Download or read book Graph Representation Learning written by William L. William L. Hamilton and published by Springer Nature. This book was released on 2022-06-01 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Graph-structured data is ubiquitous throughout the natural and social sciences, from telecommunication networks to quantum chemistry. Building relational inductive biases into deep learning architectures is crucial for creating systems that can learn, reason, and generalize from this kind of data. Recent years have seen a surge in research on graph representation learning, including techniques for deep graph embeddings, generalizations of convolutional neural networks to graph-structured data, and neural message-passing approaches inspired by belief propagation. These advances in graph representation learning have led to new state-of-the-art results in numerous domains, including chemical synthesis, 3D vision, recommender systems, question answering, and social network analysis. This book provides a synthesis and overview of graph representation learning. It begins with a discussion of the goals of graph representation learning as well as key methodological foundations in graph theory and network analysis. Following this, the book introduces and reviews methods for learning node embeddings, including random-walk-based methods and applications to knowledge graphs. It then provides a technical synthesis and introduction to the highly successful graph neural network (GNN) formalism, which has become a dominant and fast-growing paradigm for deep learning with graph data. The book concludes with a synthesis of recent advancements in deep generative models for graphs—a nascent but quickly growing subset of graph representation learning.

Download or read book WHO Expert Consultation on Rabies written by World Health Organization and published by World Health Organization. This book was released on 2005-12-31 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 99% of all human rabies deaths occur in the developing world and although effective and economical control measures are available the disease has not been brought under control throughout most of the affected countries. Given that a major factor in the low level of commitment to rabies control is a lack of accurate data on the true public health impact of the disease this report of a WHO Expert Consultation begins by providing new data on the estimated burden of the disease and its distribution in the world. It also reviews recent progress in the classification of rabies viruses rabies pathogenesis and diagnosis rabies pre- and post-exposure prophylaxis the management of rabies patients and canine as well as wildlife rabies prevention and control.

Download or read book Modeling Financial Time Series with S PLUS written by Eric Zivot and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of financial econometrics has exploded over the last decade This book represents an integration of theory, methods, and examples using the S-PLUS statistical modeling language and the S+FinMetrics module to facilitate the practice of financial econometrics. This is the first book to show the power of S-PLUS for the analysis of time series data. It is written for researchers and practitioners in the finance industry, academic researchers in economics and finance, and advanced MBA and graduate students in economics and finance. Readers are assumed to have a basic knowledge of S-PLUS and a solid grounding in basic statistics and time series concepts. This Second Edition is updated to cover S+FinMetrics 2.0 and includes new chapters on copulas, nonlinear regime switching models, continuous-time financial models, generalized method of moments, semi-nonparametric conditional density models, and the efficient method of moments. Eric Zivot is an associate professor and Gary Waterman Distinguished Scholar in the Economics Department, and adjunct associate professor of finance in the Business School at the University of Washington. He regularly teaches courses on econometric theory, financial econometrics and time series econometrics, and is the recipient of the Henry T. Buechel Award for Outstanding Teaching. He is an associate editor of Studies in Nonlinear Dynamics and Econometrics. He has published papers in the leading econometrics journals, including Econometrica, Econometric Theory, the Journal of Business and Economic Statistics, Journal of Econometrics, and the Review of Economics and Statistics. Jiahui Wang is an employee of Ronin Capital LLC. He received a Ph.D. in Economics from the University of Washington in 1997. He has published in leading econometrics journals such as Econometrica and Journal of Business and Economic Statistics, and is the Principal Investigator of National Science Foundation SBIR grants. In 2002 Dr. Wang was selected as one of the "2000 Outstanding Scholars of the 21st Century" by International Biographical Centre.

Download or read book Radiopharmaceuticals for Therapy written by F. F. (Russ) Knapp and published by Springer. This book was released on 2016-01-20 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1844 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1938 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Edible Insects written by Arnold van Huis and published by Bright Sparks. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edible insects have always been a part of human diets, but in some societies there remains a degree of disdain and disgust for their consumption. Although the majority of consumed insects are gathered in forest habitats, mass-rearing systems are being developed in many countries. Insects offer a significant opportunity to merge traditional knowledge and modern science to improve human food security worldwide. This publication describes the contribution of insects to food security and examines future prospects for raising insects at a commercial scale to improve food and feed production, diversify diets, and support livelihoods in both developing and developed countries. It shows the many traditional and potential new uses of insects for direct human consumption and the opportunities for and constraints to farming them for food and feed. It examines the body of research on issues such as insect nutrition and food safety, the use of insects as animal feed, and the processing and preservation of insects and their products. It highlights the need to develop a regulatory framework to govern the use of insects for food security. And it presents case studies and examples from around the world. Edible insects are a promising alternative to the conventional production of meat, either for direct human consumption or for indirect use as feedstock. To fully realise this potential, much work needs to be done by a wide range of stakeholders. This publication will boost awareness of the many valuable roles that insects play in sustaining nature and human life, and it will stimulate debate on the expansion of the use of insects as food and feed.

Download or read book Black Holes in the Era of Gravitational Wave Astronomy written by Manuel Arca Sedda and published by Elsevier. This book was released on 2024-06-03 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Black Holes in the Era of Gravitational-Wave Astronomy provides a multidisciplinary, up-to-date view of the physics of black holes, along with an exhaustive overview of crucial open questions and recent advancements in the astrophysics of black holes in the wake of incredible advancements made in the last decade. It includes discussions on improvements in theoretical modeling and observational perspectives for black holes of all sizes, along with associated challenges. The book's structure and themes will enable an entwined understanding of black hole physics at all scales, thus avoiding the compartmentalized view that is typical of more specialized manuscripts and reviews.This book is a complete reference for scientists interested in a multidirectional approach to the study of black holes. It provides substantial discussions about the interplay of different types of black holes and gives professionals a heterogeneous and comprehensive overview of the astrophysics of black holes of all masses. Focuses on recent advances and future perspectives surrounding black holes, providing researchers with a clear view of cutting-edge research Offers readers a multidisciplinary, fresh view on black holes, discussing and reviewing the most recent advancements in theoretical, numerical and observational techniques put in place to detect black holes Provides a bridge among different black hole areas, fostering new collaborations among professionals working in different, but intrinsically interconnected fields

Download or read book Medical Epigenetics written by Trygve Tollefsbol and published by Academic Press. This book was released on 2016-06-21 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1976 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Temporal Bone Cancer written by Paul W. Gidley and published by Springer. This book was released on 2018-05-03 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprehensively reviews the current literature on temporal bone cancer and the multidisciplinary approaches used to managing these rare tumors. The text will review important medical issues as they specifically relate to temporal bone cancer such as advanced imaging, pathologic classification, skull base surgery, plastic reconstructive surgery, and advances in osseointegrated implants for hearing restoration. Additional chapters are dedicated to the evaluation and management, diagnostic radiology, surgical planning and techniques, radiotherapy, chemotherapy, and rehabilitation. An emphasis is placed on the multidisciplinary approach required for the optimal care of these rare tumors. Written by leaders in the field, Temporal Bone Cancer will be an invaluable resource for residents and fellows in Otolaryngology, Neurosurgery and Neurotology, and clinicians with interest in the primary tumors of the temporal bone.

Download or read book Combinational Immunotherapy of Cancer Novel Targets Mechanisms and Strategies written by Xuyao Zhang and published by Frontiers Media SA. This book was released on 2024-01-15 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.

Download or read book Novel Diagnostic Tools and Biomarkers in Hematologic Malignancies written by Mina Luqing Xu and published by Frontiers Media SA. This book was released on 2022-03-15 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Science Citation Index written by and published by . This book was released on 1995 with total page 2544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1964- have guides and journal lists.

Download or read book Molecular Aspects of Alcohol and Nutrition written by Vinood B. Patel and published by Academic Press. This book was released on 2015-11-06 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Aspects of Alcohol and Nutrition is a valuable resource for nutrition researchers and nutritionists who study or treat alcohol-related diseases. Experts from across the field of alcohol research explain how alcohol disrupts normal fat, carbohydrate, and protein metabolic processes occurring in the liver as well as other parts of the body. The book discusses how this can lead to alcoholic liver disease (ALD) as well as contribute to the onset of Type 2 diabetes and the metabolic syndrome. It also explores how alcohol affects nutrient absorption in the gastrointestinal tract and can lead to anemia and reduced amounts of fat soluble vitamins. This book explores both the primary and secondary consequences of alcohol consumption. Chapters in the first section investigate the basic science of alcohol metabolism – focusing on how alcohol and its toxic metabolites disrupt and impair normal nutrient regulation at the molecular level. Further chapters explore how alcohol affects many extra-hepatic organs and tissues as well as the secondary consequences of alcohol consumption such as reduced levels of minerals like magnesium, calcium, and trace elements like zinc. Offers a valuable resource for nutrition researchers and nutritionists who study alcohol-related diseases and attempt to treat them through nutritional strategies Explores how alcohol and its toxic metabolite acetaldehyde disrupt and impair normal macro and micro nutrient regulation at the molecular level Investigates how alcohol affects and interferes with cell signaling, cell death pathways, calcium homeostasis leading to osteoporosis, oxygen balance, as well as the pathophysiology of alcohol consumption and abuse

Download or read book Differential Diagnoses in Surgical Pathology Tumors and their Mimickers E Book written by Fadi W Abdul-Karim and published by Elsevier Health Sciences. This book was released on 2023-02-08 with total page 819 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource to solve challenging cases and sign out with confidence! An all-new volume in the popular Foundations in Diagnostic Pathology series, Differential Diagnoses in Surgical Pathology: Tumors and Their Mimickers is a crucial foundation text for residents and pathologists. Packed with information that helps you quickly differentiate entities that have similar, overlapping histopathologic features, it guides you through the decision-making process, providing a road map to the main differential diagnostic considerations that must be addressed when formulating a diagnosis. Practical and affordable, this resource is ideal for study and review, as well as for everyday surgical pathology practice. Key features of this practical text include: Concise summaries of clinical and pathologic findings that guide you through the decision-making process, with coverage of most common and uncommon differential diagnoses in surgical pathology. Numerous high-quality illustrations of similar-looking but distinct entities for easy side-by-side comparison. Illustrations for each entity accompanied by a clear, concise histopathologic descriptions that highlight how they are distinguished from one another. A consistent, user-friendly format and at-a-glance boxes and tables throughout the text, as well as selected references for further study.

Download or read book Diagnostic Histopathology of Tumors written by Christopher D. M. Fletcher and published by Elsevier Health Sciences. This book was released on 2007-03-29 with total page 1931 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up to date and comprehensive, the New Edition of Fletcher's renowned Diagnostic Histopathology of Tumors provides you with today's best knowledge on the pathologic diagnosis of human tumors. This 3rd edition incorporates all of the latest ancillary diagnostic and prognostic techniques so you can effectively evaluate and confidently interpret suspected tumor specimens. Plus, more than 50 internationally recognized authorities and over 3,100 full-color illustrations provide you with an up-to-date account of tumor morphology, the application of modern diagnostic techniques (including molecular genetics), and key aspects of differential diagnosis. Features over 3,000 high-quality full-color illustrations, providing visual guidance to each tumor or tumor-like entity. Presents correlations of gross appearances to microscopic findings for virtually every tumor type. Includes detailed discussions of differential diagnosis. Provides full coverage of all the latest classification schemes. Incorporates the latest advances in molecular biology and immunohistochemistry throughout. Presents an increased focus on everyday diagnostic problems you are likely to encounter. Features extensively rewritten gynecology and hematology chapters. Uses additional diagnostic flow charts and summary tables for easy retrieval of information. Includes more differential diagnosis tables for better recognition and evaluation of similar looking entities.