Download or read book Sexual Reproduction in Animals and Plants written by Hitoshi Sawada and published by Springer. This book was released on 2014-02-07 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of the International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants, where many plant and animal reproductive biologists gathered to discuss their recent progress in investigating the shared mechanisms and factors involved in sexual reproduction. This now is the first book that reviews recent progress in almost all fields of plant and animal fertilization. It was recently reported that the self-sterile mechanism of a hermaphroditic marine invertebrate (ascidian) is very similar to the self-incompatibility system in flowering plants. It was also found that a male factor expressed in the sperm cells of flowering plants is involved in gamete fusion not only of plants but also of animals and parasites. These discoveries have led to the consideration that the core mechanisms or factors involved in sexual reproduction may be shared by animals, plants and unicellular organisms. This valuable book is highly useful for reproductive biologists as well as for biological scientists outside this field in understanding the current progress of reproductive biology.
Download or read book Rodent Malaria written by R. Killick-Kendrick and published by Elsevier. This book was released on 2012-12-02 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rodent Malaria reviews significant findings concerning malaria parasites of rodents, including their taxonomy, zoogeography, and evolution, along with life cycles and morphology; genetics and biochemistry; and concomitant infections. This volume is organized into eight chapters and begins by sketching out the history of the discovery of rodent as well as aspects of parasitology, immunology, and chemotherapy. These concepts are investigated two decades following Ignace Vincke's major discovery and Meir Yoeli's successful establishment of the method of cyclical transmission of the parasite. The following chapters focus on the taxonomy and systematics of the subgenus Vinckeia, with reference to the concepts of species and subspecies of animals and the degree to which they apply to malaria parasites, in particular to those of rodents. The discussion then shifts to how the rodent malaria parasites provide a unique insight into the subcellular organization of Plasmodium species, the use of rodent malaria as an experimental model to study immunological responses, and infectious agents that interact with malaria parasites. The book concludes with a chapter on malaria chemotherapy, with emphasis on the value of rodent malaria in antimalarial drug screening and the use of antimalarial drugs as biological probes. This book will be of interest to protozoologists and physicians as well as those from other disciplines including biochemistry, immunology, pharmacology, cell biology, and genetics.
Download or read book Genetic Transformation of the Malaria Parasite Plasmodium Berghei written by Melissa Ruth Van Dijk and published by . This book was released on 1997 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zsfassung in niederl. Sprache.
Download or read book Intra Erythrocytic Differentiation of Plasmodium Berghei written by Barend Mons and published by . This book was released on 1986 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Download or read book Characterization of and Immunization with a Population of Plasmodium Berghei Enriched in Merozoites written by Kenneth Wayne Saul and published by . This book was released on 1976 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on Intercurrent Plasmodium Berghei and Trypanosoma Lewisi Infections in Rats written by Azra Shahidi and published by . This book was released on 1964 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria Methods and Protocols written by Denise L. Doolan and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Plasmodium spp. parasite was identified as the causative agent of malaria in 1880, and the mosquito was identified as the vector in 1897. Despite subsequent efforts focused on the epidemiology, cell biology, immunology, molecular biology, and clinical manifestations of malaria and the Plasmodium parasite, there is still no licensed vaccine for the prevention of malaria. Physical barriers (bed nets, window screens) and chemical prevention methods (insecticides and mosquito repellents) intended to interfere with the transmission of the disease are not highly effective, and the profile of resistance of the parasite to chemoprophylactic and chemotherapeutic agents is increasing. The dawn of the new millennium has seen a resurgence of interest in the disease by government and philanthropic organizations, but we are still faced with compl- ities of the parasite, the host, and the vector, and the interactions among them. Malaria Methods and Protocols offers a comprehensive collection of protocols describing conventional and state-of-the-art techniques for the study of malaria, as well as associated theory and potential problems, written by experts in the field. The major themes reflected here include assessing the risk of infection and severity of disease, laboratory models, diagnosis and typing, molecular biology techniques, immunological techniques, cell biology techniques, and field applications.
Download or read book Parasitemia and Survival in Inbred Strains of Mice Infected with Plasmodium Berghei written by Joseph Greenberg and published by . This book was released on 1957 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Changing Patterns of Virulence in the Murine Malaria Parasite Plasmodium Berghei written by Soheir Mostafa El-Naggar and published by . This book was released on 1981 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Course of Infection with Plasmodium Berghei in Inbred CF 1 Mice and written by Ira Singer and published by . This book was released on 1954 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on Parasitemic Crisis in Plasmodium Berghei Infected Rats written by John Wesley Barnwell and published by . This book was released on 1980 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Erythrocytic Development of Plasmodium Berghei and Tissue Reactions to this Parasite written by Seth A. Obeng and published by . This book was released on 1952 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cellular Reactions to Infections with Plasmodium Berghei in the White Mouse and the Effects of Various Agents and Procedures on the Course of Infection written by Ira Singer and published by . This book was released on 1953 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oral and Nasal Infectivity and Immunogenicity of Plasmodium Berghei and Yoelii Sporozoites and Longevity of Plasmodium Falciparum Trophozoites and SchizontsMohammed written by Mohammed A. S. Alshahrani and published by . This book was released on 2017 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of the most problematic diseases that human being has ever confronted. The quest for an effective, robust vaccine has been going on for more than a century. The whole Plasmodium sporozoites vaccine strategy has proven to be the best approach for eliciting up to 70% protection and for up to 6 months after the last immunization. Most of the robust vaccines that we have nowadays against several microbiological organisms are given by either oral or nasal routes. Infectivity and immunogenicity of Plasmodium berghei ANKA and P. yoelii Nigeriensis sporozoites have never been tested against BALB/c or C57BL/6 mice after being inoculated via oral and nasal routes. Results of this study show that inoculation of sporozoites of the species P. berghei or P. yoelii into BALB/c or C57BL/6 mice are infective and immunogenic. Furthermore, there was a cross-reactivity between the two parasite species when tested against several synthetic peptides. These findings shed light on the importancy of the oral and nasal canal as routes for experimentations of the immunization regime.The large subunit vaccines development concentrated on the erythrocytic stage of malaria parasites has generated disappointing results, Therefore, there is currently a renewed focus on the whole Plasmodium blood stage parasite. In the current study, we aim to assess whether it is possible to obtain a living, whole entity of the blood stage that can be kept alive under minimal conditions and ideally without cryopreservation which could be used in developing countries a live, whole organism blood stage vaccine. we examined the viability as well as the invasiveness potency of Plasmodium falciparum parasites after being isolated from RBCs and incubated at 37 ̊C and RT. We showed here that the Plasmodium parasites were able to retain their invasiveness for 16 days despite being incubated at far lower temperature (at RT) than the optimal temperature. Also we showed that the Plasmodium falciparum at late trophozoites and early schizonts were capable to remain viable for 10 months (nearly 300 days) outside the RBCs at RT.The diversity of malaria disease in animals is larger ecologically and systematically than we commonly expected. The Plasmodium genus is a member within the order Haemosporidia, is consider one of the largest genus in this order, and currently encompass more than 250 Plasmodium species. Most of these species have only been defined morphologically. Most animals show simultaneous infections with more than one species of Plasmodium and most species descriptions originated from such multiple infections, which prevents the molecular characterization of most Plasmodium species as sequence data cannot be assigned to particular morphospecies. We have successfully developed genus- and species-specific FISH probes based on the small and large ribosomal subunit for Plasmodium falciparum as a proof of concept for the interrogation of animal morphospecies of Plasmodium parasites. This will open up the future for molecular screening of animal malaria, not only in blood samples but also in fecal samples, and might lead to a better understanding of the epidemiology and ecology of malaria parasites in many animal species in temperate and in tropical regions.
Download or read book Saving Lives Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.
Download or read book Breaking the cycle attacking the malaria parasite in the liver written by Ute Frevert and published by Frontiers Media SA. This book was released on 2016-01-06 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Medical Centre’s and Sanaria's derived chemoprophylaxis with sporozoites vaccines. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria.
