Download or read book Plasmonics Powered Hybrid Platform for Label Free Bio sensing written by ZHONGBO YAN and published by . This book was released on 2017 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface plasmons (SPs) are coherent delocalized electron oscillations that exist at the metal-dielectric interface. The charge motion in the surface plasmon creates intense electromagnetic fields at certain locations of the interface, which are referred to as "hot spots". The intense electromagnetic field associated with the excitation of surface plasmons has found applications in various bio-sensing techniques. A unique plasmonic hybrid platform, graphene-Au pyramid structure, was invented by our group. The hybrid platform provides an ultra intense surface plasmon field and has a bio-compatible surface, making it a powerful tool for bio-sensing. The work to refine the nanostructure for generation of stronger surface plasmon field has been intensively explored by my group mates. Aside from generation of stronger surface plasmon fields, this research was done to improve several surface plasmon based techniques through the hybrid platform and to explore their applications in the label free bio-sensing field. The ultimate goal of my thesis work is to develop an integrated system for biological detection and analysis with high sensitivity and specificity. In the bio-sensing field, especially in regards to remote detection in an analyte, the biological entities (e.g. biomolecules and cells) of interest are always dispersed in the solution. This would be a concern if we were using plasmon resonance powered techniques by themselves. The first part of this research focuses on Plasmonic tweezers, a manipulation technique to attract and capture biological entities onto the plasmonics surface. Plasmonic tweezers is noninvasive manipulation technique, in which a near-field gradient force is generated by the surface plasmon field around hot spots. It can be used to precisely control the position of biological entities. However, the near-field property of plasmonic tweezer limits its functional range in capturing biological samples. To remedy this problem, electrostatic bias is used in conjunction with plasmonic tweezers. Electrostatic bias produces a long range force whose effects spread across the entire space between a pair of electrodes. It compensates for the plasmonic tweezers' short range limitation by "condensing" molecules throughout the analyte to a layer immediately adjacent to the plasmonic surface. By using plasmonic tweezers and an electrostatic force together, the biological entities can be confined to sub-wavelength dimensions near the hot spots. For the plasmonics based bio-detection methods, the hot spots are always where the signal generates from. Therefore, this self-aligned trapping method is used to effectively increase the sensitivity and selectivity of bio-sensing techniques. After the biological entities are attracted to the plasmonics surface, the next step is to develop specific detection techniques. The second part of this thesis is to demonstrate the capability of the surface-enhanced Raman spectroscopy (SERS) techniques based on a nanopyramid array hybrid platform. SERS is a surface-sensitive technique employing strong plasmon resonance fields to enhance the Raman signal by several orders of magnitude. This enables even the detection of single molecules. Also, compared with other nanostructures, the hybrid platform has distinct advantages. The nanopyramid array is an open structure, in which hot spots are located between neighboring pyramids. As such, large biomolecules and biological entities can easily move into these regions and their Raman signals can be enhanced. By introducing single layer graphene, the hybrid platform provides a bio-friendly surface, preventing biological entities from being affected by toxic metals such as silver. The signal of the graphene layer can also serve as a built-in gauge of local electromagnetic field intensity used to indicate the distribution of the hot spots. These properties make the hybrid platform a powerful tool for biological detection and analysis. In this thesis work, the hybrid platform is employed to generate SERS signals of biological samples, in particular, the characterization of exosomes and T-cells. However, the biological entities would naturally bring variations to the SERS signals due variations in the type and quantity of their chemical compositions. In our research, principle component analysis (PCA) is also employed to interpret the SERS data and provide a statistical investigation of the biological samples. To achieve dynamic monitoring of biological processes, higher sensitivity and temporal resolution are preferred. In the last part of this thesis, another label free bio-sensing technique, surface-enhanced coherent anti-Stokes Raman spectroscopy (SECARS), was developed based on the hybrid platform. A multiplicative enhancement of the Raman signal over CARS and SERS is achieved using a novel SECARS setup. Compared to previous setups, it shows a broadband feature with high spectral resolution, which is preferred in biological detection. The novel setup based on the hybrid platform could be a powerful tool for not only the characterization of biological entities but also the dynamic monitoring of various biological processes.
Download or read book Label Free Biosensing written by Michael J. Schöning and published by Springer. This book was released on 2018-07-20 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices
Download or read book Superfocusing Biosensing and Modulation in Plasmonics written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanoscience And Technology A Collection Of Reviews From Nature Journals written by Peter Rodgers and published by World Scientific. This book was released on 2009-08-21 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 35 review articles on nanoscience and nanotechnology that were first published in Nature Nanotechnology, Nature Materials and a number of other Nature journals. The articles are all written by leading authorities in their field and cover a wide range of areas in nanoscience and technology, from basic research (such as single-molecule devices and new materials) through to applications (in, for example, nanomedicine and data storage).
Download or read book World Scientific Reference On Plasmonic Nanomaterials Principles Design And Bio applications In 5 Volumes written by and published by World Scientific. This book was released on 2022-03-04 with total page 2475 pages. Available in PDF, EPUB and Kindle. Book excerpt: World Scientific Reference on Plasmonic Nanomaterials: Principles, Design and Bio-applications is a book collection that encompasses multiple aspects of the exciting and timely field of nanoplasmonics, under the coordination of international plasmonic nanomaterials expert, Dr Luis Liz-Marzán. Plasmonics has a long history, from stained glass in ancient cathedrals, through pioneering investigations by Michael Faraday, all the way into the nanotechnology era, where it blossomed into an extremely active field of research with potential applications in a wide variety of technologies.Given the breadth of the materials, phenomena and applications related to plasmonics, this Reference Set offers a collection of chapters within dedicated volumes, focusing on the description of selected phenomena, with an emphasis in chemistry as an enabling tool for the fabrication of, often sophisticated, plasmonic nanoarchitectures and biomedicine as the target application.Basic principles of surface plasmon resonances are described, as well as those mechanisms related to related phenomena such as surface-enhanced spectroscopies or plasmonic chirality. Under the guidance of theoretical models, wet chemistry methods have been implemented toward the synthesis of a wide variety of nanoparticles with different compositions and tailored morphology. But often the optimal nanoarchitecture requires post-synthesis treatments, including functionalization of nanoparticle surfaces, application of external stimuli toward self-assembly into well-defined supraparticle structures and so-called supercrystals. All such nanomaterials can find applications in various biomedical aspects, most often in relation to diagnosis, through either the detection of disease biomarkers at extremely low concentrations or the design of bioimaging methods for in vivo monitoring. Additionally, novel therapeutic tools can also profit from plasmonic nanomaterials, such as photothermal therapy or nanocatalysis.The reference set thus offers comprehensive information of an extremely active subset within the world of plasmonic nanomaterials and their applications, which aims at not just collecting existing knowledge but also promoting further research and technology transfer into the market and the clinic.
Download or read book Nanomaterials Based Sensing Platforms written by Aneeya K. Samantara and published by CRC Press. This book was released on 2022-02-03 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensors are effective tools used to carry out cost-effective, fast, and reliable sensing for a wide range of applications. This volume presents a brief history behind sensing technology and highlights a broad range of biosensing techniques based on optical and electrochemical response methods. Starting from the traditional enzyme-based biosensing method to functionalized nanostructure-based sensors, this book also provides a detailed overview of some of the advanced sensing methodologies based on photonic crystal cavity-based sensing devices. The authors showcase the extraordinary success of nanomaterials, their current strategical exploitation, and an unprecedented pool of possibilities they hold for the future. Many of the technologies have been developed recently for the sensing of various bioanalytes and molecules, some of which have been included in this book through dedicated chapters. The book looks at various sensors, such as for biosensing, electrochemical sensing, gas sensing, photoelectrochemical sensing, and colorimetric sensing, all of which have shown vast potential.
Download or read book Optochemical Nanosensors written by Andrea Cusano and published by Taylor & Francis. This book was released on 2016-04-19 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the state of the art in optical and chemical nanosensors for industrial, environmental, diagnostic, security, and medical applications. It summarizes the various types and developments in optical and chemical sensor technology and then explains how the integration of optical/chemical sensors and nanomaterials creates new opportunities. The text also reviews optochemical sensors, starting from the basics in optoelectronics and concluding with the principles of operation at the basis of optochemical devices. The authors offer insight into future trends in this growing field and present a range of applications in the fields of medicine, security, and bioterrorism.
Download or read book Plasmonic Nanosensors for Biological and Chemical Threats written by Adil Denizli and published by CRC Press. This book was released on 2024-06-14 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and chemical warfare agents, including viruses, bacteria, and explosive and radioactive compounds, can induce illness or death in humans, animals, and plants. Plasmonic nanosensors as detection tools of these agents offer significant advantages, including rapid detection, sensitivity, selectivity, and portability. This book explores novel and updated research on different types of plasmonic nanosensors for analysis of biological and chemical threat agents. It covers a brief theory of plasmonic nanosensors, summarizes the state-of-art in the molecular recognition of biological and chemical threat agents, and describes the application of various types of nanosensors in the detection of these threat agents. This book • Brings together recent academic research from an interdisciplinary approach including chemistry, biology, and nanotechnology. • Discusses current trends and developments. • Describes applications of a variety of different types of plasmonic nanosensors. • Explores outlooks and expectations for this technology. Showcasing the latest achievements in plasmonic nanosensors, this book will appeal to researchers in materials, chemical, and environmental engineering as well as chemistry interested in exploring the application of sensors to support environmental monitoring and global health.
Download or read book Nanotechnology Characterization Tools for Biosensing and Medical Diagnosis written by Challa S.S.R. Kumar and published by Springer. This book was released on 2018-05-02 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eighth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Biosensing and Medical Diagnosis. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.
Download or read book Electroanalytical Applications of Quantum Dot Based Biosensors written by Bengi Uslu and published by Elsevier. This book was released on 2021-05-19 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantum dots (QDs) are hybrid organic/inorganic nanoparticles with novel physical properties. QDs have two components: an inorganic core and an optically active coated shell. Moreover, surface coatings can be applied to QDs to modify the particle as needed for experiments. Hydrophilic coatings prevent leaking of metal cargo from the core, enhancing the solubility in biological contexts and bind molecules, such as receptor–ligands, antibodies, therapeutic, and diagnostic macromolecules for enhanced effects. Their high surface-to-volume ratio allows multiple functional groups to attach onto the surface of the particles at constant surface volume. Silicon-, gallium-, indium-, or germanium-based; cadmium-based; and carbon-based QDs have already been used in many applications, such as imaging probes for the engineering of multifunctional nanodevices. Superior properties of QDs make them an excellent system in technology and biotechnology.This book describes electroanalytical applications of QD-based nanobiosensors, including brief information about the synthesis and characterization of QDs and basics of electroanalytical methods, followed by QDs in electrochemical biomimetic sensors, QDs in microchips, inorganic materials doped QDs, QD-based electrochemical DNA biosensors, electroluminescence for biomarker analysis using aptamer-based QDs, QD-based photoelectrochemical techniques, enzyme-based nanobiosensors using QDs, QD-based electrochemical immunosensors, and QD-modified nanosensors in drug analysis. Outlines QD-based applications for drug, food, clinical, and environmental science Shows how the properties of QDs make them effective ingredients in biosensing applications Assesses the major challenges in integrating QDs in biosensing systems
Download or read book Spectral Sensing Research for Water Monitoring Applications and Frontier Science and Technology for Chemical Biological and Radiological Defense written by Dwight L. Woolard and published by World Scientific. This book was released on 2008 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides unique perspectives on both state-of-the-art hyperspectral techniques for the early-warning monitoring of water supplies against chemical, biological and radiological (CBR) contamination effects as well as the emerging spectroscopic science and technology base that will be used to support an array of CBR defense and security applications in the future. The technical content in this book lends itself to the non-traditional requirements for point and stand-off detection that have evolved out of the US joint services programs over many years. In particular, the scientific and technological work presented seeks to enable hyperspectral-based sensing and monitoring that is real-time; in-line; low in cost and labor; and easy to support, maintain and use in military- and security-relevant scenarios.
Download or read book Optical Biosensors written by Frances S. Ligler and published by Elsevier. This book was released on 2011-10-13 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Biosensors, Second Edition describes the principles of successful systems, examples of applications, and evaluates the advantages and deficiencies of each. It also addresses future developments on two levels: possible improvements in existing systems and emerging technologies that could provide new capabilities in the future. The book is formatted for ease of use and is therefore suitable for scientists and engineers, students and researcher at all levels in the field. Comprehensive analysis and review of the underlying principles by optical biosensors Updates and informs on all the latest developments and hot topic areas Evaluates current methods showing the advantages and disadvantages of various systems involved
Download or read book Fiber Optic Sensors and Applications written by Swee Chuan Tjin and published by MDPI. This book was released on 2020-12-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue focuses on all aspects of the recent research and development related to fiber optic sensors. The recent advances in fiber-based sensing technologies have enabled both fundamental studies and a wide spectrum of applications. The goal of this Special Issue is to bring attention to the most recent results in the field of fiber optic sensors, including new mechanisms, materials, processes, and applications.
Download or read book Nanoplasmonic Sensors written by Alexandre Dmitriev and published by Springer Science & Business Media. This book was released on 2012-07-31 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compendium of the finest research in nanoplasmonic sensing done around the world in the last decade. It describes basic theoretical considerations of nanoplasmons in the dielectric environment, gives examples of the multitude of applications of nanoplasmonics in biomedical and chemical sensing, and provides an overview of future trends in optical and non-optical nanoplasmonic sensing. Specifically, readers are guided through both the fundamentals and the latest research in the two major fields nanoplasmonic sensing is applied to – bio- and chemo-sensing – then given the state-of-the-art recipes used in nanoplasmonic sensing research.
Download or read book Hybrid Nanoplasmonic nanophotonic Devices for On chip Biochemical Sensing and Spectroscopy written by Maysamreza Chamanzar and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hybrid plasmonic-photonic structures were introduced as novel platforms for on-chip biochemical sensing and spectroscopy. By appropriate coupling of photonic and plasmonic modes, a hybrid architecture was realized that can benefit from the advantages of integrated photonics such as the low propagation loss, ultra-high Q modes, and robustness, as well as the advantages of nanoplasmonics such as extreme light localization, large sensitivities, and ultra-high field enhancements to bring about unique performance advantages for efficient on-chip sensing. These structures are highly sensitive and can effectively interact with the target biological and chemical molecules. It was shown that interrogation of single plasmonic nanoparticles is possible using a hybrid waveguide and microresonator-based structure, in which light is efficiently coupled from photonic structures to the integrated plasmonic structures. The design, implementation, and experimental demonstration of hybrid plasmonic-photonic structures for lab-on-chip biochemical sensing applications were discussed. The design goal was to achieve novel, robust, highly efficient, and high-throughput devices for on-chip sensing. The sensing scenarios of interest were label-free refractive index sensing and SERS. Nanofabrication processes were developed to realize the hybrid plasmonic-photonic structures. Silicon nitride was used as the material platform to realize the integrated photonic structure, and gold was used to realize plasmonic nanostructures. Special optical characterization setups were designed and implemented to test the performance of these nanoplasmonic and nanophotonic structures. The integration of the hybrid plasmonic-photonic structures with microfluidics was also optimized and demonstrated. The hybrid plasmonic-photonic-fluidic structures were used to detect different analytes at different concentrations. A complete course of research from design, fabrication, and characterization to demonstration of sensing applications was conducted to realize nanoplasmonic and integrated photonic structures. The novel structures developed in this research can open up new potentials for biochemical sensors with advanced on-chip functionalities and enhanced performances.
Download or read book Advanced Biosensors for Health Care Applications written by Dr. Inamuddin and published by Elsevier. This book was released on 2019-06-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. Describes advanced nanomaterials for biosensor applications Relates the properties of available nanomaterials to specific biomarkers applications Includes diagnosis and electrochemical studies based on biosensors Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies Describes novel strategies for developing a new class of assay systems to retrieve the desired health information
Download or read book Surface Plasmon Resonance Based Sensors written by Jiri Homola and published by Springer Science & Business Media. This book was released on 2006-08-18 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive treatment of the field of SPR sensors, in three parts. Part I introduces principles of surface plasmon resonance bio-sensors, electromagnetic theory of surface plasmons, theory of SPR sensors and molecular interactions at sensor surfaces. Part II examines the development of SPR sensor instrumentation and functionalization methods. Part III reviews applications of SPR biosensors in the study of molecules, and in environmental monitoring, food safety and medical diagnostics.
