Download or read book Pyrazoline Derivatives as Antitubercular Agents written by Vaibhav Jain and published by . This book was released on 2012-02 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis (MTB), the pathogenic agent of tuberculosis (TB), is responsible for the death of 2-3 million people annually and for a global economic toll of $12 billion each year. Thus, there is an urgent need to develop new therapeutics for tuberculosis, to reduce the duration of treatment and to provide a more effective therapy for MDR TB and for latent tuberculosis infection. In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1H-pyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structure of compounds were proved by IR, MASS, 1HNMR spectroscopy data and elemental analysis. . The antitubercular activity of these compounds were evaluated by microdilution method against M. Tuberculosis H37Rv micobactrium strain of M. Tuberculosis compared with standard INH, RIF & ETM.
Download or read book Synthesized Pyrazoline Carbothioamide As Potent Antitubercular Agent written by Dhrubo Jyoti Sen and published by LAP Lambert Academic Publishing. This book was released on 2012-05 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brief introduction of M.tuberculosis has been summarized. Pharmacological importance and literature survey of pyrazolo derivatives has been summarized. All the synthesized compounds were characterized by UV, IR, Mass and 1H-NMRspectroscopy. All the newly synthesized compounds have been screened for antibacterial activity. Streptomycin was used as standard reference drug. Compound 57b has been found to have better antibacterial activity against gram+ve bacteria S.aureus and B.subtilis as compared to other synthesized compounds. Compounds 57b, 58a, 58b have been found to have better activity against gram-ve bacteria. None of the compound has been found to be equipotent with standard streptomycin. All the newly synthesized compounds were screened for antitubercular activity. Compound 57b has been found to be most potent among the series having MIC 6.25 µg/ml. Others synthesised compounds have been found to be active (having MIC 57a: 500 µg/ml, 57c: 25 µg/ml, 58a: 25 µg/ml, 58b: 62.5 µg/ml, 58c: 250 µg/ml). None of the compound has been found to be equipotent with standard isoniazid.
Download or read book Some Pyrazoline Derivatives as Anti microbial Agents written by Manish Kumar Agrawal and published by . This book was released on 2016-10-30 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Genetics of Mycobacteria written by Graham F. Hatfull and published by John Wiley & Sons. This book was released on 2014-09-02 with total page 1428 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive collection of perspectives by experts in mycobacterial molecular biology Mycobacterium tuberculosis causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. Tuberculosis was named a global health emergency by the World Health Organization, a distinction no other disease has received. Although the study of mycobacterial genetics has expanded dramatically, with new investigations into mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 remain today. Advances in our understanding of mycobacterial genetics have been reflected in exciting recent developments. New diagnostic approaches can identify drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge. Written by leading experts in the field, Molecular Genetics of Mycobacteria, Second Edition, Discusses key areas of current research in mycobacterial genetics Explains the genetics of the physiology, metabolism, and drug sensitivities of M. tuberculosis Presents genetic approaches for manipulating M. tuberculosis This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.
Download or read book Flavonoids and Phenolics written by Simone Carradori and published by Bentham Science Publishers. This book was released on 2022-12-02 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Each chapter follows a specific format for a phytochemical agent with common chemical features: • General background on the (phyto)chemistry of the scaffold • General background on the pharmacological profile of the scaffold • A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships) • In silico analysis of the crucial interactions with the biological target • Clinical studies and patent survey (if available) on the new and proposed structures The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.
Download or read book N Heterocycles written by Keshav Lalit Ameta and published by Springer Nature. This book was released on 2022-04-23 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the recent advancements for the synthesis of small- and medium-sized azaheterocycles, including pyrroles, indoles, pyrimidines, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, and 1,2,3-triazoles, which are significant scaffolds for compounds with pharmaceutical uses. The book also discusses various properties and performance attributes of azaheterocycles including their bioactivity and synthetic strategies. Given the contents, the book will be a valuable reference for students, researchers, and professionals interested in organic synthesis and medicinal chemistry.
Download or read book Manual of Microbiology written by Kanika Sharma and published by Anshan Pub. This book was released on 2007 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an excellent supplementary textbook, written in simple language and easy to understand even for beginners. All topics related to microbiology are covered - general aspects like techniques, culture and identification of bacteria, bacterial genetics, water, soil and food microbiology and the study of viruses and fungi. Medical microbiology is also discussed, dealing with sample collection and identification of common pathogenic bacteria. The book has a unique style - a basic idea of the topic is given followed by various laboratory methods presented systematically, keeping in mind problems faced by students and also stressing the "do's and don'ts" whilst carrying out various experiments. Diagrams and flow charges help to make learning easier and more interesting. And the final chapters contain instructions on practical exercises written to enable the student to perform them with confidence and ease. This is a superb step-by-step guide for microbiology students.
Download or read book Green Approaches in Medicinal Chemistry for Sustainable Drug Design written by Bimal Krishna Banik and published by Elsevier. This book was released on 2024-06-07 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry 2e encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This first volume of the second edition covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources including plants and agricultural materials. Highlights the need for the adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these factors Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability
Download or read book Thiazole and Its Derivatives written by Jacques V. Metzger and published by . This book was released on 1979 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Chemical Biology An Approach In Future Perspectives Volume 3 written by Dr. Nandeshwarappa B. P. M. Sc., Ph.D. and published by Shineeks Publishers. This book was released on 2023-06-21 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Chemical Biology – Volume 3 The current book summary envisages the basic aspects of chemistry and biology thoughts, with the allied area of multidiscipline which comprises applications of chemical and biological disciplines and these are significant literatureto innovative minds to enrich their knowledge by research topics as anilluminative element to focus it in their research studies in the field of sciences. The book highlights research objectives on synthetic chemistry, newer approach of synthesis process and their various applications in in vitro and in vivo level as per the pharmaceutical industry requirements for commercialize the product to cure the various diseases and ailments for science and society. Recent innovations are highly applied and as per the demand of pharma sector and these are new perspectives to troubleshoot the newer problems with the help of molecular approach and bioinformatics applications.Understanding by the assimilation of basic to applied core research concepts in chemistry and their allied branches brings many applications, using novel methodologies, classic principles, defined protocols, emerging technologies by knowing similar issues and their impact in current-day problems in the science field. Hence, it’s multidisciplinary research to emphasize novel synthetic molecules which exhibit to safer, cheaper, and ecological drug for futuremedicine. The applications aimed on humans and animals as an important therapeutic drug for pharma industry. It is highly comprehensive book volume summarising various features of An Approach to Future Perspectives for academic research and industrial research in advanced level for all the learners in the area of chemistry and biology. It would be the best literature for the researchers and it can be a key reference book for the findings of new research problems to work for new drug discovery. This book has been peer-reviewed and free from plagiarism; hence it is highly useful for science and technology. It’s our great pleasure to wish all the readers, researchers, and industrialists to utilize it to accomplish new milestones as an innovation and novel discovery for future perspectives.
Download or read book Frontiers in Drug Design Discovery Volume 10 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2021-02-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field. The tenth volume of this series brings together reviews covering topics related to the treatment of neoplasms, systems biology, respiratory diseases among others. Topics included in this volume are: - Recombinant Protein Production: from Bench to Biopharming - Plant Virus Nanoparticles and Virus like Particles (VLPs): Applications in Medicine - MAO Inhibitory Activity Of 4, 5-Dihydro-1 HPyrazole Derivatives: A Platform To Design Novel Antidepressants - Flavonoids Antagonize Effects of Alcohol in Cultured Hippocampal Neurons: A Drug Discovery Study - Hybrid Smart Materials for Topical Drug Delivery: Application of Scaffolds.
Download or read book Recent Advances in the Synthesis of Organic Compounds to Combat Neglected Tropical Diseases written by Adilson Beatriz and published by Bentham Science Publishers. This book was released on 2014-08-04 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Health Organization (WHO) has reported 14 diseases that are occurring exclusively in tropical areas. Most of these diseases are infectious and mainly affect poor populations. Some of these diseases include malaria, dengue fever, leishmaniasis and Chagas disease. Therefore, an acute need for increasing the arsenal of drugs is required to fight against these neglected diseases for the guaranteed recovery and relief of many patients. This E-book gathers important scientific research performed by scientists worldwide showing the state of the art of Medicinal Chemistry dedicated to the synthesis of compounds that are potentially bioactive against the causative agents of neglected diseases. The contents of this book include chapters on recent advances in synthetic organic compounds for the prevention of Chagas disease, recent advances in the discovery of small organic molecules for the prevention and treatment of dengue fever, leishmaniasis, leprosy, therapeutic arsenal and drug discovery for lymphatic filariasis, therapeutic agents for the treatment of malaria, schistosomiasis and synthetic organic compounds as potential antitubercular drugs. This book is intended for undergraduate and graduate students in institutes, colleges, universities and academies who want to specialize in the field of organic synthesis and medicinal chemistry.This book will also be a valuable resource of information for researchers in this field.
Download or read book Pyrazole Preparation and Uses written by Dilipkumar Pal and published by Nova Science Publishers. This book was released on 2020-08-11 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has comprehensively reviewed the latest information on pyrazoles, their preparations and uses. It provides extended ideas on pyrazole and its derivatives including their synthesis, chemistry, structure activity relationship (SAR) and therapeutic applications. The health promoting properties of these pyrazoles are discussed in this book with different therapeutic applications of pyrazole scaffold. Topics related to pyrazole and its analogues as potential anticancer, anti-angiogenesis, antiviral, antioxidative, anti-convulsive, anthelmintic, anti-inflammatory, antidiabetic agents are described in this book in detail. Furthermore, current status and future prospects of pyrazole moiety in drug discovery, importance of it in plant systems, its relevance in neurological drug discovery, its potency as herbicidal and antimicrobial agents have been enumerated through different chapters. In a summary, this book is a valuable resource for research scholars, academics, students, industrialists and subject experts working in the multidisciplinary fields like medicinal chemistry, synthetic chemistry, biochemistry, pharmacology, natural product chemistry and other related areas in the field of pyrazole derivatives drug discovery and research.
Download or read book Substituent Constants for Correlation Analysis in Chemistry and Biology written by Corwin Hansch and published by John Wiley & Sons. This book was released on 1979 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quinoxalines written by Vakhid A. Mamedov and published by Springer. This book was released on 2016-04-26 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the fundamental aspects of quinoxaline chemistry: synthesis, reactions, mechanisms, structure, properties, and uses. The first four chapters present a survey of the developments in quinoxaline chemistry since the publication of the monograph on “Condensed Pyrazines” by Cheeseman and Cookson in 1979. These chapters give comprehensive coverage of all the methods of the synthesis of quinoxalines and the important quinoxaline-containing ring systems such as thiazolo[3,4-a]-, pyrrolo[1,2-a]-, and imidazo[1,5-a]quinoxalines. Chapter five describes many new methods for the construction of quinoxaline macrocycles, which are important in applications such as optical devices and materials. The final chapter reviews all previously known rearrangements of heterocyclic systems that lead to benzimidazole derivatives. Mamedov critically analyses these transformations to reveal a novel acid-catalyzed rearrangement of quinoxalinones giving 2-heteroarylbenzimidazoles and 1-heteroarylbenzimidazolones in the presence of nucleophilic reactants (MAMEDOV Heterocycle Rearrangement). This book is of interest to researchers in the fields of heterocyclic and synthetic organic chemistry.
Download or read book S Heterocycles written by Shrikaant Kulkarni and published by Royal Society of Chemistry. This book was released on 2024-07-24 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterocyclic compounds are vital in synthetic chemistry, pharmaceuticals, agrochemicals, and materials science. The concept of S-heterocyclic compounds revolves around organic compounds that contain heterocyclic rings, and sulfur (S) is one of the heteroatoms within the ring structure. S-enabled heterocycles have emerged as one of the key classes of heterocycles and have attracted tremendous attention attributed to their identity as ‘privileged pharmacological structures’ across natural products and highly active pharmaceutical agents. This edited volume reports the latest developments in practical and selective reactions and methods and provides details of the structural diversity of heterocycles. Together, the chapters provide a comprehensive view of the diversity of methods, properties, and the variety of applications in the construction of S-heterocycles. Divided into four parts, the book covers in part one the chemistry, synthesis pathways, property profile, and applications of thiazoles, and includes five chapters. Part two details thiadiazoles and part three thiopyrans, thiazine, and thiazepine. Lastly, part four focuses on thiophenes. This volume will be of immense help to academicians, researchers, and students pursuing research and looking at the future of heterocyclic chemistry.
Download or read book Recent Developments in the Synthesis and Applications of Pyridines written by Parvesh Singh and published by Elsevier. This book was released on 2022-09-17 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook for organic chemists working on innovative approaches to the synthesis of pyridines. Written by scientists in both academia and industry and designed to be a standalone reference, the book features reviews, research results and case studies on synthetic methods and applications of pyridine-based chemotypes. The book will bridge the gap between industry and academia by presenting recent innovative approaches to the synthesis of pyridines, diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry. The role of computational chemistry in the development of pyridine-based bioactive molecules is also included. This reference is essential for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry. Includes a detailed review of recent research on the reactivity, synthesis and applications of pyridines Features concise accounts of the reactivity, synthetic and optimized protocols Discusses the medicinal, inorganic and polymer chemistry applications of pyridines
