Download or read book Reggin America in the Mirror written by Y. M. Srotsecna and published by . This book was released on 2019-06-17 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eric is not racist--or at least he thought he wasn't. That would be tested on the night he went out to celebrate becoming partners with one of the most prestigious law firms in Mississippi. While out with his friends William and Sean, Eric has an encounter with a cabdriver. This leads to one of the most extraordinary events of his life.Follow Eric as he goes through decade after decade of American history with one exception: everything is exactly the same except that the skin tones are reversed. This will be one of the most talked-about books in a long time, along with an ending that will leave you in awe.
Download or read book Reggin America in the Mirror written by Y.M. Srotsecna and published by AuthorHouse. This book was released on 2019-06-17 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eric is not racist—or at least he thought he wasn’t. That would be tested on the night he went out to celebrate becoming partners with one of the most prestigious law firms in Mississippi. While out with his friends William and Sean, Eric has an encounter with a cabdriver. This leads to one of the most extraordinary events of his life. Follow Eric as he goes through decade after decade of American history with one exception: everything is exactly the same except that the skin tones are reversed. This will be one of the most talked-about books in a long time, along with an ending that will leave you in awe.
Download or read book In the Looking Glass written by Rebecca K. Shrum and published by JHU Press. This book was released on 2017-08-30 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolving technology of the looking glass -- First glimpses : mirrors in seventeenth-century New England -- Looking glass ownership in early America -- Reliable mirrors and troubling visions : nineteenth-century white -- Understandings of sight -- Fashioning whiteness -- Mirrors in black and red -- Epilogue
Download or read book Man in the Mirror written by Mackney Mc Donnell and published by . This book was released on 2019-06-07 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever looked in the mirror and saw more than just your reflection? This book takes a deep look past that reflection and into the reflection of the African American in America. Outlining the socio, economic, and psychological battles faced by African Americans in society. After looking further into the mirror, we also see how these battles shape our decisions regarding all aspects of our lives including the way we eat, spend, perceive ourselves, and interact with our own people. By looking a little deeper, it takes us into a little soul searching on how we can change so that we can grow into a powerful people. Ultimately our reflection helps us reach an Epiphany which illustrates our growth and development through collectively self-educating ourselves, reinforcing self-worth, networking and reinforcing our communities, building legacies, and establishing generational wealth.
Download or read book Mirror on America written by and published by . This book was released on 2009 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Mirrors of Washington written by Anonymous and published by Legare Street Press. This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mirrors of Washington is a book that offers a fascinating glimpse into the politics and society of Washington. Its author is unknown, but the book is considered an important primary source on the history of the United States. The book offers intriguing insights into the personalities and motivations of some of America's most famous politicians. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book Hirschsprung s Disease and Allied Disorders written by Prem Puri and published by Springer. This book was released on 2019-05-23 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third edition of a comprehensive study of the neuronal disorders of the lower gastrointestinal tract in children. Important new studies and progress in research on bowel motility and motility disorders are covered in detail as well as new aspects concerning the embryology, functional anatomy of the enteric nervous system. In particular new insights have been received from the studies in the genetics of Hirschsprung's disease. Special emphasis is laid on new surgical techniques, especially on the laparoscopic approach in combination with Soave's or Duhamel's technique.
Download or read book Immune maturation and modulation in childhood allergies written by Johanna Huoman and published by Linköping University Electronic Press. This book was released on 2020-10-15 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of allergic diseases has in the past century increased among children in affluent societies. Underlying causes are incompletely disentangled, but decreased diversity in environmental and microbial exposures could drive allergy development. Allergic individuals possess imbalanced immune responses, skewed in favour of Th2 cells along with lesser Th1 and Treg responses. As allergy development early in life increases the risk of developing further allergic manifestations later, early prevention is key. Thus, interventions in pregnancy, early life and childhood may modulate immunity towards tolerance, although underpinnings of immune maturation and modulation in allergy prevention throughout childhood are not entirely understood. In this thesis, these questions are addressed in children with a high propensity of developing allergic disease or who already have manifested allergies. Chemokines are crucial for immune cell recruitment to the allergic reaction site, and associate with allergy development in childhood. In Paper I, circulating levels of the allergy-related chemokines CCL17, CCL18, CCL22, CXCL10 and CXCL11 were studied in the natural course of allergic disease. Elevated levels of the Th2/Treg-regulated chemokine CCL18 in infancy and childhood associated with development of asthma and/or sensitisation. Moreover, this finding conferred higher odds of developing asthma and sensitisation from early school age until adolescence. Additionally, increased levels of the Th1-associated chemokines CXCL10 after birth, and decreased levels of CXCL11 at birth, preceded asthma development later in life. Hence, Paper I showed that circulating chemokine levels in different ways precede allergy development. Epigenetic modifications, such as DNA methylation, comprise a link between the genetic setup and environmental exposures, and regulate processes such as Th cell differentiation. Perinatal treatment with Lactobacillus reuteri and ?-3 fatty acids prevent development of some IgE-mediated manifestations. However, the drivers of the immunostimulating and pro-resolving effects of these treatments are sparsely examined. In Papers II and III, epigenome-wide DNA methylation patterns in CD4+ cells upon pre-and postnatal L. reuteri supplementation alone or in combination with ?-3 fatty acids were studied. In Paper II, the greatest epigenome wide differential methylation was evident at birth, mainly directed towards hypomethylation, indicating transcriptional availability of affected genes. Network analyses revealed several immune related pathways, and a relationship of differentially methylated genes to allergy development. Thus, prenatal L. reuteri treatment seemingly poises Th cells towards immune activation at birth, possibly influencing immune maturation as well as allergy development in the child. In Paper III, epigenome-wide DNA methylation patterns were surveyed at birth. In this on-going trial, mothers are treated during the latter half of pregnancy with a combination of L. reuteri and ?-3 fatty acids. Four different treatment groups were studied, and the largest differential methylation was seen in the double active treatment group. In contrast to Paper II, most CpGs and genes were hypermethylated, indicating repressed gene transcription. In line with Paper II, network analyses showed that T cell and immune mediated pathways were affected by treatment, and synergistic effects of the double treatment were indicated. Taken together, prenatal treatment with L. reuteri and/or ?-3 fatty acids altered the epigenome to different extents at birth, mainly towards hypermethylation, and often affected immune related pathways. Immunomodulatory effects of sublingual immunotherapy in children and adolescents are scarcely investigated. In Paper IV, circulating and salivary immune mediators were investigated in timothy grass-pollen allergic children treated with sublingual immunotherapy. Actively treated children had elevated levels of timothy grass pollen-specific IgA antibodies in saliva, along with increased circulating levels of the Th1-associated chemokines CXCL10 and CXCL11, both after treatment ending and two years later. Taken together, sublingual immunotherapy modulates local and peripheral immune responses in children with timothy grass pollen-induced allergy, by augmenting Th1-responses, lessening Th2-responses and inducing immunomodulatory responses, suggesting induction of tolerance, also partly in the long-term. Altogether, the studies in this thesis have shown altered immune regulation in children developing allergies. Moreover, immunomodulatory effects of prenatal treatment with probiotics and ?-3 fatty acids, and sublingual immunotherapy in children with grass pollen-induced allergic disease, were revealed. DNA methylation patterns and immunologic mediators in blood and saliva could potentially serve as appropriate biomarkers for allergic disease. Long term health benefits can be reached by intervening early in life, and further knowledge about the mechanisms behind this could promote the prevention of allergic diseases and hence improve the quality of life for children and adolescents. Förekomsten av allergiska sjukdomar, som böjveckseksem, hösnuva och astma, har under det senaste århundradet ökat markant bland barn i industrialiserade samhällen. De bakomliggande orsakerna är inte helt klarlagda, men samhälleliga förändringar har minskat vår mångfaldiga exponering för bakterier, virus och parasiter. Detta skulle kunna ligga till grund för immunförsvarets felaktiga reaktion mot egentligen ofarliga ämnen som ses vid allergier. Hos allergiska individer är immunförsvaret obalanserat, med en relativ övervikt av det så kallade Thjälpar- 2 (Th2)-svaret gentemot Th1- och det regulatoriska T-cells (Treg)-svaret. Allergiska sjukdomar utvecklas ofta tidigt i livet, vilket ökar risken för att utveckla vidare allergier senare i livet. Därför är det viktigt att motverka den allergiska marschens framfart tidigt genom förebyggande behandlingar. Ett tillvägagångsätt är att påbörja behandling under graviditeten och tidiga barndomen hos barn med hög risk för att bli allergiska, då grunden för immunsystemet läggs redan under fosterlivet. För redan utvecklade allergier är det tänkbart att omforma dessa immunsvar med immunterapi, som kan minska symptom av befintliga allergier samtidigt som det är möjligt att motverka utvecklingen av senare allergier. Det är dock inte helt klarlagt hur immunutmognaden under barndomen är reglerad, eller hur dessa typer av behandlingar skulle kunna påverka allergiutveckling under den perioden. I denna avhandling undersöks immunutmognad vid allergiutveckling hos barn, och möjliga immunmodulerande förebyggande behandlingar hos barn med genetisk benägenhet att bli allergiska eller som redan utvecklat allergisk sjukdom. För att celler ska rekryteras till platsen för en allergisk reaktion krävs bland annat s.k. kemokiner. I det första arbetet undersöktes dessa lockelseämnen, då våra tidigare studier visat att nivåerna av vissa kemokiner vid födseln förutspår utvecklingen av allergi hos barn. De allergirelaterade kemokinerna CCL17, CCL18, CCL22, CXCL10 och CXCL11 analyserades i blodprover vid födseln, 1 och 8 års ålder hos barn från en populationsbaserad observationsstudie. Förhöjda nivåer av CCL18, ett kemokin under reglering av både Th2- och Treg-svar, uppmättes vid 1 och/eller 8 års ålder hos barn som hade astma (särskilt svår astma) och/eller var sensibiliserade. De ökade nivåerna associerade också till högre odds för utveckling av astma från tidig skolålder upp till övre tonåren, med liknande resultat för sensibilisering. Även ökade nivåer av de Th1-associerade kemokinerna CXCL10 efter födseln och minskade nivåer av CXCL11 vid födseln föregick utvecklingen av astma senare i livet. Det första arbetet visade alltså på att cirkulerande kemokiner på olika vis föregår utvecklingen av allergier hos barn och ungdomar. Som länk mellan arv och miljö står s.k. epigenetiska modifieringar, vilka reglerar genaktiviteten utan att förändra den genetiska koden i arvsmassan. Till dessa modifieringar räknas DNAmetylering, en process som bl.a. styr utmognad av de allergirelaterade T-hjälparcellerna. Vi har i tidigare separata studier med den probiotiska stammen Lactobacillus reuteri och omega-3- behandling visat förebyggande av vissa IgE-medierade allergier. Vad som föranleder de immunstimulerande och immunmodulerande effekterna av behandlingarna är dock otillräckligt undersökt. I det andra och tredje arbetet undersöktes hur L. reuteri separat eller i kombination med omega-3-fettsyror påverkar DNA-metyleringsmönster i CD4+ Th-celler hos barn som behandlats före och efter födseln. I det andra arbetet undersöktes DNA-metyleringsmönster både lokalt och i hela genomet vid födseln, ett och två års ålder. Behandling med L. reuteri förändrade DNA-metyleringsmönster i allergirelaterade T-hjälparceller mest vid födseln mot s.k. hypometylering, vilket pekar på ökad tillgänglighet av generna för proteinuttryck. Vidare nätverksanalyser visade att flera immunrelaterade processer påverkades av behandlingen. Därtill var generna från nätverket till stor del associerade med allergiutveckling. Maternell behandling med L. reuteri under den sista graviditetsmånaden tycks alltså förändra DNA-metyleringsmönster i T-hjälparceller hos fostret mot ökad immunaktivering vid födseln, vilket i sin tur skulle kunna påverka både immunutmognad och allergiutveckling hos barnet. I likhet med det andra arbetet undersöktes i det tredje arbetet DNA-metyleringsmönster i hela epigenomet, fast endast vid födseln. I denna pågående studie behandlas mödrarna under den andra halvan av graviditeten med en kombination av L. reuteri och omega-3-fettsyror. Fyra olika behandlingsgrupper undersöktes och den största förändringen i DNA-metylering återfanns i den kombinerade aktiva behandlingsgruppen. I motsats till det andra arbetet var dock de flesta CpG positionerna och generna hypermetylerade, vilket tyder på att genernas tillgänglighet för proteinuttryck hämmas. I linje med det andra arbetet framkom T-cells- och immunrelaterade signalvägar i nätverksanalyser på dessa gener, och det fanns indikationer på synergistiska effekter mellan behandlingarna. Det tredje arbetet visade att behandling med L. reuteri och/eller omega- 3-fettsyror under senare delen av graviditeten förändrar T-hjälparcellernas epigenom i olika grad främst mot hypermetylering, och ofta påverkar immunrelaterade signalvägar. Relevansen av dessa fynd kommer i framtida studier att undersökas på proteinnivå och i relation till allergiutveckling. Med allergenspecifik immunterapi är det möjligt att modulera immunsvaret hos allergiska individer mot ett tolerant immunsvar, men effekter av sublingual immunterapi på immunförsvaret hos barn och ungdomar är knapphändigt undersökta. I det fjärde arbetet undersöktes olika immunologiska mediatorer i blod och saliv hos barn med gräspollenallergi, som deltagit i en studie med sublingual immunterapi. Nivåerna av allergirelaterade cytokiner och kemokiner undersöktes i blodprover från inklusionstillfället, efter tre år med behandling samt två år efter avslutad behandling i plasmaprov och allergenstimulerade blodceller. Dessutom mättes total-IgA, sekretoriskt IgA och gräspollenspecifikt IgA i saliv vid samma tillfällen. Barn som fått aktiv behandling hade högre nivåer av gräspollenspecifika IgA-antikroppar i saliv både när behandlingen avslutades och två år efter. Därtill ökade nivåerna av de Th1-associerade kemokinerna CXCL10 och CXCL11 i blodet vid samma tidpunkter. Sammantaget visade resultaten från det fjärde arbetet att behandlingen med sublingual immunterapi hos barn med gräspollenallergi modulerar immunsvaret både lokalt och i cirkulationen genom att öka Th1- svar, minska Th2-svar och inducera immunreglerande svar, vilket indikerar att tolerans har utvecklats hos dessa barn, delvis även på lång sikt. Sammanfattningsvis har studierna i denna avhandling visat på förändrad immunreglering hos barn som utvecklar allergi. Dessutom påvisades immunmodulerande effekter av prenatal behandling med probiotika och omega-3-fettsyror samt av sublingual immunterapi hos barn med gräspollenallergi. DNA-metyleringsmönster och immunologiska mediatorer i blod och saliv skulle kunna fungera som lämpliga biomarkörer för allergisk sjukdom, vilket är ett viktig led i att kunna förutsäga allergiutveckling och förbättra den kliniska behandlingen av allergier bland barn och ungdomar. Långsiktiga hälsofördelar kan uppnås genom att ingripa tidigt i livet, och vidare kunskap om mekanismerna bakom detta skulle kunna främja förebyggandet av allergiska sjukdomar och således kunna förbättra livskvaliteten för barn och ungdomar.
Download or read book Heart Development and Disease written by Benoit G. Bruneau and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Development of the heart is a complex process and can lead to serious congenital disease if the process goes awry. This book provides a detailed description of the cell lineages involved in heart development and how their migration and morphogenesis are controlled. It also examines the genetic and environmental bases for congenital heart disease and how model systems are revealing more about the processes involved"--
Download or read book MLA International Bibliography of Books and Articles on the Modern Languages and Literatures written by Modern Language Association of America and published by . This book was released on 2002 with total page 2358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1969- include ACTFL annual bibliography of books and articles on pedagogy in foreign languages 1969-
Download or read book Horringer Parish Registers written by Horringer, Eng. (Parish) and published by . This book was released on 1900 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Palliative Care in Pediatric Oncology written by Joanne Wolfe and published by Springer. This book was released on 2017-12-20 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is the first to focus on comprehensive interdisciplinary care approaches aimed at enhancing the wellbeing of children with cancer and their families throughout the illness experience. Among the topics addressed are the epidemiology of pediatric cancer distress, including physical, emotional, social, and spiritual dimensions; the role of the interdisciplinary team; communication and advance care planning; symptom prevention and management; care at the end of life; family bereavement care; and approaches to ease clinician distress. The contributing authors are true experts and provide guidance based on the highest available level of evidence in the field. The book has not only an interdisciplinary but also an international perspective; it will appeal globally to all clinicians caring for children with cancer, including physicians, nurses, psychosocial clinicians, and chaplains, among others.
Download or read book Naval Documents of the American Revolution written by United States. Naval History Division and published by . This book was released on 1964 with total page 1408 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the tradition of the preceding volumes - the first of which was published in 1964 - this work synthesizes edited documents, including correspondence, ship logs, muster rolls, orders, and newspaper accounts, that provide a comprehensive understanding of the war at sea in the spring of 1778. The editors organize this wide array of texts chronologically by theater and incorporate French, Italian, and Spanish transcriptions with English translations throughout.
Download or read book A Whole Lot of History written by Kimberley Walsh and published by Headline. This book was released on 2013-09-26 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2002 - along with Cheryl Cole, Nadine Coyle, Sarah Harding and Nicola Roberts - Kimberley Walsh won a place in the Popstars The Rivals band Girls Aloud, and her life changed forever. Ten years later, after six platinum albums, twenty top-ten singles, a Brit Award, an entry in the Guinness Book of Records and a triumphant sell-out reunion tour, the girls have decided to go their separate ways. What better time for Kimberley - a professional, hardworking businesswoman as well as a multi-talented actress and songstress - to tell her story. What was it like behind the scenes of a such a hugely successful band? Was there any truth in the rumours of endless feuds within Girls Aloud? How did she manage to maintain such a strong loving relationship with her partner Justin during the 10 years she was in the band? And how does it feel when your best friend becomes the most famous person in the land? Full of the warmth and laughter that makes Kimberley such a national treasure, with lots of insider secrets revealed too, this book is like curling up on the sofa for a gossip with a friend. There is lots still to come from the UK's favourite Northern lass. Just watch this space.
Download or read book Skulduggery Pleasant written by Derek Landy and published by Harper Collins. This book was released on 2011-02-22 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meet Skulduggery Pleasant Ace Detective Snappy Dresser Razor–tongued Wit Crackerjack Sorcerer and Walking, Talking, Fire-throwing Skeleton —as well as ally, protector, and mentor of Stephanie Edgley, a very unusual and darkly talented twelve-year-old. These two alone must defeat an all-consuming ancient evil. The end of the world? Over his dead body.
Download or read book Pediatric Neurology written by James F Bale Jr and published by CRC Press. This book was released on 2011-12-15 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing patterns of disease can be the first step to successful management of the child with a neurological problem; this is emphasized by the authors throughout the book. Their concise, precise account reflects the remarkable recent advances in pediatric neurology and related disciplines, while stressing the fundamentals of clinical examination and history taking in reaching an accurate diagnosis. The book begins with a detailed discussion of neurological examination techniques and the basic formulation of differential diagnoses and management, using neuroradiology, electrophysiology, cerebrospinal fluids, genetic and metabolic testing. The second section of the book follows a problem-based approach, just as diseases present in the real world. It employs practical, symptom- and sign-based strategies for virtually all conditions encountered by the practitioner. The final section on neurological emergencies recognizes that such conditions present first to someone other than a pediatric neurologist. This new color handbook is illustrated throughout by a wealth of top-quality clinical photos and imaging, and is of interest to pediatric neurologists, general pediatricians, primary care physicians and emergency physicians, in training and practice.
Download or read book Practical Guide to Epilepsy written by Mark Manford and published by . This book was released on 2003 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is part of a series designed to fulfill the need for a simple guide to common neurological disorders for the non-specialist, who is required to diagnose and manage these conditions as part of their clinical practice.
