Download or read book Protein Families written by Christine A. Orengo and published by John Wiley & Sons. This book was released on 2014-02-03 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: New insights into the evolution and nature of proteins Exploring several distinct approaches, this book describes the methods for comparing protein sequences and protein structures in order to identify homologous relationships and classify proteins and protein domains into evolutionary families. Readers will discover the common features as well as the key philosophical differences underlying the major protein classification systems, including Pfam, Panther, SCOP, and CATH. Moreover, they'll discover how these systems can be used to understand the evolution of protein families as well as understand and predict the degree to which structural and functional information are shared between relatives in a protein family. Edited and authored by leading international experts, Protein Families offers new insights into protein families that are important to medical research as well as protein families that help us understand biological systems and key biological processes such as cell signaling and the immune response. The book is divided into three sections: Section I: Concepts Underlying Protein Family Classification reviews the major strategies for identifying homologous proteins and classifying them into families. Section II: In-Depth Reviews of Protein Families focuses on some fascinating super protein families for which we have substantial amounts of sequence, structural and functional data, making it possible to trace the emergence of functionally diverse relatives. Section III: Review of Protein Families in Important Biological Systems examines protein families associated with a particular biological theme, such as the cytoskeleton. All chapters are extensively illustrated, including depictions of evolutionary relationships. References at the end of each chapter guide readers to original research papers and reviews in the field. Covering protein family classification systems alongside detailed descriptions of select protein families, this book offers biochemists, molecular biologists, protein scientists, structural biologists, and bioinformaticians new insight into the evolution and nature of proteins.

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Functional Profile of the Lipocalin Protein Family written by Maria Dolores Ganfornina and published by Frontiers Media SA. This book was released on 2022-05-24 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Practical Protein Bioinformatics written by Florencio Pazos and published by Springer. This book was released on 2014-11-28 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes more than 60 web-accessible computational tools for protein analysis and is totally practical, with detailed explanations on how to use these tools and interpret their results and minimal mentions to their theoretical basis (only when that is required for making a better use of them). It covers a wide range of tools for dealing with different aspects of proteins, from their sequences, to their three-dimensional structures, and the biological networks they are immersed in. The selection of tools is based on the experience of the authors that lead a protein bioinformatics facility in a large research centre, with the additional constraint that the tools should be accessible through standard web browsers without requiring the local installation of specific software, command-line tools, etc. The web tools covered include those aimed to retrieve protein information, look for similar proteins, generate pair-wise and multiple sequence alignments of protein sequences, work with protein domains and motifs, study the phylogeny of a family of proteins, retrieve, manipulate and visualize protein three-dimensional structures, predict protein structural features as well as whole three-dimensional structures, extract biological information from protein structures, summarize large protein sets, study protein interaction and metabolic networks, etc. The book is associated to a dynamic web site that will reflect changes in the web addresses of the tools, updates of these, etc. It also contains QR codes that can be scanned with any device to direct its browser to the tool web site. This monograph will be most valuable for researchers in experimental labs without specific knowledge on bioinformatics or computing.

Download or read book Machine Learning and Data Mining written by Ryszad S. Michalski and published by Wiley. This book was released on 1998-04-22 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the new computational tools to get the most out of your information system. This practical guide, the first to clearly outline the situation for the benefit of engineers and scientists, provides a straightforward introduction to basic machine learning and data mining methods, covering the analysis of numerical, text, and sound data.

Download or read book Biomarkers in Leishmaniasis written by Javier Moreno and published by Frontiers Media SA. This book was released on 2020-01-15 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Plant Comparative Genomics written by Alejandro Pereira-Santana and published by Springer Nature. This book was released on 2022-07-11 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book presents recent methodologies for the task of inspecting the genomic world of plants, extracting valuable information, and presenting it in a readable way. With a focus on bioinformatics tools, the volume explores phylogenetics and evolution, Omics analysis, as well as experimental procedures for trait characterization. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of vital expert implementation advice that will lead to successful results. Authoritative and practical, Plant Comparative Genomics serves as an ideal resource for researchers looking to implement comparative tools in order to explore their genomic data for their daily scientific work.

Download or read book Computational Methods for Protein Structure Prediction and Modeling written by Ying Xu and published by Springer Science & Business Media. This book was released on 2010-05-05 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume Two of this two-volume sequence presents a comprehensive overview of protein structure prediction methods and includes protein threading, De novo methods, applications to membrane proteins and protein complexes, structure-based drug design, as well as structure prediction as a systems problem. A series of appendices review the biological and chemical basics related to protein structure, computer science for structural informatics, and prerequisite mathematics and statistics.

Download or read book New Chemistry and New Opportunities from the Expanding Protein Universe written by Kurt Wüthrich and published by World Scientific. This book was released on 2014-11-10 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, and design and application of small molecule drugs, biologics and biosimilars. This fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow. Contents:New Chemistry in the Expanding Protein Universe:Novel Chemistry Still to be Found in Nature (C T Walsh)Natural Product Biosynthesis in the Genomic Age (W A van der Donk)Peptide Dendrimers and Polycyclic Peptides (J-L Reymond)What can Comparative Genomics Reveal about the Mechanisms of Protein Function Evolution? (N L Dawson, R Studer, N Furnham, D Lees, S Das, J Thornton and C Orengo)Exploring Chromatin Biology Using Protein Chemistry (T W Muir)Our Expanding Protein Universe (A Godzik)The Scientific Impact of Freely Available Chemical Probes (A M Edwards)Discussions of Session 1Exploring Enzyme Families and Enzyme Catalysis:Mechanistic Enzymology and Catalyst Design (D Hilvert)Looking in New Directions for the Origins of Enzymatic Rate Accelerations (J P Klinman)Computational Enzyme Design and Methods to Predict the Role of Remote Mutations (K N Houk)Discovering Novel Enzymes, Metabolites and Pathways (J A Gerlt)Programming New Chemistry into the Genetic Code of Cells and Animals (J W Chin)Expanding the Enzyme Universe through a Marriage of Chemistry and Evolution (F H Arnold)Controlled Radical Reactions in Biology and the Importance of Metallo-Cofactor Biosynthesis (J Stubbe)Discussions of Session 2Microbiomes and Carbohydrate Chemistry:Structural Basis for Host/Commensal-Microbe Interactions in the Human Distal Gut Microbiome (I A Wilson)Carbohydrate Chemistry and Biology (C-H Wong)Chemical Biological Proteomics of Bacterial Protein Functionalities in the Human Distal Gut Microbiome (D W Wolan)Automated Oligosaccharide Synthesis: From Insights into Fundamental Glycobiology to Vaccines and Diagnostics (P H Seeberger)Carbohydrate-Active Enzymes in Microbiomes (B Henrissat)The Microbiome(s): Microbiota, Families, Functions (A Godzik)N-Linked Protein Glycosylation (M Aebi)Discussions of Session 3GPCRs and Transporters: Ligands, Cofactors, Drug Development:GPCRs and Transporters: Ligands, Cofactors, Drug Development (G von Heijne)Studies of GPCR Conformations in Non-Crystalline Milieus (K Wüthrich)The Seven Transmembrane Superfamily (R C Stevens)Nanobodies for the Structural and Functional Investigation of GPCR Transmembrane Signaling (E Pardon and J Steyaert)The Hidden Pharmacology of the Human GPCR-ome (B L Roth)Structures and Reaction Mechanisms of ABC Transporters (K Locher)Discussions of Session 4Biologicals and Biosimilars:Biologicals and Biosimilars (S Ghose and M G Grütter)Platform Technologies for the Artificial Pseudo-Natural Product Discovery (H Suga)Anticalins® & Pasylation®: New Concepts for Biopharmaceutical Drug Development from Protein Design (A Skerra)From Natural Antibodies to Synthetic Proteins (S S Sidhu)From Intact Antibodies to Armed Antibodies (D Neri)Regulating Cellular Life Death and Development Using Intracellular Combinatorial Antibody Libraries (R Lerner, J Xie, H Zhang, K Yea, J Blanchard and K Baldwin)Nanobodies: A Universe of Variable Domains and a Toolbox for Many Trades (L Wyns)Discussions of Session 5Proteins in Supramolecular Machines:Assembly of Filamentous Type 1 Pili from Uropathogenic Escherichia Coli Strains (R Glockshuber)HIV Envelope and Influenza Hemagglutinin Fusion Glycoproteins and the Quest for a Universal Vaccine (I A Wilson)Deconstruction of Iterative Polyketide Synthases (C A Townsend)Regulating Ribosome Pausing During Translation (M V Rodnina)The Molecular Mechanics of the Ribosome (J Zhou, L Lancaster, Z Guo, J P Donohue and H F Noller)Exploring the Dynamics of Supramolecular Machines with Cryo-Electron Microscopy (J Frank)Crystallographic Studies of Eukaryotic Ribosomes and Functional Insights (N Ban)Discussions of Session 6 Readership: Graduates and researchers in protein structure, structural biology and genomics. Key Features:Unique approach to the topic, an outstanding group of contributors, extensive inclusion of otherwise unpublished materialKeywords:Proteins;Structural Biology;Structural Genomics;GPCRs;Drug Development

Download or read book Atlas of Protein Sequence and Structure written by and published by . This book was released on 1973 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genome Evolution written by Axel Meyer and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances. This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context, provide evidence regarding the relative importance of gene duplication. The alternative explanation is that the evolution of regulatory elements that control the expression of and interactions among genes has been a more important force in shaping evolutionary innovation. This collection of papers will be of interest to all academic and industry researchers working in the fields of molecular biology, biotechnology, genomics and genome centers.

Download or read book Protein Modelling written by Andrew Gamble and published by Springer. This book was released on 2014-11-13 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, a detailed description of cutting-edge computational methods applied to protein modeling as well as specific applications are presented. Chapters include: the application of Car-Parrinello techniques to enzyme mechanisms, the outline and application of QM/MM methods, polarizable force fields, recent methods of ligand docking, molecular dynamics related to NMR spectroscopy, computer optimization of absorption, distribution, metabolism and excretion extended by toxicity for drugs, enzyme design and bioinformatics applied to protein structure prediction. A keen emphasis is laid on the clear presentation of complex concepts, since the book is primarily aimed at Ph.D. students, who need an insight in up-to-date protein modeling. The inclusion of descriptive, color figures will allow the reader to get a pictorial representation of complicated structural issues.

Download or read book Protein Protein Interactions written by Krishna Mohan Poluri and published by Springer Nature. This book was released on 2021-05-19 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments. Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Download or read book BCL 2 Protein Family written by Claudio Hetz and published by Springer Science & Business Media. This book was released on 2011-01-12 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‐2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.

Download or read book Food Allergy Molecular Basis and Clinical Practice written by M. Ebisawa and published by Karger Medical and Scientific Publishers. This book was released on 2015-05-21 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: 0

Download or read book Protein Folding Evolution and Design written by Eugene I. Shakhnovich and published by IOS Press. This book was released on 2001 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the results of broad, interdisciplinary effort to study proteins in physical and evolutionary perpective. Among authors are physicists, computational, chemists, crystallographers and evolutionary biologists. Experimental and theoretical developments from molecules to cells are presented, providing a broad picture of modern biophysical chemistry.

Download or read book Sequence Evolution Function written by Eugene V. Koonin and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.