Download or read book Quantitative Structure Activity Relationships in Drug Design Predictive Toxicology and Risk Assessment written by Roy, Kunal and published by IGI Global. This book was released on 2015-02-28 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.

Download or read book Quantitative Structure Activity Relationships of Drugs written by John Topliss and published by Elsevier. This book was released on 2012-12-02 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry, Volume 19: Quantitative Structure-Activity Relationships of Drugs is a critical review of the applications of various quantitative structure-activity relationship (QSAR) methodologies in different drug therapeutic areas and discusses the results in terms of their contribution to medicinal chemistry. After briefly describing the developments in QSAR research, this 12-chapter volume goes on discussing the contributions of QSAR methodology in elucidating drug action and rational development of drugs against bacterial, fungal, viral, and other parasitic infections of man. Other chapters explore the mode of action and QSAR of antitumor, cardiovascular, antiallergic, antiulcer, antiarthritic, and nonsteroidal antiinflammatory drugs (NSAID) agents. The discussion then shifts to the pharmacologic effects and QSAR analysis of central nervous system agents, steroids, and other hormones. A chapter examines the major chemicals affecting insects and mites, with particular emphasis on the parameters of binding correlation and reactivity for insect and mite enzymes. The concluding chapters cover the limitations of the QSAR approach in the quantitative treatment of drug absorption, distribution, and metabolism. This volume is of great value to medicinal chemists, scientists, and researchers.

Download or read book A Study of Quantitative Relationships as They Might be Developed in a Class of College Algebra by Teaching the Class According to Some Well defined Educational Principles written by Floyd E. Bowling and published by . This book was released on 1953 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Using Stata for Quantitative Analysis written by Kyle C. Longest and published by SAGE. This book was released on 2012 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using Stata for Quantitative Analysis is an applied, self-teaching resource. It is written in such a way that a reader with no experience with statistical software can sit down and be working with data in a very short amount of time. The author proposes to teach the language of Stata from an intuitive perspective, furthering students’ overall retention, using many screen shots from Stata to guide students.

Download or read book A Method of Introduction to Quantitative Relationships in Ninth Grade General Science written by Gene Wooldridge and published by . This book was released on 1961 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative Relationships Between Chemical Structure Chromatographic Retention and Biological Activity written by Bor-Kuan Chen and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative Structure written by Roman Kaliszan and published by Wiley-Interscience. This book was released on 1987-10-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of computers in numerical characterization of molecular structures has given chemists fundamentally new information on chemical structures, leading to major developments in physical, analytical, and medicinal chemistry. This book, written by a pioneer in the field, extends and updates research on quantitative structure retention relationships (QSRR) by consolidating and critically reviewing the extensive literature on the subject while providing basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Coverage includes detailed discussions of the general theories and mechanisms of chromatographic separations, prediction of retention coefficients, statistical techniques and formal requirements of QSRR studies, specific applications of chromatographic data, and much more. Also provides several carefully selected figures and tables plus extensive bibliographies.

Download or read book Quantitative Structure Activity Relationships written by Tichy and published by Birkhäuser. This book was released on 2014-08-23 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The conference on "Chemical Structure-Biological Activity: Quantitative Approaches" was held in Prague, Czechoslovakia, on June 27-29, 1973. It took place under the auspices of the J .E. PurkynC! Czechoslovak Medical SOciety, the Czechoslovak Chemi cal SOciety, and the International Society of Quantwn Biology (Organizing Commit tee: A. David, Chairman; M. Tichy, Secretary General; K. Bo~ek, J. Kopeck~·, R. Zahradnik). This volume contains the lectures and communications presented at the conference. There has been an ever increasing interest, especially during the last eight years, in the study of the quantitative relationships between the chemical structure of substan ces and their biological activity (QSAR - quantitative structure-activity relationships). One of the reasons for this increasing interest has been the desire to fmd ways of estimating the quantitative characteristics of a given biological activity as well as to shorten time and reduce the costs of research into optimally active compounds. In contrast to qualitative studies seeking the critical biologically active group, the QSAR approach involves the search for that property, or those properties, which determine the magnitude of the biological effect. Methods of physical chemistry and quantum chemistry appear to be suitable for estimating the quantitative characteristics of the biological activity of different compounds. Forecasting the specific activity of a certain substance by means of theoretical methods is still a matter of future devel opment. One of the basic ideas of QSAR studies is to work with a series of chemical compounds thereby enabling the collection and classification of experimental data.

Download or read book Quantitative Structure Activity Relationships written by Miloň Tichý and published by Birkhäuser. This book was released on 1976 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The conference on "Chemical Structure-Biological Activity: Quantitative Approaches" was held in Prague, Czechoslovakia, on June 27-29, 1973. It took place under the auspices of the J .E. PurkynC! Czechoslovak Medical SOciety, the Czechoslovak Chemi cal SOciety, and the International Society of Quantwn Biology (Organizing Commit tee: A. David, Chairman; M. Tichy, Secretary General; K. Bo ek, J. Kopeck ., R. Zahradnik). This volume contains the lectures and communications presented at the conference. There has been an ever increasing interest, especially during the last eight years, in the study of the quantitative relationships between the chemical structure of substan ces and their biological activity (QSAR - quantitative structure-activity relationships). One of the reasons for this increasing interest has been the desire to fmd ways of estimating the quantitative characteristics of a given biological activity as well as to shorten time and reduce the costs of research into optimally active compounds. In contrast to qualitative studies seeking the critical biologically active group, the QSAR approach involves the search for that property, or those properties, which determine the magnitude of the biological effect. Methods of physical chemistry and quantum chemistry appear to be suitable for estimating the quantitative characteristics of the biological activity of different compounds. Forecasting the specific activity of a certain substance by means of theoretical methods is still a matter of future devel opment. One of the basic ideas of QSAR studies is to work with a series of chemical compounds thereby enabling the collection and classification of experimental data."

Download or read book Quantitative Analysis of Questionnaires written by Steve Humble and published by Routledge. This book was released on 2020-01-08 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the techniques required to understand, interpret and quantify the processes involved when exploring structures and relationships in questionnaire data, Quantitative Analysis of Questionnaires provides the knowledge and capability for a greater understanding of choice decisions. The ideal companion for non-mathematical students with no prior knowledge of quantitative methods, it highlights how to uncover and explore what lies within data that cannot be achieved through descriptive statistics. This book introduces significance testing, contingency tables, correlations, factor analysis (exploratory and confirmatory), regression (linear and logistic), discrete choice theory and item response theory. Using simple and clear methodology, and rich examples from a range of settings, this book: provides hands-on analysis with data sets from both SPSS and Stata packages; explores how to articulate the calculations and theory around statistical techniques; offers workable examples in each chapter with concepts, applications and proofs to help produce a higher quality of research outputs; discusses the use of formulas in the appendix for those who wish to explore a greater mathematical understanding of the concepts. Quantitative Analysis of Questionnaires is the ideal introductory textbook for any student looking to begin and or improve statistical learning as well as interpretation.

Download or read book Design Synthesis and Quantitative Structural Activity Relationships of Carboxylate Ligands for the HisB10 Binding Site of Hexameric Insulin and the Use of Dynamic Nuclear Magnetic Resonance DNMR Spectroscopy to Probe the Phenolic Ligand Binding Mechanism written by Donald James Keidel and published by . This book was released on 2007 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative Structure activity Relationship written by Fatma Kandemirli and published by BoD – Books on Demand. This book was released on 2017-08-30 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book, which is related to QSAR in sciences, is divided into five main chapters. The first chapter is the Introductory chapter. The second chapter aims to provide an update of the recent advances in the field of rational design of PDE inhibitors. The third chapter includes designing a series of peptidic inhibitors that possessed a substrate transition-state analog and evaluating the structure-activity relationship of the designed inhibitors, based on docking and scoring, using the docking simulation software Molecular Operating Environment. The aim of the forth chapter is to develop structure-property relationships for the qualitative and quantitative prediction of the reverse-phase liquid chromatographic retention times of chlorogenic acids. The final chapter aims to determine the model of interactions between the natural compounds with anti-inflammatory molecular target by molecular docking analysis.

Download or read book Chemistry written by Theodore Lawrence Brown and published by . This book was released on 2017-01-03 with total page 1248 pages. Available in PDF, EPUB and Kindle. Book excerpt: NOTE: This edition features the same content as the traditional text in a convenient, three-hole-punched, loose-leaf version. Books a la Carte also offer a great value; this format costs significantly less than a new textbook. Before purchasing, check with your instructor or review your course syllabus to ensure that you select the correct ISBN. Several versions of MyLab(tm)and Mastering(tm) platforms exist for each title, including customized versions for individual schools, and registrations are not transferable. In addition, you may need a Course ID, provided by your instructor, to register for and use MyLab and Mastering products. For courses in two-semester general chemistry. Accurate, data-driven authorship with expanded interactivity leads to greater student engagement Unrivaled problem sets, notable scientific accuracy and currency, and remarkable clarity have made Chemistry: The Central Science the leading general chemistry text for more than a decade. Trusted, innovative, and calibrated, the text increases conceptual understanding and leads to greater student success in general chemistry by building on the expertise of the dynamic author team of leading researchers and award-winning teachers. In this new edition, the author team draws on the wealth of student data in Mastering(tm)Chemistry to identify where students struggle and strives to perfect the clarity and effectiveness of the text, the art, and the exercises while addressing student misconceptions and encouraging thinking about the practical, real-world use of chemistry. New levels of student interactivity and engagement are made possible through the enhanced eText 2.0 and Mastering Chemistry, providing seamlessly integrated videos and personalized learning throughout the course . Also available with Mastering Chemistry Mastering(tm) Chemistry is the leading online homework, tutorial, and engagement system, designed to improve results by engaging students with vetted content. The enhanced eText 2.0 and Mastering Chemistry work with the book to provide seamless and tightly integrated videos and other rich media and assessment throughout the course. Instructors can assign interactive media before class to engage students and ensure they arrive ready to learn. Students further master concepts through book-specific Mastering Chemistry assignments, which provide hints and answer-specific feedback that build problem-solving skills. With Learning Catalytics(tm) instructors can expand on key concepts and encourage student engagement during lecture through questions answered individually or in pairs and groups. Mastering Chemistry now provides students with the new General Chemistry Primer for remediation of chemistry and math skills needed in the general chemistry course. If you would like to purchase both the loose-leaf version of the text and MyLab and Mastering, search for: 0134557328 / 9780134557328 Chemistry: The Central Science, Books a la Carte Plus MasteringChemistry with Pearson eText -- Access Card Package Package consists of: 0134294165 / 9780134294162 MasteringChemistry with Pearson eText -- ValuePack Access Card -- for Chemistry: The Central Science 0134555635 / 9780134555638 Chemistry: The Central Science, Books a la Carte Edition

Download or read book Thinking Mathematically written by Charlesbridge Publishing Staffs and published by . This book was released on 2001-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative Structure Activity Relationship QSAR Models of Mutagens and Carcinogens written by Romualdo Benigni and published by CRC Press. This book was released on 2003-02-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals. This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on

Download or read book Quantitative Relationships Between Structure and Physical Properties of 4 substituted 2 nitrophenols written by Morris Rapoport and published by . This book was released on 1961 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantitative Evaluation of the Whole Petroleum System written by Xiongqi Pang and published by Springer Nature. This book was released on 2023-10-25 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces a complete quantitative evaluation system of the Whole Petroleum System (WPS) on theory and expounds the correlation and difference between conventional and unconventional oil and gas reservoirs and resources, with large number of well-prepared charts and novel expressions. It has important guiding significance for the exploration and development of conventional and unconventional oil and gas all over the world and provides valuable insights for reader with an interest in petroleum geology.