Download or read book Human Prion Diseases written by and published by Elsevier. This book was released on 2018-06-07 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms
Download or read book Prion Diseases written by John Collinge (MD.) and published by . This book was released on 1997 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists,veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide the most up-to-date and authoritative summary available of the field. Contents include human and animal prion diseases; pathology and cell biology of prion diseases; and prion protein structure.
Download or read book Madness and Memory written by Stanley B. Prusiner and published by Yale University Press. This book was released on 2014-04-29 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.
Download or read book Neurodegeneration and Prion Disease written by David R. Brown and published by Springer Science & Business Media. This book was released on 2005-05-06 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.
Download or read book Advancing Prion Science written by Institute of Medicine and published by National Academies Press. This book was released on 2003-03-20 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.
Download or read book Prions Prions Prions written by Stanley B. Prusiner and published by Springer. This book was released on 2011-09-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature. Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.
Download or read book Prions written by Claudio Soto and published by CRC Press. This book was released on 2005-12-20 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy
Download or read book Fatal Protein written by Rosalind M. Ridley and published by . This book was released on 1998 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a clear and authoritative account of the prion diseases for the non-specialist. It deals with the history of scrapie in sheep, the spread of kuru through cannibalism in Papua New Guinea, BSE, which has killed 170,000 cattle in the UK, and the question of whether the newvariant form of Creutzfeld-Jakob disease (CJD) results from eating BSE-infected meat. All aspects of the diseases are covered, including genetics, clinical aspects, laboratory research, epidemiology, and field studies. Accessibly written by authors who are leading researchers in the field, it is thefirst book to provide a scientifically accurate yet readable account of these topical diseases.
Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.
Download or read book The Social Construction of Disease written by Kiheung Kim and published by Routledge. This book was released on 2006-11-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: A historical exploration of scientific disputes on the causation of so-called ‘prion diseases’, this fascinating book covers diseases including Scrapie, Creutzfeldt-Jakob Disease (CJD) and Bovine Spongiform Encephalopathy (BSE). Firstly tracing the twentieth-century history of disease research and biomedicine, the text then focuses on the relations between scientific practice and wider social transformations, before finally building upon the sociologically informed methodological framework. Incisive and thought-provoking, The Social Construction of Disease provides a valuable contribution to that well-established tradition of social history of science, which refers primarily to the theoretical works of the sociology of scientific knowledge.
Download or read book Deadly Feasts written by Richard Rhodes and published by Simon and Schuster. This book was released on 2012-12-11 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this brilliant and gripping medical detective story. Richard Rhodes follows virus hunters on three continents as they track the emergence of a deadly new brain disease that first kills cannibals in New Guinea, then cattle and young people in Britain and France -- and that has already been traced to food animals in the United States. In a new Afterword for the paperback, Rhodes reports the latest U.S. and worldwide developments of a burgeoning global threat.
Download or read book Harrison s Neurology in Clinical Medicine 3E written by Stephen Hauser and published by McGraw Hill Professional. This book was released on 2013-04-08 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurology – as only Harrison’s can cover it Featuring a superb compilation of chapters related to neurology that appear in Harrison’s Principles of Internal Medicine, Eighteenth Edition, this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features Current, complete coverage of clinically important topics in neurology, including Clinical Manifestations of Neurologic Diseases, Diseases of the Nervous System, Chronic Fatigue Syndrome, Psychiatric Disorders, and Alcoholism and Drug Dependency NEW CHAPTERS discuss the pathogenesis and treatment and syncope; dizziness and vertigo; peripheral neuropathy; neuropsychiatric problems among war veterans; and advances in deciphering the pathogenesis of common psychiatric disorders Integration of pathophysiology with clinical management 118 high-yield questions and answers drawn from Harrison’s Principles of Internal Medicine Self-Assessment and Board Review, 18e Content updates and new developments since the publication of Harrison’s Principles of Internal Medicine, 18e 58 chapters written by physicians who are recognized experts in the field of clinical neurology Helpful appendix of laboratory values of clinical importance
Download or read book Infectious Diseases from Nature Mechanisms of Viral Emergence and Persistence written by C.J. Peters and published by Springer Science & Business Media. This book was released on 2006-06-07 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence". The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.
Download or read book Prion Diseases written by Martin H. Groschup and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.
Download or read book Prions and Diseases written by Wen-Quan Zou and published by Springer Nature. This book was released on 2023-01-01 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
Download or read book Prions and Diseases written by Wen-Quan Zou and published by Springer Science & Business Media. This book was released on 2012-11-08 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
Download or read book Essential Neuropsychology A Concise Handbook for Adult Practitioners written by Jonathan DeRight and published by Springer Nature. This book was released on 2021-12-09 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to provide brief-but-comprehensive information that can aid in rapid differential diagnosis and allow for more thorough follow-up if needed. This guide is intended to fit easily into the pocket of a lab coat or on your desk, giving readers an efficient way to find information about a specific disease or disorder to prepare for an upcoming case. The book is divided into two parts: Part 1 involves general psychometric and reference information including score classifications, formulas for score conversion, likelihood chaining, and reliable change, psychometric data for stand-alone and embedded PVTs, and the effects of common medications on cognition. Part 2 of the book is organized alphabetically by disease or disorder to promote quick searching, and each chapter provides straightforward information including definitions, subtypes, etiology, epidemiology, course, diagnostic criteria, expectations for test results, and links to more comprehensive sources. Whenever possible, information is gathered through up-to-date literature and high quality pubilcations such as systematic reviews or meta-analyses. Helpful references are provided for more extensive follow-up or further reading.
