Download or read book Pseudomonas aeruginosa the Superbug written by Silpi Basak and published by Cambridge Scholars Publishing. This book was released on 2022-07-12 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pseudomonas aeruginosa is one of the most commonly isolated bacterial species in clinical microbiology laboratories and it causes infections in hospitalized patients with strains resistant to many antimicrobials. In addition, it can form a biofilm especially in cystic fibrosis patients and patients with medical devices. Extracellular polymeric substances (EPS) or extracellular matrixes in biofilm prevent access of antimicrobial agents, disinfectants, and host-produced immune responses. Antimicrobial resistance in Pseudomonas aeruginosa is multifactorial and can be due to mutation, transfer of genes by plasmids, or transposons, among other causes. Production of β-lactamases causes resistance to β-lactam drugs including Carbapenems. Against this background of emergence of antibiotic resistance, this book studies different types of β-lactamases routinely produced by Pseudomonas aeruginosa strains in clinical microbiology laboratories. It shows that, although molecular methods like Polymerase Chain Reaction (PCR) are the gold standard for detection of different types of β-lactamases, they are very costly and require expertise.

Download or read book Superbugs written by William Hall (Author of Superbugs) and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Superbugs describes this growing global threat, the systematic failures that have led to it, and solutions that governments, industries, and public health specialists can adopt.--

Download or read book The Perfect Predator written by Steffanie Strathdee and published by Hachette Books. This book was released on 2019-02-26 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.

Download or read book Pseudomonas Aeruginosa written by Dinesh Sriramulu and published by BoD – Books on Demand. This book was released on 2019-10-02 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pseudomonas aeruginosa, though unfamiliar as an aggressive invader, has gained importance in the scientific community due to its association with cystic fibrosis (CF) and its ability to construct biofilms resilient to host defense. The chronic nature of CF allows this bacterium to colonize, adapt, and evolve at its own pace, thereby causing further complications in CF patients. With its huge genetic repertoire and plasticity of the genome, P. aeruginosa has been able to alter its contents by way of deletions, insertions, inversions, and so on. Therefore scientists and researchers are eager to study this bacterium in diverse and unusual niches. Written by experts from around the world, this book describes and discusses the various mechanisms of adaptation and evolution displayed by P. aeruginosa.

Download or read book Pseudomonas Aeruginosa written by Theerthankar Das and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging antibiotic resistance of bacteria is driving us to catastrophic failure of the healthcare system. Pseudomonas aeruginosa is one such pathogen that is responsible for causing nosocomial infections, urinary tract infections, cystic fibrosis, otitis media, and infections of wounds and burns. P. aeruginosa is a critical pathogen as defined by the World Health Organization (WHO) due to its intrinsic and adaptive competence to defy antibiotics and persist as a superbug. This book covers a wide array of subjects relevant to bacterial biofilms specifically focusing on P. aeruginosa and associated infections. It provides readers with a clear and comprehensive overview of biofilm formation and associated detrimental impacts. In addition, this book also examines topics related to biosynthesis virulence factors by P. aeruginosa to facilitate biofilm formation, antibiotic resistance mechanisms, and infections.

Download or read book Superbugs written by Stephanie Watson and published by The Rosen Publishing Group, Inc. This book was released on 2010-01-15 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides information on the increase of drug-resistant germs called "superbugs" and different viewpoints on how to deal with the issue.

Download or read book Pseudomonas Aeruginosa written by Theerthankar Das and published by . This book was released on 2021-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Pseudomonas aeruginosa written by Alain Filloux and published by Springer Nature. This book was released on 2022-10-18 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the wide set of well-regulated virulence factors and defense mechanisms of Pseudomonas aeruginosa focusing on stress responses and the evolution of this opportunistic human pathogen. Pseudomonas aeruginosa is responsible for one out of ten hospital infections. Additionally, this Gram-negative bacterium is accountable for persistent infections in immunocompromised individuals and the leading cause of chronic lung infections in cystic fibrosis patients. This book provides insight on the metabolic versatility of Pseudomonas aeruginosa and its mechanisms for biofilm formation that make this organism highly efficient in causing infections. The book invites the readers to learn more about the intrinsic ability of Pseudomonas aeruginosa to resist a wide variety of antimicrobial agents due to the concerted action of multidrug efflux pumps, antibiotic-degrading enzymes, and the low permeability of bacterial cellular envelopes. Particular focus is put on the evolutionary role of different types of protein-secretion systems in pathogenesis, flagella and their role in chemotaxis and surface sensing, and host-pathogen interactions. This book is a useful introduction to the field for junior scientists interested in the biology and pathogenesis of Pseudomonas aeruginosa. It is also an interesting read for advanced scientists and medical specialists working within this field, providing a broader view of the topic beyond their specific area of specialization.

Download or read book Pseudomonas aeruginosa written by Osama Darwesh and published by BoD – Books on Demand. This book was released on 2024-05-29 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume, Pseudomonas aeruginosa - New Perspectives and Applications, is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in immunology and microbiology. Chapters address such topics as P. aeruginosa and hospital-acquired infections, the multidrug resistance of P. aeruginosa, the role of P. aeruginosa in bacterial pathogenesis, and more. The book provides a thorough overview of the latest research efforts by international authors and opens new possible research paths for further novel developments in the field.

Download or read book Pseudomonas aeruginosa as an Opportunistic Pathogen written by Mario Campa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Download or read book Pseudomonas Aeruginosa Biology Genetics and Host pathogen Interactions written by Dara W. Frank and published by Frontiers E-books. This book was released on 2012-02-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opportunistic pathogen Pseudomonas aeruginosa offers a rich variety of biologically relevant topics to explore and serves as a model system to understand the interactions of Gram-negative bacteria with human hosts. The organism adapts readily to most environments. It has a large and variable genome with a great deal of metabolic potential. P. aeruginosa encodes a variety of regulatory systems to fine tune gene expression and integrate environmental signals. This organism can infect both plants and animals and produces a plethora of enzymes and factors that can overcome host defenses. Moreover, it has the ability to change between the states of a sedentary colonizer to an invasive and highly motile organism. Clinically, the bacterium is resistant to many antibiotics making it difficult to treat and impossible to eradicate from the lungs of patients with cystic fibrosis. Intrinsic antibiotic resistance combined with an armamentarium of tissue degradative enzymes makes it imperative to possess a comprehensive understanding of the biology, genetics and pathogenesis of this organism so that novel therapeutics based on virulence product neutralization can be designed and implemented. This Research Topics issue will be devoted to updating the current understanding of P. aeruginosa systems as they relate to its different lifestyles in different environments. The underlying theme is to provide broad overviews and to integrate protein structure-function and gene regulation as it relates to the biology of this bacterium.

Download or read book Understanding the Creeping Crisis written by Arjen Boin and published by Springer Nature. This book was released on 2021-05-10 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book explores a special species of trouble afflicting modern societies: creeping crises. These crises evolve over time, reveal themselves in different ways, and resist comprehensive responses despite periodic public attention. As a result, these crises continue to creep in front of our eyes. This book begins by defining the concept of a creeping crisis, showing how existing literature fails to properly define and explore this phenomenon and outlining the challenges such crises pose to practitioners. Drawing on ongoing research, this book presents a diverse set of case studies on: antimicrobial resistance, climate change-induced migration, energy extraction, big data, Covid-19, migration, foreign fighters, and cyberattacks. Each chapter explores how creeping crises come into existence, why they can develop unimpeded, and the consequences they bring in terms of damage and legitimacy loss. The book provides a proof-of-concept to help launch the systematic study of creeping crises. Our analysis helps academics understand a new species of threat and practitioners recognize and prepare for creeping crises.

Download or read book Superbugs Crisis written by Jerry H Stevenson and published by Independently Published. This book was released on 2024-01-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Embark on an extraordinary journey into the microscopic world of phage therapy with our groundbreaking book, 'Phage Revolution: Confronting Superbugs.' As the global superbug crisis threatens millions, this narrative unveils a tapestry of hope, innovation, and life-changing discoveries. In 'Superbugs crisis, ' witness gripping personal stories like Cynthia Horton's battle against antibiotic-resistant infections and Tom Patterson's miraculous recovery from 'Iraqibacter.' Explore the looming global threat of antibiotic resistance, with statistical insights and predictions for 2050 that will leave you on the edge of your seat. Dive into the riveting chapters detailing the unique mechanisms of bacteriophages-nature's tiny predators-and their game-changing role in combating drug-resistant infections. Follow Cynthia's remarkable journey with phage treatment and delve into compelling case studies of successful interventions that defy conventional medical wisdom. Unravel the mystery behind the 2023 eye infection outbreak linked to over-the-counter eye drops, connecting the dots between Cynthia's ear bacteria and the crisis. Join the CDC's investigation into the rare strain of Pseudomonas aeruginosa, showcasing the real-world impact of phage therapy in action. In this narrative, witness Tom Patterson's near-death experience and the race against time that led to his recovery through powerful phage cocktails. Explore the latest advancements in phage therapy 3.0, mapping phages and antibiotics for optimal synergy, and uncover the potential of genetic engineering for tailored interventions. Discover the real-world applications and ongoing clinical trials of phage therapy for various infections, including its revolutionary potential to decolonize drug-resistant bacterial populations. As the book navigates challenges and envisions future directions, it prompts crucial reflections on ethical considerations and the transformative role of phages in overcoming antibiotic resistance. 'Superbugs Crisis' leaves readers inspired and equipped to join the battle. This isn't just a book; it's a vital tool in reshaping the future of medicine. Don't miss your chance to be part of the phage revolution-secure your copy now and become a beacon of change in the fight against superbugs."

Download or read book Superbugs written by Matt McCarthy and published by Penguin. This book was released on 2020-06-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Bestseller "An amazing, informative book that changes our perspective on medicine, microbes and our future." --Siddhartha Mukherjee, MD, New York Times bestselling author of The Emperor of All Maladies A New York Times bestselling author shares this exhilarating story of cutting-edge science and the race against the clock to find new treatments in the fight against the antibiotic-resistant bacteria known as superbugs. Physician, researcher, and ethics professor Matt McCarthy is on the front lines of a groundbreaking clinical trial testing a new antibiotic to fight lethal superbugs, bacteria that have built up resistance to the life-saving drugs in our rapidly dwindling arsenal. This trial serves as the backdrop for the compulsively readable Superbugs, and the results will impact nothing less than the future of humanity. Dr. McCarthy explores the history of bacteria and antibiotics, from Alexander Fleming's discovery of penicillin, to obscure sources of innovative new medicines (often found in soil samples), to the cutting-edge DNA manipulation known as CRISPR, bringing to light how we arrived at this juncture of both incredible breakthrough and extreme vulnerability. We also meet the patients whose lives are hanging in the balance, from Remy, a teenager with a dangerous and rare infection, to Donny, a retired New York City firefighter with a compromised immune system, and many more. The proverbial ticking clock will keep readers on the edge of their seats. Can Dr. McCarthy save the lives of his patients infected with the deadly bacteria, who have otherwise lost all hope?

Download or read book Pseudomonas Aeruginosa written by L. D. Sabath and published by . This book was released on 1980 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Resistance of Pseudomonas Aeruginosa written by Michael Robert Withington Brown and published by John Wiley & Sons. This book was released on 1975 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Superbug written by Geoffrey Cannon and published by Virgin Books Limited. This book was released on 1995 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: For 50 years, medicine has attacked bacteria with antibiotics. But antibiotics put at risk our ability to resist disease. New plagues of infection caused by superbugs (bacteria that have learned to resist antibiotics) threaten our health. This book suggests that antibiotics do more harm than good.