Download or read book Receptor Dynamics in Neural Development written by Christopher Ariel Shaw and published by . This book was released on 1996 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written
Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.
Download or read book Receptor Dynamics in Neural Development written by Christopher Ari Shaw and published by CRC Press. This book was released on 1996-02-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of what receptors do in the nervous system, how they do it, the mechanisms by which receptor function is regulated, and the consequences of normal and abnormal receptor function. It contains a series of interrelated chapters describing key neurotransmitter receptors, protein kinases, and protein phosphatases, and details their expression and composition in the development of the central nervous system (CNS).
Download or read book Neural Development and Plasticity written by R. Ranney Mize and published by Elsevier Science Limited. This book was released on 1996 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Progress in Brain Research volume is the outgrowth of a symposium entitled "Neural Development and Plasticity" which was held in New Orleans, Louisiana. The reader will find substantial new information about the mechanisms underlying growth cone dynamics, about molecules involved in axon outgrowth and cell adhesion, the role of proteoglycans and glial factors in directing or confirming axons to their appropriate targets, and the role of myelin-associated growth inhibitors. The book will contribute new ideas and identifies new questions of primary importance to developmental neurobiology.
Download or read book Receptors in the Developing Nervous System written by Ian S. Zagon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors for cell hormones, growth factors, Fourth, alterations in the development of neu and neurotransmitters are involved in the ral receptors may have profound implications control and modulation of an enormous array for the structure and function of the of biological processes. The development of organism. As much as possible, the reper these receptors has distinct spatial and tem cussions of disrupting the orchestration of poral arrangements, and alterations in this receptor development in the nervous system pattern during embryogenesis can have signi are discussed. In many instances, however, ficant consequences for the well-being of the we are just beginning to learn about some fetus, infant, child and adult. The developing receptors and the authors may not be in a nervous system is particularly dependent on position to discuss the consequences of recep receptors because its period of structural and tor dysfunction. functional organization extends through both In designing these two volumes, we have prenatal and postnatal phases. Moreover, asked major figures in each field to review the receptors are a key element in neural com literature, to apprise the audience of their munication in both the developing and adult latest findings, and to provide a perspective on organism, so that the ontogeny of receptors is the role of receptors in the developing nervous crucial in determining the myriad connections system. These books are intended to sum forming the circuitry of the nervous system.
Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Download or read book The Enteric Nervous System written by John Barton Furness and published by . This book was released on 1987 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modulation of Microtubule Dynamics in Netrin Signaling written by Huai Huang and published by . This book was released on 2017 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal development proceeds through several stages, such as axon and dendrite differentiation, elongation, branching, and pathfinding. Extracellular guidance cues play an essential role in these processes. Activation of downstream signaling of guidance receptors eventually leads to the cytoskeleton rearrangement. Microtubules (MTs), as one form of the cytoskeleton, play an important role in axon and dendrite outgrowth, elongation and branching. Netrin-1, a canonical guidance molecule, binds to its receptors Deleted in Colorectal Cancer (DCC), Down Syndrome Cell Adhesion Molecule (DSCAM) and uncoordinated-5 (UNC5) mediating neuronal development. Our recent studies have shown that TUBB3, a neuronal ß-tubulin isotype III, directly binds to DCC and Netrin-1 induces this interaction. Results from multiple function assays indicate that TUBB3 is specifically involved in Netrin-1-induced axon outgrowth and guidance. Heterozygous missense mutations in human TUBB3 gene result in a spectrum of brain malformations associated with defects in axon guidance, neuronal migration, and differentiation. However, the molecular mechanisms underlying mutation-related axon guidance abnormalities are unclear. Here, we provide evidence that TUBB3 mutations impair Netrin/DCC signaling in the developing nervous system. The interaction of DCC with most of TUBB3 mutants (eight out of twelve) is significantly reduced compared to the wild type TUBB3. TUBB3 mutants R262C and A302V exhibit decreased subcellular colocalization with DCC in the growth cones of primary neurons. Netrin-1 enhances the interaction of endogenous DCC with wild type human TUBB3, but not with R262C or A302V, in primary neurons. Netrin-1 also increases the co-sedimentation of DCC with polymerized MTs in primary neurons expressing wild type TUBB3, but not R262C or A302V. Expression of either R262C or A302V not only suppresses Netrin-1-induced neurite outgrowth, branching and attraction in vitro, but also causes defects in spinal cord commissural axon projection and pathfinding in ovo. Our study reveals that missense TUBB3 mutations specifically disrupt Netrin/DCC-mediated attractive signaling. MT dynamics play an important role in Netrin-1-promoted axon outgrowth, branching, and axon pathfinding. However, the mechanism by which Netrin-1 regulates this process is not clear. The MT-associated protein (MAP) tau regulates MT stability and dynamics, which are important for neuronal development in the nervous system. Our study shows that tau interacts with the Netrin receptor DCC, and Netrin-1 induces this interaction in primary neurons. Tau colocalizes with DCC in the growth cone of primary neurons and Netrin-1 induces this colocalization. Activation of JNK, GSK-3 and Src family kinases are important for Netrin-1-induced DCC/tau interaction. Knockdown of tau inhibits Netrin-1-induced axon outgrowth, branching and commissural axon attraction in vitro and leads to defects in commissural axon projection in the chick spinal cord in vivo. These findings suggest that tau is involved in Netrin-1 signaling and essential for Netrin-1-promoted neuronal development. In general, these studies are focusing on the role of MT component protein TUBB3 and MT-associated protein tau in the Netrin-1 signaling. The study of TUBB3 mutants further validates the essential role of TUBB3 in Netrin-1-mediated neuronal development by showing that TUBB3 mutants A302V and R262C found in patients disrupt the function of TUBB3 in Netrin-1-mediated neurite outgrowth, axon branching and attraction. The study of tau reveals that tau is involved in Netrin-1-mediated neuronal development. However, the questions regarding the relationship between TUBB3 and tau in Netrin signaling need to be further addressed. For instance, whether Netrin-1 regulates the interaction between tau and TUBB3, and whether the interaction between DCC and tau is dependent upon the presence of TUBB3 need to be clarified.
Download or read book Developing Brain Behaviour written by John Dobbing and published by Elsevier. This book was released on 1997-08-13 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Certain long chain polyunsaturated fatty acids (LCPUFAs) are thought to be essential components of the nutrition of infants, including those prematurely born, in the sense that they cannot be synthesises by the immature organism and must therefore be supplied in the diet. Breast milk contains these substances, but many manufactured infant formulae do not.An absence of dietary LCPUFAs has been thought to affect the development of the brain and retina, possibly leading to abnormalties in cognitive and visual function. Considerable multidisciplinary research has been carried out to investigate this proposition. Diets free from LCPUFAs have been compared with supplemented formulae, or with breast milk.The conclusions from this research were critically examined by a group of leading paediatricians, nutritionists, experts in visual science and developmental behavioural scientists at a 'Dobbing Workshop' held in the United States in late February, 1997. Each of the Chapters was precirculated to the whole group, commented on before the Workshop, and then exhaustively discussed. The Chapters and Commentaries which are published here have therefore undergone a more extensive peer-review process than is usually the case.
Download or read book Membrane Organization and Dynamics written by Amitabha Chattopadhyay and published by Springer. This book was released on 2017-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The chapters cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide the reader with a comprehensive understanding of the underlying membrane dynamics and function, which will help to develop robust dynamic models for the understanding of membrane function in healthy and diseased states. In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu. This volume will address the dynamic nature of membrane proteins within the membrane and will provide the reader with an up-to date overview of the theory and practical approaches that can be used. This volume will be invaluable to researchers working in a wide range of scientific areas, from biochemistry and molecular biology to biophysics and protein science. Students of these fields will also find this volume very useful. This book will also be of great use to those who are interested in the dynamic nature of biological processes.
Download or read book Mapping the Brain and Its Functions written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant advances in brain research have been made, but investigators who face the resulting explosion of data need new methods to integrate the pieces of the "brain puzzle." Based on the expertise of more than 100 neuroscientists and computer specialists, this new volume examines how computer technology can meet that need. Featuring outstanding color photography, the book presents an overview of the complexity of brain research, which covers the spectrum from human behavior to genetic mechanisms. Advances in vision, substance abuse, pain, and schizophrenia are highlighted. The committee explores the potential benefits of computer graphics, database systems, and communications networks in neuroscience and reviews the available technology. Recommendations center on a proposed Brain Mapping Initiative, with an agenda for implementation and a look at issues such as privacy and accessibility.
Download or read book Atlas of the Developing Mouse Brain written by George Paxinos and published by Academic Press. This book was released on 2020-03-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of the Developing Mouse Brain, Second Edition builds on the features of successful first edition, providing a comprehensive and convenient reference for all areas of the mouse brain at Fetal-Day 17.5 (E17.5), Day-of-Birth (P0), and Day-Six postnatal (P6). The book also delineates the parts of the eye, features of the skull, ganglia, nerves, arteries, veins, bones and foramina. This atlas is an essential tool for researchers and students who study the development of the mouse brain, or for those who interpret findings from genetic manipulation. - Contains 176 high-resolution color scans of Nissl-stained coronal sections of the brain and skull of the fetal (E17.5), day-of-birth (P0), and day-six postnatal mouse (P6) - Includes diagrams that delineate all structures of the brain, as well as peripheral nerves, ganglia, muscles, bones, veins and arteries of the head - Presents approximately 5000 corrections and updates from the first edition - Includes color codes of the veins, arteries, nerves and ganglions of the skull in diagrams
Download or read book The Theoretical Foundation of Dendritic Function written by Wilfrid Rall and published by MIT Press. This book was released on 1995 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of fifteen previously published papers, some of them not widely available, have been carefully chosen and annotated by Rall's colleagues and other leading neuroscientists.
Download or read book Mayo Clinic Medical Neurosciences written by Eduardo E. Benarroch and published by Oxford University Press. This book was released on 2017-11-06 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
