle is fought for better cardiovascular health. According to the 1997 World Health Report, 15 million deaths (i. e. 30% of the total number of deaths) were attributable to cardiovascular diseases and this number is on the rise. The projection for the year 2020 is quite alarming with an expected cardiovascular mortality reaching 50 million. Much of this burden is projected to occur in developing countries, more specifically in the most populous countries of the world, namely China and India. These countries are already burdened with infectious and parasitic diseases and are trying to eradicate such diseases. With increasing life expectancies people all over the world, especially in developing coun tries, are exposed to degenerative atherosclerosis resulting in increased cardiovascu lar mortality and morbidity. In developing countries, resources available for health care are very limited. For example many of the African countries spend less than $10 per person per year on his/her entire health care let alone cardiovascular health. The average health care budget for nearly two thirds of the global population is well below $100 per year, on a per capita basis. Therefore, in developing countries health promotion and primary prevention are the frontiers by necessity. Improving awareness and health education is not only a matter of choice but is an absolute necessity.
Download or read book Mechanisms of Shear Stress induced Atherosclerotic Plaque Regression written by Stefania Simeone and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Background Differences in shear stress form the basis of the differences in atherosclerosis predilection. Plaques form in regions of low, oscillating flow, whereas vessels exposed to high, steady shear stress tend to remain lesion-free due to the release of protective factors from the endothelial layer, primarily nitric oxide. While progressing plaques are characterized by the persistent entry of immune cells in the vascular wall, regressing plaques are characterized by 2 key features, effective emigration and efferocytosis of these immune cells. We hypothesize that shear stress reverses atherosclerosis by promoting macrophage exit from plaque (emigration) and more efficient uptake of cellular debris (efferocytosis). Methods In vivo: The arteriovenous fistula (AVF) is a surgical model established in the laboratory, whereby the right carotid artery is anastomosed into the right jugular vein, creating an arterio-venous shunt. We studied atherosclerotic plaques in the brachiocephalic artery (BCA), the plaque-prone vessel that links the aorta with the right carotid artery. Low density lipoprotein receptor (LDLR) knockout (KO) mice were placed on a high-fat diet. Sham and AVF surgery was performed at week 12 and mice were kept on a high-fat diet for a further 4 weeks (week 16). Control mice were sacrificed at week 12. In vitro: Endothelial cells (ECs) were co-cultured with macrophages in a shear stress cone system wherein ECs were exposed to high or low shear stress and macrophages were exposed to the EC effluent. Results The AVF procedure increases the shear stress in the BCA but does not alter serum lipid levels. Using this AVF model in mice, we found that elevated shear stress can reverse the atherosclerotic process, reducing plaque size. This increased shear stress also leads to decreased necrotic core size, increased matrix metalloproteinase (MMP) activity, increased MMP-9 expression and decreased collagen IV in addition to increased macrophage migration. MMP or endothelial nitric oxide synthase inhibition abolished shear stress-induced plaque regression. MMP inhibition also decreases macrophage migration with specific MMP-9 inhibition having the same effect. Using the in vitro shear stress co-culture apparatus to mimic the plaque environment, we found that uptake of apoptotic cells by macrophages was higher in the high shear conditions with MMP inhibition having no effect. However, a cytokine array on the co-culture effluent revealed a potential role for specific cytokines. Conclusions Our findings suggest that not only is shear stress protective against plaque development but it can effectively reverse the atherosclerotic process without interfering with plasma lipid levels. Shear stress acting on ECs may influence the cells within the plaque by increasing macrophage mobility and efferocytosis, the combination of which likely leads to plaque regression. These results and future work will help us further identify the molecular mechanisms that cause the atheroprotective effects of shear stress, in hopes of identifying new therapeutic targets for the treatment of atherosclerosis and cardiovascular diseases. " --
Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Download or read book Atherosclerotic Plaque Regression and Arterial Reverse Remodelling in Carotid and Femoral Arteries by Statin Use in Primary Prevention Setting Ultrasound Findings written by Cesare Rusconi and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerotic Plaque Regression and Arterial Reverse Remodelling in Carotid and Femoral Arteries by Statin Use in Primary Prevention Setting: Ultrasound Findings.
Download or read book Intracranial Atherosclerosis written by Jong S. Kim and published by John Wiley & Sons. This book was released on 2009-01-26 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracranial atherosclerosis is the dominant cause of stroke inover 70% of the world’s population. Globalization is leadingto an increasingly heterogeneous society everywhere. Advances inimaging techinology allow this previously inaccessible pathology tobe clinically studied. Edited by internationally renowned clinicians, IntracranialAtherosclerosis is the first book to examine intracranialcauses of stroke. Clinical practice is allied with basic science toguide all those with an interest in stroke on the diagnosis andmanagement of intracranial atherosclerosis.
Download or read book Imaging Coronary Atherosclerosis written by Stephen J. Nicholls and published by Humana. This book was released on 2016-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 50 years, coronary angiography has been the mainstay of diagnosing and quantifying the extent of coronary artery disease. However appreciation of the inherent limitations of conventional angiography has led to a plethora of new imaging modalities, each with their relative strengths and potential pitfalls. Advances in these techniques have given clinicians, as well as researchers, an overwhelming amount of information and the need for thoughtful interpretation. This outstanding book provides a comprehensive overview of the current status of imaging of coronary atherosclerosis. Covering the wide variety of available imaging modalities, the book provides state-of-the-art knowledge from leading authorities in each area. In their discussion, the authors include both invasive and non-invasive modalities, including the gold standard coronary angiography, the growing field of IVUS, and novel techniques such as functional imaging, molecular imaging, and the integration of biomarkers. The key concepts and practical information given in this volume will provide the reader with the necessary understanding to choosing appropriate imaging studies and building confidence in their skill set with each.
Download or read book Fundamentals of Vascular Biology written by Margarethe Geiger and published by Springer. This book was released on 2019-05-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-structured textbook offers essential knowledge on the vascular system. The reader will learn the properties, basic cellular mechanisms and development of the different parts of the vascular system (including the heart), gain knowledge on vascular and related diseases, and will be made familiar with common and most current methods and techniques applied to analyze the vascular system in patients, in animal models, and ex vivo. This book is based on a PhD Course for students from various bioscientific backgrounds given at the Medical University of Vienna, and it will be a valuable resource for Master ́s Students in vascular biology and biomedicine in general and a helpful tool for young researchers world-wide wishing to gain or refresh their knowledge in this field.
Download or read book Pathobiology of the Human Atherosclerotic Plaque written by Seymour Glagov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study of blood vessels at that time, so that details of the infrastructure and cellular composition of the artery wall and of atherosclerotic lesions were presented in some detail. There was, as one result of these explorations, considerable discussion of morphologic evidence suggesting that the principal cell involved in the atherogenic process was neither the fibroblast nor the macrophage, as had been supposed, but the smooth muscle cell. In particular, the findings indicated that this cell could incorporate lipid and become a foam cell.
