Download or read book Quantitative Receptor Autoradiography in Opioid Peptide and Receptor Knockout Mice written by Sian Clarke and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Receptor Autoradiography in Mu and Kappa opioid Knockout Mice written by Susan J. Slowe and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Receptor Autoradiography in Opoid Peptide and Receptor Knockout Mice written by S. Clarke and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peptide Receptors Part II written by A. Bjorklund and published by Elsevier. This book was released on 2002-12-13 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
Download or read book Peptide Receptors written by Remi Quirion and published by Gulf Professional Publishing. This book was released on 2000 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
Download or read book The Kappa Opioid Receptor written by Lee-Yuan Liu-Chen and published by Springer Nature. This book was released on 2021-11-25 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Methods in Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2001-06-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, pain research has become one of the most rapidly growing areas of neuroscience activity. Methods in Pain Research brings together in a single volume a survey of the methods that can be used to study a reaction or 'sensory report' in humans that can only be inferred by indirect means in animal or tissues studies. It presents
Download or read book Transgenic Models in Pharmacology written by Lutz Hein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date information on animal models generated by transgenic or gene targeting techniques. Naturally, the focus is on the mouse system. Each chapter has been written by leading experts in the field and gives an overview on existing animal models. This is facilitated by tables, which list the most important genetically engineered animal models and their phenotypes. This book aims at illustrating the impact of transgenic animal models in the field of Experimental Pharmacology and Toxicology, which includes their role in the understanding of basic cellular mechanisms, the evaluation of potential drug targets or the testing for drug effects.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Delta Opioid Receptor Pharmacology and Therapeutic Applications written by Emily M. Jutkiewicz and published by Springer. This book was released on 2018-09-27 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Molecular Targets for the Treatment of Pain written by Tally Largent-Milnes and published by Frontiers Media SA. This book was released on 2021-02-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor John Streicher is a co-founder and equity partner of Teleport Pharmaceuticals, LLC. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Download or read book The Dentate Gyrus A Comprehensive Guide to Structure Function and Clinical Implications written by Helen E. Scharfman and published by Elsevier. This book was released on 2011-09-22 with total page 841 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role in diverse clinical conditions, from depression to epilepsy and traumatic brain injury. The primary goal of this book is to provide a context, or background, upon which the detailed knowledge of the current era can be appreciated. A series of overviews are provided to clarify essentials related to structural organization and development, cellular components, neurotransmitters and neuromodulators, plasticity, and clinical relevance. * Covers the topic comprehensively from anatomy to cellular and systems perspectives* Includes basic research and addresses translational implications, so it will be useful to both researchers in the laboratory and clinicians who conduct experiments in humans* Chapters provide fundamentals, but also details and ample references for further review of the topic
Download or read book The Delta Receptor written by Kwen-Jen Chang and published by CRC Press. This book was released on 2003-12-11 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Delta Receptor spans current research in delta receptor biology, pharmacology, physiology, and chemistry to identify, advance, and inspire the development of novel drug candidates. It demonstrates the potential significance and impact of the delta receptor in the therapy and treatment of medical conditions such as pain, gastrointestinal disorders, bladder dysfunction, and depression, as well as heart attack prevention. This reference examines the pathophysiological functions and mechanisms of receptor-selective drugs. Documenting key advances in the field, The Delta Receptor represents the most comprehensive and up-to-date studies on receptor applications currently available.
Download or read book Serotonin Receptors in Neurobiology written by Amitabha Chattopadhyay and published by CRC Press. This book was released on 2007-05-17 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l
Download or read book Brain Research written by and published by . This book was released on 1999-04 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of Drug Addiction written by Rafael Maldonado and published by Springer Science & Business Media. This book was released on 2002-09-12 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.
