Download or read book Prions and Mad Cow Disease written by Brian K. Nunnally and published by CRC Press. This book was released on 2003-10-17 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The alarm sounded by Canada's confirmed case of bovine spongiform encephalopathy (BSE) has reaffirmed the exigency of establishing improved safeguards and more aggressive surveillance protocols in North America and around the world. Research converging on the probable causative agent--prion proteins--calls for intensive assessment of the headway gained in tracing prions, testing for transmissible neurodegenerative diseases, and developing methods for cornering the epidemic. With an illustrious panel of 36 international contributors, this timely book marshals techniques for prion protein assay and diagnosis of transmissible spongiform encephalopathies (TSEs).
Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.
Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2003-04-20 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.
Download or read book Mad Cow U S A written by Sheldon Rampton and published by . This book was released on 1997 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mad Cow U.S.A. shatters the false belief that the government and food industry would never let it happen here. Even as tens of thousands of cows died in Britain, the government denied the risk to human beings. Knowing the similar risk in the U.S., government and industry have managed a successful public relations offensive to keep Americans in the dark. Rampton and Stauber expose, for the first time, the deadly game of "dementia roulette" being played with our food supply.
Download or read book How the Cows Turned Mad written by Maxime Schwartz and published by Univ of California Press. This book was released on 2004-09-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: "How the Cows Turned Mad tells the story of a disease that continues to elude on many levels. Yet science has come far in understanding its origins, incubation, and transmission. This book is a case history that illuminates the remarkable progression of science."--BOOK JACKET.
Download or read book Deadly Feasts written by Richard Rhodes and published by Simon and Schuster. This book was released on 2012-12-11 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this brilliant and gripping medical detective story. Richard Rhodes follows virus hunters on three continents as they track the emergence of a deadly new brain disease that first kills cannibals in New Guinea, then cattle and young people in Britain and France -- and that has already been traced to food animals in the United States. In a new Afterword for the paperback, Rhodes reports the latest U.S. and worldwide developments of a burgeoning global threat.
Download or read book Prions written by Claudio Soto and published by CRC Press. This book was released on 2005-12-20 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy
Download or read book Brain Trust written by Colm A. Kelleher and published by Simon and Schuster. This book was released on 2004-10-19 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the cattle-borne sickness known as Mad Cow Disease first appeared in America in 2003, authorities were quick to assure the nation that the outbreak was isolated, quarantined, and posed absolutely no danger to the general public. What we were not told was that the origins of the sickness may already have been here and suspected for a quarter of a century. This illuminating exposé of the threat to our nation's health reveals for the first time how Mad Cow Disease (a.k.a. Bovine Spongiform Encephalopathy) has jumped species, infecting humans in the form of Creutzfeldt-Jakob Disease (CJD), and may be hidden in the enormous increase in the number of Alzheimer's cases since 1979. Detailing the history and biology of Mad Cow Disease, Brain Trust discloses how an investigation into the mysterious deaths in a group of cannibals in a remote part of the world evolved into a research program in the United States that may have had unforeseen and frightening consequences. The shocking questions examined include: • Have millions of Americans already been exposed to the prions known to cause Mad Cow Disease through years of eating tainted beef? • Does the epidemic of prion disease spreading like wildfire through the nation's deer and elk pose a threat to hunters and venison eaters? • Are the cattle mutilations discovered in the last 30 years part of a covert, illegal sampling program designed to learn how far the deadly prions have spread throughout the nation's livestock and beef products? Exposing the devastating truth about Mad Cow Disease and a new theory of the possible consequences of a little-known government research program and the potential national health catastrophe that may be the result, Brain Trust inoculates Americans with an effective cure: the truth.
Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. - Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms - Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans - Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
Download or read book Handbook of Veterinary Neurology E Book written by Michael D. Lorenz and published by Elsevier Health Sciences. This book was released on 2010-12-07 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Veterinary Neurology provides quick access to vital information on neurologic conditions in a wide range of species, including canine, feline, bovine, caprine, equine, ovine, and porcine. A problem-oriented approach makes it easy to diagnose and treat neurologic problems in small and large animals. The coverage of disorders by problem, not by established disease diagnosis, emulates how animals present to the veterinary hospital and simplifies the formulation of a correct diagnosis. Within each chapter, discussions of neurologic disease include a review of the localization criteria and the diseases that can cause that problem, plus treatment and surgical techniques. Lead author Michael D. Lorenz brings decades of experience to neurologic assessment, using a diagnostic approach that requires minimal knowledge of neuroanatomy. - A problem-based approach is organized by presenting sign rather than by condition, guiding you to logical conclusions regarding diagnosis and treatment. - Algorithms diagram the logic necessary to localize lesions and to formulate diagnostic plans. - Coverage of current diagnostic techniques includes the use of diagnostic tools, such as radiology, spinal fluid analysis, electrodiagnosis, and MR imaging. - Case histories in each chapter present a problem and the results of the neurologic examination, then ask you to solve the problem by localizing the lesion, listing probable causes, and making a diagnostic plan. Answers are provided at the back of the book. - A consistent format for each case history includes signalment, history, physical examination findings, and neurologic examination. - A comprehensive appendix describes species and breeds that have a congenital predisposition for particular neurologic diseases. - Extensive references make it easy to pursue in-depth research of more advanced topics. - A companion website includes 20 narrated video clips with accompanying PowerPoint slides that correlate to the case histories in the book, covering neurologic assessment and clinical problems such as paresis of one limb, tetraparesis, stupor, seizures, ataxia of the head and limbs, and cranial nerve disorders. - Two new co-authors, Jean Coates and Marc Kent, board-certified in neurology, enhance the credibility of this edition. - A full-color design and numerous illustrations include enhanced images of neuroanatomy and pathology.
Download or read book Fatal Flaws written by Jay Ingram and published by Yale University Press. This book was released on 2013-03-19 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: DIVThe story of the revolutionary science that is unraveling the mysteries of mad cow and other fatal brain diseases/div
Download or read book The Prion Protein written by Jorg Tatzelt and published by . This book was released on 2010 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.
Download or read book The Family That Couldn t Sleep written by D. T. Max and published by Random House. This book was released on 2006-09-05 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: For two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass. What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world. In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described “pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study. With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.
Download or read book Fatal Protein written by Rosalind M. Ridley and published by . This book was released on 1998 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a clear and authoritative account of the prion diseases for the non-specialist. It deals with the history of scrapie in sheep, the spread of kuru through cannibalism in Papua New Guinea, BSE, which has killed 170,000 cattle in the UK, and the question of whether the newvariant form of Creutzfeld-Jakob disease (CJD) results from eating BSE-infected meat. All aspects of the diseases are covered, including genetics, clinical aspects, laboratory research, epidemiology, and field studies. Accessibly written by authors who are leading researchers in the field, it is thefirst book to provide a scientifically accurate yet readable account of these topical diseases.
Download or read book Prion Biology written by Stanley B. Prusiner and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book examines our under-standing of their structure, biochemistry, and pathophysiology.
Download or read book Neurobiology of Brain Disorders written by Michael J. Zigmond and published by Elsevier. This book was released on 2014-12-03 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. - Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment - Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain - Illustrated in full color - Each chapter provides in-text summary points, special feature boxes, and research questions - Provides an up-to-date synthesis of primary source material
Download or read book Review of Medical Microbiology and Immunology 15E written by Warren E. Levinson and published by McGraw-Hill Education / Medical. This book was released on 2018-05-10 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The most concise, clinically relevant, and current review of medical microbiology and immunology Review of Medical Microbiology and Immunology is a succinct, high-yield review of the medically important aspects of microbiology and immunology. It covers both the basic and clinical aspects of bacteriology, virology, mycology, parasitology, and immunology and also discusses important infectious diseases using an organ system approach. The book emphasizes the real-world clinical application of microbiology and immunology to infectious diseases and offers a unique mix of narrative text, color images, tables and figures, Q&A, and clinical vignettes. • Content is valuable to any study objective or learning style • Essential for USMLE review and medical microbiology coursework • 650 USMLE-style practice questions test your knowledge and understanding • 50 clinical cases illustrate the importance of basic science information in clinical diagnosis • A complete USMLE-style practice exam consisting of 80 questions helps you prepare for the exam • Pearls impart important basic science information helpful in answering questions on the USMLE • Concise summaries of medically important organisms • Self-assessment questions with answers appear at the end of each chapter • Color images depict clinically important findings, such as infectious disease lesions • Gram stains of bacteria, electron micrographs of viruses, and microscopic images depict fungi, protozoa, and worms • Chapters on infectious diseases from an organ system perspective
