Download or read book Recruitment of Neutrophils Into Lung by CXC Chemokines written by Andrew C. Merry and published by . This book was released on 2003 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemokines in the Lung written by Robert M. Strieter and published by CRC Press. This book was released on 2003-01-22 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference discusses the role of chemokines in mediating leukocyte trafficking, angiogenesis, tumor cell metastasis, host defense, trauma-induced lung injury, and the progression of AIDS in the lung, and studies cytokines as natural agents for modulating diseases that affect the lung.
Download or read book Functions of Neutrophils During Respiratory Coronavirus Infection of Rats written by Joanna Rzepka and published by . This book was released on 2012 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of lower respiratory tract infections (LRI) is often associated with dysregulated and exacerbated immune response. Immune response to LRI is often triggered by virus-infected target cells, such as epithelial cells that line the respiratory tract. It is critical to understand how the epithelium regulates immediate immune responses to be able to manipulate these responses for host's benefits. Animal models are often used to examine immunopathogenesis associated with diseases. Rat coronavirus (RCoV) is a natural pathogen of rats, used as a model for studying respiratory tract diseases caused by coronaviruses. This dissertation aims to clarify the role of the alveolar epithelium in mediating neutrophil responses to RCoV-infection and examines the role of neutrophils in a timely virus clearance and induction of lung tissue damage. Infection of rats with RCoV resulted in prompt recruitment of increased numbers of neutrophils to the lungs of infected animals. The peak of neutrophil recruitment coincided with observable, transient lung tissue injury, which was resolved soon after neutrophil counts in the lung had dropped to the homeostasis level. Interestingly, only in the presence of neutrophils infectious RCoV was effectively cleared from the lungs within 8 days after exposure of the animal to the virus. Depletion of neutrophils before the infection caused increased morbidity and mortality, without causing lung tissue damage. The second and the third chapters of this dissertation aim to clarify the role of alveolar epithelial cells, infected with RCoV, in mediation of neutrophil chemotaxis and inhibition of their apoptosis. Infection of type I alveolar epithelial cells, cultured in vitro, was performed to characterize signaling molecules involved in chemotaxis of neutrophils during RCoV infection and inhibition of their apoptosis. Epithelium-produced CXC chemokines, signaling through CXCR2 receptor on the surface of neutrophils, directed the recruitment of neutrophils and prolonged their life span. The presence of infectious virus particles was not required to elicit these effects. Understanding how the interactions between infected alveolar epithelial cells and the innate immune system, in particular neutrophils, are stimulated during infection with respiratory coronaviruses, will help in designing effective therapeutic strategies for pulmonary viral infections.
Download or read book The Neutrophil written by Marco A. Cassatella and published by Karger Medical and Scientific Publishers. This book was released on 2003-01-01 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past, neutrophils were often reduced to their ability to release preformed mediators and kill pathogens. The present volume of Chemical Immunology and Allergy, however, offers a very broad and timely view by highlighting the versatile functions of neutrophils in inflammatory, immune and antitumoral responses. Leading investigators uncover novel aspects of neutrophils, such as their capacity to control gene expression at the transcriptional level, or respond to proinflammatory cytokines, cytokine receptor chains (gc) and endogenous anti-inflammatory lipid mediators. Further points under discussion are neutrophils presenting antigens, activating T cells, participating in chemokine networking, and producing IL-12 and other cytokines during infectious diseases. Among the most original findings presented in this publication figure the observations that neutrophils cause increased vascular permeability during acute inflammation, regulate directly the angiogenic process, and influence tumor development. A final article offers a detailed description of the molecular processes affecting neutrophil cell death and survival. Unique in its field, this valuable volume is recommended reading not only for immunologists and pathologists, but also for cell biologists, hematologists and immunobiologists.
Download or read book Translational Immunotherapy of Brain Tumors written by John H. Sampson and published by Academic Press. This book was released on 2017-02-06 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors
Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Download or read book Inflammation and Immunity in Depression written by Bernhard Baune and published by Academic Press. This book was released on 2018-05-23 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions
Download or read book The Neutrophil written by Jon S. Abramson and published by Oxford University Press, USA. This book was released on 1993 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third book in the group devoted to the "natural" immune system, this volume provides the ideal detailed, up-to-date overview of neutrophil function. Distilling new information alongside observations of the past, the book focuses on some of the most critical developments in currentneutrophil research. Specific examples of diseases resulting from neutrophil dysfunction and deficiency are brought to life by clinical case studies. An essential source of current research into this exciting field, this volume will be invaluable for advanced students and researchers in immunology,cell biology, and medicine.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sertoli Cell Biology written by Michael K. Skinner and published by Elsevier. This book was released on 2004-11-23 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sertoli cells assist in the production of sperm in the male reproductive system. This book provides a state-of-the-art update on the topic of sertoli cells and male reproduction. It addresses such highly topical areas as stem cells, genomics, and molecular genetics, as well as provides historical information on the discovery of this type of cell, and the pathophysiology of male infertility. * Presents the state-of-the-art research on topics such as stem cell research, transplantation and genomics* Includes contributions from leaders in the field, including several members of the National Academy of Science
Download or read book Ventilator Induced Lung Injury written by Didier Dreyfuss and published by CRC Press. This book was released on 2006-03-21 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Cons
Download or read book Environmental and Occupational Medicine written by William N. Rom and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 1862 pages. Available in PDF, EPUB and Kindle. Book excerpt: PROPOSAL DESCRIPTION: Now in its updated Fourth Edition, this classic text provides comprehensive coverage of all aspects of occupational and environmental medicine. The book offers accurate, current information on the history, causes, prevention, and treatment of a wide range of environmental and occupational diseases and includes numerous case studies.This edition includes more information on gene-environment interactions. The section on air pollution has been completely reorganized. Other Fourth Edition highlights include expanded coverage of government responses to the field and a new chapter on children's environmental health. Now in its updated Fourth Edition, this classic text provides comprehensive coverage of all aspects of occupational and environmental medicine. The book offers accurate, current information on the history, causes, prevention, and treatment of a wide range of environmental and occupational diseases and includes numerous case studies. This edition includes more information on gene-environment interactions. The section on air pollution has been completely reorganized. Other Fourth Edition highlights include expanded coverage of government responses to the field and a new chapter on children's environmental health.
Download or read book Acute Respiratory Distress Syndrome written by Augustine M.K. Choi and published by CRC Press. This book was released on 2016-04-19 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS).Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS.Highlights include:the definition,
Download or read book Liver Diseases 2 Vols written by Shakir Ali and published by CRC Press. This book was released on 2006-01-03 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state-of-art information summarizing the current understanding of a range of liver diseases, and reviews some key diagnostic and therapeutic advances. The book is a collection of selected clinical and scientific topics divided into two volumes, each divided into two sections. The first volume treats the cellular, biochemical and
Download or read book Index Medicus written by and published by . This book was released on 2001 with total page 1660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Fungal Immunology written by Paul L. Fidel and published by Springer Science & Business Media. This book was released on 2006-04-09 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of all known immune mechanisms for medically important fungal pathogens from the organ perspectives of the human body. This authoritative guide is organized by organ system, as one particular fungus can have several different effects.
Download or read book Viral Evasion Mechanisms of the Host Response written by Ricardo Martín Gómez and published by Frontiers Media SA. This book was released on 2020-04-06 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt:
