Download or read book Rationale of Biological Response Modifiers in Cancer Treatment written by Eiro Tsubura and published by . This book was released on 1985 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Screening for Biological Response Modifiers Methods and Rationale written by James E. Talmadge and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents. The initial observations stimulated a search for new chemotherapeutic agents which might have increased antitumor activity with less toxicity for normal tissues. To aid in the search for these new chemicals and to attempt to distinguish among the many toxic chemicals which might be candidates for clinical studies, the National Cancer Institute, the pharmaceutical industry, and the cancer research laboratories of most Western nations developed systems for "screening" drugs for antitumor activity. Perhaps the most extensive screening program was established by the National Cancer Institute (1). This screening program has evolved over the last two decades, an evolution which has been repeatedly reviewed (2-5). Various screening programs in use have examined over 500,000 compounds as potential anticancer agents. From these, there are now approximately forty anticancer drugs in clinical use. The utiliy of these compounds and their toxicities have been reviewed on many occasions. It is now apparent that more active and less toxic anticancer drugs are needed. It is also clear that the current screening programs are identifying compounds with similar levels of activity and with continuing moderate to severe toxicity (6).
Download or read book Combination Therapies 2 written by Institute for Advanced Studies in Immunology & Aging and published by Plenum Publishing Corporation. This book was released on 1993 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 2nd International Symposium on Combination Therapies for Cancer held in Sicily (Italy) in May 1992. Papers address the mechanism of action and rationale for use of biological response modifiers (BRM) in the treatment of cancer. BRM's possible role in treating infectious diseases,
Download or read book Biological Response Modifiers written by National Cancer Institute (U.S.) Subcommittee on Biological Response Modifiers and published by . This book was released on 1983 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Response Modifiers and Cancer Therapy written by J. W. Chiao and published by Marcel Dekker. This book was released on 1988 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Response Modifiers in Human Oncology and Immunology written by Andor Szentivanyi and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topic of biological response modifiers has attracted the attention of many biomedical investigators, including immunologists, oncologists, pharmacologists, microbiologists, and biochemists, as well as clinical practitioners of medicine. This has occurred mainly because of the realization that the complex system of cellular and humoral interactions culminating in a productive immune response is under exquisite regulatory control for normal immune responses and that loss of control may markedly influence the capability of a host to respond in a productive manner to the numerous immunologic "insults" encountered in the environment. Furthermore, biological response modification is considered by many to be a natural offshoot of the relatively new application of "immunotherapy" to cancer. It is widely recognized that "immunotherapy" was practiced at the end of the last century and the beginning of this century when it was recognized that microbial infections were caused by distinct species of bacteria and that passive administration of serum con taining antibody to these microbes or their products could, in many cases, favorably influence the outcome of an infectious process.
Download or read book Combination Therapies written by E. Garaci and published by Springer. This book was released on 2012-10-21 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade many of the key lymphokines, hormones and growth factors that help regulate the immune system have been defined. These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases. Advances in this area have also led to rethinking therapies against a range of autoimmune disorders and other diseases associated with immune and endocrine imbalances. BRMs currently are being applied clinically as both primary and adjunctive therapy to enhance the effectiveness of traditional treatments by maximizing their activities and to protect critical tissues against intolerable chemotherapeutic and radiation damage. Present constraints against the use of BRMs revolve around the nature of these substances in vivo, where many of their actions and the majority of their interactions and synergies remain to be elucidated. For example, as these molecules are thought to exert their effects locally, the systemic administration of lymphokines, cytokines and growth factors at doses adequate to produce a wanted anti-tumor effect in many instances is intolerably toxic. Efforts to overcome this formidable problem have led scientists to begin to explore the transfer of genes known to encode for these molecules into cells which otherwise inadequately elicit or produce anti-tumor or anti-infective responses.
Download or read book Biological Response Modifiers Interferons Double Stranded RNA and 2 5 Oligoadenylates written by W.E.G. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.
Download or read book Cancer Chemotherapy and Biotherapy written by Bruce A. Chabner and published by Lippincott Williams & Wilkins. This book was released on 2010-11-08 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated to include the newest drugs and those currently in development, Cancer Chemotherapy and Biotherapy, Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Chapters emphasize pharmacology and mechanisms of action at the molecular and cellular levels, followed by clinical activity and toxicity, both acute and delayed. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.
Download or read book Cancer Chemotherapy and Biological Response Modifiers Annual written by Herbert Michael Pinedo and published by . This book was released on 1987 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its ninth year the Cancer Chemotherapy Annual series has been renamed, reformatted and expanded to include a section on biological response modifiers. It is, and will remain, the only medium for oncologists to keep pace with the many thousands of articles published in their field. The international board of some seventy contributors now also includes experts in biological therapeutics, who have evaluated their segment of the international medical literature. The editors, H.M. Pinedo and B.A. Chabner, have secured the assistance of D.L. Longo, who qualifies as the director of the Biological Response Modifiers Program of the National Cancer Institute in Frederick, MD, USA.
Download or read book Biological Approaches to Cancer Treatment written by Malcolm S. Mitchell and published by McGraw-Hill Professional Publishing. This book was released on 1993 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique monograph reviews the biological principles of cancer immunotherapy & focuses specifically on biomodulation-the use of any substance to augment the host's antitumor response. Coverage begins with a detailed overview of the immunological basis on which biological therapy is grounded. Here, interactions among elements of the immune response are stressed throughout. Next, the text focuses on treatment including various forms of immunotherapy & future directions of cancer therapy in this rapidly expanding area.
Download or read book Cancer Chemotherapy and Biological Response Modifiers written by H. M. Pinedo and published by Elsevier Science & Technology. This book was released on 1993-01-01 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the recent major advances that have been made in the understanding of cancer biology, which have resulted in the development of both new classes of anti-cancer agents and new approaches to cancer treatment.
Download or read book Cancer Chemotherapy Immunotherapy and Biotherapy written by Bruce Chabner and published by LWW. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Thoroughly revised and reformatted, the sixth edition of Cancer Chemotherapy, Immunotherapy and Biotherapy reflects recent significant changes in cancer treatment. This newly streamlined edition contains full-color illustrations, more tables for quick reference, and new immunotherapy and molecular targeted therapy content that brings you fully up to date with the state of the art in all current cancer therapies. Provides thorough, comprehensive coverage of the scientific and clinical aspects of immunotherapy, biotherapy, and chemotherapy. Includes significantly expanded information on immunotherapy and molecular targeted therapy, as well as the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Features a new, full-color format, a newly streamlined presentation. and more tables and figures throughout for quick access to high-yield information. Explains the rationale for use of drugs in specific schedules and combinations and offers guidelines for dose adjustment in specific situations. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.
Download or read book Cancer Chemotherapy and Biological Response Modifiers written by Herbert M. Pinedo and published by . This book was released on 1988 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Chemotherapy Immunotherapy and Biotherapy written by Bruce A. Chabner and published by LWW. This book was released on 2024-08-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on individual patient needs, Cancer Chemotherapy, Immunotherapy and Biotherapy: Principles and Practice, Seventh Edition, provides thorough, comprehensive information from Drs. Bruce A. Chabner, Dan L. Longo, and an authoritative team of clinicians and scientists working at renowned cancer centers across the globe. It covers fundamental information about mechanism of action, pharmacokinetics, clinical toxicity, and drug interactions, all essential to the safe and effective use of the drug. Features full-color illustrations, numerous tables for quick reference and new content that brings you fully up to date with the state of the art in all current cancer therapies Contains the latest information on immunotherapy and molecular targeted therapy as well as all drugs and biological agents, their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance Reflects recent significant changes in cancer treatment, including new combination agents, new agents specifically related to CAR-T and checkpoint inhibitors, and new antibody conjugates Explains the rationale for use of drugs in specific schedules and combinations and offers guidelines for dose adjustment in specific situations
Download or read book Cancer Chemotherapy and Biological Response Modifiers written by H. M. Pinedo and published by Elsevier Science Health Science Division. This book was released on 1997 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Chemotherapy and Biological Response Modifiers has provided its readers with a comprehensive, definitive annual review of the literature in the fields of cancer biology, pharmacology, treatment and management. Its contributors are internationally renowned figures in the field of oncology. This volume contains 30 chapters reviewing recent developments within specific subject areas of oncological research. Having this up to date information on hand will ensure that you are well informed, so you can stay at the forefront of your profession.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
