Download or read book Quinone Methides written by S. E. Rokita and published by John Wiley & Sons. This book was released on 2009-02-17 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multidisciplinary perspectives and approaches to quinone methides research The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective. This inaugural volume in the series, Quinone Methides, represents the first book devoted to this fascinating and useful intermediate. The authors of this work reflect the many disciplines and approaches to quinone methides research. The volume therefore covers a broad range of topics, including theoretical treatments, generation and detection of intermediates, characterization and applications in chemistry and biochemistry, and biological reactivity. Among the chapters are: Photochemical generation and characterization of quinone methides Quinone methide stabilization by metal complexation Self-immolative dendrimers based on quinone methides Characterization of quinone methides by spectral global fitting and 13C labeling Formation and reactions of xenobiotic quinone methides in biology Quinone methides in lignification With this collection of topics, readers already familiar with quinone methides have the opportunity to advance their own research by discovering new inspiration and opportunities in allied areas. Moreover, the range of topics and perspectives covered make this volume accessible to readers with a broad range of interests, including organic and physical chemistry, biochemistry, biotechnology, and pharmaceutics.
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Download or read book A study of the chemistry of quinone methides written by Stanley Bruce Cavitt and published by . This book was released on 1961 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quinone Methides written by Wenjin Yang and published by . This book was released on 1991 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Physical Organic Chemistry written by John P. Richard and published by Academic Press. This book was released on 2011-09-12 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Physical Organic Chemistry provides the chemical community with authoritative and critical assessments of the many aspects of physical organic chemistry. The field is a rapidly developing one, with results and methodologies finding application from biology to solid state physics. Reviews the application of quantitative and mathematical methods towards understanding chemical problems Covers organic, organometallic, bioorganic, enzymes and materials topics
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2017-12-01 with total page 8639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Download or read book Para quinone Methides written by Kenneth Dale Turnbull and published by . This book was released on 1991 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quinone Methides as Electrophilic Sinks written by Jon Douglas Rainier and published by . This book was released on 1993 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Insect Physiology written by and published by Academic Press. This book was released on 2010-10-27 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Insect Physiology publishes volumes containing important, comprehensive and in-depth reviews on all aspects of insect physiology. It is an essential reference source for invertebrate physiologists and neurobiologists, entomologists, zoologists and insect biochemists. First published in 1963, the serial is now edited by Steven Simpson and Jerome Casas to provide an international perspective. Contributions from the leading researchers in entomology Discusses physiological diversity in insects Includes in-depth reviews with valuable information for a variety of entomology disciplines
Download or read book Biological Reactive Intermediates Vi written by Patrick M. Dansette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.
Download or read book Quinone Methides written by Mariia Vladimirovna Sutton and published by . This book was released on 2019 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: Efficient generation of quinone methides (QMs) from quinone methide precursors (QMPs) under mild conditions, such as reagent free UV-light irradiation, and exceptional reactivity of QMs towards nucleophiles and, in case of o-QMs, towards dienophiles have attracted a lot of attention to these compounds in computation, chemical, biological and engineering spheres. Our research group has demonstrated successful application of o-napthoquinone methide precursors (o-NQMPs) as photolabile protecting groups (PPGs) and linkers, that can be employed in the design of multifunctional surfaces, used as PPGs for biological molecules that carry different functional groups and as a linker for peptide and protein reversible modification. o-QMs and p-QMs demonstrate different chemical properties and different reactivity. However, to the best of our knowledge, the molecules containing competing o-NQM and p-QM moieties, have not been studied. Thus, the major goal of the first project was to develop and synthesize novel QMPs with ability to generate o-NQM and p-QM under light irradiation. Physical properties, chemical properties, such as ability to react with nucleophiles and undergo inter- and intra-molecular Diels-Alder reaction, as well as kinetic behavior of new QM-system have been studied. We were also interested in investigating the ability of o-NQMPs decorated with thiol moieties to form "smart" polymers, that could be generated upon UV-light irradiation. The photo-induced degradation of the polymers could be achieved on demand upon light irradiation in the presence of vinyl ethers. Unfortunately, light-induced polymerization of the synthesized monomers resulted in exclusive formation of oligomers. Another project has been focused on the development of a novel photocleavable analog of calcium-selective chelating ligand, which was based on the combination of properties of photolabile 3-(hydroxymethyl)-2-naphthol core and high calcium affinity of 1,2-bis(o-aminophenoxy)ethane-N, N, N', N'-tetraacetic acid (BAPTA). Finally, we have worked towards the design of a new fluorogenic PPG that could also serve as an intracellular pH indicator. 9H-xanthene-1,8,9-triol derivatives can be considered as photoactivatable fluorophores and fluorogenic PPGs, as 9H-xanthen-1,8,9-triols are expected to generate relatively stable quinone methide upon UV-light irradiation. Due to its structural similarity with fluorescein derivatives, we expected 8-hydroxy-1H-xanthen-1-one to be highly fluorescent. However, attempted synthesis resulted in the formation of a different unexpected product.
Download or read book Handbook of Polymer Degradation written by S. Halim Hamid and published by CRC Press. This book was released on 2000-06-30 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers recent advances in polymer degradation and stabilization. Focuses on the basics of photo- and bio-degradability. Delineates special and general environmental parameters such as solar irradiation, temperature, and agrochemical exposure. Surveys plastic waste disposal strategies such as recycling, incineration, chemical recovery by pyrolysis, and source reduction.
Download or read book Activity Based Proteomics written by Herman S. Overkleeft and published by Humana Press. This book was released on 2018-07-10 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on explorative activity-based proteomics, biomedical applications of activity-based proteomics, and chemical strategies in activity-based proteomics providing a concise overview of activity-based protein profiling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Activity-Based Proteomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Download or read book Biological Reactive Intermediates IV written by Charlotte M. Witmer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.
Download or read book Chemistry of Protein and Nucleic Acid Cross Linking and Conjugation written by Shan S. Wong and published by CRC Press. This book was released on 2011-10-10 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross
Download or read book Plant Polyphenols written by Richard W. Hemingway and published by Springer Science & Business Media. This book was released on 1992-09-30 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Second North American Tannin Conference on Plant Polyphenols held in Houghton, Michigan, June 17-21, 1991
Download or read book Mass Spectrometry in Drug Metabolism and Disposition written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
