Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Download or read book Territory written by David Delaney and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This short introduction conveys the complexities associated with the term "territory" in a clear and accessible manner. It surveys the field and brings theory to ground in the case of Palestine. A clear and accessible introduction to the complexities associated with the term "territory". Provides an interdisciplinary survey of the many strands of research in the field. Addresses specific areas including interpretations of territorial structures; the relationship between territoriality and scale; the validity and fluidity of territory; and the practical, social processes associated with territorial re-configurations. Stresses that our understanding of territory is inseparable from our understanding of power. Uses Israel/Palestine as an extended illustrative case study. The author’s strong legal and geographical background gives the work an authoritative perspective.

Download or read book Oxidative Stress and Chronic Degenerative Diseases written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2013-05-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Download or read book Crossfire written by Roberta Johnson and published by University Press of Kentucky. This book was released on 2014-07-11 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The marriage of philosophy and fiction in the first third of Spain's twentieth century was a fertile one. It produced some truly notable offspring -- novels that cross genre boundaries to find innovative forms, and treatises that fuse literature and philosophy in new ways. In her illuminating interdisciplinary study of Spanish fiction of the "Silver Age," Roberta Johnson places this important body of Spanish literature in context through a synthesis of social, literary, and philosophical history. Her examination of the work of Miguel de Unamuno, Pio Baroja, Azorin, Ramon Perez de Ayala, Juan Ramon Jimenez, Gabriel Miro, Pedro Salinas, Rosa Chacel, and Benjamin Jarnes brings to light philosophical frictions and debates and opens new interpersonal and intertextual perspectives on many of the period's most canonical novels. Johnson reformulates the traditional discussion of generations and "isms" by viewing the period as an intergenerational complex in which writers with similar philosophical and personal interests constituted dynamic groupings that interacted and constantly defined and redefined one another. Current narratological theories, including those of Todorov, Genette, Bakhtin, and Martinez Bonati, assist in teasing out the intertextual maneuvers and philosophical conflicts embedded in the novels of the period, while the sociological and biographical material bridges the philosophical and literary analyses. The result, solidly grounded in original archival research, is a convincingly complete picture of Spain's intellectual world in the first thirty years of this century. Crossfire should revolutionize thinking about the Generation of '98 and the Generation of '14 by identifying the heterogeneous philosophical sources of each and the writers' reactions to them in fiction.

Download or read book Essentials for Child Development Associates Working with Young Children written by Carol Brunson Day and published by Ingram. This book was released on 2004-11-01 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Volcanic Unrest written by Joachim Gottsmann and published by Springer. This book was released on 2018-12-18 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book summarizes the findings of the VUELCO project, a multi-disciplinary and cross-boundary research funded by the European Commission's 7th framework program. It comprises four broad topics: 1. The global significance of volcanic unrest 2. Geophysical and geochemical fingerprints of unrest and precursory activity 3. Magma dynamics leading to unrest phenomena 4. Bridging the gap between science and decision-making Volcanic unrest is a complex multi-hazard phenomenon. The fact that unrest may, or may not lead to an imminent eruption contributes significant uncertainty to short-term volcanic hazard and risk assessment. Although it is reasonable to assume that all eruptions are associated with precursory activity of some sort, the understanding of the causative links between subsurface processes, resulting unrest signals and imminent eruption is incomplete. When a volcano evolves from dormancy into a phase of unrest, important scientific, political and social questions need to be addressed. This book is aimed at graduate students, researchers of volcanic phenomena, professionals in volcanic hazard and risk assessment, observatory personnel, as well as emergency managers who wish to learn about the complex nature of volcanic unrest and how to utilize new findings to deal with unrest phenomena at scientific and emergency managing levels. This book is open access under a CC BY license.

Download or read book Historical Archaeologies of Transhumance across Europe written by Eugene Costello and published by Routledge. This book was released on 2018-03-05 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transhumance is a form of pastoralism that has been practised around the world since animals were first domesticated. Such seasonal movements have formed an important aspect of many European farming systems for several thousand years, although they have declined markedly since the nineteenth century. Ethnographers and geographers have long been involved in recording transhumant practices, and in the last two decades archaeologists have started to add a new material dimension to the subject. This volume brings together recent advances in the study of European transhumance during historical times, from Sweden to Spain, Romania to Ireland, and beyond that even Newfoundland. While the focus is on the archaeology of seasonal sites used by shepherds and cowherds, the contributions exhibit a high degree of interdisciplinarity. Documentary, cartographic, ethnographic and palaeoecological evidence all play a part in the examination of seasonal movement and settlement in medieval and post-medieval landscapes. Notwithstanding the obvious diversity across Europe in terms of livestock, distances travelled and socio-economic context, an extended introduction to the volume shows that cross-cutting themes are now emerging, including mobility, gendered herding, collective land-use, the agency of non-elite people and competition for grazing and markets. The book will appeal not only to archaeologists, but to historians, geographers, ethnographers, palaeoecologists and anyone interested in rural lifeways across Europe.

Download or read book An Introduction to High Pressure Science and Technology written by Jose Manuel Recio and published by CRC Press. This book was released on 2016-01-05 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to High-Pressure Science and Technology provides you with an understanding of the connections between the different areas involved in the multidisciplinary science of high pressure. The book reflects the deep interdisciplinary nature of the field and its close relationship with industrial applications.Thirty-nine specialists in high

Download or read book Evolutionary Ecology of Plant Herbivore Interaction written by Juan Núñez-Farfán and published by Springer Nature. This book was released on 2020-07-30 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant-herbivore interactions are a central topic in evolutionary ecology. Historically, their study has been a cornerstone for coevolutionary theory. Starting from classic ecological studies at the phenotypic level, it has since expanded to molecular and genomic approaches. After a historical perspective, the book’s subsequent chapters cover a wide range of topics: from populations to ecosystems; plant- and herbivore-focused studies; in natural and in man-modified ecosystems; and both micro- and macro-evolutionary levels. All chapters include valuable background information and empirical evidence. Given its scope, the book will be of interest to both students and researchers, and will hopefully stimulate further research in this exciting field of evolutionary biology.

Download or read book Progress in Mycology written by M.K. Rai and published by Scientific Publishers. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is aimed to provide the readers with current trends in the field of Mycology in general and fungal biotechnology in particular. The book would be of utmost importance to students, researchers and teachers of botany, mycology, microbiology, fungal biotechnology and nanotechnology. The readers should find the book full of information and reader-friendly.

Download or read book The Sciences in the European Periphery During the Enlightenment written by Kostas Gavroglu and published by Springer Science & Business Media. This book was released on 2001-02-28 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles in this volume of ARCHIMEDES examine particular cases of `reception' in ways that emphasize pressing historiographical and methodological issues. Such issues arise in any consideration of the transmission and appropriation of scientific concepts and practices that originated in the several `centers' of European learning, subsequently to appear (often in considerably altered guise) in regions at the European periphery. They discuss the transfer of new scientific ideas, the mechanisms of their introduction, and the processes of their appropriation at the periphery. The themes that frame the discussions of the complex relationship between the origination of ideas and their reception include the ways in which the ideas of the Scientific Revolution were introduced, the particularities of their expression in each place, the specific forms of resistance encountered by these new ideas, the extent to which such expression and resistance displays national characteristics, the procedures through which new ways of dealing with nature were made legitimate, and the commonalities and differences between the methods developed by scholars for handling scientific issues.

Download or read book Bioactive Compounds from Natural Sources Second Edition written by Corrado Tringali and published by CRC Press. This book was released on 2011-09-27 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.

Download or read book The Routledge Handbook of Critical Resource Geography written by Matthew Himley and published by Routledge. This book was released on 2021-07-13 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook provides an essential guide to the study of resources and their role in socio-environmental change. With original contributions from more than 60 authors with expertise in a wide range of resource types and world regions, it offers a toolkit of conceptual and methodological approaches for documenting, analyzing, and reimagining resources and the worlds with which they are entangled. The volume has an introduction and four thematic sections. The introductory chapter outlines key trajectories for thinking critically with and about resources. Chapters in Section I, "(Un)knowing resources," offer distinct epistemological entry points and approaches for studying resources. Chapters in Section II, "(Un)knowing resource systems," examine the components and logics of the capitalist systems through which resources are made, circulated, consumed, and disposed of, while chapters in Section III, "Doing critical resource geography: Methods, advocacy, and teaching," focus on the practices of critical resource scholarship, exploring the opportunities and challenges of carrying out engaged forms of research and pedagogy. Chapters in Section IV, "Resource-making/world-making," use case studies to illustrate how things are made into resources and how these processes of resource-making transform socio-environmental life. This vibrant and diverse critical resource scholarship provides an indispensable reference point for researchers, students, and practitioners interested in understanding how resources matter to the world and to the systems, conflicts, and debates that make and remake it.

Download or read book Biology written by Teresa Audesirk and published by Pearson. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes 45 case studies and essays under the topics: Earth watch; Health watch; A closer look at ...; Scientific inquiry; Links to everyday life.

Download or read book Contemporary Environmental Issues and Challenges in Era of Climate Change written by Pooja Singh and published by Springer Nature. This book was released on 2019-11-16 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few decades, unprecedented global population growth has led to increased demand for food and shelter. At the same time, extraction of natural resources beyond the Earth’s resilience capacity has had a devastating effect on ecosystems and environmental health. Furthermore, climate change is having a significant impact in a number of areas, including the global hydrological cycle, ecosystem functioning, coastal vulnerability, forest ecology, food security, and agricultural sustainability. According to the Intergovernmental Panel on Climate Change (IPCC), only immediate and sustained action will prevent climate change causing irreversible and potentially catastrophic damage to our environment. This book presents various scientific views and concepts, research, reviews, and case studies on contemporary environmental issues in changing climate scenarios and highlights different adaptation measures. Increasing awareness of modern-day patterns of climate change, it addresses questions often raised by environmental scientists, researchers, policymakers and general readers.

Download or read book S o Francisco Craton Eastern Brazil written by Monica Heilbron and published by Springer. This book was released on 2016-12-05 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The region of the São Francisco river valley in eastern Brazil encompasses two main components of the geologic framework of the South American continent: the São Francisco craton and its marginal orogenic belts. Cratons, as the oldest, differentiated and relatively stable pieces of the continental lithosphere, preserve a substantial part of the Earth's memory. Orogenic belts, on the other hand, record collisional processes that occurred during a limited time span. Because of their topographic relief, mountain belts developed along craton margins provide however access to rock successions not exposed in the low lands of the adjacent cratons. The combination of geologic information obtained in cratonic domains and their marginal orogenic belts thus form the basis for deciphering substantial periods of Earth’s history. Corresponding to the most intensively studied portion of the Precambrian nucleus of the South American plate, the São Francisco craton and its margins host a rock record that spans from the Paleoarchean to the Cenozoic. Precambrian sedimentary successions that witness ancient Earth processes - many of them of global significance - are especially well preserved and exposed in this region. With all these attributes the São Francisco craton together with its fringing orogenic belts can be viewed as a ‘continent within a continent’ or a ‘continent in miniature’.

Download or read book Handbook of Industrial Drying written by Arun S. Mujumdar and published by CRC Press. This book was released on 2006-11-08 with total page 1310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Still the Most Complete, Up-To-Date, and Reliable Reference in the FieldDrying is a highly energy-intensive operation and is encountered in nearly all industrial sectors. With rising energy costs and consumer demands for higher quality dried products, it is increasingly important to be aware of the latest developments in industrial drying technolog